Interleukins and STAT Signaling

Vitamins and Hormones

Volumn 74, Issue , 2006, Pages 165-206

  Haque, S Jaharul ^a   Sharma, Pankaj ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN DERIVATIVE; JANUS KINASE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL; CHEMISTRY; CLASSIFICATION; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN CONFORMATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; INTERLEUKINS; JANUS KINASES; MICE; PROTEIN CONFORMATION; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 33947714618     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(06)74007-9     Document Type: Review

References (241)

1. Abbas A.K., and Litchman A.H. "Cellular and Molecular Immunolgy." (2003), Elsevier Science, Philadelphia, PA
2. Adachi T., and Alam R. The mechanism of IL-5 signal transduction. Am. J. Physiol. 275 (1998) C623-C633
3. Akaishi H., Takeda K., Kaisho T., Shineha R., Satomi S., Takeda J., and Akira S. Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int. Immunol. 10 (1998) 1747-1751
4. Akimoto T., Numata F., Tamura M., Takata Y., Higashida N., Takashi T., Takeda K., and Akira S. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 187 (1998) 1537-1542
5. Akira S., Nishio Y., Inoue M., Wang X.J., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., and Kishimoto T. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77 (1994) 63-71
6. Alexander W.S., and Hilton D.J. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu. Rev. Immunol. 22 (2004) 503-529
7. Alexander W.S., Starr R., Fenner J.E., Scott C.L., Handman E., Sprigg N.S., Corbin J.E., Cornish A.L., Darwiche R., Owczarek C.M., Kay T.W., Nicola N.A., et al. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98 (1999) 597-608
8. Alonzi T., Maritano D., Gorgoni B., Rizzuto G., Libert C., and Poli V. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol. Cell. Biol. 21 (2001) 1621-1632
9. Ansel K.M., Lee D.U., and Rao A. An epigenetic view of helper T cell differentiation. Nat. Immunol. 4 (2003) 616-623
10. Aoki K., Shimoda K., Oritani K., Matsuda T., Kamezaki K., Muromoto R., Numata A., Tamiya S., Haro T., Ishikawa F., Takase K., Yamamoto T., et al. Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx. Exp. Hematol. 31 (2003) 1317-1322
11. Arora T., Liu B., He H., Kim J., Murphy T.L., Murphy K.M., Modlin R.L., and Shuai K. PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. J. Biol. Chem. 278 (2003) 21327-21330
12. Bazan J.F. Haemopoietic receptors and helical cytokines. Immunol. Today 11 (1990) 350-354
13. Bazan J.F. Shared architecture of hormone binding domains in type I and II interferon receptors. Cell 61 (1990) 753-754
14. Bazan J.F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87 (1990) 6934-6938
15. Becker S., Groner B., and Muller C.W. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394 (1998) 145-151
16. Begitt A., Meyer T., van Rossum M., and Vinkemeier U. Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain. Proc. Natl. Acad. Sci. USA 97 (2000) 10418-10423
17. Bendinelli P., Maroni P., Pecori Giraldi F., and Piccoletti R. Leptin activates Stat3, Stat1 and AP-1 in mouse adipose tissue. Mol. Cell. Endocrinol. 168 (2000) 11-20
18. Bhattacharya S., and Schindler C. Regulation of Stat3 nuclear export. J. Clin. Invest. 111 (2003) 553-559
19. Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L., et al. Interleukin 20: Discovery, receptor identification, and role in epidermal function. Cell 104 (2001) 9-19
20. Boulay J.L., O'Shea J.J., and Paul W.E. Molecular phylogeny within type I cytokines and their cognate receptors. Immunity 19 (2003) 159-163
21. Bourdeau A., Dube N., and Tremblay M.L. Cytoplasmic protein tyrosine phosphatases, regulation and function: The roles of PTP1B and TC-PTP. Curr. Opin. Cell. Biol. 17 (2005) 203-209
22. Bunting K.D., Bradley H.L., Hawley T.S., Moriggl R., Sorrentino B.P., and Ihle J.N. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood 99 (2002) 479-487
23. Chakraborty A., and Tweardy D.J. Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils. J. Leukoc. Biol. 64 (1998) 675-680
24. Chapman R.S., Lourenco P.C., Tonner E., Flint D.J., Selbert S., Takeda K., Akira S., Clarke A.R., and Watson C.J. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev. 13 (1999) 2604-2616
25. Chatterjee-Kishore M., Wright K.L., Ting J.P., and Stark G.R. How Stat1 mediates constitutive gene expression: A complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J. 19 (2000) 4111-4122
26. Chen X., Vinkemeier U., Zhao Y., Jeruzalmi D., Darnell Jr. J.E., and Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93 (1998) 827-839
27. Chilton P.M., and Fernandez-Botran R. Production of soluble IL-4 receptors by murine spleen cells is regulated by T cell activation and IL-4. J. Immunol. 151 (1993) 5907-5917
28. Christodoulopoulos P., Cameron L., Nakamura Y., Lemiere C., Muro S., Dugas M., Boulet L.P., Laviolette M., Olivenstein R., and Hamid Q. TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: Evidence for differential signal transducer and activator of transcription 6 expression. J. Allergy Clin. Immunol. 107 (2001) 586-591
29. Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., and Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science 278 (1997) 1803-1805
30. Chung J., Uchida E., Grammer T.C., and Blenis J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol. Cell. Biol. 17 (1997) 6508-6516
31. Coffman R.L., Ohara J., Bond M.W., Carty J., Zlotnik A., and Paul W.E. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136 (1986) 4538-4541
32. Copeland N.G., Gilbert D.J., Schindler C., Zhong Z., Wen Z., Darnell Jr. J.E., Mui A.L., Miyajima A., Quelle F.W., Ihle J.N., and Jenkins N.A. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics 29 (1995) 225-228
33. Crawford R.M., Finbloom D.S., Ohara J., Paul W.E., and Meltzer M.S. B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J. Immunol. 139 (1987) 135-141
34. Croker B.A., Krebs D.L., Zhang J.G., Wormald S., Willson T.A., Stanley E.G., Robb L., Greenhalgh C.J., Forster I., Clausen B.E., Nicola N.A., Metcalf D., et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4 (2003) 540-545
35. Cui Y., Riedlinger G., Miyoshi K., Tang W., Li C., Deng C.X., Robinson G.W., and Hennighausen L. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol. Cell Biol. 24 (2004) 8037-8047
36. Darnell Jr. J.E. STATs and gene regulation. Science 277 (1997) 1630-1635
37. Darnell Jr. J.E., Kerr I.M., and Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 (1994) 1415-1421
38. Decker T., and Kovarik P. Serine phosphorylation of STATs. Oncogene 19 (2000) 2628-2637
39. Dillon S.R., Sprecher C., Hammond A., Bilsborough J., Rosenfeld-Franklin M., Presnell S.R., Haugen H.S., Maurer M., Harder B., Johnston J., Bort S., Mudri S., et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat. Immunol. 5 (2004) 752-760
40. DiSanto J.P., Muller W., Guy-Grand D., Fischer A., and Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc. Natl. Acad. Sci. USA 92 (1995) 377-381
41. Domanski P., and Colamonici O.R. The type-I interferon receptor. The long and short of it. Cytokine Growth Factor Rev. 7 (1996) 143-151
42. Dreuw A., Radtke S., Pflanz S., Lippok B.E., Heinrich P.C., and Hermanns H.M. Characterization of the signaling capacities of the novel gp130-like cytokine receptor. J. Biol. Chem. 279 (2004) 36112-36120
43. Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., and Renauld J.C. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J. Immunol. 167 (2001) 3545-3549
44. Dumoutier L., Lejeune D., Hor S., Fickenscher H., and Renauld J.C. Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3. Biochem. J. 370 (2003) 391-396
45. Durbin J.E., Hackenmiller R., Simon M.C., and Levy D.E. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84 (1996) 443-450
46. Endo T.A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., Matsumoto A., Tanimura S., Ohtsubo M., Misawa H., Miyazaki T., Leonor N., et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 (1997) 921-924
47. Feldman G.M., Rosenthal L.A., Liu X., Hayes M.P., Wynshaw-Boris A., Leonard W.J., Hennighausen L., and Finbloom D.S. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90 (1997) 1768-1776
48. Firmbach-Kraft I., Byers M., Shows T., Dalla-Favera R., and Krolewski J.J. tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene 5 (1990) 1329-1336
49. Frantsve J., Schwaller J., Sternberg D.W., Kutok J., and Gilliland D.G. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell. Biol. 21 (2001) 3547-3557
50. Fu X.Y., Schindler C., Improta T., Aebersold R., and Darnell Jr. J.E. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. USA 89 (1992) 7840-7843
51. Gadina M., Hilton D., Johnston J.A., Morinobu A., Lighvani A., Zhou Y.J., Visconti R., and O'Shea J.J. Signaling by type I and II cytokine receptors: Ten years after. Curr. Opin. Immunol. 13 (2001) 363-373
52. Gascan H., Gauchat J.F., Roncarolo M.G., Yssel H., Spits H., and de Vries J.E. Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4 + T cell clones. J. Exp. Med. 173 (1991) 747-750
53. Gately M.K., Renzetti L.M., Magram J., Stern A.S., Adorini L., Gubler U., and Presky D.H. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses. Annu. Rev. Immunol. 16 (1998) 495-521
54. Geijsen N., Koenderman L., and Coffer P.J. Specificity in cytokine signal transduction: Lessons learned from the IL-3/IL-5/GM-CSF receptor family. Cytokine Growth Factor Rev. 12 (2001) 19-25
55. Ghosh M.K., Sharma P., Harbor P.C., Rahaman S.O., and Haque S.J. PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene 24 (2005) 7290-7300
56. Girault J.A., Labesse G., Mornon J.P., and Callebaut I. Janus kinases and focal adhesion kinases play in the 4.1 band: A superfamily of band 4.1 domains important for cell structure and signal transduction. Mol. Med. 4 (1998) 751-769
57. Goldsby R.A., Kindt T.A., Osborne B.A., and Kuby J. "Immunology." (2003), W. H. Freeman and Company, New York, NY
58. Gough N.M., Rakar S., Harpur A., and Wilks A.F. Localization of genes for two members of the JAK family of protein tyrosine kinases to murine chromosomes 4 and 19. Mamm. Genome 6 (1995) 247-248
59. Haan C., Is'harc H., Hermanns H.M., Schmitz-Van De Leur H., Kerr I.M., Heinrich P.C., Grotzinger J., and Behrmann I. Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction. J. Biol. Chem. 276 (2001) 37451-37458
