Positron emission tomography quantification of [11C]-DASB binding to the human serotonin transporter: Modeling strategies

Journal of Cerebral Blood Flow and Metabolism

Volumn 21, Issue 11, 2001, Pages 1342-1353

  Ginovart, N ^a   Wilson, A A ^a   Meyer, J H ^a   Hussey, D ^a   Houle, S ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Human; Modeling; PET; Serotonin transporter; 11C DASB

Indexed keywords

BENZONITRILE; SEROTONIN TRANSPORTER;

ACCURACY; ADULT; ARTICLE; BINDING KINETICS; CEREBELLUM; COMPARTMENT MODEL; CURVE FITTING; FEMALE; HUMAN; LIGAND BINDING; MALE; MATHEMATICAL ANALYSIS; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE ASSAY; REFERENCE VALUE; SIMULATION;

EID: 0035200087     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200111000-00010     Document Type: Article

References (49)

1. 11C]NNC 112 in humans: Validation and reproducibility
2. 123I] IDAM
3. A new look at the statistical model identification
4. 3H] paroxetine binding to serotonin uptake sites in human brain tissue
5. Modeling alternatives for cerebral carbon-11-iomazenil kinetics
6. 11C](+)McN-5652: Assessment of methods
7. Requirements and implementation of a flexible kinetic modeling tool
8. Parameters estimation in positron emission tomography
9. 18F]cyclofoxy and positron emission tomography
10. 3]imipramine binding sites in control and parkinsonian brains
11. r25I] ADAM to serotonin transporters in rat brain
12. 3H] Paroxetine
13. Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides
14. 2-dopamine receptors studied by PET: A comparison to the equilibrium analysis
15. 11C]WAY-100635 for PET
16. 11C]cyanoimipramine
17. 11C]DASB
18. 11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites
19. 11C]raclopride binding
20. 11C]flumazenil and kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography
21. 123I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters
22. Simplified reference tissue model for PET receptor studies
23. 11C]raclopride studies
24. 3H]paroxetine binding, a marker of serotonin uptake sites
25. 123I] iomazenil binding to benzodiazepine receptors in nonhuman primates: I. Kinetic modeling of single bolus experiments
26. 11C]-sertraline
27. Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age
28. Evaluation of the Karolinska new positron camera: The Scanditronix PC2048-15B
29. 11C-methyl]-(-)-Cocaine PET studies in human subjects
30. An algorithm for least-squares estimation on non-linear parameters
31. Pyrroloisoquinoline antidepressants. 3. A focus on serotonin
32. A JAVA environment for medical image analysis: Initial application for brain PET quantification
33. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography
34. 123I]IDAM, 5-iodo-2-((2-((dimethylamino) methyl)phenyl)thio)benzyl alcohol
35. 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): An improved serotonin transporter ligand
36. 11C]McN 5652
37. 11C]Flumazenil
38. Modeling of carbon-11-acetate kinetics by simultaneously fitting data from multiple ROIs coupled by common parameters
39. Estimating the dimension of a model
40. 11C]fluoxetine in a monkey brain
41. 11C]venlafaxine: Serotonin uptake inhibition, biodistribution and binding in living pig brain
42. Tritiated imipramine binding sites are decreased in the frontal cortex of suicides
43. Automated three-dimensional registration of magnetic resonance and positron emission tomography brain images by multiresolution optimisation of voxel similarity measures
44. 18F]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET
45. 11C]McN5652
46. 11C]MDL 100,907
47. Radiosynthesis of carbon-11 labelled N-Methyl-2-(arylthio)benzylamines: Potential radiotracers for the serotonin reuptake receptor
48. 11C]-labeled 2-(phenylthio)araalkylamines
49. 11C]-iodomethane: A remarkably simple captive solvent method