Synthesis and monoamine transporter affinity of front bridged tricyclic 3β-(4′-halo or 4′-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2β-position

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 17, 2006, Pages 4661-4663

  Zeng, Fanxing ^a   Jarkas, Nachwa ^a   Owens, Michael J ^b   Kilts, Clinton D ^b   Nemeroff, Charles B ^b   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Carbon 11; NET; PET; SERT; Tropane

Indexed keywords

3BETA (4' IODO)PHENYLTROPANE; CARBENE; DOPAMINE TRANSPORTER; NORADRENALIN TRANSPORTER; SEROTONIN TRANSPORTER; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

ANIMALS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; POLYCYCLIC COMPOUNDS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746233399     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.098     Document Type: Article

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