60. Hanks S.K., Quinn A.M., and Hunter T. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science 241 (1988) 42-52
61. Hannigan G.E., and Williams B.R. Interferon-alpha activates binding of nuclear factors to a sequence element in the c-fos proto-oncogene 5′-flanking region. J. Interferon Res. 12 (1992) 355-361
62. Haque S.J., and Williams B.R. Signal transduction in the interferon system. Semin. Oncol. 25 (1998) 14-22
63. Haque S.J., Flati V., Deb A., and Williams B.R. Roles of protein-tyrosine phosphatases in Stat1 alpha-mediated cell signaling. J. Biol. Chem. 270 (1995) 25709-25714
64. Haque S.J., Wu Q., Kammer W., Friedrich K., Smith J.M., Kerr I.M., Stark G.R., and Williams B.R. Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1. Proc. Natl. Acad. Sci. USA 94 (1997) 8563-8568
65. Haque S.J., Harbor P., Tabrizi M., Yi T., and Williams B.R. Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J. Biol. Chem. 273 (1998) 33893-33896
66. Haque S.J., Harbor P.C., and Williams B.R. Identification of critical residues required for suppressor of cytokine signaling-specific regulation of interleukin-4 signaling. J. Biol. Chem. 275 (2000) 26500-26506
67. Harpur A.G., Andres A.C., Ziemiecki A., Aston R.R., and Wilks A.F. JAK2, a third member of the JAK family of protein tyrosine kinases. Oncogene 7 (1992) 1347-1353
68. Heaney M.L., and Golde D.W. Soluble cytokine receptors. Blood 87 (1996) 847-857
69. Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., and Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374 (2003) 1-20
70. Heldin C.H. Dimerization of cell surface receptors in signal transduction. Cell 80 (1995) 213-223
71. Hermiston M.L., Xu Z., and Weiss A. CD45: A critical regulator of signaling thresholds in immune cells. Annu. Rev. Immunol. 21 (2003) 107-137
72. Hilkens C.M., Is'harc H., Lillemeier B.F., Strobl B., Bates P.A., Behrmann I., and Kerr I.M. A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130. FEBS Lett. 505 (2001) 87-91
73. Huang M., Dorsey J.F., Epling-Burnette P.K., Nimmanapalli R., Landowski T.H., Mora L.B., Niu G., Sinibaldi D., Bai F., Kraker A., Yu H., Moscinski L., et al. Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene 21 (2002) 8804-8816
74. Hubbard S.R., Wei L., Ellis L., and Hendrickson W.A. Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372 (1994) 746-754
75. Ihle J.N. Cytokine receptor signalling. Nature 377 (1995) 591-594
76. Ihle J.N. The Stat family in cytokine signaling. Curr. Opin. Cell Biol. 13 (2001) 211-217
77. Irie-Sasaki J., Sasaki T., Matsumoto W., Opavsky A., Cheng M., Welstead G., Griffiths E., Krawczyk C., Richardson C.D., Aitken K., Iscove N., Koretzky G., et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409 (2001) 349-354
78. Jiang H., Harris M.B., and Rothman P. IL-4/IL-13 signaling beyond JAK/STAT. J. Allergy Clin. Immunol. 105 (2000) 1063-1070
79. Johnson L.N., Noble M.E., and Owen D.J. Active and inactive protein kinases: Structural basis for regulation. Cell 85 (1996) 149-158
80. Kamizono S., Hanada T., Yasukawa H., Minoguchi S., Kato R., Minoguchi M., Hattori K., Hatakeyama S., Yada M., Morita S., Kitamura T., and Kato H. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J. Biol. Chem. 276 (2001) 12530-12538
81. Kamura T., Sato S., Haque D., Liu L., Kaelin Jr. W.G., Conaway R.C., and Conaway J.W. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12 (1998) 3872-3881
82. Kaplan D.H., Shankaran V., Dighe A.S., Stockert E., Aguet M., Old L.J., and Schreiber R.D. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc. Natl. Acad. Sci. USA 95 (1998) 7556-7561
83. Kaplan M.H., Schindler U., Smiley S.T., and Grusby M.J. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4 (1996) 313-319
84. Kaplan M.H., Sun Y.L., Hoey T., and Grusby M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382 (1996) 174-177
85. Kawamura M., McVicar D.W., Johnston J.A., Blake T.B., Chen Y.Q., Lal B.K., Lloyd A.R., Kelvin D.J., Staples J.E., Ortaldo J.R., and O'Shea J.J. Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc. Natl. Acad. Sci. USA 91 (1994) 6374-6378
86. Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W., Lin P.F., Luo W., and Yang Y.C. Human interleukin-9: Genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. Blood 77 (1991) 1436-1441
87. Khodarev N.N., Beckett M., Labay E., Darga T., Roizman B., and Weichselbaum R.R. STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc. Natl. Acad. Sci. USA 101 (2004) 1714-1719
88. Kile B.T., Schulman B.A., Alexander W.S., Nicola N.A., Martin H.M., and Hilton D.J. The SOCS box: A tale of destruction and degradation. Trends Biochem. Sci. 27 (2002) 235-241
89. Kim T.K., and Maniatis T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science 273 (1996) 1717-1719
90. Kishimoto T., Taga T., and Akira S. Cytokine signal transduction. Cell 76 (1994) 253-262
91. Kono D.H., Owens D.G., and Wechsler A.R. Jak3 maps to chromosome 8. Mamm. Genome 7 (1996) 476-477
92. Kotenko S.V., and Pestka S. Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. Oncogene 19 (2000) 2557-2565
