Synthesis and biological evaluation of [11C]talopram and [ 11C]talsupram: Candidate PET ligands for the norepinephrine transporter

Nuclear Medicine and Biology

Volumn 31, Issue 6, 2004, Pages 705-718

  McConathy, Jonathan ^a   Owens, Michael J ^a   Kilts, Clinton D ^a   Malveaux, Eugene J ^a   Camp, Vernon M ^a   Votaw, John R ^a   Nemeroff, Charles B ^a   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carbon 11; Monoamine transporter ligands; Norepinephrine transporter; Positron emission tomography; Talopram; Talsupram

Indexed keywords

1,3 DIHYDRO 1,1 DIMETHYL 3 PHENYLBENZO[C]FURAN; 1,3 DIHYDRO 1,1 DIMETHYL 3 PHENYLBENZO[C]THIOPHENE; 1,3 DIHYDRO 3,3 DIMETHYL 1 PHENYLBENZO[C]FURAN 1 PROPANAMINE; 1,3 DIHYDRO 3,3 DIMETHYL 1 PHENYLBENZO[C]THIOPHENE 1 PROPANAMINE; 1,3 DIHYDRO N (TERT BUTOXYCARBONYL) N,3,3 TRIMETHYL 1 PHENYLBENZO[C] THIOPHENE 1 PROPANAMINE; 1,3 DIHYDRO N MENTHOXYACETYL N,3,3 TRIMETHYL 1 PHENYLBENZO[C]THIOPHENE 1 PROPANAMINE; 1,3 DIHYDRO N,3,3 TRIMETHYL 1 PHENYLBENZO[C]FURAN 1 PROPANAMINE; 1,3 DIHYDRO N,3,3 TRIMETHYL 1 PHENYLBENZO[C]THIOPHENE 1 PROPANAMINE; 1,3 DIHYDRO N,N,3,3 DIMETHYL N (2 FLUOROETHYL) 1 PHENYLBENZO[C]FURAN 1 PROPANAMINE; 1,3 DIHYDRO N,N,3,3 TETRAMETHYL 1 PHENYLBENZOTHIOPHENE 1 PROPANAMINE; 2 CHLORO ALPHA,ALPHA DIMETHYLBENZENEMETHANOL; BENZENE DERIVATIVE; BENZYL 2 CHLORO ALPHA,ALPHA DIMETHYLBENZYL SULFIDE; BENZYL DERIVATIVE; FURAN DERIVATIVE; LIGAND; METHANOL DERIVATIVE; NORADRENALIN TRANSPORTER; TALOPRAM; TALSUPRAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ISOTOPE LABELING; LIGAND BINDING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RHESUS MONKEY;

ALKYLATION; ANIMALS; BENZOFURANS; BINDING, COMPETITIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; INDICATORS AND REAGENTS; LIGANDS; MACACA MULATTA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; POSITRON-EMISSION TOMOGRAPHY; PROPYLAMINES; RADIOPHARMACEUTICALS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; SYMPORTERS; THIOPHENES; TISSUE DISTRIBUTION;

EID: 3042789525     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2003.05.001     Document Type: Article

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