Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 (N-fluoroalkyl) labeled 2β-carbomethoxy-3β-(4′-(3- furyl)phenyl)-tropanes and -nortropanes: Candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography

Journal of Medicinal Chemistry

Volumn 48, Issue 22, 2005, Pages 7080-7083

  Stehouwer, Jeffrey S ^a   Plisson, Christophe ^a   Jarkas, Nachwa ^a   Zeng, Fanxing ^a   Voll, Ronald J ^a   Williams, Larry ^a   Martarello, Laurent ^a   Votaw, John R ^a   Tamagnan, Gilles ^b   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2BETA CARBOMETHOXY 3BETA [4' (3 FURYL)PHENYL]NORTROPANE C 11; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; CARBON 11; DOPAMINE TRANSPORTER; FLUORINE 18; N (2 FLUOROETHYL) 2BETA CARBOMETHOXY 3BETA [4' (3 FURYL)PHENYL]NORTROPANE F 18; N (3 FLUOROPROPYL) 2BETA CARBOMETHOXY 3BETA [4' (3 FURYL)PHENYL]NORTROPANE; N (4 FLUOROBUTYL) 2BETA CARBOMETHOXY 3BETA [4' (3 FURYL)PHENYL]NORTROPANE; N METHYL 2BETA CARBOMETHOXY 3BETA [4' (3 FURYL)PHENYL]TROPANE C 11; NORADRENALIN TRANSPORTER; NORTROPANE DERIVATIVE; SEROTONIN TRANSPORTER; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CAUDATE NUCLEUS; CELL STRAIN HEK293; CEREBELLUM; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYNOMOLGUS MONKEY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MEDULLA OBLONGATA; MESENCEPHALON; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIMATE; PUTAMEN; RHESUS MONKEY; THALAMUS;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CARBON RADIOISOTOPES; CELL LINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FLUORINE RADIOISOTOPES; FURANS; HUMANS; LIGANDS; MACACA FASCICULARIS; MACACA MULATTA; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; NORTROPANES; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 27444439092     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0504095     Document Type: Article

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