93. Kotenko S.V., Izotova L.S., Mirochnitchenko O.V., Esterova E., Dickensheets H., Donnelly R.P., and Pestka S. Identification of the functional interleukin-22 (IL-22) receptor complex: The IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J. Biol. Chem. 276 (2001) 2725-2732
94. Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., and Donnelly R.P. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat. Immunol. 4 (2003) 69-77
95. Krishnan K., Singh B., and Krolewski J.J. Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor. J. Biol. Chem. 273 (1998) 19495-19501
96. Kumar A., Toscani A., Rane S., and Reddy E.P. Structural organization and chromosomal mapping of JAK3 locus. Oncogene 13 (1996) 2009-2014
97. Kuperman D., Schofield B., Wills-Karp M., and Grusby M.J. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187 (1998) 939-948
98. Lang R., Pauleau A.L., Parganas E., Takahashi Y., Mages J., Ihle J.N., Rutschman R., and Murray P.J. SOCS3 regulates the plasticity of gp130 signaling. Nat. Immunol. 4 (2003) 546-550
99. Leaman D.W., Pisharody S., Flickinger T.W., Commane M.A., Schlessinger J., Kerr I.M., Levy D.E., and Stark G.R. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol. Cell. Biol. 16 (1996) 369-375
100. Lee C., Piazza F., Brutsaert S., Valens J., Strehlow I., Jarosinski M., Saris C., and Schindler C. Characterization of the Stat5 protease. J. Biol. Chem. 274 (1999) 26767-26775
101. Leek J.P., Hamlin P.J., Bell S.M., and Lench N.J. Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization. Cytogenet. Cell Genet. 79 (1997) 208-209
102. Lehmann U., Schmitz J., Weissenbach M., Sobota R.M., Hortner M., Friederichs K., Behrmann I., Tsiaris W., Sasaki A., Schneider-Mergener J., Yoshimura A., Neel B.G., et al. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J. Biol. Chem. 278 (2003) 661-671
103. Leonard W.J. Cytokines and immunodeficiency diseases. Nat. Rev. Immunol. 1 (2001) 200-208
104. Leonard W.J., and O'Shea J.J. Jaks and STATs: Biological implications. Annu. Rev. Immunol. 16 (1998) 293-322
105. Levine S.J. Mechanisms of soluble cytokine receptor generation. J. Immunol. 173 (2004) 5343-5348
106. Levy D., Larner A., Chaudhuri A., Babiss L.E., and Darnell Jr. J.E. Interferon-stimulated transcription: Isolation of an inducible gene and identification of its regulatory region. Proc. Natl. Acad. Sci. USA 83 (1986) 8929-8933
107. Levy D.E., Kessler D.S., Pine R., and Darnell Jr. J.E. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes Dev. 3 (1989) 1362-1371
108. Lin J.X., Mietz J., Modi W.S., John S., and Leonard W.J. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J. Biol. Chem. 271 (1996) 10738-10744
109. Liu B., Liao J., Rao X., Kushner S.A., Chung C.D., Chang D.D., and Shuai K. Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA 95 (1998) 10626-10631
110. Liu B., Mink S., Wong K.A., Stein N., Getman C., Dempsey P.W., Wu H., and Shuai K. PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat. Immunol. 5 (2004) 891-898
111. Liu B., Yang R., Wong K.A., Getman C., Stein N., Teitell M.A., Cheng G., Wu H., and Shuai K. Negative regulation of NF-kappaB signaling by PIAS1. Mol. Cell. Biol. 25 (2005) 1113-1123
112. Liu L., McBride K.M., and Reich N.C. STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc. Natl. Acad. Sci. USA 102 (2005) 8150-8155
113. Liu X., Robinson G.W., Wagner K.U., Garrett L., Wynshaw-Boris A., and Hennighausen L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 11 (1997) 179-186
114. Ma J., Zhang T., Novotny-Diermayr V., Tan A.L., and Cao X. A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J. Biol. Chem. 278 (2003) 29252-29260
115. Maiti N.R., Sharma P., Harbor P.C., and Haque S.J. Serine phosphorylation of Stat6 negatively controls its DNA-binding function. J. Interferon. Cytokine. Res. 25 (2005) 553-563
116. Mantovani A., Locati M., Vecchi A., Sozzani S., and Allavena P. Decoy receptors: A strategy to regulate inflammatory cytokines and chemokines. Trends Immunol. 22 (2001) 328-336
117. Marine J.C., McKay C., Wang D., Topham D.J., Parganas E., Nakajima H., Pendeville H., Yasukawa H., Sasaki A., Yoshimura A., and Ihle J.N. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell 98 (1999) 617-627
118. Marine J.C., Topham D.J., McKay C., Wang D., Parganas E., Stravopodis D., Yoshimura A., and Ihle J.N. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98 (1999) 609-616
119. McBride K.M., McDonald C., and Reich N.C. Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor. EMBO J. 19 (2000) 6196-6206
120. McBride K.M., Banninger G., McDonald C., and Reich N.C. Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J. 21 (2002) 1754-1763
121. Meraz M.A., White J.M., Sheehan K.C., Bach E.A., Rodig S.J., Dighe A.S., Kaplan D.H., Riley J.K., Greenlund A.C., Campbell D., Carver-Moore K., DuBois R.N., et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84 (1996) 431-442
122. Metcalf D., Greenhalgh C.J., Viney E., Willson T.A., Starr R., Nicola N.A., Hilton D.J., and Alexander W.S. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405 (2000) 1069-1073
123. Meyer T., Gavenis K., and Vinkemeier U. Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3. Exp. Cell. Res. 272 (2002) 45-55
