Immunolocalization of the cocaine- and antidepressant-sensitive 1- norepinephrine transporter

Journal of Comparative Neurology

Volumn 420, Issue 2, 2000, Pages 211-232

  Schroeter, Sally ^a   Apparsundaram, Subbu ^a   Wiley, Ronald G ^a,b   Miner, Leeann H ^c   Sesack, Susan R ^c   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Brain; Catecholamine; Dopamine hydroxylase; Epinephrine; Immunohistochemistry; Synaptophysin; Vas deferens

Indexed keywords

ANTIDEPRESSANT AGENT; CARRIER PROTEIN; COCAINE; NORADRENALIN; NORADRENALIN TRANSPORTER; PSYCHOSTIMULANT AGENT; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

AFFECTIVE NEUROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTONOMIC DYSFUNCTION; BRAIN REGION; CELL LABELING; CONTROLLED STUDY; DRUG TARGETING; MALE; NERVE CELL LESION; NERVE PROJECTION; NEUROMODULATION; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPTOSOME; ULTRASTRUCTURE;

ANIMALS; ANIMALS, NEWBORN; ANTIDEPRESSIVE AGENTS; AXONS; BRAIN; CARRIER PROTEINS; CELL CULTURE TECHNIQUES; COCAINE; DOPAMINE UPTAKE INHIBITORS; EPITOPES; IMMUNOHISTOCHEMISTRY; MALE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; SYMPORTERS;

EID: 0034194496     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3     Document Type: Article

References (137)

1. Ahn J, Mundigl O, Muth TR, Rudnick G, Caplan MJ. 1996. Polarized expression of GABA transporters in Madin-Darby canine kidney cells and cultured hippocampal neurons. J Biol Chem 271:6917-6924.
2. Apparsundaram S, Moore KR, Malone MD, Hartzell HC, Blakely RD. 1997. Molecular cloning and characterization of an l-epinephrine transporter from sympathetic ganglia of the bullfrog, Rana catesbiana. J Neurosci 17:2691-2702.
3. Apparsundaram S, Schroeter S, Giovanetti E, Blakely RD. 1998a. Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins. J Pharmacol Exp Ther 287:744-751.
4. Apparsundaram S, Sung U, Kendall D, Blakely RD. 1998b. Regulated association of syntaxin I with norepinephrine transporters. Soc Neurosci Abstr 24:276.
5. Axelrod J. 1971. Noradrenaline: fate and control of its biosynthesis. Science 173:598-606.
6. Axelrod J, Kopin IJ. 1969. The uptake, storage, release, and metabolism of noradrenaline in sympathetic nerves. Prog Brain Res 31:21-32.
7. Blakely RD, Apparsundaram S. 1998. Structural diversity in the catecholamine transporter gene family: molecular cloning and characterization of an L-epinephrine transporter from bullfrog sympathetic ganglia. Adv Pharmacol 42:206-210.
8. Böhm M, La Rosée K, Schwinger RHG, Erdmann E. 1995. Evidence for reduction of norepinephrine uptake sites in the failing human heart. J Am Coll Cardiol 25:146-153.
9. Böhm M, Castellano M, Flesch M, Maack C, Moll M, Paul M, Schiffer F, Zolk O. 1998. Chamber-specific alterations of norepinephrine uptake sites in cardiac hypertrophy. Hypertension 32:831-837.
10. Bonisch H, Brüss M. 1994. The noradrenaline transporter of the neuronal plasma membrane. Ann NY Acad Sci 733:193-202.
11. Brüss M, Hammermann R, Brimijoin S, Bonisch H. 1995. Antipeptide antibodies confirm the topology of the human norepinephrine transporter. J Biol Chem 270:9197-9201.
12. Buck KJ, Amara SG. 1994. Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium. Proc Natl Acad Sci USA 91:12584-12588.
13. Buck KJ, Amara SG. 1995. Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants. Mol Pharmacol 48:1030-1037.
14. Bunin MA, Wightman RM. 1999. Paracrine neurotransmission in the CNS: involvement of 5-HT. TINS 22:377-382.
15. Burrows GD, Maguire KP, Norman TR. 1998. Antidepressant efficacy and tolerability of the selective norepinephrine reuptake inhibitor reboxetine: a review. J Clin Psychiatry 59(suppl 14):4-7.
