-
1
-
-
0002237194
-
An introduction to the cytokines
-
ed. NA Nicola. New York: Oxford Univ. Press
-
Nicola NA. 1994. An introduction to the cytokines. In Guidebook to Cytokines and Their Receptors, ed. NA Nicola. New York: Oxford Univ. Press
-
(1994)
Guidebook to Cytokines and Their Receptors
-
-
Nicola, N.A.1
-
2
-
-
0002843205
-
An introduction to cytokine receptors
-
ed. NA Nicola. New York: Oxford Univ. Press
-
Hilton DJ. 1994. An introduction to cytokine receptors. In Guidebook to Cytokines and Their Receptors, ed. NA Nicola. New York: Oxford Univ. Press
-
(1994)
Guidebook to Cytokines and Their Receptors
-
-
Hilton, D.J.1
-
3
-
-
0035367819
-
Signaling by type I and II cytokine receptors: Ten years after
-
Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, et al. 2001. Signaling by type I and II cytokine receptors: ten years after. Curr. Opin. Immunol. 13:363-73
-
(2001)
Curr. Opin. Immunol.
, vol.13
, pp. 363-373
-
-
Gadina, M.1
Hilton, D.2
Johnston, J.A.3
Morinobu, A.4
Lighvani, A.5
-
4
-
-
0025102756
-
Haemopoietic receptors and helical cytokines
-
Bazan JF. 1990. Haemopoietic receptors and helical cytokines. Immunol. Today. 11:350-54
-
(1990)
Immunol. Today
, vol.11
, pp. 350-354
-
-
Bazan, J.F.1
-
5
-
-
0028921573
-
Jaks and Stats in signalling by the cytokine receptor superfamily
-
Ihle JN, Kerr IM. 1995. Jaks and Stats in signalling by the cytokine receptor superfamily. Trends Genet. 11:69-74
-
(1995)
Trends Genet.
, vol.11
, pp. 69-74
-
-
Ihle, J.N.1
Kerr, I.M.2
-
6
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
-
Darnell JE Jr, Kerr IM, Stark GR. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-21
-
(1994)
Science
, vol.264
, pp. 1415-1421
-
-
Darnell Jr., J.E.1
Kerr, I.M.2
Stark, G.R.3
-
7
-
-
0030840464
-
STATs and gene regulation
-
Darnell JE Jr. 1997. STATs and gene regulation. Science 277:1630-35
-
(1997)
Science
, vol.277
, pp. 1630-1635
-
-
Darnell Jr., J.E.1
-
8
-
-
0029014206
-
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
-
Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, et al. 1995. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:2816-26
-
(1995)
EMBO J.
, vol.14
, pp. 2816-2826
-
-
Yoshimura, A.1
Ohkubo, T.2
Kiguchi, T.3
Jenkins, N.A.4
Gilbert, D.J.5
-
9
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signalling
-
Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, et al. 1997. A family of cytokine-inducible inhibitors of signalling. Nature 387:917-21
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
Willson, T.A.2
Viney, E.M.3
Murray, L.J.4
Rayner, J.R.5
-
10
-
-
0030839112
-
A new protein containing an SH2 domain that inhibits JAK kinases
-
Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, et al. 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387:921-24
-
(1997)
Nature
, vol.387
, pp. 921-924
-
-
Endo, T.A.1
Masuhara, M.2
Yokouchi, M.3
Suzuki, R.4
Sakamoto, H.5
-
11
-
-
0030755934
-
Structure and function of a new STAT-induced STAT inhibitor
-
Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, et al. 1997. Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924-29
-
(1997)
Nature
, vol.387
, pp. 924-929
-
-
Naka, T.1
Narazaki, M.2
Hirata, M.3
Matsumoto, T.4
Minamoto, S.5
-
12
-
-
0031559588
-
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
-
Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, et al. 1997. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem. Biophys. Res. Commun. 237:79-83
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.237
, pp. 79-83
-
-
Minamoto, S.1
Ikegame, K.2
Ueno, K.3
Narazaki, M.4
Naka, T.5
-
13
-
-
13144258732
-
Twenty proteins containing a C-terminal SOCS box form five structural classes
-
Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, et al. 1998. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 95:114-19
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 114-119
-
-
Hilton, D.J.1
Richardson, R.T.2
Alexander, W.S.3
Viney, E.M.4
Willson, T.A.5
-
14
-
-
0036558025
-
The SOCS box: A tale of destruction and degradation
-
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ. 2002. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 27:235-41
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 235-241
-
-
Kile, B.T.1
Schulman, B.A.2
Alexander, W.S.3
Nicola, N.A.4
Martin, H.M.5
Hilton, D.J.6
-
15
-
-
0037127270
-
Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: Two routes for STAT5 target gene induction by erythropoietin
-
Jegalian AG, Wu H. 2002. Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin. J. Biol. Chem. 277:2345-52
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2345-2352
-
-
Jegalian, A.G.1
Wu, H.2
-
17
-
-
0343775617
-
Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame
-
Schluter G, Boinska D, Nieman-Seyde SC. 2000. Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame. Biochem. Biophys. Res. Commun. 268:255-61
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.268
, pp. 255-261
-
-
Schluter, G.1
Boinska, D.2
Nieman-Seyde, S.C.3
-
18
-
-
0037423763
-
Cloning and characterization of a functional promoter of the human SOCS-3 gene
-
He B, You L, Uematsu K, Matsangou M, Xu Z, et al. 2003. Cloning and characterization of a functional promoter of the human SOCS-3 gene. Biochem. Biophys. Res. Commun. 301:386-91
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.301
, pp. 386-391
-
-
He, B.1
You, L.2
Uematsu, K.3
Matsangou, M.4
Xu, Z.5
-
19
-
-
0032779561
-
The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
-
Donnelly RP, Dickensheets H, Finbloom DS. 1999. The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J. Interferon Cytokine Res. 19:563-73
-
(1999)
J. Interferon Cytokine Res.
, vol.19
, pp. 563-573
-
-
Donnelly, R.P.1
Dickensheets, H.2
Finbloom, D.S.3
-
20
-
-
0035865517
-
STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma
-
Brender C, Nielsen M, Kaltoft K, Mikkelsen G, Zhang Q, et al. 2001. STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma. Blood 97:1056-62
-
(2001)
Blood
, vol.97
, pp. 1056-1062
-
-
Brender, C.1
Nielsen, M.2
Kaltoft, K.3
Mikkelsen, G.4
Zhang, Q.5
-
21
-
-
0030956715
-
CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
-
Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, et al. 1997. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89:3148-54
-
(1997)
Blood
, vol.89
, pp. 3148-3154
-
-
Matsumoto, A.1
Masuhara, M.2
Mitsui, K.3
Yokouchi, M.4
Ohtsubo, M.5
-
22
-
-
17944383969
-
A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: A distinct biochemical difference between STAT5A and STAT5B
-
Verdier F, Rabionet R, Gouilleux F, Beisenherz-Huss C, Varlet P, et al. 1998. A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B. Mol. Cell Biol. 18:5852-60
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 5852-5860
-
-
Verdier, F.1
Rabionet, R.2
Gouilleux, F.3
Beisenherz-Huss, C.4
Varlet, P.5
-
23
-
-
0032716979
-
STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver
-
Davey HW, McLachlan MJ, Wilkins RJ, Hilton DJ, Adams TE. 1999. STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver. Mol. Cell Endocrinol. 158:111-16
-
(1999)
Mol. Cell Endocrinol.