124. Meyer T., Marg A., Lemke P., Wiesner B., and Vinkemeier U. DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev. 17 (2003) 1992-2005
125. Mikita T., Campbell D., Wu P., Williamson K., and Schindler U. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 16 (1996) 5811-5820
126. Mitsui Y., and Senda T. Elucidation of the basic three-dimensional structure of type I interferons and its functional and evolutionary implications. J. Interferon Cytokine Res. 17 (1997) 319-326
127. Miyajima A., Mui A.L., Ogorochi T., and Sakamaki K. Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82 (1993) 1960-1974
128. Miyata S., Matsuyama T., Kodama T., Nishioka Y., Kuribayashi K., Takeda K., Akira S., and Sugita M. STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells. Clin. Exp. Allergy 29 (1999) 114-123
129. Miyoshi K., Shillingford J.M., Smith G.H., Grimm S.L., Wagner K.U., Oka T., Rosen J.M., Robinson G.W., and Hennighausen L. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J. Cell. Biol. 155 (2001) 531-542
130. Moriggl R., Topham D.J., Teglund S., Sexl V., McKay C., Wang D., Hoffmeyer A., van Deursen J., Sangster M.Y., Bunting K.D., Grosveld G.C., and Ihle J.N. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10 (1999) 249-259
131. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., and Coffman R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136 (1986) 2348-2357
132. Mowen K.A., Tang J., Zhu W., Schurter B.T., Shuai K., Herschman H.R., and David M. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell 104 (2001) 731-741
133. Muller M., Briscoe J., Laxton C., Guschin D., Ziemiecki A., Silvennoinen O., Harpur A.G., Barbieri G., Witthuhn B.A., Schindler C., Pellegrini S., Wilks A.F., et al. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366 (1993) 129-135
134. Muto A., Watanabe S., Itoh T., Miyajima A., Yokota T., and Arai K. Roles of the cytoplasmic domains of the alpha and beta subunits of human granulocyte-macrophage colony-stimulating factor receptor. J. Allergy Clin. Immunol. 96 (1995) 1100-1114
135. Naka T., Narazaki M., Hirata M., Matsumoto T., Minamoto S., Aono A., Nishimoto N., Kajita T., Taga T., Yoshizaki K., Akira S., and Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor. Nature 387 (1997) 924-929
136. Nakajima H., Shores E.W., Noguchi M., and Leonard W.J. The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. J. Exp. Med. 185 (1997) 189-195
137. Nakajima H., Suzuki K., and Iwamoto I. Lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing. Cytokine Growth Factor Rev. 14 (2003) 375-380
138. Narazaki M., Fujimoto M., Matsumoto T., Morita Y., Saito H., Kajita T., Yoshizaki K., Naka T., and Kishimoto T. Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. Proc. Natl. Acad. Sci. USA 95 (1998) 13130-13134
139. Nelms K., Keegan A.D., Zamorano J., Ryan J.J., and Paul W.E. The IL-4 receptor: Signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17 (1999) 701-738
140. Neubauer H., Cumano A., Muller M., Wu H., Huffstadt U., and Pfeffer K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93 (1998) 397-409
141. Nicholson S.E., Willson T.A., Farley A., Starr R., Zhang J.G., Baca M., Alexander W.S., Metcalf D., Hilton D.J., and Nicola N.A. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18 (1999) 375-385
142. Niu G., Wright K.L., Huang M., Song L., Haura E., Turkson J., Zhang S., Wang T., Sinibaldi D., Coppola D., Heller R., Ellis L.M., et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21 (2002) 2000-2008
143. Nosaka T., van Deursen J.M., Tripp R.A., Thierfelder W.E., Witthuhn B.A., McMickle A.P., Doherty P.C., Grosveld G.C., and Ihle J.N. Defective lymphoid development in mice lacking Jak3. Science 270 (1995) 800-802
144. O'Shea J.J., and Watford W. A peek at PIAS. Nat. Immunol. 5 (2004) 875-876
145. O'Shea J.J., Gadina M., and Schreiber R.D. Cytokine signaling in 2002: New surprises in the Jak/Stat pathway. Cell 109 Suppl. (2002) S121-S131
146. O'Shea J.J., Pesu M., Borie D.C., and Changelian P.S. A new modality for immunosuppression: Targeting the JAK/STAT pathway. Nat. Rev. Drug Discov. 3 (2004) 555-564
147. O'Shea J.J., Kanno Y., Chen X., and Levy D.E. Cell signaling. Stat acetylation: A key facet of cytokine signaling?. Science 307 (2005) 217-218
148. O'Shea J.J., Park H., Pesu M., Borie D., and Changelian P. New strategies for immunosuppression: Interfering with cytokines by targeting the Jak/Stat pathway. Curr. Opin. Rheumatol. 17 (2005) 305-311
149. Ohtani T., Ishihara K., Atsumi T., Nishida K., Kaneko Y., Miyata T., Itoh S., Narimatsu M., Maeda H., Fukada T., Itoh M., Okano H., et al. Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12 (2000) 95-105
150. Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K., Zonin F., Vaisberg E., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 (2000) 715-725
151. Oritani K., Medina K.L., Tomiyama Y., Ishikawa J., Okajima Y., Ogawa M., Yokota T., Aoyama K., Takahashi I., Kincade P.W., and Matsuzawa Y. Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors. Nat. Med. 6 (2000) 659-666
152. Ozaki K., and Leonard W.J. Cytokine and cytokine receptor pleiotropy and redundancy. J. Biol. Chem. 277 (2002) 29355-29358