16. Burton LD, Kippenberger AG, Lingen B, Brüss M, Bonisch H, Christie DL. 1998. A variant of the bovine noradrenaline transporter reveals the importance of the C-terminal region for correct targeting to the membrane and functional expression. Biochem J 330:909-914.
17. Carboni E, Tanda GL, Frau R, Chiara GD. 1990. Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals J Neurochem 55:1067-1070.
18. Cases O, Lebrand C, Giros B. Vitalis T, De Maeyer E, Caron MG, Price DJ, Gaspar P, Seif I. 1998. Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. J Neurosci 18:6914-6927.
19. 3H]nisoxetine binding sites in the cat brain: an autoradiographic study. Neuroscience 69:259-270.
20. 10 dopamine regions of rat brain: characterization and responsiveness to cocaine. J Pharmacol Exp Ther 267:379-389.
21. Chen N-H, Reith MEA. 1994. Effects of locally applied cocaine, lidocaine, and various uptake blockers on monamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monamine interrelationships. J Neurochem 63:1701-1713.
22. Ciliax BJ, Heilman C, Demchyshyn LL, Pristupa ZB, Ince E, Hersch SM, Niznik HB, Levey AI. 1995. The dopamine transporter: immunochemical characterization and localization in brain. J Neurosci 15:1714-1723.
23. Comer AM, Qi J, Christie DL, Gibbons HM, Lipski J. 1998. Noradrenaline transporter expression in the pons and medulla oblongata of the rat: localisation to noradrenergic and some C1 adrenergic neurones. Mol Brain Res 62:65-76.
24. Cooper JR, Bloom FE , Roth RH. 1991. The biochemical basis of neuropharmacology. New York: Oxford University Press.
25. Cragg SJ, Rice ME, Greenfield SA. 1997. Heterogeneity of electrically evoked dopamine release and reuptake in substantia nigra, ventral tegmental area, and striatum. J Neurophysiol 77:863-873.
26. Cubells JF, Kim KS, Baker H, Volpe BT, Chung Y, Houpt TA, Wessel TC, Job TH. 1995. Differential in vivo regulation of mRNA encoding the norepinephrine transporter and tyrosine hydroxylase in rat adrenal medulla and locus ceruleus. J Neurochem 65:502-509.
27. Dahlstrom A, Fuxe K. 1964. Evidence for the existence of monamine-containing neurons in the central nervous system. I. Demonstration of monamines in the cell bodies of brain stem neurons. Acta Physiol Scand 62:1-55.
28. 5 dopamine receptors. J Neurochem 66:222-232.
29. Daws LC, Toney GM, Gerhardt GA. Frazer A. 1998. In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. J Pharmacol Exp Ther 286:967-976.
30. Delfs JM, Zhu Y, Druhan JP, Aston-Jones GS. 1998. Origin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat. Brain Res 806: 127-140.
31. Descarries L, Umbriaco D. 1995. Ultrastructural basis of monamine and acetylcholine function in CNS. Semin Neurosci 7:309-318.
32. Descarries L, Watkins KC, Lapierre Y. 1977. Noradrenergic axon terminals in the cerebral cortex of rat. III. Topometric ultrastructural analysis. Brain Res 133:197-222.
33. Descarries L, Lemay B, Doucet G, Berger B. 1987. Regional and laminar density of the dopamine innervation in adult rat cerebral cortex. Neuroscience 21:807-824.
34. Du X-J, Woodcock EA, Little PJ, Esler MD, Dart AM. 1998. Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms. J Cardiovasc Pharmacol 32:621-628.
35. Eisenhofer G, Esler MD, Cox HS, Meredith IT, Jennings GL, Brush JE, Jr., Goldstein DS. 1990. Differences in the neuronal removal of circulating epinephrine and norepinephrine. J Clin Endocrinol Metab 70:1710-1720.
36. Floras JS, Sole MJ, Morris BL. 1990. Desipramme blocks augmented neurogenic vasoconstrictor responses to epinephrine. Hypertension 15: 132-139.
37. Foote SL, Bloom FE, Aston-Jones G. 1983. Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol Rev 63: 844-914.
38. Frazer A, Daws LC. 1998. Serotonin transporter function in vivo: Assessment by chronoamperometry. Ann NY Acad Sci 861:217-229.
39. Freed C, Revay R, Vaughan RA, Kriek E, Grant S, Uhl GR, Kuhar MJ. 1995. Dopamine transporter immunoreactivity in rat brain. J Comp Neurol 359:340-349.
