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Volumn 12, Issue 6, 2002, Pages 503-511

The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development

Author keywords

Molecular imaging; Positron emission tomography; Single photon emission computed tomography

Indexed keywords

ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BENZAMIDE; BENZODIAZEPINE DERIVATIVE; BUTYROPHENONE; CITALOPRAM; CLONAZEPAM; CLOZAPINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; FLUMAZENIL; FLUPENTIXOL; HALOPERIDOL; METHYLPHENIDATE; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; NEW DRUG; OLANZAPINE; PAROXETINE; PINDOLOL; QUETIAPINE; RACLOPRIDE; RISPERIDONE; SEROTONIN 1A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; SERTINDOLE; TRACER; UNINDEXED DRUG; ZIPRASIDONE; ZOTEPINE;

EID: 0036895218     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(02)00099-8     Document Type: Article
Times cited : (108)

References (78)
  • 1
    • 0030027545 scopus 로고    scopus 로고
    • Central benzodiazepine receptor occupancy by zolpidem in the human brain as assessed by positron emission tomography
    • Abadie P., Rioux P., Scatton B., Zarifian E., Barre L., Patat A., Baron J.C. Central benzodiazepine receptor occupancy by zolpidem in the human brain as assessed by positron emission tomography. Eur. J. Pharmacol. 295:1996;35-44.
    • (1996) Eur. J. Pharmacol. , vol.295 , pp. 35-44
    • Abadie, P.1    Rioux, P.2    Scatton, B.3    Zarifian, E.4    Barre, L.5    Patat, A.6    Baron, J.C.7
  • 4
    • 1942458169 scopus 로고    scopus 로고
    • Pindolol binding to 5-HT1A receptors in the human brain confirmed with positron emission tomography
    • Andree B., Thorberg S.O., Halldin C., Farde L. Pindolol binding to 5-HT1A receptors in the human brain confirmed with positron emission tomography. Psychopharmacology (Berl.). 144:1999;303-305.
    • (1999) Psychopharmacology (Berl.) , vol.144 , pp. 303-305
    • Andree, B.1    Thorberg, S.O.2    Halldin, C.3    Farde, L.4
  • 9
    • 0033946969 scopus 로고    scopus 로고
    • Striatal and temporal cortical D2/D3 receptor occupancy by olanzapine and sertindole in vivo: A [123I]epidepride single photon emission tomography (SPET) study
    • Bigliani V., Mulligan R.S., Acton P.D., Ohlsen R.I., Pike V.W., Ell P.J., Gacinovic S., Kerwin R.W., Pilowsky L.S. Striatal and temporal cortical D2/D3 receptor occupancy by olanzapine and sertindole in vivo: a [123I]epidepride single photon emission tomography (SPET) study. Psychopharmacologia. 150:2000;132-140.
    • (2000) Psychopharmacologia , vol.150 , pp. 132-140
    • Bigliani, V.1    Mulligan, R.S.2    Acton, P.D.3    Ohlsen, R.I.4    Pike, V.W.5    Ell, P.J.6    Gacinovic, S.7    Kerwin, R.W.8    Pilowsky, L.S.9
  • 10
    • 0032817821 scopus 로고    scopus 로고
    • In vivo occupancy of striatal and temporal cortical D2/D3 dopamine receptors by typical antipsychotic drugs. [123I]Epidepride single photon emission tomography (SPET) study
    • Bigliani V., Mulligan R.S., Acton P.D., Visvikis D., Ell P.J., Stephenson C., Kerwin R.W., Pilowsky L.S. In vivo occupancy of striatal and temporal cortical D2/D3 dopamine receptors by typical antipsychotic drugs. [123I]Epidepride single photon emission tomography (SPET) study. Br. J. Psychiatry. 175:1999;231-238.