, vol.158
, pp. 111-116
-
-
Davey, H.W.1
McLachlan, M.J.2
Wilkins, R.J.3
Hilton, D.J.4
Adams, T.E.5
-
24
-
-
0030930196
-
STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression
-
Feldman GM, Rosenthal LA, Liu X, Hayes MP, Wynshaw-Boris A, et al. 1997. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90:1768-76
-
(1997)
Blood
, vol.90
, pp. 1768-1776
-
-
Feldman, G.M.1
Rosenthal, L.A.2
Liu, X.3
Hayes, M.P.4
Wynshaw-Boris, A.5
-
25
-
-
0036338213
-
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
-
Lee CK, Raz R, Gimeno R, Gertner R, Wistinghausen B, et al. 2002. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 17:63-72
-
(2002)
Immunity
, vol.17
, pp. 63-72
-
-
Lee, C.K.1
Raz, R.2
Gimeno, R.3
Gertner, R.4
Wistinghausen, B.5
-
26
-
-
0035159504
-
Listeria monocytogenes modulates macrophage cytokine responses through STAT serine phosphorylation and the induction of suppressor of cytokine signaling 3
-
Stoiber D, Stockinger S, Steinlein P, Kovarik J, Decker T. 2001. Listeria monocytogenes modulates macrophage cytokine responses through STAT serine phosphorylation and the induction of suppressor of cytokine signaling 3. J. Immunol. 166:466-72
-
(2001)
J. Immunol.
, vol.166
, pp. 466-472
-
-
Stoiber, D.1
Stockinger, S.2
Steinlein, P.3
Kovarik, J.4
Decker, T.5
-
27
-
-
0037219733
-
In vivo activation of the interleukin-6 receptor/gp130 signaling pathway in pituitary corticotropes of lipopolysaccharide-treated rats
-
Gautron L, Lafon P, Tramu G, Laye S. 2003. In vivo activation of the interleukin-6 receptor/gp130 signaling pathway in pituitary corticotropes of lipopolysaccharide-treated rats. Neuroendocrinology 77:32-43
-
(2003)
Neuroendocrinology
, vol.77
, pp. 32-43
-
-
Gautron, L.1
Lafon, P.2
Tramu, G.3
Laye, S.4
-
28
-
-
0034234797
-
Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: Partial role of autocrine/paracrine interferon-alpha/beta
-
Crespo A, Filla MB, Russell SW, Murphy WJ. 2000. Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-alpha/beta. Biochem. J. 349:99-104
-
(2000)
Biochem. J.
, vol.349
, pp. 99-104
-
-
Crespo, A.1
Filla, M.B.2
Russell, S.W.3
Murphy, W.J.4
-
29
-
-
0033197958
-
Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma
-
Stoiber D, Kovarik P, Cohney S, Johnston JA, Steinlein P, Decker T. 1999. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma. J. Immunol. 163:2640-47
-
(1999)
J. Immunol.
, vol.163
, pp. 2640-2647
-
-
Stoiber, D.1
Kovarik, P.2
Cohney, S.3
Johnston, J.A.4
Steinlein, P.5
Decker, T.6
-
30
-
-
18744371050
-
SOCS-1 participates in negative regulation of LPS responses
-
Nakagawa R, Naka T, Tsutsui H, Fujimoto M, Kimura A, et al. 2002. SOCS-1 participates in negative regulation of LPS responses. Immunity 17:677-87
-
(2002)
Immunity
, vol.17
, pp. 677-687
-
-
Nakagawa, R.1
Naka, T.2
Tsutsui, H.3
Fujimoto, M.4
Kimura, A.5
-
31
-
-
0036850946
-
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
-
Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, et al. 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17:583-91
-
(2002)
Immunity
, vol.17
, pp. 583-591
-
-
Kinjyo, I.1
Hanada, T.2
Inagaki-Ohara, K.3
Mori, H.4
Aki, D.5
-
32
-
-
20244389693
-
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
-
Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, et al. 1999. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18:1309-20
-
(1999)
EMBO J.
, vol.18
, pp. 1309-1320
-
-
Yasukawa, H.1
Misawa, H.2
Sakamoto, H.3
Masuhara, M.4
Sasaki, A.5
-
33
-
-
0035168683
-
JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling
-
Sporri B, Kovanen PE, Sasaki A, Yoshimura A, Leonard WJ. 2001. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. Blood 97:221-26
-
(2001)
Blood
, vol.97
, pp. 221-226
-
-
Sporri, B.1
Kovanen, P.E.2
Sasaki, A.3
Yoshimura, A.4
Leonard, W.J.5
-
34
-
-
0033555258
-
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
-
Nicholson SE, Willson TA, Farley A, Starr R, Zhang JG, et al. 1999. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18:375-85
-
(1999)
EMBO J.
, vol.18
, pp. 375-385
-
-
Nicholson, S.E.1
Willson, T.A.2
Farley, A.3
Starr, R.4
Zhang, J.G.5
-
35
-
-
0038676954
-
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2
-
Fairlie WD, De Souza D, Nicola NA, Baca M. 2003. Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2. Biochem. J. 372:495-502
-
(2003)
Biochem. J.
