Synthesis and transporter binding properties of 3β-(4'-alkyl-, 4'- alkenyl-, and 4'-alkynylphenyl)nortropane-2β-carboxylic acid methyl esters: Serotonin transporter selective analogs

Journal of Medicinal Chemistry

Volumn 39, Issue 20, 1996, Pages 4027-4035

  Blough, Bruce E ^a   Abraham, Philip ^a   Lewin, Anita H ^a   Kuhar, Michael J ^b   Boja, John W ^b   Ivy Carroll, F ^a  

^a RTI INTERNATIONAL   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYL 8 AZABICYCLO[3.2.1]OCTANE 2 CARBOXYLIC ACID METHYL ESTER; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; DOPAMINE; DRUG CARRIER; NISOXETINE; NORADRENALIN; PAROXETINE; SEROTONIN TRANSPORTER; TROPARIL;

AMINE TRANSPORT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TRANSPORT; LIGAND BINDING; NONHUMAN; RAT; RECEPTOR AFFINITY;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CARRIER PROTEINS; COCAINE; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; FLUOXETINE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; NOREPINEPHRINE; NORTROPANES; PAROXETINE; RADIOLIGAND ASSAY; RATS; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 0029796134     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960409s     Document Type: Article

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