    • (1999) Br. J. Psychiatry , vol.175 , pp. 231-238
    • Bigliani, V.1    Mulligan, R.S.2    Acton, P.D.3    Visvikis, D.4    Ell, P.J.5    Stephenson, C.6    Kerwin, R.W.7    Pilowsky, L.S.8
  • 11
    • 0031685344 scopus 로고    scopus 로고
    • Possible serotonergic mechanisms underlying the antidepressant and anti-obsessive-compulsive disorder responses
    • Blier P., de Montigny C. Possible serotonergic mechanisms underlying the antidepressant and anti-obsessive-compulsive disorder responses. Biol. Psychiatry. 44:1998;313-323.
    • (1998) Biol. Psychiatry , vol.44 , pp. 313-323
    • Blier, P.1    De Montigny, C.2
  • 12
    • 0028985379 scopus 로고
    • Dopamine D2 receptor blockade in vivo with the novel antipsychotics risperidone and remoxipride - An 123I-IBZM single photon emission tomography (SPET) study
    • Busatto G.F., Pilowsky L.S., Costa D.C., Ell P.J., Verhoeff N.P., Kerwin R.W. Dopamine D2 receptor blockade in vivo with the novel antipsychotics risperidone and remoxipride - an 123I-IBZM single photon emission tomography (SPET) study. Psychopharmacologia. 117:1995;55-61.
    • (1995) Psychopharmacologia , vol.117 , pp. 55-61
    • Busatto, G.F.1    Pilowsky, L.S.2    Costa, D.C.3    Ell, P.J.4    Verhoeff, N.P.5    Kerwin, R.W.6
  • 13
    • 0026775521 scopus 로고
    • Regionally specific effects of atypical antipsychotic drugs on striatal fos expression: The nucleus accumbens shell as a locus of antipsychotic action
    • Deutch A.Y., Lee M.C., Iadarola M.J. Regionally specific effects of atypical antipsychotic drugs on striatal fos expression: the nucleus accumbens shell as a locus of antipsychotic action. Mol. Cell. Neurosci. 3:1992;332-341.
    • (1992) Mol. Cell. Neurosci. , vol.3 , pp. 332-341
    • Deutch, A.Y.1    Lee, M.C.2    Iadarola, M.J.3
  • 17
    • 0026718710 scopus 로고
    • Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects
    • Farde L., Nordstrom A.L., Wiesel F.A., Pauli S., Halldin C., Sedvall G. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch. Gen. Psychiatry. 49:1992;538-544.
    • (1992) Arch. Gen. Psychiatry , vol.49 , pp. 538-544
    • Farde, L.1    Nordstrom, A.L.2    Wiesel, F.A.3    Pauli, S.4    Halldin, C.5    Sedvall, G.6
  • 18
    • 0028798102 scopus 로고
    • Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients
    • Farde L., Nyberg S., Oxenstierna G., Nakashima Y., Halldin C., Ericsson B. Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients. J. Clin. Psychopharmacol. 15:1995;19S-23S.
    • (1995) J. Clin. Psychopharmacol. , vol.15
    • Farde, L.1    Nyberg, S.2    Oxenstierna, G.3    Nakashima, Y.4    Halldin, C.5    Ericsson, B.6
  • 19
    • 0030609108 scopus 로고    scopus 로고
    • A PET study of [C-11]FLB 457 binding to extrastriatal D-2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients
    • Farde L., Suhara T., Nyberg S., Karlsson P., Nakashima Y., Hietala J., Halldin C. A PET study of [C-11]FLB 457 binding to extrastriatal D-2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients. Psychopharmacology (Berl.). 133:1997;396-404.
    • (1997) Psychopharmacology (Berl.) , vol.133 , pp. 396-404
    • Farde, L.1    Suhara, T.2    Nyberg, S.3    Karlsson, P.4    Nakashima, Y.5    Hietala, J.6    Halldin, C.7
  • 22
    • 0011799357 scopus 로고    scopus 로고
    • In vivo molecular imaging: Ligand development and research applications
    • C. Nemeroff. Philadelphia: Lippincott, Williams & Wilkins
    • Fuyita M., Innis R.B. In vivo molecular imaging: ligand development and research applications. Nemeroff C. Neuropsychopharmacology, The Fifth Generation of Progress. 2002;411-425 Lippincott, Williams & Wilkins, Philadelphia.