40. Friedman JI, Adler DN, Davis KL. 1999 The role of norepinephrine in the pathophysiology of cognitive disorders: potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease. Biol Psychiatry 46:1243-1252.
41. Fritschy J-M, Grzanna R. 1989. Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals. Neuroscience 181.
42. Fritschy J-M, Grzanna R. 1991. Selective effects of DSP-4 on locus coeruleus axons: are there pharmacologically different types of noradrenergic axons in the central nervous system? Prog Brain Res 88:257-268.
43. Fritz JD, Jayanthi LD, Thoreson MA, Blakely RD. 1998. Cloning and chromosomal mapping of the murine norepinephrine transporter. J Neurochem 70:2241-2251.
44. Ganguly PK, Beamish RE, Dhalla KS, Innes IR, Dhalla NS. 1987. Norepinephrine storage, distribution, and release in diabetic cardiomyopathy. Am J Physiol 252:E734-E739.
45. Geffen LB, Jessell TM, Cuello AC, Iversen LL. 1976. Release of DA from dendrites in rat substantia nigra. Nature 260:258-260.
46. 3H]nisoxetine binding in rat brain. J Neurochem 64:2792-2800.
47. Giros B, Mestikawy SE, Bertrand L. Caron MG. 1991. Cloning and functional characterization of a cocaine-sensitive dopamine transporter. FEBS Lett 295:149-154.
48. Giros B, Wang YM, Suter S, McLeskey SB, Pifl C, Caron MG. 1994. Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. J Biol Chem 269:15985-15988.
49. Griffith R, Sutin J. 1996. Reactive astrocyte formation in vivo is regulated by noradrenergic axons. J Comp Neurol 371:362-375.
50. Groves PM, Wilson CJ. 1980. Monoaminergic presynaptic axons and dendrites in rat locus coeruleus seen in reconstructions of serial sections. J Comp Neurol 193:853-862.
51. Gründemann D, Schechinger B, Rappold GA, Schömig E. 1998. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nature Neurosci 1:349-351.
52. Gu HH, Ahn J, Caplan MJ. Blakely RD, Levey AI, Rudnick G. 1996. Cell-specific sorting of biogenic amine transporters expressed in epithelial cells. J Biol Chem 271:18100-18106.
53. Hallman H, Jonsson G. 1984. Pharmacological modifications of the neurotoxic action of the noradrenaline neurotoxin DSP4 on central noradrenaline neurons. Eur J Pbarmacol 103:269-278.
54. Hersch SM, Yi H. Heilman CJ, Edwards RH, Levey AI. 1997. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. J Comp Neurol 388:211-227.
55. Higgins D, Lein PJ, Osterhout DJ, Johnson MI. (1981). Tissue culture of mammalian autonomic neurons. In: Banker G, Goslin K, editors. Culturing nerve cells. Cambridge: MIT Press. p 177-205.
56. Hoffman BJ, Hansson SR, Mezey E, Palkovits M. 1998. Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system. Front Neuroendocrinol 19:187-231.
57. Hung HC, Lee EH 1996. The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: role of BDNF gene expression. Brain Res Mol Brain Res 41:14-26.
58. Hurtley SM. 1993. Recycling of a secretory granule membrane protein after stimulated secretion. J Cell Sci 106:649-656.
59. Hökfelt T, Goldstein M, Fuxe K, Johansson O, Verhofstad A, Steinbusch H, Penke B, Vargas J. (1980). Histochemical identification of adrenaline containing cells with special reference to neurons. In: Fuxe K, Goldstein M, Hökfelt B, Hökfelt T, editors. Central adrenaline neurons. Basic aspects and their role in cardiovascular functions. Oxford: Pergamon Press. p 19-47.
60. Hökfelt T, Johansson O, Goldstein M. (1984a). Central catecholamine neurons as revealed by immunohistochemistry with special reference to adrenaline neurons. In: Björklund A, Hökfelt T, editors. Handbook of chemical neuroanatomy: Classical Transmitters in the CNS. Amsterdam: Elsevier. p 157-276.
61. Hökfelt T, Märtensson R, Björklund A, Kleinau S, Goldstein M. (1984b). Distributional maps of tyrosine-hydroxylase-immunoreactive neurons in the rat brain. In: Björklund A, Hökfelt T, editors. Handbook of chemical neuroanatomy: classical transmitters in the CNS. Amsterdam: Elsevier, p 277-379.