153. Parganas E., Wang D., Stravopodis D., Topham D.J., Marine J.C., Teglund S., Vanin E.F., Bodner S., Colamonici O.R., van Deursen J.M., Grosveld G., and Ihle J.N. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93 (1998) 385-395
154. Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168 (2002) 5699-5708
155. Park C., Li S., Cha E., and Schindler C. Immune response in Stat2 knockout mice. Immunity 13 (2000) 795-804
156. Park S.H., Yamashita H., Rui H., and Waxman D.J. Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: Impact on STAT5 transcriptional activity. Mol. Endocrinol. 15 (2001) 2157-2171
157. Park S.Y., Saijo K., Takahashi T., Osawa M., Arase H., Hirayama N., Miyake K., Nakauchi H., Shirasawa T., and Saito T. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 3 (1995) 771-782
158. Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J. Biol. Chem. 277 (2002) 47517-47523
159. Pernis A.B., and Rothman P.B. JAK-STAT signaling in asthma. J. Clin. Invest. 109 (2002) 1279-1283
160. Pestka S., Krause C.D., Sarkar D., Walter M.R., Shi Y., and Fisher P.B. Interleukin-10 and related cytokines and receptors. Annu. Rev. Immunol. 22 (2004) 929-979
161. Qu C.K. The SHP-2 tyrosine phosphatase: Signaling mechanisms and biological functions. Cell Res. 10 (2000) 279-288
162. Quelle F.W., Sato N., Witthuhn B.A., Inhorn R.C., Eder M., Miyajima A., Griffin J.D., and Ihle J.N. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol. Cell. Biol. 14 (1994) 4335-4341
163. Rahaman S.O., Harbor P.C., Chernova O., Barnett G.H., Vogelbaum M.A., and Haque S.J. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21 (2002) 8404-8413
164. Rahaman S.O., Sharma P., Harbor P.C., Aman M.J., Vogelbaum M.A., and Haque S.J. IL-13R(alpha)2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Res. 62 (2002) 1103-1109
165. Ramana C.V., Gil M.P., Schreiber R.D., and Stark G.R. Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling. Trends Immunol. 23 (2002) 96-101
166. Rane S.G., and Reddy E.P. JAK3: A novel JAK kinase associated with terminal differentiation of hematopoietic cells. Oncogene 9 (1994) 2415-2423
167. Riedy M.C., Dutra A.S., Blake T.B., Modi W., Lal B.K., Davis J., Bosse A., O'Shea J.J., and Johnston J.A. Genomic sequence, organization, and chromosomal localization of human JAK3. Genomics 37 (1996) 57-61
168. Rodig S.J., Meraz M.A., White J.M., Lampe P.A., Riley J.K., Arthur C.D., King K.L., Sheehan K.C., Yin L., Pennica D., Johnson Jr. E.M., and Schreiber R.D. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93 (1998) 373-383
169. Rout M.P., Aitchison J.D., Magnasco M.O., and Chait B.T. Virtual gating and nuclear transport: The hole picture. Trends Cell Biol. 13 (2003) 622-628
170. Rozwarski D.A., Gronenborn A.M., Clore G.M., Bazan J.F., Bohm A., Wlodawer A., Hatada M., and Karplus P.A. Structural comparisons among the short-chain helical cytokines. Structure 2 (1994) 159-173
171. Sano S., Itami S., Takeda K., Tarutani M., Yamaguchi Y., Miura H., Yoshikawa K., Akira S., and Takeda J. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 18 (1999) 4657-4668
172. Sano S., Takahama Y., Sugawara T., Kosaka H., Itami S., Yoshikawa K., Miyazaki J., van Ewijk W., and Takeda J. Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival. Immunity 15 (2001) 261-273
173. Schaper F., Gendo C., Eck M., Schmitz J., Grimm C., Anhuf D., Kerr I.M., and Heinrich P.C. Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression. Biochem. J. 335 Part 3 (1998) 557-565
174. Schindler C. Cytokines and JAK-STAT signaling. Exp. Cell Res. 253 (1999) 7-14
175. Schindler C., and Darnell Jr. J.E. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway. Annu. Rev. Biochem. 64 (1995) 621-651
176. Schindler U., Wu P., Rothe M., Brasseur M., and McKnight S.L. Components of a Stat recognition code: Evidence for two layers of molecular selectivity. Immunity 2 (1995) 689-697
177. Schwaller J., Parganas E., Wang D., Cain D., Aster J.C., Williams I.R., Lee C.K., Gerthner R., Kitamura T., Frantsve J., Anastasiadou E., Loh M.L., et al. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol. Cell 6 (2000) 693-704
178. Seki Y., Hayashi K., Matsumoto A., Seki N., Tsukada J., Ransom J., Naka T., Kishimoto T., Yoshimura A., and Kubo M. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc. Natl. Acad. Sci. USA 99 (2002) 13003-13008
179. Sekimoto T., Imamoto N., Nakajima K., Hirano T., and Yoneda Y. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1. EMBO J. 16 (1997) 7067-7077
180. Sexl V., Piekorz R., Moriggl R., Rohrer J., Brown M.P., Bunting K.D., Rothammer K., Roussel M.F., and Ihle J.N. Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96 (2000) 2277-2283
181. Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.C., Zdanov A., Donnelly R.P., and Kotenko S.V. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. J. Immunol. 172 (2004) 2006-2010
182. Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S., Whitmore T.E., Kuestner R., Garrigues U., Birks C., Roraback J., Ostrander C., Dong D., et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat. Immunol. 4 (2003) 63-68
183. Sherman M.A., Powell D.R., and Brown M.A. IL-4 induces the proteolytic processing of mast cell STAT6. J. Immunol. 169 (2002) 3811-3818