, vol.372
, pp. 495-502
-
-
Fairlie, W.D.1
De Souza, D.2
Nicola, N.A.3
Baca, M.4
-
36
-
-
0037162397
-
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
-
De Souza D, Fabri LJ, Nash A, Hilton DJ, Nicola NA, Baca M. 2002. SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 41:9229-36
-
(2002)
Biochemistry
, vol.41
, pp. 9229-9236
-
-
De Souza, D.1
Fabri, L.J.2
Nash, A.3
Hilton, D.J.4
Nicola, N.A.5
Baca, M.6
-
37
-
-
0034612271
-
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
-
Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, et al. 2000. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. USA 97:6493-98
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6493-6498
-
-
Nicholson, S.E.1
De Souza, D.2
Fabri, L.J.3
Corbin, J.4
Willson, T.A.5
-
38
-
-
0034724677
-
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
-
Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F. 2000. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275:12848-56
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12848-12856
-
-
Schmitz, J.1
Weissenbach, M.2
Haan, S.3
Heinrich, P.C.4
Schaper, F.5
-
39
-
-
0037414817
-
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
-
Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, et al. 2003. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J. Biol. Chem. 278:661-71
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 661-671
-
-
Lehmann, U.1
Schmitz, J.2
Weissenbach, M.3
Sobota, R.M.4
Hortner, M.5
-
40
-
-
0035666295
-
Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited
-
Friederichs K, Schmitz J, Weissenbach M, Heinrich PC, Schaper F. 2001. Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited. Eur. J. Biochem. 268:6401-7
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 6401-6407
-
-
Friederichs, K.1
Schmitz, J.2
Weissenbach, M.3
Heinrich, P.C.4
Schaper, F.5
-
41
-
-
0001421697
-
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
-
Bjorbak C, Lavery HJ, Bates SH, Olson RK, Davis SM, et al. 2000. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275:40649-57
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40649-40657
-
-
Bjorbak, C.1
Lavery, H.J.2
Bates, S.H.3
Olson, R.K.4
Davis, S.M.5
-
42
-
-
0034548763
-
Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
-
Eyckerman S, Broekaert D, Verhee A, Vandekerckhove J, Tavernier J. 2000. Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett. 486:33-37
-
(2000)
FEBS Lett.
, vol.486
, pp. 33-37
-
-
Eyckerman, S.1
Broekaert, D.2
Verhee, A.3
Vandekerckhove, J.4
Tavernier, J.5
-
43
-
-
0038784346
-
Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells
-
Hermans MH, van de Geijn GJ, Antonissen C, Gits J, van Leeuwen D, et al. 2003. Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells. Blood 101:2584-90
-
(2003)
Blood
, vol.101
, pp. 2584-2590
-
-
Hermans, M.H.1
Van De Geijn, G.J.2
Antonissen, C.3
Gits, J.4
Van Leeuwen, D.5
-
44
-
-
0036681955
-
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction
-
Hortner M, Nielsch U, Mayr LM, Johnston JA, Heinrich PC, Haan S. 2002. Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. J. Immunol. 169:1219-27
-
(2002)
J. Immunol.
, vol.169
, pp. 1219-1227
-
-
Hortner, M.1
Nielsch, U.2
Mayr, L.M.3
Johnston, J.A.4
Heinrich, P.C.5
Haan, S.6
-
45
-
-
0033305402
-
Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
-
Hansen JA, Lindberg K, Hilton DJ, Nielsen JH, Billestrup N. 1999. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins. Mol. Endocrinol. 13:1832-43
-
(1999)
Mol. Endocrinol.
, vol.13
, pp. 1832-1843
-
-
Hansen, J.A.1
Lindberg, K.2
Hilton, D.J.3
Nielsen, J.H.4
Billestrup, N.5
-
46
-
-
0033544899
-
SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
-
Ram PA, Waxman DJ. 1999. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J. Biol. Chem. 274:35553-61
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35553-35561
-
-
Ram, P.A.1
Waxman, D.J.2
-
47
-
-
0036105755
-
A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor
-
Hortner M, Nielsch U, Mayr LM, Heinrich PC, Haan S. 2002. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur. J. Biochem. 269:2516-26
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 2516-2526
-
-
Hortner, M.1
Nielsch, U.2
Mayr, L.M.3
Heinrich, P.C.4
Haan, S.5
-
48
-
-
0034703097
-
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
-
Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A. 2000. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275:29338-47
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29338-29347
-
-
Sasaki, A.1
Yasukawa, H.2
Shouda, T.3
Kitamura, T.4
Dikic, I.5
Yoshimura, A.6
-
49
-
-
0033037268
-
SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
-
Cohney SJ, Sanden D, Cacalano NA, Yoshimura A, Mui A, et al. 1999. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell Biol. 19:4980-88
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 4980-4988
-
-
Cohney, S.J.1
Sanden, D.2
Cacalano, N.A.3
Yoshimura, A.4
Mui, A.5
-
50
-
-
0035148616
-
Interleukin 9 induces expression of three cytokine signal inhibitors: Cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling
-
Lejeune D, Demoulin JB, Renauld JC. 2001. Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling. Biochem. J. 353:109-16
-
(2001)
Biochem. J.
, vol.353
, pp. 109-116
-
-
Lejeune, D.1
Demoulin, J.B.2
Renauld, J.C.3
-
51
-
-
0033504732
-
IL-4 signaling is regulated through the recruitment of phosphatases, kinases, and SOCS proteins to the receptor complex
-
Losman J, Chen XP, Jiang H, Pan PY, Kashiwada M, et al. 1999. IL-4 signaling is regulated through the recruitment of phosphatases, kinases, and SOCS proteins to the receptor complex. Cold Spring Harbor Symp. Quant. Biol. 64:405-16
-
(1999)
Cold Spring Harbor Symp. Quant. Biol.
, vol.64
, pp. 405-416
-
-
Losman, J.1
Chen, X.P.2
Jiang, H.3
Pan, P.Y.4
Kashiwada, M.5
-
52
-
-
0035199166
-
Design and application of a cytokine-receptor-based interaction trap
-
Eyckerman S, Verhee A, der Heyden JV, Lemmens I, Ostade XV, et al. 2001. Design and application of a cytokine-receptor-based interaction trap. Nat. Cell Biol. 3:1114-19
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1114-1119
-
-
Eyckerman, S.1
Verhee, A.2
Der Heyden, J.V.3
Lemmens, I.4
Ostade, X.V.5
-
53
-
-
0035209861
-
Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor
-
Dif F, Saunier E, Demeneix B, Kelly PA, Edery M. 2001. Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor. Endocrinology 142:5286-93
-
(2001)
Endocrinology
, vol.142
, pp. 5286-5293
-
-
Dif, F.1
Saunier, E.2
Demeneix, B.3
Kelly, P.A.4
Edery, M.5
-
54
-
-
0033570054
-
CIS associates with the interleukin-2 receptor β chain and inhibits interleukin-2-dependent signaling
-
Aman MJ, Migone T-S, Sasaki A, Ascherman DP, Zhu M, et al. 1999. CIS associates with the interleukin-2 receptor β chain and inhibits interleukin-2-dependent signaling. J. Biol. Chem. 274:30266-72
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30266-30272
-
-
Aman, M.J.1
Migone, T.-S.2
Sasaki, A.3
Ascherman, D.P.4
Zhu, M.5
-
55
-
-
0033609928
-
Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling
-
Pezet A, Favre H, Kelly PA, Edery M. 1999. Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. J. Biol. Chem. 274:24497-502
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24497-24502
-
-
Pezet, A.1
Favre, H.2
Kelly, P.A.3
Edery, M.4
-
56
-
-
0037174816
-
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling
-
Greenhalgh CJ, Metcalf D, Thaus AL, Corbin JE, Uren R, et al. 2002. Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J. Biol. Chem. 277:40181-14
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40181-40214
-
-
Greenhalgh, C.J.1
Metcalf, D.2
Thaus, A.L.3
Corbin, J.E.4
Uren, R.5
-
57
-
-
0032573161
-
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
-
Narazaki M, Fujimoto M, Matsumoto T, Morita Y, Saito H, et al. 1998. Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. Proc. Natl. Acad. Sci. USA 95:13130-34
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13130-13134
-
-
Narazaki, M.1
Fujimoto, M.2
Matsumoto, T.3
Morita, Y.4
Saito, H.5
-
58
-
-
13044263097
-
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
-
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, et al. 1999. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96:2071-76
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2071-2076
-
-
Zhang, J.G.1
Farley, A.2
Nicholson, S.E.3
Willson, T.A.4
Zugaro, L.M.5
-
59
-
-
0032535364
-
The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
-
Kamura T, Sato S, Haque D, Liu L, Kaelin WG, et al. 1998. The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12:3872-81
-
(1998)
Genes Dev.