62. Iversen LL. 1971. Role of transmitter uptake mechanisms in synaptic neurotransmission. Br J Pharmacol 41:571-591.
63. Jacob G, Shannon JR, Costa F, Furlan R, Biaggioni I, Mosqueda-Garcia R, Robertson RM, Robertson D. 1999. Abnormal norepinephrine clearance and adrenoreceptor sensitivity in idiopathic orthostatic intolerance. Circulation 99:1706-1712.
64. Jayanthi LD, Prasad PD, Ramamoorthy S, Mahesh VB, Leibach FH, Ganapathy V. 1993. Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter. Biochemistry 32:12178-17185.
65. Jellinger KA. 1997. Morphological substrates of dementia in parkinsonism: a critical update. J Neural Transm [Suppl] 51:57-82.
66. Kaleczyc J, Timmermans J-P, Majewski M, Lakomy M, Scheuerman DW. 1998. Immunohistochemical characteristics of nerve fibres supplying the porcine vas deferens. A colocalisation study. Histochem Cell Biol 107:229-241.
67. 3H]dopamine is taken up and released from nondopaminergic nerve terminals in the rat substantia nigra in vitro. J Neurochem 45:137-144.
68. 3H]norepinephrine by primary astrocyte cultures and its inhibition by tricyclic antidepressants. J Neurochem 40:1265-1270.
69. Kippenberger AG, Palmer DJ, Comer AM, Lipski J, Burton LD, Christie DL. 1999. Localization of the noradrenaline transporter in rat adrenal medulla and PC12 cells: evidence for its association with secretory granules in PC12 cells. J Neurochem 73:1024-1032.
70. Kitayama S, Ikeda T, Mitsuhata C, Sato T, Monta K, Dohi T. 1999. Dominant negative isoform of rat norepinephrine transporter produced by alternative RNA splicing. J Biol Chem 274:10731-10736.
71. Klepper A, Herbert H. 1991. Distribution and origin of noradrenergic and serotonergic fibers in the cochlear nucleus and inferior colliculus of the rat. Brain Res 557:190-201.
72. Klimek V, Stockmeier C, Overholser J, Meltzer HY, Kalka S, Dilley G, Ordway GA. 1997. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J Neurosci 17:8451-8458.
73. Li JY, Jahn R, Dahlström A. 1996. Axonal transport and targeting of the t-SNAREs SNAP-25 and syntaxin 1 in the peripheral nervous system. Eur J Cell Biol 70:12-22.
74. +/ Cl neurotransmitter transporters. Methods Enzymol 296:425-436.
75. Lincoln J. 1995. Innervation of cerebral arteries by nerves containing 5-hydroxytryptamine and noradrenaline. Pharmacol Ther 68:473-501.
76. Lorang D, Amara SG, Simerly RB. 1993. Cell-type specific expression of catecholamine transporters in the rat brain. J Neurosci 14:4903-4914.
77. Maeda T, Kojima Y, Arai R, Fujimiya M, Kimura H, Kitahama K, Geffard M. 1991. Monoaminergic interaction in the central nervous system: a morphological analysis in the locus coeruleus of the rat. Comp Biochem Physiol 98C:193-202.
78. Magyar K, Szende B, Lengyel J, Tarczali J, Szatmáry I. 1998. The neuroprotective and neuronal rescue effects of (-)-deprenyl. J Neural Transm [Suppl] 52:109-123.
79. 4 receptor in human cerebral cortex and striatum. J Neurochem 66:915.
80. McLean JH, Shipley MT, Nickell WT, Aston JG, Reyher CK. 1989. Chemoanatomical organization of the noradrenergic input from locus coeruleus to the olfactory bulb of the adult rat. J Comp Neurol 285:339-349.
81. Melikian HE, McDonald JK, Gu H, Rudnick G, Moore KR, Blakely RD. 1994. Human norepinephrine transporter: biosynthetic studies using a site-directed polyclonal antibody. J Biol Chem 269:12290-12297.
82. Melikian HE, Ramamoorthy S, Tate CG, Blakely RD. 1996. Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition. Mol Pharmacol 50:266-276.
83. Miller GW, Staley JK, Heilman CJ, Perez JT, Mash DC, Rye DB, Levey AI. 1997. Immunochemical analysis of dopamine transporter protein in Parkinson's disease. Ann Neurol 41:530-539.
84. Moore RY, Bloom FE. 1979. Central catecholamine neuron system: anatomy and physiology of the norepinephrine and epinephrine systems. Annu Rev Neurosci 2:113.