184. Shimoda K., van Deursen J., Sangster M.Y., Sarawar S.R., Carson R.T., Tripp R.A., Chu C., Quelle F.W., Nosaka T., Vignali D.A., Doherty P.C., Grosveld G., et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380 (1996) 630-633
185. Shimoda K., Kato K., Aoki K., Matsuda T., Miyamoto A., Shibamori M., Yamashita M., Numata A., Takase K., Kobayashi S., Shibata S., Asano Y., et al. Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 13 (2000) 561-571
186. Shimoda K., Tsutsui H., Aoki K., Kato K., Matsuda T., Numata A., Takase K., Yamamoto T., Nukina H., Hoshino T., Asano Y., Gondo H., et al. Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice. Blood 99 (2002) 2094-2099
187. Shuai K. The STAT family of proteins in cytokine signaling. Prog. Biophys. Mol. Biol. 71 (1999) 405-422
188. Shuai K., and Liu B. Regulation of JAK-STAT signalling in the immune system. Nat. Rev. Immunol. 3 (2003) 900-911
189. Shuai K., and Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol. 5 (2005) 593-605
190. Shuai K., Schindler C., Prezioso V.R., and Darnell Jr. J.E. Activation of transcription by IFN-gamma: Tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258 (1992) 1808-1812
191. Shultz L.D., Schweitzer P.A., Rajan T.V., Yi T., Ihle J.N., Matthews R.J., Thomas M.L., and Beier D.R. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73 (1993) 1445-1454
192. Snow J.W., Abraham N., Ma M.C., Abbey N.W., Herndier B., and Goldsmith M.A. STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells. Blood 99 (2002) 95-101
193. Socolovsky M., Fallon A.E., Wang S., Brugnara C., and Lodish H.F. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: A direct role for Stat5 in Bcl-X(L) induction. Cell 98 (1999) 181-191
194. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., and Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 67 (1998) 227-264
195. Starr R., and Hilton D.J. Negative regulation of the JAK/STAT pathway. Bioessays 21 (1999) 47-52
196. Starr R., Willson T.A., Viney E.M., Murray L.J., Rayner J.R., Jenkins B.J., Gonda T.J., Alexander W.S., Metcalf D., Nicola N.A., and Hilton D.J. A family of cytokine-inducible inhibitors of signalling. Nature 387 (1997) 917-921
197. Strehlow I., and Schindler C. Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation. J. Biol. Chem. 273 (1998) 28049-28056
198. Suzuki K., Nakajima H., Kagami S., Suto A., Ikeda K., Hirose K., Hiwasa T., Takeda K., Saito Y., Akira S., and Iwamoto I. Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J. Exp. Med. 196 (2002) 27-38
199. Takahashi T., and Shirasawa T. Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases. FEBS Lett. 342 (1994) 124-128
200. Takeda K., Tanaka T., Shi W., Matsumoto M., Minami M., Kashiwamura S., Nakanishi K., Yoshida N., Kishimoto T., and Akira S. Essential role of Stat6 in IL-4 signalling. Nature 380 (1996) 627-630
201. Takeda K., Noguchi K., Shi W., Tanaka T., Matsumoto M., Yoshida N., Kishimoto T., and Akira S. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 94 (1997) 3801-3804
202. Takeda K., Kaisho T., Yoshida N., Takeda J., Kishimoto T., and Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161 (1998) 4652-4660
203. Takeda K., Clausen B.E., Kaisho T., Tsujimura T., Terada N., Forster I., and Akira S. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10 (1999) 39-49
204. Tebo J.M., Kim H.S., Gao J., Armstrong D.A., and Hamilton T.A. Interleukin-10 suppresses IP-10 gene transcription by inhibiting the production of class I interferon. Blood 92 (1998) 4742-4749
205. Teglund S., McKay C., Schuetz E., van Deursen J.M., Stravopodis D., Wang D., Brown M., Bodner S., Grosveld G., and Ihle J.N. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93 (1998) 841-850
206. ten Hoeve J., de Jesus Ibarra-Sanchez M., Fu Y., Zhu W., Tremblay M., David M., and Shuai K. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 2B (2002) 5662-5668
207. Thierfelder W.E., van Deursen J.M., Yamamoto K., Tripp R.A., Sarawar S.R., Carson R.T., Sangster M.Y., Vignali D.A., Doherty P.C., Grosveld G.C., and Ihle J.N. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382 (1996) 171-174
208. Thomis D.C., Gurniak C.B., Tivol E., Sharpe A.H., and Berg L.J. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270 (1995) 794-797
209. Tomkinson A., Kanehiro A., Rabinovitch N., Joetham A., Cieslewicz G., and Gelfand E.W. The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5. Am. J. Respir. Crit. Care Med. 160 (1999) 1283-1291
210. Tussie-Luna M.I., Bayarsaihan D., Seto E., Ruddle F.H., and Roy A.L. Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. Proc. Natl. Acad. Sci. USA 99 (2002) 12807-12812
211. Udy G.B., Towers R.P., Snell R.G., Wilkins R.J., Park S.H., Ram P.A., Waxman D.J., and Davey H.W. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. USA 94 (1997) 7239-7244
212. Ungureanu D., Saharinen P., Junttila I., Hilton D.J., and Silvennoinen O. Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol. Cell. Biol. 22 (2002) 3316-3326
213. Uze G., Lutfalla G., and Mogensen K.E. Alpha and beta interferons and their receptor and their friends and relations. J. Interferon Cytokine Res. 15 (1995) 3-26
