PET evaluation of novel radioflourinated reboxetine analogs as norepinephrine transporter probes in the monkey brain

Synapse

Volumn 53, Issue 2, 2004, Pages 57-67

  Schou, Magnus ^a   Halldin, Christer ^a   Sóvágó, Judit ^a   Pike, Victor W ^b   Hall, Håkan ^a   Gulyás, Balázs ^a   Mozley, P David ^c   Dobson, David ^c   Shchukin, E ^a   Innis, Robert B ^b   Farde, Lars ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

FMeNER; FMeNER D 2; Monkey; Norepinephrine transporter; PET; Reboxetine

Indexed keywords

2 [ALPHA (2 FLUOROMETHOXYPHENOXY)BENZYL]MORPHOLINE F 18; 2 [ALPHA (2 FLUOROMETHOXYPHENOXY)BENZYL]MORPHOLINE H 2; BROMINE DERIVATIVE; BROMOFLUOROMETHANE; CARBON 11; DESIPRAMINE; DEUTERIUM; DRUG METABOLITE; FLUORINE 18; FLUOROMETHANE F 18; MORPHOLINE DERIVATIVE; NORADRENALIN TRANSPORTER; NORETHYLREBOXETINE C 11; RADIOLIGAND; REBOXETINE; REBOXETINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BRAIN MAPPING; BRAIN REGION; CONTROLLED STUDY; DEFLUORINATION; DRUG PURITY; HUMAN; HUMAN TISSUE; MONKEY; NEUROIMAGING; NOISE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOCHEMISTRY;

ANIMALS; BRAIN; FEMALE; FLUORINE RADIOISOTOPES; MACACA FASCICULARIS; MORPHOLINES; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROTEIN BINDING; SYMPORTERS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 19244366615     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.20031     Document Type: Article

References (20)

1. Brunello NMJ, Kasper S, Leonard B, Montgomery S, Nelson J, Paykel E, Versiani M, Racagni G. 2002. The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacol 12:461-475.
2. 3H]Nisoxetine binding sites in the cat brain: an autoradiographic study. Neuroscience 69:259-270.
3. Ding Y, Lin K, Garza V, Carter P, Alexoff D, Logan J, Shea C, Xu Y, King P. 2003. Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs. Synapse 50:345-352.
4. 3H]mazindol autoradiography. J Comp Neurol 304:419-434.
5. 2 for MAO B mapping. J Nucl Med 36:1255-1262.
6. Hall H, Halldin C, Farde L, Sedvall G. 1998. Whole hemisphere autoradiography of the postmortem human brain. Nucl Med Biol 25:715-719.
7. Halldin C, Swahn C-G, Farde L, Sedvall G. 1995. Radioligand disposition and metabolism. In: Comar D, editor. PET for drug development and evaluation. Dordrecht: Klüwer Academic Publishers. p 55-65.
8. 1-dopamine receptors. J Nucl Med 39:2061-2068.
9. Hamill T, Burns H, Eng W, Ryan C, Krause S, Gibson R, Hargreaves R. 2002. An improved fluorine-18 labeled neurokinin-1 receptor ligand. Mol Imaging Biol 4(Suppl 1):S34.
10. Hargreaves R. 2002. Imaging substance P receptors (NK1) in the living human brain using positron emission tomography. J Clin Psychiatry 63(Suppl 11):18-24.
11. 18F]fluorocholine. Appl Radiat Isot 57:347-352.
12. 11C]NNC 756 as new radioligands for the D1-Dopamine receptor. Psychopharmacology 113:149-156.
13. Klimek V, Stockmeier C, Overholser J, Meltzer H, Kalka S, Dilley G, Ordway G. 1997. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J Neurosci 17:8451-8458.
14. 18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse 47:45-53.
15. 11C]MeNER. Nucl Med Biol 30:707-714.
16. Spencer T, Heiligenstein J, Biederman J, Faries D, Kratochvil C, Conners C, Potter W. 2002. Results from 2 proof-of-concept, placebo-controlled studies of atomoxetine in children with attention-deficit/hyperactivity disorder. J Clin Psychiatry 63:1140-1147.
17. Tejani-Butt S. 1992. [3H]Nisoxetine: A radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding. J Pharm Exp Ther 260:427-436.
18. Tejani-Butt S, Yang J, Zaffar H. 1993. Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease. Brain Res 631:147-150.
19. Wienhard K, Dahlbom M, Eriksson L, Michel C, Bruckbauer T, Pietrzyk U, Heiss W. 1994. The ECAT Exact HR: Performance of a new high resolution positron scanner. J Comput Assist Tomogr 18:110-118.
20. Wilson A, Johnson D, Mozley P, Hussey D, Ginovart N, Nobrega J, Garcia A, Meyer J, Houle S. 2003. Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter. Nucl Med Biol 30:85-92.