, vol.12
, pp. 3872-3881
-
-
Kamura, T.1
Sato, S.2
Haque, D.3
Liu, L.4
Kaelin, W.G.5
-
60
-
-
0036233985
-
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1
-
Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O. 2002. Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol. Cell Biol. 22:3316-26
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 3316-3326
-
-
Ungureanu, D.1
Saharinen, P.2
Junttila, I.3
Hilton, D.J.4
Silvennoinen, O.5
-
61
-
-
0035864739
-
The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells
-
Monni R, Santos SC, Mauchauffe M, Berger R, Ghysdael J, et al. 2001. The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells. Oncogene 20:849-58
-
(2001)
Oncogene
, vol.20
, pp. 849-858
-
-
Monni, R.1
Santos, S.C.2
Mauchauffe, M.3
Berger, R.4
Ghysdael, J.5
-
62
-
-
0035918239
-
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
-
Kamizono S, Hanada T, Yasukawa H, Minoguchi S, Kato R, et al. 2001. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J. Biol. Chem. 276:12530-38
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12530-12538
-
-
Kamizono, S.1
Hanada, T.2
Yasukawa, H.3
Minoguchi, S.4
Kato, R.5
-
63
-
-
0035818573
-
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
-
Zhang JG, Metcalf D, Rakar S, Asimakis M, Greenhalgh CJ, et al. 2001. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc. Natl. Acad. Sci. USA 98:13261-65
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13261-13265
-
-
Zhang, J.G.1
Metcalf, D.2
Rakar, S.3
Asimakis, M.4
Greenhalgh, C.J.5
-
64
-
-
0036595049
-
Suppressors of cytokine signalling (SOCS) in the immune system
-
Alexander WS. 2002. Suppressors of cytokine signalling (SOCS) in the immune system. Nat. Rev. Immunol. 2:410-16
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 410-416
-
-
Alexander, W.S.1
-
65
-
-
0034801684
-
SOCS proteins: Negative regulators of cytokine signaling
-
Krebs DL, Hilton DJ. 2001. SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19:378-87
-
(2001)
Stem Cells
, vol.19
, pp. 378-387
-
-
Krebs, D.L.1
Hilton, D.J.2
-
66
-
-
0031758256
-
The CIS/JAB family: Novel negative regulators of JAK signaling pathways
-
Yoshimura A. 1998. The CIS/JAB family: novel negative regulators of JAK signaling pathways. Leukemia 12:1851-57
-
(1998)
Leukemia
, vol.12
, pp. 1851-1857
-
-
Yoshimura, A.1
-
67
-
-
13044276245
-
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
-
Naka T, Matsumoto T, Narazaki M, Fujimoto M, Morita Y, et al. 1998. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc. Natl. Acad. Sci. USA 95:15577-82
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15577-15582
-
-
Naka, T.1
Matsumoto, T.2
Narazaki, M.3
Fujimoto, M.4
Morita, Y.5
-
68
-
-
0032564463
-
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
-
Starr R, Metcalf D, Elefanty AG, Brysha M, Willson TA, et al. 1998. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. USA 95:14395-99
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14395-14399
-
-
Starr, R.1
Metcalf, D.2
Elefanty, A.G.3
Brysha, M.4
Willson, T.A.5
-
69
-
-
0035862334
-
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
-
Kawazoe Y, Naka T, Fujimoto M, Kohzaki H, Morita Y, et al. 2001. Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J. Exp. Med. 193:263-69
-
(2001)
J. Exp. Med.
, vol.193
, pp. 263-269
-
-
Kawazoe, Y.1
Naka, T.2
Fujimoto, M.3
Kohzaki, H.4
Morita, Y.5
-
70
-
-
0035395873
-
SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice
-
Lindeman GJ, Wittlin S, Lada H, Naylor MJ, Santamaria M, et al. 2001. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev. 15:1631-36
-
(2001)
Genes Dev.
, vol.15
, pp. 1631-1636
-
-
Lindeman, G.J.1
Wittlin, S.2
Lada, H.3
Naylor, M.J.4
Santamaria, M.5
-
71
-
-
0037438475
-
Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis
-
Cornish AL, Davey GM, Metcalf D, Purton JF, Corbin JE, et al. 2003. Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J. Immunol. 170:878-86
-
(2003)
