2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): An improved serotonin transporter ligand

Nuclear Medicine and Biology

Volumn 27, Issue 3, 2000, Pages 249-254

  Oya, Shunichi ^a   Choi, Seok Rye ^a   Hou, Catherine ^a   Mu, Mu ^a   Kung, Mei Ping ^a   Acton, Paul D ^a   Siciliano, Michael ^a   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antidepressants; Brain imaging agents; Radioiodination; SPECT

Indexed keywords

2 ((2 ((DIMETHYLAMINO)METHYL)PHENYL)THIO) 5 IODOPHENYLAMINE; ANTIDEPRESSANT AGENT; IODINE 125; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BABOON; BINDING SITE; BRAIN; CENTRAL NERVOUS SYSTEM; DEPRESSION; ISOTOPE LABELING; LIGAND BINDING; MENTAL DISEASE; NONHUMAN; RADIOIODINATION; RAT; SEROTONINERGIC SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; CARRIER PROTEINS; CINANSERIN; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; IODINE RADIOISOTOPES; LIGANDS; LLC-PK1 CELLS; MAGNETIC RESONANCE IMAGING; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MEMBRANES; NERVE TISSUE PROTEINS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RADIOPHARMACEUTICALS; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPECTROPHOTOMETRY, INFRARED; SWINE; SYMPORTERS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0034077167     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00084-6     Document Type: Article

References (24)

1. 123I]IDAM. Eur. J. Nucl. Med. 26:1999;854-861.
2. 123I]ODAM. Eur. J. Nucl. Med. 26:1999;1359-1362.
3. 125I]5-Iodo-6-nitroquipazine A potent and selective ligand for the 5-hydroxytryptamine uptake complex II in vivo studies in rats . Brain Res. 619:1993;236-246.
4. Eckelman W.C. Sensitivity of new radiopharmaceuticals. Nucl. Med. Biol. 25:1998;169-173.
5. Frazer A. Antidepressants. J. Clin. Psychiatry. 6:1997;9-25.
6. Gu H., Wall S.C., Rudnick G. Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J. Biol. Chem. 269:1994;7124-7130.
7. Hou C., Kung M. P., Mu M. and Kung H. F. (1998) Evaluation of IPT and Re-TRODAT-1 in cell lines expressing monoamine transporters [abstract 241.21]. Society for Neuroscience Program 28th Annual Meeting, Los Angeles, CA 112.
8. Jagust W.J., Eberling J.L., Biegon A., Taylor S.E., VanBrocklin H.F., Jordon S., Hanrahan S.M., Roberts J.A., Brennan K.M., Mathis C.A. Iodine-123-5-iodo-6-nitroquipazine SPECT radiotracer to image the serotonin transporter . J. Nucl. Med. 37:1996;1207-1214.
9. 123I]IDAM as a novel SPECT tracer for serotonin transporters. Eur. J. Nucl. Med. 26:1999;844-853.
10. Maryanoff E.M., Vaught J.L., Shank R.P., McComsey D.F., Costanzo M.J., Nortey S.O. Pyrroloisoquinoleines antidepressants. 3. A focus on serotonin. J. Med. Chem. 33:1990;2793-2797.
11. Mathis C.A., Biegon A., Taylor S.E., Enas J.D., Hanrahan S.M. [I-125]5-Iodo-6-nitro-2-piperazinylquinoline A potent and selective ligand for the serotonin uptake complex . Eur. J. Pharmacol. 210:1992;103-104.
12. 125I]5-Iodo-6-nitroquipazine A potent and selective ligand for the 5-hydroxytryptamine uptake complex I in vitro studies . Brain Res. 619:1993;229-235.
13. Owens M.J., Nemeroff C.B. Role of serotonin in the pathophysiology of depression Focus on the serotonin transporter . Clin. Chem. 40:1994;288-295.
14. 123I] IDAM, 5-Iodo-2-((2-((dimethylamino) methyl)phenyl)thio)benzyl alcohol . J. Med. Chem. 42:1999;333-335.
15. Pike V.W. Radioligands for PET studies of central 5-HT receptors and re-uptake sites - Current status. Nucl. Med. Biol. 22:1995;1011-1018.
16. Schindlbauer H. Reactions with dimethylformamide. I. Synthesis of carboxylic acid dimethylamides. Monatsh. Chem. 99:1968;1799-1807.
17. Staley J.K., Malison R.T., Innis R.B. Imaging of the serotonergic system Interactions of neuroanatomical and functional abnormalities of depression . Biol. Psychiatry. 44:1998;534-549.
18. Suehiro M., Musachio J.L., Dannals R.F., Mathews W.B., Ravert H.T., Scheffel U., Wagner H.N. An improved method for the synthesis of radiolabeled MCN5652 via thioester precursors. Nucl. Med. Biol. 22:1995;543-545.
19. Suehiro M., Scheffel U., Dannals R.F., Ravert H.T., Ricaurte G.A., Wagner H.N. A PET radiotracer for studying serotonin uptake sites Carbon-11-McN-5652Z . J. Nucl. Med. 34:1993;120-127.
20. Szabo Z., Kao P. F., Marenco S., Suehiro M., Ravert H. T., Mathews W. B., Kim S. E., Wong D. F., Dannals R. F., Scheffel U. and Wagner H. N. Jr. (1994) Imaging 5-HT transporter sites in human brain with C-11 MCN5652. J. Nucl. Med. 35(suppl. 85).
21. 11C]MCN5652 extraction of characteristic images by artificial neural-network analysis. Behav. Brain Res. 73:1995;221-224.
22. 11C](+)MCN5652. Synapse. 20:1995;37-43.
23. Szabo Z., Mohamadiyeh M., Scheffel U., Matthews W. B., Ravert H. T., Szabo K., Palmon S. and Dannals R. F. (1996) Impulse-response function and kinetic-model of C-11-labeled (+)MCN5652. J. Nucl. Med. 37(suppl. 125).
24. 11C]McN5652. J. Cereb. Blood Flow Metab. 15:1995;798-805.