    • (2002) Neuropsychopharmacology, The Fifth Generation of Progress , pp. 411-425
    • Fuyita, M.1    Innis, R.B.2
  • 23
    • 0031060716 scopus 로고    scopus 로고
    • Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine
    • Gatley S.J., Volkow N.D., Gifford A.N., Ding Y.S., Logan J., Wang G.J. Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. Biochem. Pharmacol. 53:1997;43-52.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 43-52
    • Gatley, S.J.1    Volkow, N.D.2    Gifford, A.N.3    Ding, Y.S.4    Logan, J.5    Wang, G.J.6
  • 25
    • 0031963279 scopus 로고    scopus 로고
    • Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia
    • Gefvert O., Bergstrom M., Langstrom B., Lundberg T., Lindstrom L., Yates R. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacologia. 135:1998;119-126.
    • (1998) Psychopharmacologia , vol.135 , pp. 119-126
    • Gefvert, O.1    Bergstrom, M.2    Langstrom, B.3    Lundberg, T.4    Lindstrom, L.5    Yates, R.6
  • 27
    • 0032580805 scopus 로고    scopus 로고
    • N-[11C]Methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic
    • Hagberg G., Gefvert O., Bergstrom M., Wieselgren I.M., Lindstrom L., Wiesel F.A., Langstrom B. N-[11C]Methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic. Psychiatry Res. 82:1998;147-160.
    • (1998) Psychiatry Res. , vol.82 , pp. 147-160
    • Hagberg, G.1    Gefvert, O.2    Bergstrom, M.3    Wieselgren, I.M.4    Lindstrom, L.5    Wiesel, F.A.6    Langstrom, B.7
  • 28
    • 0034931817 scopus 로고    scopus 로고
    • Brain radioligands - State of the art and new trends
    • Halldin C., Gulyas B., Langer O., Farde L. Brain radioligands - state of the art and new trends. Q. J. Nucl. Med. 45:2001;139-152.
    • (2001) Q. J. Nucl. Med. , vol.45 , pp. 139-152
    • Halldin, C.1    Gulyas, B.2    Langer, O.3    Farde, L.4
  • 29
    • 0029026941 scopus 로고
    • The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: A PET study
    • Kapur S., Remington G., Zipursky R.B., Wilson A.A., Houle S. The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study. Life Sci. 57:1995;PL103-PL107.
    • (1995) Life Sci. , vol.57
    • Kapur, S.1    Remington, G.2    Zipursky, R.B.3    Wilson, A.A.4    Houle, S.5
  • 30
    • 0035094264 scopus 로고    scopus 로고
    • Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis
    • Kapur S., Seeman P. Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: a new hypothesis. Am. J. Psychiatry. 158:2001;360-369.
    • (2001) Am. J. Psychiatry , vol.158 , pp. 360-369
    • Kapur, S.1    Seeman, P.2
  • 31
    • 0034025771 scopus 로고    scopus 로고
    • Relationship between dopamine D(2) occupancy, clinical response, and side effects: A double-blind PET study of first-episode schizophrenia
    • Kapur S., Zipursky R., Jones C., Remington G., Houle S. Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am. J. Psychiatry. 157:2000;514-520.
    • (2000) Am. J. Psychiatry , vol.157 , pp. 514-520
    • Kapur, S.1    Zipursky, R.2    Jones, C.3    Remington, G.4    Houle, S.5
  • 32
    • 0034091239 scopus 로고    scopus 로고
    • A positron emission tomography study of quetiapine in schizophrenia: A preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy
    • Kapur S., Zipursky R., Jones C., Shammi C.S., Remington G., Seeman P. A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy. Arch. Gen. Psychiatry. 57:2000;553-559.