85. Moore RY, Card JP. (1984). Noradrenaline-containing neuron systems. In: Björkland A, Hökfelt T, editors. Handbook of chemical neuroanatomy: classical transmitters in the CNS. Amsterdam: Elsevier, p 123-156.
86. 4 receptors in GABAergic neurons of the primate brain. Nature 381:245.
87. 4 receptors. Eur J Pharmacol 319:379-383.
88. Ni B, Rosteck PR Jr, Nadi NS, Paul SM. 1994. Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter. Proc Natl Acad Sci USA 91:5607-5611.
89. Nirenberg MJ, Chan J, Pohorille A, Vaughan RA, UhI GR, Kuhar MJ, Pickel VM. 1997a. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. J Neurosci 17:6899-6907.
90. Nirenberg MJ, Chan J, Vaughan RA, Uhl GR, Kuhar MJ, Pickel VM. 1997b. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. J Neurosci 17:5255-5262.
91. Nirenberg MJ, Vaughan RA, Uhl GR, Kuhar MJ, Pickel VM. 1996. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. J Neurosci 16:436-447.
92. Nyquist-Battie C, Cochran PK, Evans VR, Hitchcock JM, Unal C. 1996. Regulation of sympathetic presynaptic components in rat left ventricle during ligation of abdominal aorta. Am J Physiol 271:H1547-H1554.
93. Ordway GA. 1997. Pathophysiology of the locus coeruleus in suicide. Ann NY Acad Sci 836:233-252.
94. Ordway GA, Stockmeier CA, Cason GW, Klimek V. 1997. Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei. J Neurosci 17:1710-1719.
95. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. 1997. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-1322.
96. Pacholczyk T, Blakely RD, Amara SG. 1991. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 350:350-354.
97. Paczkowski NJ, Vuocolo HE, Bryan-Lluka LJ. 1996. Conclusive evidence for distinct transporters for 5-hydroxytryptamine and noradrenaline in pulmonary endothelial cells of the rat. Naunyn-Schmiedebergs Arch Pharmacol 353:423-430.
98. Papadopoulos GC, Parnavelas JG, Buijs RM. 1989. Light and electron microscopic immunocytochemical analysis of the noradrenaline innervation of the rat visual cortex. J Neurocytol 18:303-310.
99. Paxinos G, Watson C. 1986. The rat brain in stereotaxic coordinates. San Diego: Academic Press.
100. Perego C, Vanoni C, Villa A, Longhi R, Kaech SM, Frohli E, Hajnal A, Kim SK, Pietrini G. 1999. PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells. EMBO J 18:2384-2393.
101. Pickel VM, Chan J. 1999. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens. J Neurosci 19:7356-7366.
102. 3-noradrenaline in the hypothalamus. Neurosci Behav Physiol 7:29-33.
103. Qian Y, Melikian HE, Rye DB, Levey Al, Blakely RD. 1995. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J Neurosci 1261:1261-1274.
104. Renick SE, Kleven DT, Chan J, Stenius K, Milner TA, Pickel VM, Fremeau RT Jr. 1999. The mammalian brain high-affinity L-proline transporter is enriched preferentially in synaptic vesicles in a subpopulation of excitatory nerve terminals in rat forebrain. J Neurosci 19:21-33.
105. Ritz MC, Cone EJ. Kuhar MJ. 1990. Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study. Life Sci 46:635-645.
106. 3H] noradrenaline into rat hypothalamic slices. J Neurochem 49:821-827.
107. Sacchetti G, Bernini M, Bianchetti A, Parini S, Invernizzi RW, Samanin R. 1999. Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain. Br J Pharmacol 128:1332-1338.
108. Sakumoto T, Tohyama M, Satoh K, Kimoto Y, Kinugasa T, Tanizawa O, Kurachi K, Shimizu N. 1978. Afferent fiber connections from lower brain stem to hypothalamus studied by the horseradish peroxidase method with special reference to noradrenaline innervation. Exp Brain Res 31:81-94.
109. Saper CB. 1987. Function of the locus coeruleus. Trends Neurosci 10:343-344.
110. Schomig A, Haass M, Richardt G. 1991. Catecholamine release and arrhythmias in acute myocardial ischaemia. Eur Heart J 12:38-47.
111. 3H-noradrenaline in isolated vasa deferentia and atria of the rat. Naunyn-Schmiedebergs Arch Pharmacol 340:502-508.
