Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

Immunity

Volumn 13, Issue 4, 2000, Pages 561-571

  Shimoda, Kazuya ^a,b   Kato, Kouji ^a,b   Aoki, Kenichi ^a,b   Matsuda, Tadashi ^d   Miyamoto, Akitomo ^c,e   Shibamori, Masafumi ^f   Yamashita, Masakatsu ^g   Numata, Akihiko ^a,b   Takase, Ken ^a,b   Kobayashi, Shinji ^a,b   Shibata, Shouichirou ^a,b   Asano, Yoshinobu ^a,b   Gondo, Hisashi ^a,b   Sekiguchi, Kazuo ^f   Nakayama, Keiko ^a,e   Nakayama, Toshinori ^g   Okamura, Takashi ^a,b   Okamura, Seiichi ^a,b,h   Niho, Yoshiyuki ^a,b,i   Nakayama, Kei ichi ^a,c,e  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^g CHIBA UNIVERSITY   (Japan)

^h NATIONAL HOSPITAL ORGANIZATION KYUSHU MEDICAL CENTER   (Japan)

ⁱ CHIHAYA HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTOKINE RECEPTOR; INTERLEUKIN 12; JANUS KINASE; PROTEIN TYK2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE;

EID: 0033711641     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00055-8     Document Type: Article

References (30)

1. Interleukin 12 (IL-12) induces tyrosine phosphorylation of Jak2 and tyk2: Differential use of Janus family kinases by IL-2 and IL-12
2. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
3. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
4. IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of Stat1α and Stat3 complexes in human T cells and monocytes
5. Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes
6. A major role for the protein tyrosine kinase Jak1 in the Jak/Stat signal transduction pathway in response to interleukin-6
7. Cytokine receptor signalling
8. STATs: Signal transducers and activators of transcription
9. Signaling through the hematopoietic cytokine receptors
10. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
11. Impaired IL-12 responses and enhanced development of Th2 cells in Stat-4-deficient mice
12. B cell stimulation factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes
13. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the Jak-Stat signaling pathway
14. The protein tyrosine kinase Jak1 complements defects in interferon-α/β and γ-signal transduction
15. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
16. Defective lymphoid development in mice lacking Jak3
17. Jak2 is essential for signaling through a variety of cytokine receptors
18. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
19. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway
20. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
21. Jak1 plays an essential role for receptor phosphorylation and stat activation in response to granulocyte colony-stimulating factor
22. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
23. Cross talk between interferon-α and -α/β signaling components in caveolar membrane domains
24. Requirement for Stat4 in interleukin-12-mediated responses of natural killer T cells
25. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
26. A protein tyrosine kinase in the interferon alpha/beta signaling pathway
27. Complementation by the protein tyrosine kinase Jak2 of a mutant cell line defective in the interferon-α signal transduction pathway
28. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
29. Involvement of the Jak-3 Janus kinase in signaling by interleukin 2 and 4 in lymphoid and myeloid cells
30. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin4 receptor function and type-2 helper T cell differentiation