    • (2000) Arch. Gen. Psychiatry , vol.57 , pp. 553-559
    • Kapur, S.1    Zipursky, R.2    Jones, C.3    Shammi, C.S.4    Remington, G.5    Seeman, P.6
  • 33
    • 0032982714 scopus 로고    scopus 로고
    • Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia
    • Kapur S., Zipursky R.B., Remington G. Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia. Am. J. Psychiatry. 156:1999;286-293.
    • (1999) Am. J. Psychiatry , vol.156 , pp. 286-293
    • Kapur, S.1    Zipursky, R.B.2    Remington, G.3
  • 35
    • 0031596816 scopus 로고    scopus 로고
    • Sertindole and dopamine D2 receptor occupancy in comparison to risperidone, clozapine and haloperidol - A 123I-IBZM SPECT study
    • Kasper S., Tauscher J., Kufferle B., Barnas C., Hesselmann B., Asenbaum S., Podreka I., Brucke T. Sertindole and dopamine D2 receptor occupancy in comparison to risperidone, clozapine and haloperidol - a 123I-IBZM SPECT study. Psychopharmacologia. 136:1998;367-373.
    • (1998) Psychopharmacologia , vol.136 , pp. 367-373
    • Kasper, S.1    Tauscher, J.2    Kufferle, B.3    Barnas, C.4    Hesselmann, B.5    Asenbaum, S.6    Podreka, I.7    Brucke, T.8
  • 37
    • 0030770818 scopus 로고    scopus 로고
    • Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels
    • Knable M.B., Heinz A., Raedler T., Weinberger D.R. Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels. Psychiatry Res. 75:1997;91-101.
    • (1997) Psychiatry Res. , vol.75 , pp. 91-101
    • Knable, M.B.1    Heinz, A.2    Raedler, T.3    Weinberger, D.R.4
  • 38
    • 0030781165 scopus 로고    scopus 로고
    • IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol
    • Kufferle B., Tauscher J., Asenbaum S., Vesely C., Podreka I., Brucke T., Kasper S. IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol. Psychopharmacologia. 133:1997;323-328.
    • (1997) Psychopharmacologia , vol.133 , pp. 323-328
    • Kufferle, B.1    Tauscher, J.2    Asenbaum, S.3    Vesely, C.4    Podreka, I.5    Brucke, T.6    Kasper, S.7
  • 39
    • 0034947217 scopus 로고    scopus 로고
    • Higher occupancy of muscarinic receptors by olanzapine than risperidone in patients with schizophrenia. A[123I]-IDEX SPECT study
    • Lavalaye J., Booij J., Linszen D.H., Reneman L., van Royen E.A. Higher occupancy of muscarinic receptors by olanzapine than risperidone in patients with schizophrenia. A[123I]-IDEX SPECT study. Psychopharmacologia. 156:2001;53-57.
    • (2001) Psychopharmacologia , vol.156 , pp. 53-57
    • Lavalaye, J.1    Booij, J.2    Linszen, D.H.3    Reneman, L.4    Van Royen, E.A.5
  • 41
    • 0030456714 scopus 로고    scopus 로고
    • Benzodiazepine site pharmacokinetic/pharmacodynamic quantification in man: Direct measurement of drug occupancy and effects on the human brain in vivo
    • Malizia A.L., Gunn R.N., Wilson S.J., Waters S.H., Bloomfield P.M., Cunningham V.J., Nutt D.J. Benzodiazepine site pharmacokinetic/pharmacodynamic quantification in man: direct measurement of drug occupancy and effects on the human brain in vivo. Neuropharmacology. 35:1996;1483-1491.
    • (1996) Neuropharmacology , vol.35 , pp. 1483-1491
    • Malizia, A.L.1    Gunn, R.N.2    Wilson, S.J.3    Waters, S.H.4    Bloomfield, P.M.5    Cunningham, V.J.6    Nutt, D.J.7
  • 42
    • 0034667307 scopus 로고    scopus 로고
    • Pindolol augmentation of antidepressant treatment: Recent contributions from brain imaging studies
    • Martinez D., Broft A., Laruelle M. Pindolol augmentation of antidepressant treatment: recent contributions from brain imaging studies. Biol. Psychiatry. 48:2000;844-853.