J. Immunol.
, vol.170
, pp. 878-886
-
-
Cornish, A.L.1
Davey, G.M.2
Metcalf, D.3
Purton, J.F.4
Corbin, J.E.5
-
72
-
-
0033520467
-
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
-
Marine JC, Topham DJ, McKay C, Wang D, Parganas E, et al. 1999. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98:609-16
-
(1999)
Cell
, vol.98
, pp. 609-616
-
-
Marine, J.C.1
Topham, D.J.2
McKay, C.3
Wang, D.4
Parganas, E.5
-
74
-
-
0033520326
-
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
-
Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, et al. 1999. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98:597-608
-
(1999)
Cell
, vol.98
, pp. 597-608
-
-
Alexander, W.S.1
Starr, R.2
Fenner, J.E.3
Scott, C.L.4
Handman, E.5
-
75
-
-
0034255408
-
The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene
-
Metcalf D, Di Rago L, Mifsud S, Hartley L, Alexander WS. 2000. The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene. Proc. Natl. Acad. Sci. USA 97:9174-79
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9174-9179
-
-
Metcalf, D.1
Di Rago, L.2
Mifsud, S.3
Hartley, L.4
Alexander, W.S.5
-
76
-
-
0033046429
-
Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1
-
Metcalf D, Alexander WS, Elefanty AG, Nicola NA, Hilton DJ, et al. 1999. Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1. Leukemia 13:926-34
-
(1999)
Leukemia
, vol.13
, pp. 926-934
-
-
Metcalf, D.1
Alexander, W.S.2
Elefanty, A.G.3
Nicola, N.A.4
Hilton, D.J.5
-
77
-
-
0035933805
-
Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo
-
Brysha M, Zhang JG, Bertolino P, Corbin JE, Alexander WS, et al. 2001. Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo. J. Biol. Chem. 276:22086-89
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22086-22089
-
-
Brysha, M.1
Zhang, J.G.2
Bertolino, P.3
Corbin, J.E.4
Alexander, W.S.5
-
78
-
-
0027530790
-
Interferon-gamma arrests proliferation and causes apoptosis in stromal cell/interleukin-7-dependent normal murine pre-B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin-positive B cells
-
Grawunder U, Melchers F, Rolink A. 1993. Interferon-gamma arrests proliferation and causes apoptosis in stromal cell/interleukin-7-dependent normal murine pre-B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin-positive B cells. Eur. J. Immunol. 23:544-51
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 544-551
-
-
Grawunder, U.1
Melchers, F.2
Rolink, A.3
-
79
-
-
0034725044
-
SOCS-1 can suppress CD3zeta- And Syk-mediated NF-AT activation in a non-lymphoid cell line
-
Matsuda T, Yamamoto T, Kishi H, Yoshimura A, Muraguchi A. 2000. SOCS-1 can suppress CD3zeta- and Syk-mediated NF-AT activation in a non-lymphoid cell line. FEBS Lett. 472:235-40
-
(2000)
FEBS Lett.
, vol.472
, pp. 235-240
-
-
Matsuda, T.1
Yamamoto, T.2
Kishi, H.3
Yoshimura, A.4
Muraguchi, A.5
-
80
-
-
0035008978
-
SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo
-
Naka T, Tsutsui H, Fujimoto M, Kawazoe Y, Kohzaki H, et al. 2001. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 14:535-45
-
(2001)
Immunity
, vol.14
, pp. 535-545
-
-
Naka, T.1
Tsutsui, H.2
Fujimoto, M.3
Kawazoe, Y.4
Kohzaki, H.5
-
81
-
-
0038807434
-
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
-
Eyles JL, Metcalf D, Grusby MJ, Hilton DJ, Starr R. 2002. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J. Biol. Chem. 277:43735-40
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43735-43740
-
-
Eyles, J.L.1
Metcalf, D.2
Grusby, M.J.3
Hilton, D.J.4
Starr, R.5
-
82
-
-
0037008769
-
Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor
-
Chong MM, Thomas HE, Kay TW. 2002. Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor. J. Biol. Chem. 277:27945-52
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27945-27952
-
-
Chong, M.M.1
Thomas, H.E.2
Kay, T.W.3
-
83
-
-
0034624986
-
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts
-
Morita Y, Naka T, Kawazoe Y, Fujimoto M, Narazaki M, et al. 2000. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Proc. Natl. Acad. Sci. USA 97:5405-10
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5405-5410
-
-
Morita, Y.1
Naka, T.2
Kawazoe, Y.3
Fujimoto, M.4
Narazaki, M.5
-
86
-
-
0035871862
-
Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes
-
Trop S, De Sepulveda P, Zuniga-Pflucker JC, Rottapel R. 2001. Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes. Blood 97:2269-77
-
(2001)
Blood
, vol.97
, pp. 2269-2277
-
-
Trop, S.1
De Sepulveda, P.2
Zuniga-Pflucker, J.C.3
Rottapel, R.4
-
87
-
-
0034663932
-
Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice
-
Fujimoto M, Naka T, Nakagawa R, Kawazoe Y, Morita Y, et al. 2000. Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice. J. Immunol. 165:1799-806
-
(2000)
J. Immunol.
, vol.165
, pp. 1799-1806
-
-
Fujimoto, M.1
Naka, T.2
Nakagawa, R.3
Kawazoe, Y.4
Morita, Y.5
-
88
-
-
0036672918
-
Maintaining the norm: T-cell homeostasis
-
Jameson SC. 2002. Maintaining the norm: T-cell homeostasis. Nat. Rev. Immunol. 2:547-56
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 547-556
-
-
Jameson, S.C.1
-
89
-
-
0037927824
-
SOCS-1 regulates signaling in response to IL-2 and other gamma c-dependent cytokines in peripheral T cells
-
Cornish AL, Chong MM, Davey GM, Darwiche R, Nicola NA, et al. 2003. SOCS-1 regulates signaling in response to IL-2 and other gamma c-dependent cytokines in peripheral T cells. J. Biol. Chem. 278:22755-61
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22755-22761
-
-
Cornish, A.L.1
Chong, M.M.2
Davey, G.M.3
Darwiche, R.4
Nicola, N.A.5
-
90
-
-
0033120880
-
Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction
-
Losman JA, Chen XP, Hilton D, Rothman P. 1999. Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction. J. Immunol. 162:3770-74
-
(1999)
J. Immunol.
, vol.162
, pp. 3770-3774
-
-
Losman, J.A.1
Chen, X.P.2
Hilton, D.3
Rothman, P.4
-
91
-
-
0037154210
-
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
-
Metcalf D, Mifsud S, Di Rago L, Nicola NA, Hilton DJ, Alexander WS. 2002. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc. Natl. Acad. Sci. USA 99:943-48
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 943-948
-
-
Metcalf, D.1
Mifsud, S.2
Di Rago, L.3
Nicola, N.A.4
Hilton, D.J.5
Alexander, W.S.6
-
92
-
-
0036533474
-
Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: Implications for Th cell lineage commitment and maintenance
-
Egwuagu CE, Yu CR, Zhang M, Mahdi RM, Kim SJ, Gery I. 2002. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J. Immunol. 168:3181-87
-
(2002)
J. Immunol.
, vol.168
, pp. 3181-3187
-
-
Egwuagu, C.E.1
Yu, C.R.2
Zhang, M.3
Mahdi, R.M.4
Kim, S.J.5
Gery, I.6
-
93
-
-
0036849109
-
A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo
-
Fujimoto M, Tsutsui H, Yumikura-Futatsugi S, Ueda H, Xingshou O, et al. 2002. A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo. Int. Immunol. 14:1343-50
-
(2002)
Int. Immunol.