112. Schroeter S, Levey AI, Blakely RD. 1997. Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland. Mol Cell Neurosci 9:170-184.
113. Scott DE, Krobisch Dudley G, Knigge KM. 1974. The ventricular system in neuroendocrine mechanisms II. In vivo monoamine transport by ependyma of the median eminence. Cell Tissue Res 154:1-16.
114. Sesack SR, Hawrylak VA, Matus C, Guido MA, Levey AI. 1998. Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 18:2697-2708.
115. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D. 2000. Orthostatic intolerance and tachycardia associated with norepinephrine transporter deficiency. New Engl J Med 342:541-549.
116. 3H]nisoxetine. J Pharmacol Exp Ther 284: 736-743.
117. Shipley MT, Fu L, Ennis M, Liu W-L, Aston-Jones G. 1996. Dendrites of locus coeruleus neurons extend preferentially into two pericoerulear zones. J Comp Neurol 365:56-68.
118. Simon JR, Ghetti B. 1993. Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse. Neurochem Int 22:471-477.
119. 3H-dopamine uptake into rat brain homogenates. J Pharmacol Exp Ther 165:78-86.
120. Sung U, Bauman PA, Schroeter S, Blakely RD. 1999. Cytoplasmic domains of the human norepinephrine transporter support functional expression and protein-protein interactions. Soc Neurosci Abstr 25:1964.
121. Swan MC, Najlerahim AR, Bennett JP. 1997. Expression of serotonin transporter mRNA in rat brain: presence in neuronal and non-neuronal cells and effect of paroxetine. J Chem Neuroanat 13:71-76.
122. Swanson LW, Hartman BK. 1976. The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-β-hydroxylase as a marker. J Comp Neurol 163:467-506.
123. Séguéla P, Watkins KC, Descarries L. 1989. Ultrastructural relationships of serotonin axon terminals in the cerebral cortex of the adult rat. J Comp Neurol 289:129-142.
124. Séguéla P, Watkins KC, Geffard M, Descarries L. 1990. Noradrenaline axon terminals in adult rat neocortex: an immunocytochemical analysis in serial thin sections. Neuroscience 35:249-264.
125. Tatsumi M, Groshan K, Blakely RD, Richelson E. 1997. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-258.
126. 3H]nisoxetine: a new radioligand for norepinephrine uptake sites in brain. Eur J Pharmacol 191:239-243.
127. Tejani-Butt SM, Yang J, Zaffar H. 1993. Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease. Brain Res 631:147-150.
128. Tessel RE, Kennedy LE, Burgess SK, Borchardt RT. 1978. Epinephrine in rat hypothalamus: antagonism by desipramine of 6-hydroxydopamine-induced depletion. Brain Res 153:615-617.
129. Toyohira Y, Yanagihara N, Minami K, Ueno S, Uezono Y, Tachikawa E, Kondo Y, Kashimoto T, Izumi F. 1998. Down-regulation of the noradrenaline transporter by interferon-α; in cultured bovine adrenal medullary cells. J Neurochem 70:1441-1447.
130. 3H-catecholamines in rat cerebral cortex slices. Naunyn-Schmiedebergs Arch Pharmacol 339:293-297.
131. Trendelenburg U. 1991. The TiPs lecture: functional aspects of the neuronal uptake of noradrenaline. Trends Pharmacol Sci 32:334-337.
132. Ungerer M, Chlistalla A, Richardt G. 1996. Upregulation of cardiac uptake 1 carrier in ischemic and nonischemic rat heart. Circ Res 78:1037-1043.
133. Veznedaroglu E, Milner TA. 1992. Elimination of artifactual labeling of hippocampal mossy fibers seen following pre-embedding immunogold-silver technique by pretreatment with zinc chelator. Microsc Res Tech 23:100-101.
134. Wall SC, Gu H, Rudnick G. 1995. Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: amphetamine specificity for inhibition and efflux. Mol Pharmacol 47:544-550.
135. Wong DT, Threlkeld PG, Best KL, Bymaster FP. 1982. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J Pharmacol Exp Ther 222:61-65.
136. Wrenn CC, Picklo MJ, Lappi DA, Robertson D, Wiley RG. 1996. Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings. Brain Res 740:175-184.
137. Zhou FC, Tao-Cheng J, Segu L, Patel T, Wang Y. 1998. Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence. Brain Res 241:254.