    • (2000) Biol. Psychiatry , vol.48 , pp. 844-853
    • Martinez, D.1    Broft, A.2    Laruelle, M.3
  • 46
    • 0035157572 scopus 로고    scopus 로고
    • Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: A [(11)C]DASB PET imaging study
    • Meyer J.H., Wilson A.A., Ginovart N., Goulding V., Hussey D., Hood K., Houle S. Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study. Am. J. Psychiatry. 158:2001;1843-1849.
    • (2001) Am. J. Psychiatry , vol.158 , pp. 1843-1849
    • Meyer, J.H.1    Wilson, A.A.2    Ginovart, N.3    Goulding, V.4    Hussey, D.5    Hood, K.6    Houle, S.7
  • 47
    • 0011798858 scopus 로고    scopus 로고
    • Measurement of striatal and extrastriatal D-2 receptor occupancy by clozapine and risperidone using [18F]fallypride and PET
    • Mukherjee J., Christian B.T., Narayanan T.K., Shi B., Mantil J. Measurement of striatal and extrastriatal D-2 receptor occupancy by clozapine and risperidone using [18F]fallypride and PET. Neuroimage. 11:2000;S53.
    • (2000) Neuroimage , vol.11 , pp. 53
    • Mukherjee, J.1    Christian, B.T.2    Narayanan, T.K.3    Shi, B.4    Mantil, J.5
  • 48
    • 0028991822 scopus 로고
    • D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: A PET study of schizophrenic patients
    • Nordstrom A.L., Farde L., Nyberg S., Karlsson P., Halldin C., Sedvall G. D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients. Am. J. Psychiatry. 152:1995;1444-1449.
    • (1995) Am. J. Psychiatry , vol.152 , pp. 1444-1449
    • Nordstrom, A.L.1    Farde, L.2    Nyberg, S.3    Karlsson, P.4    Halldin, C.5    Sedvall, G.6
  • 49
    • 0027520871 scopus 로고
    • Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: A double-blind PET study of schizophrenic patients
    • Nordstrom A.L., Farde L., Wiesel F.A., Forslund K., Pauli S., Halldin C., Uppfeldt G. Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients. Biol. Psychiatry. 33:1993;227-235.
    • (1993) Biol. Psychiatry , vol.33 , pp. 227-235
    • Nordstrom, A.L.1    Farde, L.2    Wiesel, F.A.3    Forslund, K.4    Pauli, S.5    Halldin, C.6    Uppfeldt, G.7
  • 50
    • 0032498871 scopus 로고    scopus 로고
    • Positron emission tomography finding of a high striatal D2 receptor occupancy in olanzapine-treated patients
    • Nordstrom A.L., Nyberg S., Olsson H., Farde L. Positron emission tomography finding of a high striatal D2 receptor occupancy in olanzapine-treated patients. Arch. Gen. Psychiatry. 55:1998;283-284.
    • (1998) Arch. Gen. Psychiatry , vol.55 , pp. 283-284
    • Nordstrom, A.L.1    Nyberg, S.2    Olsson, H.3    Farde, L.4
  • 51
    • 0033014402 scopus 로고    scopus 로고
    • Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients
    • Nyberg S., Eriksson B., Oxenstierna G., Halldin C., Farde L. Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients. Am. J. Psychiatry. 156:1999;869-875.
    • (1999) Am. J. Psychiatry , vol.156 , pp. 869-875
    • Nyberg, S.1    Eriksson, B.2    Oxenstierna, G.3    Halldin, C.4    Farde, L.5
  • 52
    • 0027341623 scopus 로고
    • 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone
    • Nyberg S., Farde L., Eriksson L., Halldin C., Eriksson B. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl.). 110:1993;265-672.
