Immune response in Stat2 knockout mice

Immunity

Volumn 13, Issue 6, 2000, Pages 795-804

  Park, C ^a   Li, S ^a   Cha, E ^a   Schindler, C ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; DEXAMETHASONE; GENE PRODUCT; PROTEIN ISGF3; PROTEIN P48; RECOMBINANT ALPHA INTERFERON; RECOMBINANT GAMMA INTERFERON; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; GENE DELETION; GENE TARGETING; IMMUNE RESPONSE; INFECTION SENSITIVITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; VESICULAR STOMATITIS VIRUS;

EID: 0034515268     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00077-7     Document Type: Article

References (49)

1. Functionally distinct isoforms of Stat5 are generated by protein processing
2. Virus-induced transient bone marrow aplasia: Major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus
3. Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections
4. Isolation and expression of an IFN-responsive Ly-6C chromosomal gene
5. Single step method for RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
6. Multiple defects of immune cell function in mice with disrupted interferon-γ genes
7. STATs and gene regulation
8. GAS elements: A few nucleotides with a major impact on cytokine-induced gene expression
9. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
10. Interferon-β is required for interferon-α production in mice fibroblasts
11. Selective loss of type I interferon-induced Stat4 activation caused by a minisatellite insertion in mouse Stat2
12. Immune response in mice that lack the interferon-γ receptor
13. Cytokine receptor signaling
14. HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons
15. A physiological role of interferon (IFN)-β from tumor: Tumor growth of a mouse bladder carinoma line MBT-2 is partially suppressed by autocrine IFN-β
16. Essential and non-redundant roles of p48 (ISGF3γ) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies
17. Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes
18. Role of STAT2 in the alpha interferon signaling pathway
19. Impairment of T and B cell development by treatment with type I interferon
20. Targeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice
21. Differential viral induction to distinct alpha-interferon genes by positive feedback through interferon regulatory factor-7
22. Type I interferons keep activated T cells alive
23. Induction of MHC class I expression by the MHC class II transactivator CIITA
24. Activation of the transcription factor ISGF3 by IFN-γ
25. Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes
26. Targeted disruption of the Stat1 gene in mice reveals unexpected physiological specificity in the JAK-STAT pathway
27. Production of a homozygous mutant ES cell with a single targeting construct
28. Functional role of type I and type II interferons in antiviral defense
29. Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors
30. Protein-DNA interactions in interferon-γ signaling
31. Murine Stat2 is uncharacteristically divergent
32. Interferon-β mediates stromal cell rescue of T-cells from apoptosis
33. Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection
34. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN-α and IFN-γ, and is likely to autoregulate the p91 gene
35. Autocrine β-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation
36. Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
37. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
38. The nature of the principal type I interferon-producing cells in human blood
39. How cells respond to interferons
40. Amino terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation
41. Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains
42. Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP
43. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
44. Induction of bystander T-cell proliferation by viruses and type I interferon in vivo
45. Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells
46. A NF-κB/c-myc-dependent survival pathway is targeted by corticosteroids in immature thymocytes
47. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
48. Production of targeted embryonic stem cell clones