Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2′- amino-4′-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands

Journal of Medicinal Chemistry

Volumn 51, Issue 2, 2008, Pages 271-281

  Jarkas, Nachwa ^a   Voll, Ronald J ^a   Williams, Larry ^a   Votaw, John R ^a   Owens, Mike ^b   Goodman, Mark M ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLAMINE DERIVATIVE; CARBON 11; CITALOPRAM; CONTRAST MEDIUM; DOPAMINE TRANSPORTER; HALIDE; IODINE 123; METHYL IODIDE; N,N DIMETHYL 2 (2' AMINO 4' HYDROXYMETHYLPHENYLTHIO) 5 BROMOBENZYLAMINE; N,N DIMETHYL 2 (2' AMINO 4' HYDROXYMETHYLPHENYLTHIO) 5 FLUOROBENZYLAMINE; N,N DIMETHYL 2 (2' AMINO 4' HYDROXYMETHYLPHENYLTHIO) 5 IODOBENZYLAMINE; N,N DIMETHYL 2 (2' AMINO 4' HYDROXYMETHYLPHENYLTHIO)BENZYLAMINE DERIVATIVE; NORADRENALIN TRANSPORTER; PHENYLTHIOPHENYL; RADIOLIGAND; SEROTONIN TRANSPORTER; SEROTONIN TRANSPORTER LIGAND; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN REGION; CEREBELLUM; DRUG BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MESENCEPHALON; METHYLATION; MONKEY; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SUBSTITUTION REACTION;

ANIMALS; BENZYLAMINES; BINDING, COMPETITIVE; BRAIN; CARBON RADIOISOTOPES; CELL LINE; HUMANS; LIGANDS; MACACA FASCICULARIS; MALE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SULFIDES; TISSUE DISTRIBUTION;

EID: 38349132686     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0707929     Document Type: Article

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