    • (1993) Psychopharmacology (Berl.) , vol.110 , pp. 265-672
    • Nyberg, S.1    Farde, L.2    Eriksson, L.3    Halldin, C.4    Eriksson, B.5
  • 54
    • 0034805368 scopus 로고    scopus 로고
    • Potentials and pitfalls using high affinity radioligands in pet and spet determinations on regional drug induced d2 receptor occupancy - A simulation study based on experimental data
    • Olsson H., Farde L. Potentials and pitfalls using high affinity radioligands in pet and spet determinations on regional drug induced d2 receptor occupancy - a simulation study based on experimental data. Neuroimage. 14:2001;936-945.
    • (2001) Neuroimage , vol.14 , pp. 936-945
    • Olsson, H.1    Farde, L.2
  • 55
    • 0034958248 scopus 로고    scopus 로고
    • Probing targets for antipsychotic drug action with PET and SPET receptor imaging
    • Pilowsky L.S. Probing targets for antipsychotic drug action with PET and SPET receptor imaging. Nucl. Med. Commun. 22:2001;829-833.
    • (2001) Nucl. Med. Commun. , vol.22 , pp. 829-833
    • Pilowsky, L.S.1
  • 56
    • 0029658332 scopus 로고    scopus 로고
    • Dopamine D2 receptor occupancy in vivo by the novel atypical antipsychotic olanzapine - A 123I IBZM single photon emission tomography (SPET) study
    • Pilowsky L.S., Busatto G.F., Taylor M., Costa D.C., Sharma T., Sigmundsson T., Ell P.J., Nohria V., Kerwin R.W. Dopamine D2 receptor occupancy in vivo by the novel atypical antipsychotic olanzapine - a 123I IBZM single photon emission tomography (SPET) study. Psychopharmacologia. 124:1996;148-153.
    • (1996) Psychopharmacologia , vol.124 , pp. 148-153
    • Pilowsky, L.S.1    Busatto, G.F.2    Taylor, M.3    Costa, D.C.4    Sharma, T.5    Sigmundsson, T.6    Ell, P.J.7    Nohria, V.8    Kerwin, R.W.9
  • 57
    • 0026643193 scopus 로고
    • Clozapine, single photon emission tomography, and the D2 dopamine receptor blockade hypothesis of schizophrenia
    • Pilowsky L.S., Costa D.C., Ell P.J., Murray R.M., Verhoeff N.P., Kerwin R.W. Clozapine, single photon emission tomography, and the D2 dopamine receptor blockade hypothesis of schizophrenia. Lancet. 340:1992;199-202.
    • (1992) Lancet , vol.340 , pp. 199-202
    • Pilowsky, L.S.1    Costa, D.C.2    Ell, P.J.3    Murray, R.M.4    Verhoeff, N.P.5    Kerwin, R.W.6
  • 59
    • 0030969323 scopus 로고    scopus 로고
    • In vivo effects on striatal dopamine D2 receptor binding by the novel atypical antipsychotic drug sertindole - A 123I IBZM single photon emission tomography (SPET) study
    • Pilowsky L.S., O'Connell P., Davies N., Busatto G.F., Costa D.C., Murray R.M., Ell P.J., Kerwin R.W. In vivo effects on striatal dopamine D2 receptor binding by the novel atypical antipsychotic drug sertindole - a 123I IBZM single photon emission tomography (SPET) study. Psychopharmacologia. 130:1997;152-158.
    • (1997) Psychopharmacologia , vol.130 , pp. 152-158
    • Pilowsky, L.S.1    O'Connell, P.2    Davies, N.3    Busatto, G.F.4    Costa, D.C.5    Murray, R.M.6    Ell, P.J.7    Kerwin, R.W.8
  • 61
    • 0035191933 scopus 로고    scopus 로고
    • Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low
    • Rabiner E.A., Bhagwagar Z., Gunn R.N., Sargent P.A., Bench C.J., Cowen P.J., Grasby P.M. Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low. Am. J. Psychiatry. 158:2001;2080-2082.