, vol.14
, pp. 1343-1350
-
-
Fujimoto, M.1
Tsutsui, H.2
Yumikura-Futatsugi, S.3
Ueda, H.4
Xingshou, O.5
-
94
-
-
0037446652
-
Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major
-
Bullen DV, Baldwin TM, Curtis JM, Alexander WS, Handman E. 2003. Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. J. Immunol. 170:4267-72
-
(2003)
J. Immunol.
, vol.170
, pp. 4267-4272
-
-
Bullen, D.V.1
Baldwin, T.M.2
Curtis, J.M.3
Alexander, W.S.4
Handman, E.5
-
95
-
-
0034502224
-
Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1
-
Diehl S, Anguita J, Hoffmeyer A, Zapton T, Ihle JN, et al. 2000. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity 13:805-15
-
(2000)
Immunity
, vol.13
, pp. 805-815
-
-
Diehl, S.1
Anguita, J.2
Hoffmeyer, A.3
Zapton, T.4
Ihle, J.N.5
-
96
-
-
0033520389
-
SOCS3 is essential in the regulation of fetal liver erythropoiesis
-
Marine JC, McKay C, Wang D, Topham DJ, Parganas E, et al. 1999. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell 98:617-27
-
(1999)
Cell
, vol.98
, pp. 617-627
-
-
Marine, J.C.1
McKay, C.2
Wang, D.3
Topham, D.J.4
Parganas, E.5
-
97
-
-
0035979275
-
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
-
Roberts AW, Robb L, Rakar S, Hartley L, Cluse L, et al. 2001. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl. Acad. Sci. USA 98:9324-29
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9324-9329
-
-
Roberts, A.W.1
Robb, L.2
Rakar, S.3
Hartley, L.4
Cluse, L.5
-
98
-
-
0028886498
-
Effect of leukemia inhibitory factor on human cytotrophoblast differentiation along the invasive pathway
-
Bischof P, Haenggeli L, Campana A. 1995. Effect of leukemia inhibitory factor on human cytotrophoblast differentiation along the invasive pathway. Am. J. Reprod. Immunol. 34:225-30
-
(1995)
Am. J. Reprod. Immunol.
, vol.34
, pp. 225-230
-
-
Bischof, P.1
Haenggeli, L.2
Campana, A.3
-
99
-
-
0037415694
-
SOCS3: An essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
-
Takahashi Y, Carpino N, Cross JC, Torres M, Parganas E, Ihle JN. 2003. SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J. 22:372-84
-
(2003)
EMBO J.
, vol.22
, pp. 372-384
-
-
Takahashi, Y.1
Carpino, N.2
Cross, J.C.3
Torres, M.4
Parganas, E.5
Ihle, J.N.6
-
100
-
-
0037938816
-
SOCS3 negatively regulates IL-6 signaling in vivo
-
Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, et al. 2003. SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4:540-45
-
(2003)
Nat. Immunol.
, vol.4
, pp. 540-545
-
-
Croker, B.A.1
Krebs, D.L.2
Zhang, J.G.3
Wormald, S.4
Willson, T.A.5
-
101
-
-
0037600741
-
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
-
Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, et al. 2003. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat. Immunol 4:551-56
-
(2003)
Nat. Immunol.
, vol.4
, pp. 551-556
-
-
Yasukawa, H.1
Ohishi, M.2
Mori, H.3
Murakami, M.4
Chinen, T.5
-
102
-
-
0038614944
-
SOCS3 regulates the plasticity of gp130 signaling
-
Lang R, Pauleau AL, Parganas E, Takahashi Y, Mages J, et al. 2003. SOCS3 regulates the plasticity of gp130 signaling. Nat. Immunol. 4:546-50
-
(2003)
Nat. Immunol.
, vol.4
, pp. 546-550
-
-
Lang, R.1
Pauleau, A.L.2
Parganas, E.3
Takahashi, Y.4
Mages, J.5
-
103
-
-
0032567353
-
The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
-
Song MM, Shuai K. 1998. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273:35056-62
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35056-35062
-
-
Song, M.M.1
Shuai, K.2
-
104
-
-
0037062503
-
Mutational switch of an IL-6 response to an interferon-gamma-like response
-
Costa-Pereira AP, Tininini S, Strobl B, Alonzi T, Schlaak JF, et al. 2002. Mutational switch of an IL-6 response to an interferon-gamma-like response. Proc. Natl. Acad. Sci. USA 99:8043-47
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8043-8047
-
-
Costa-Pereira, A.P.1
Tininini, S.2
Strobl, B.3
Alonzi, T.4
Schlaak, J.F.5
-
105
-
-
0042531736
-
Suppressor of cytokine signaling 3 (SOCS3) regulates proliferation and activation of T-helper cells
-
Yu CR, Mahdi RM, Ebong S, Vistica BP, Gery I, Egwuagu CE. 2003. Suppressor of cytokine signaling 3 (SOCS3) regulates proliferation and activation of T-helper cells. J. Biol. Chem. 278:29752-59
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 29752-29759
-
-
Yu, C.R.1
Mahdi, R.M.2
Ebong, S.3
Vistica, B.P.4
Gery, I.5
Egwuagu, C.E.6
-
106
-
-
0037450813
-
A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production
-
Matsumoto A, Seki Y, Watanabe R, Hayashi K, Johnston JA, et al. 2003. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J. Exp. Med. 197:425-36
-
(2003)
J. Exp. Med.
, vol.197
, pp. 425-436
-
-
Matsumoto, A.1
Seki, Y.2
Watanabe, R.3
Hayashi, K.4
Johnston, J.A.5
-
107
-
-
0036790814
-
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation
-
Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, et al. 2002. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc. Natl. Acad. Sci. USA 99:13003-8
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13003-13008
-
-
Seki, Y.1
Hayashi, K.2
Matsumoto, A.3
Seki, N.4
Tsukada, J.5
-
108
-
-
0000943469
-
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
-
Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, et al. 1998. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93:841-50
-
(1998)
Cell
, vol.93
, pp. 841-850
-
-
Teglund, S.1
McKay, C.2
Schuetz, E.3
Van Deursen, J.M.4
Stravopodis, D.5
-
109
-
-
0032772125
-
Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
-
Matsumoto A, Seki Y, Kubo M, Ohtsuka S, Suzuki A, et al. 1999. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol. Cell Biol. 19:6396-407
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 6396-6407
-
-
Matsumoto, A.1
Seki, Y.2
Kubo, M.3
Ohtsuka, S.4
Suzuki, A.5
-
110
-
-
0034689007
-
Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells
-
Li S, Chen S, Xu X, Sundstedt A, Paulsson KM, et al. 2000. Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells. J. Exp. Med. 191:985-94
-
(2000)