214. van Dijk T.B., Baltus B., Caldenhoven E., Handa H., Raaijmakers J.A., Lammers J.W., Koenderman L., and de Groot R.P. Cloning and characterization of the human interleukin-3 (IL-3)/IL-5/granulocyte-macrophage colony-stimulating factor receptor betac gene: Regulation by Ets family members. Blood 92 (1998) 3636-3646
215. Velazquez L., Fellous M., Stark G.R., and Pellegrini S. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 70 (1992) 313-322
216. Vignais M.L., Sadowski H.B., Watling D., Rogers N.C., and Gilman M. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol. Cell. Biol. 16 (1996) 1759-1769
217. Vilcek J. Novel interferons. Nat. Immunol. 4 (2003) 8-9
218. Vitetta E.S., Ohara J., Myers C.D., Layton J.E., Krammer P.H., and Paul W.E. Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J. Exp. Med. 162 (1985) 1726-1731
219. Wagner B.J., Hayes T.E., Hoban C.J., and Cochran B.H. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9 (1990) 4477-4484
220. Wang D., Moriggl R., Stravopodis D., Carpino N., Marine J.C., Teglund S., Feng J., and Ihle J.N. A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5. EMBO J. 19 (2000) 392-399
221. Watling D., Guschin D., Muller M., Silvennoinen O., Witthuhn B.A., Quelle F.W., Rogers N.C., Schindler C., Stark G.R., Ihle J.N., and Kerr L.M. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature 366 (1993) 166-170
222. Wei D., Le X., Zheng L., Wang L., Frey J.A., Gao A.C., Peng Z., Huang S., Xiong H.Q., Abbruzzese J.L., and Xie K. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22 (2003) 319-329
223. Welte T., Zhang S.S., Wang T., Zhang Z., Hesslein D.G., Yin Z., Kano A., Iwamoto Y., Li E., Craft J.E., Bothwell A.L., Fikrig E., et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity. Proc. Natl. Acad. Sci. USA 100 (2003) 1879-1884
224. Wilks A.F., Harpur A.G., Kurban R.R., Ralph S.J., Zurcher G., and Ziemiecki A. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11 (1991) 2057-2065
225. Witthuhn B.A., Silvennoinen O., Miura O., Lai K.S., Cwik C., Liu E.T., and Ihle J.N. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370 (1994) 153-157
226. Woetmann A., Nielsen M., Christensen S.T., Brockdorff J., Kaltoft K., Engel A.M., Skov S., Brender C., Geisler C., Svejgaard A., Rygaard J., Leick V., et al. Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3. Proc. Natl. Acad. Sci. USA 96 (1999) 10620-10625
227. Woetmann A., Brockdorff J., Lovato P., Nielsen M., Leick V., Rieneck K., Svejgaard A., Geisler C., and Odum N. Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling. J. Biol. Chem. 278 (2003) 2787-2791
228. Wormald S., and Hilton D.J. Inhibitors of cytokine signal transduction. J. Biol. Chem. 279 (2004) 821-824
229. Wu T.R., Hong Y.K., Wang X.D., Ling M.Y., Dragoi A.M., Chung A.S., Campbell A.G., Han Z.Y., Feng G.S., and Chin Y.E. SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J. Biol. Chem. 277 (2002) 47572-47580
230. Xie M.H., Aggarwal S., Ho W.H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., and Gurney A.L. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 275 (2000) 31335-31339
231. Yamamoto K., Kobayashi H., Arai A., Miura O., Hirosawa S., and Miyasaka N. cDNA cloning, expression and chromosome mapping of the human STAT4 gene: Both STAT4 and STAT1 genes are mapped to 2q32.2->q32.3. Cytogenet. Cell Genet. 77 (1997) 207-210
232. Yamaoka K., Saharinen P., Pesu M., Holt III V.E., Silvennoinen O., and O'Shea J.J. The Janus kinases (Jaks). Genome Biol. 5 (2004) 253
233. Yamashita H., Xu J., Erwin R.A., Farrar W.L., Kirken R.A., and Rui H. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells. J. Biol. Chem. 273 (1998) 30218-30224
234. Yasukawa H., Ohishi M., Mori H., Murakami M., Chinen T., Aki D., Hanada T., Takeda K., Akira S., Hoshijima M., Hirano T., Chien K.R., et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat. Immunol. 4 (2003) 551-556
235. Yi T., Gilbert D.J., Jenkins N.A., Copeland N.G., and Ihle J.N. Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6. Genomics 14 (1992) 793-795
236. Yi T.L., Cleveland J.L., and Ihle J.N. Protein tyrosine phosphatase containing SH2 domains: Characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. Mol. Cell. Biol. 12 (1992) 836-846
237. Yu H., and Jove R. The STATs of cancer: New molecular targets come of age. Nat. Rev. Cancer 4 (2004) 97-105
238. Zhang J.G., Hilton D.J., Willson T.A., McFarlane C., Roberts B.A., Moritz R.L., Simpson R.J., Alexander W.S., Metcalf D., and Nicola N.A. Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains. J. Biol. Chem. 272 (1997) 9474-9480
239. Zhang J.G., Farley A., Nicholson S.E., Willson T.A., Zugaro L.M., Simpson R.J., Moritz R.L., Cary D., Richardson R., Hausmann G., Kile B.J., Kent S.B., et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96 (1999) 2071-2076
240. Zhong Z., Wen Z., and Darnell Jr. J.E. Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264 (1994) 95-98
241. Zlotnik A., Fischer M., Roehm N., and Zipori D. Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: Enhancement of antigen presenting ability of bone marrow-derived macrophages. J. Immunol. 138 (1987) 4275-4279