    • (2001) Am. J. Psychiatry , vol.158 , pp. 2080-2082
    • Rabiner, E.A.1    Bhagwagar, Z.2    Gunn, R.N.3    Sargent, P.A.4    Bench, C.J.5    Cowen, P.J.6    Grasby, P.M.7
  • 65
    • 0028135046 scopus 로고
    • Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity
    • Robertson G.S., Matsumura H., Fibiger H.C. Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity. J. Pharmacol. Exp. Ther. 271:1994;1058-1066.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 1058-1066
    • Robertson, G.S.1    Matsumura, H.2    Fibiger, H.C.3
  • 66
    • 0030799746 scopus 로고    scopus 로고
    • PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects
    • Schlaepfer T.E., Pearlson G.D., Wong D.F., Marenco S., Dannals R.F. PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects. Am. J. Psychiatry. 154:1997;1209-1213.
    • (1997) Am. J. Psychiatry , vol.154 , pp. 1209-1213
    • Schlaepfer, T.E.1    Pearlson, G.D.2    Wong, D.F.3    Marenco, S.4    Dannals, R.F.5
  • 70
    • 0034974721 scopus 로고    scopus 로고
    • No support for regional selectivity in clozapine-treated patients: A PET study with [(11)C]raclopride and [(11)C]FLB 457
    • Talvik M., Nordstrom A.L., Nyberg S., Olsson H., Halldin C., Farde L. No support for regional selectivity in clozapine-treated patients: a PET study with [(11)C]raclopride and [(11)C]FLB 457. Am. J. Psychiatry. 158:2001;926-930.
    • (2001) Am. J. Psychiatry , vol.158 , pp. 926-930
    • Talvik, M.1    Nordstrom, A.L.2    Nyberg, S.3    Olsson, H.4    Halldin, C.5    Farde, L.6
  • 71
    • 0035236574 scopus 로고    scopus 로고
    • Choosing the right dose of antipsychotics in schizophrenia: Lessons from neuroimaging studies
    • Tauscher J., Kapur S. Choosing the right dose of antipsychotics in schizophrenia: lessons from neuroimaging studies. CNS Drugs. 15:2001;671-678.
    • (2001) CNS Drugs , vol.15 , pp. 671-678
    • Tauscher, J.1    Kapur, S.2
  • 72
    • 0032587533 scopus 로고    scopus 로고
    • In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol
    • Tauscher J., Kufferle B., Asenbaum S., Fischer P., Pezawas L., Barnas C., Tauscher-Wisniewski S., Brucke T., Kasper S. In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol. Psychopharmacologia. 141:1999;175-181.
    • (1999) Psychopharmacologia , vol.141 , pp. 175-181
    • Tauscher, J.1    Kufferle, B.2    Asenbaum, S.3    Fischer, P.4    Pezawas, L.5    Barnas, C.6    Tauscher-Wisniewski, S.7    Brucke, T.8    Kasper, S.9
  • 73
    • 0035892375 scopus 로고    scopus 로고
    • Facilitation of dopaminergic neural transmission does not affect [(11)C]SCH23390 binding to the striatal D(1) dopamine receptors, but the facilitation enhances phosphodiesterase type-IV activity through D(1) receptors: PET studies in the conscious monkey brain
    • Tsukada H., Harada N., Ohba H., Nishiyama S., Kakiuchi T. Facilitation of dopaminergic neural transmission does not affect [(11)C]SCH23390 binding to the striatal D(1) dopamine receptors, but the facilitation enhances phosphodiesterase type-IV activity through D(1) receptors: PET studies in the conscious monkey brain. Synapse. 42:2001;258-265.
    • (2001) Synapse , vol.42 , pp. 258-265
    • Tsukada, H.1    Harada, N.2    Ohba, H.3    Nishiyama, S.4    Kakiuchi, T.5


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