J. Exp. Med.
, vol.191
, pp. 985-994
-
-
Li, S.1
Chen, S.2
Xu, X.3
Sundstedt, A.4
Paulsson, K.M.5
-
111
-
-
0034729710
-
Gigantism in mice lacking suppressor of cytokine signalling-2
-
Metcalf D, Greenhalgh CJ, Viney E, Willson TA, Starr R, et al. 2000. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405:1069-73
-
(2000)
Nature
, vol.405
, pp. 1069-1073
-
-
Metcalf, D.1
Greenhalgh, C.J.2
Viney, E.3
Willson, T.A.4
Starr, R.5
-
112
-
-
85047681536
-
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)
-
Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, et al. 2002. Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol. Endocrinol. 16:1394-406
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 1394-1406
-
-
Greenhalgh, C.J.1
Bertolino, P.2
Asa, S.L.3
Metcalf, D.4
Corbin, J.E.5
-
113
-
-
0344655657
-
Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction
-
Favre H, Benhamou A, Finidori J, Kelly PA, Edery M. 1999. Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction. FEBS Lett. 453:63-66
-
(1999)
FEBS Lett.
, vol.453
, pp. 63-66
-
-
Favre, H.1
Benhamou, A.2
Finidori, J.3
Kelly, P.A.4
Edery, M.5
-
114
-
-
0035877256
-
Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs
-
Dalpke AH, Opper S, Zimmermann S, Heeg K. 2001. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166:7082-89
-
(2001)
J. Immunol.
, vol.166
, pp. 7082-7089
-
-
Dalpke, A.H.1
Opper, S.2
Zimmermann, S.3
Heeg, K.4
-
115
-
-
0345073627
-
Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: A novel mechanism for intracellular parasite suppression of activation
-
Bertholet S, Dickensheets HL, Sheikh F, Gam AA, Donnelly RP, Kenney RT. 2003. Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation. Infect. Immun. 71:2095-101
-
(2003)
Infect. Immun.
, vol.71
, pp. 2095-2101
-
-
Bertholet, S.1
Dickensheets, H.L.2
Sheikh, F.3
Gam, A.A.4
Donnelly, R.P.5
Kenney, R.T.6
-
116
-
-
0033209897
-
The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway
-
Vila-Coro AJ, Rodriguez-Frade JM, Martin De Ana A, Moreno-Ortiz MC, Martinez AC, Mellado M. 1999. The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J. 13:1699-710
-
(1999)
FASEB J.
, vol.13
, pp. 1699-1710
-
-
Vila-Coro, A.J.1
Rodriguez-Frade, J.M.2
Martin De Ana, A.3
Moreno-Ortiz, M.C.4
Martinez, A.C.5
Mellado, M.6
-
117
-
-
2642641315
-
The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor
-
Mellado M, Rodriguez-Frade JM, Aragay A, del Real G, Martin AM, et al. 1998. The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J. Immunol. 161:805-13
-
(1998)
J. Immunol.
, vol.161
, pp. 805-813
-
-
Mellado, M.1
Rodriguez-Frade, J.M.2
Aragay, A.3
Del Real, G.4
Martin, A.M.5
-
118
-
-
0037025997
-
Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation
-
Soriano SF, Hernanz-Falcon P, Rodriguez-Frade JM, De Ana AM, Garzon R, et al. 2002. Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation. J. Exp. Med. 196:311-21
-
(2002)
J. Exp. Med.
, vol.196
, pp. 311-321
-
-
Soriano, S.F.1
Hernanz-Falcon, P.2
Rodriguez-Frade, J.M.3
De Ana, A.M.4
Garzon, R.5
-
119
-
-
0033976059
-
The Jak-Stat pathway in normal and perturbed hematopoiesis
-
Ward AC, Touw I, Yoshimura A. 2000. The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood 95:19-29
-
(2000)
Blood
, vol.95
, pp. 19-29
-
-
Ward, A.C.1
Touw, I.2
Yoshimura, A.3
-
120
-
-
15444339209
-
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
-
Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, et al. 1997. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278:1309-12
-
(1997)
Science
, vol.278
, pp. 1309-1312
-
-
Lacronique, V.1
Boureux, A.2
Valle, V.D.3
Poirel, H.4
Quang, C.T.5
-
121
-
-
0030852328
-
Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
-
Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, et al. 1997. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90:2535-40
-
(1997)
Blood
, vol.90
, pp. 2535-2540
-
-
Peeters, P.1
Raynaud, S.D.2
Cools, J.3
Wlodarska, I.4
Grosgeorge, J.5
-
122
-
-
0035036625
-
Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation
-
Frantsve J, Schwaller J, Sternberg DW, Kutok J, Gilliland DG. 2001. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell Biol. 21:3547-57
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 3547-3557
-
-
Frantsve, J.1
Schwaller, J.2
Sternberg, D.W.3
Kutok, J.4
Gilliland, D.G.5
-
123
-
-
0037182762
-
The tumor suppressor activity of SOCS-1
-
Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho JM, et al. 2002. The tumor suppressor activity of SOCS-1. Oncogene 21:4351-62
-
(2002)
Oncogene
, vol.21
, pp. 4351-4362
-
-
Rottapel, R.1
Ilangumaran, S.2
Neale, C.3
La Rose, J.4
Ho, J.M.5
-
124
-
-
0036493796
-
Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: Possible inadequacy of a negative feedback mechanism
-
Schultheis B, Carapeti-Marootian M, Hochhaus A, Weisser A, Goldman JM, Melo JV. 2002. Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism. Blood 99:1766-75
-
(2002)
Blood
, vol.99
, pp. 1766-1775
-
-
Schultheis, B.1
Carapeti-Marootian, M.2
Hochhaus, A.3
Weisser, A.4
Goldman, J.M.5
Melo, J.V.6
-
125
-
-
0035042611
-
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
-
Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, et al. 2001. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat. Genet. 28:29-35
-
(2001)
Nat. Genet.
, vol.28
, pp. 29-35
-
-
Yoshikawa, H.1
Matsubara, K.2
Qian, G.S.3
Jackson, P.4
Groopman, J.D.5
-
126
-
-
0036883618
-
Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas
-
Nagai H, Kim YS, Konishi N, Baba M, Kubota T, et al. 2002. Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas. Cancer Lett. 186:59-65
-
(2002)
Cancer Lett.
, vol.186
, pp. 59-65
-
-
Nagai, H.1
Kim, Y.S.2
Konishi, N.3
Baba, M.4
Kubota, T.5
-
127
-
-
0037227602
-
Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas
-
Nagai H, Naka T, Terada Y, Komazaki T, Yabe A, et al. 2003. Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. J. Hum. Genet. 48:65-69
-
(2003)
J. Hum. Genet.
, vol.48
, pp. 65-69
-
-
Nagai, H.1
Naka, T.2
Terada, Y.3
Komazaki, T.4
Yabe, A.5
-
128
-
-
0035068349
-
Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis
-
Nagai H, Kim YS, Lee KT, Chu MY, Konishi N, et al. 2001. Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis. J. Hepatol. 34:416-21
-
(2001)
J. Hepatol.
, vol.34
, pp. 416-421
-
-
Nagai, H.1
Kim, Y.S.2
Lee, K.T.3
Chu, M.Y.4
Konishi, N.5
-
129
-
-
0038546657
-
SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia
-
Chen CY, Tsay W, Tang JL, Shen HL, Lin SW, et al. 2003. SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. Genes Chromosomes Cancer 37:300-5
-
(2003)
Genes Chromosomes Cancer
, vol.37
, pp. 300-305
-
-
Chen, C.Y.1
Tsay, W.2
Tang, J.L.3
Shen, H.L.4
Lin, S.W.5
-
130
-
-
0038784365
-
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
-
Galm O, Yoshikawa H, Esteller M, Osieka R, Herman JG. 2003. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood 101:2784-88
-
(2003)
Blood
, vol.101
, pp. 2784-2788
-
-
Galm, O.1
Yoshikawa, H.2
Esteller, M.3
Osieka, R.4
Herman, J.G.5
-
131
-
-
0037108433
-
Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells
-
Sakai I, Takeuchi K, Yamauchi H, Narumi H, Fujita S. 2002. Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells. Blood 100:2926-31
-
(2002)
Blood
, vol.100
, pp. 2926-2931
-
-
Sakai, I.1
Takeuchi, K.2
Yamauchi, H.3
Narumi, H.4
Fujita, S.5
-
132
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, et al. 2001. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med. 193:471-81
-
(2001)
J. Exp. Med.
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
Yoshida, T.4
Kamizono, S.5
-
133
-
-
0038269009
-
Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease
-
Lovato P, Brender C, Agnholt J, Kelsen J, Kaltoft K, et al. 2003. Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J. Biol. Chem. 278:16777-81
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16777-16781
-
-
Lovato, P.1
Brender, C.2
Agnholt, J.3
Kelsen, J.4
Kaltoft, K.5
-
134
-
-
0035667907
-
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
-
Shouda T, Yoshida T, Hanada T, Wakioka T, Oishi M, et al. 2001. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J. Clin. Invest. 108:1781-88
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1781-1788
-
-
Shouda, T.1
Yoshida, T.2
Hanada, T.3
Wakioka, T.4
Oishi, M.5
-
135
-
-
85047687240
-
Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
-
Egan PJ, Lawlor KE, Alexander WS, Wicks IP. 2003. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J. Clin. Invest. 111:915-24
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 915-924
-
-
Egan, P.J.1
Lawlor, K.E.2
Alexander, W.S.3
Wicks, I.P.4
-
136
-
-
0042967672
-
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses
-
Seki YI, Inoue H, Nagata N, Hayashi K, Fukuyama S, et al. 2003. SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat. Med. 9:1047-54
-
(2003)
Nat. Med.
, vol.9
, pp. 1047-1054
-
-
Seki, Y.I.1
Inoue, H.2
Nagata, N.3
Hayashi, K.4
Fukuyama, S.5
-
137
-
-
0036644335
-
Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1
-
Federici M, Giustizieri ML, Scarponi C, Girolomoni G, Albanesi C. 2002. Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1. J. Immunol. 169:434-42
-
(2002)
J. Immunol.
, vol.169
, pp. 434-442
-
-
Federici, M.1
Giustizieri, M.L.2
Scarponi, C.3
Girolomoni, G.4
Albanesi, C.5
-
138
-
-
0036275657
-
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
-
Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, et al. 2002. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol. Cell Biol. 22:4567-78
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 4567-4578
-
-
Krebs, D.L.1
Uren, R.T.2
Metcalf, D.3
Rakar, S.4
Zhang, J.G.5
-
139
-
-
0037064542
-
The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex
-
Jones SA, Rose-John S. 2002. The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochim. Biophys. Acta 1592:251-63
-
(2002)
Biochim. Biophys. Acta
, vol.1592
, pp. 251-263
-
-
Jones, S.A.1
Rose-John, S.2
-
140
-
-
0029973560
-
Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1
-
Jiao H, Berrada K, Yang W, Tabrizi M, Platanias LC, Yi T. 1996. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol. Cell. Biol. 16:6985-92
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6985-6992
-
-
Jiao, H.1
Berrada, K.2
Yang, W.3
Tabrizi, M.4
Platanias, L.C.5
Yi, T.6
-
141
-
-
0027935780
-
Protein tyrosine phosphorylation in the regulation of hematopoiesis by receptors of the cytokine-receptor superfamily
-
Ihle JN, Witthuhn BA, Quelle FW, Silvennoinen O, Tang B, Yi T. 1994. Protein tyrosine phosphorylation in the regulation of hematopoiesis by receptors of the cytokine-receptor superfamily. Blood Cells 20:65-80, discussion 2
-
(1994)
Blood Cells
, vol.20
, pp. 65-80
-
-
Ihle, J.N.1
Witthuhn, B.A.2
Quelle, F.W.3
Silvennoinen, O.4
Tang, B.5
Yi, T.6
-
142
-
-
0037064549
-
Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response
-
Qu CK. 2002. Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. Biochim. Biophys. Acta 1592:297-301
-
(2002)
Biochim. Biophys. Acta
, vol.1592
, pp. 297-301
-
-
Qu, C.K.1
-
143
-
-
0035905767
-
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
-
Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, et al. 2001. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409:349-54
-
(2001)
Nature
, vol.409
, pp. 349-354
-
-
Irie-Sasaki, J.1
Sasaki, T.2
Matsumoto, W.3
Opavsky, A.4
Cheng, M.5
-
144
-
-
0037047335
-
CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase
-
Yamada T, Zhu D, Saxon A, Zhang K. 2002. CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase. J. Biol. Chem. 277:28830-35
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28830-28835
-
-
Yamada, T.1
Zhu, D.2
Saxon, A.3
Zhang, K.4
-
145
-
-
0036033161
-
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
-
Yamamoto T, Sekine Y, Kashima K, Kubota A, Sato N, et al. 2002. The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem. Biophys. Res. Commun. 297:811-17
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.297
, pp. 811-817
-
-
Yamamoto, T.1
Sekine, Y.2
Kashima, K.3
Kubota, A.4
Sato, N.5
-
146
-
-
0036138705
-
A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: Dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus
-
Aoki N, Matsuda T. 2002. A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol. Endocrinol. 16:58-69
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 58-69
-
-
Aoki, N.1
Matsuda, T.2
|