Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins

Molecular and Cellular Biology

Volumn 16, Issue 4, 1996, Pages 1759-1769

  Vignais, Marie Luce ^a   Sadowski, Henry B ^a,e   Watling, Diane ^b   Rogers, Neil C ^b   Gilman, Michael ^a,c,d  

^a Watson School of Biological Sciences   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c Ariad Pharmaceutical   (United States)

^d ARIAD PHARMACEUTICALS INC   (United States)

^e MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; INTERFERON RECEPTOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL STRAIN 3T3; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROSARCOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR IMMUNOLOGY;

EID: 0029966664     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.4.1759     Document Type: Article

References (56)

1. Akira, S., Y. Nishio, M. Inoue, X. J. Wang, S. Wei, T. Matsusaka, K. Yoshida, T. Sudo, M. Narato, and T. Kishimoto. 1994. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77:63-71.
2. Argetsinger, L. S., G. S. Campbell, X. Yang, B. A. Witthuhn, O. Silvennoinen, J. N. Ihle, and C. Carter-Su. 1993. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74:237-244.
3. Beadling, C., D. Guschin, B. A. Witthuhn, A. Ziemiecki, J. N. Ihle, I. M. Kerr, and D. A. Cantrell. 1994. Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. EMBO J 13:5605-5615.
4. Briscoe, J., D. Guschin, and M. Muller. 1994. Just another signalling pathway. Curr. Biol. 4:1033-1035.
5. Campbell, G. S., L. S. Argetsinger, J. N. Ihle, P. A. Kelly, J. A. Rillema, and C. Carter-Su. 1994. Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants. Proc. Natl. Acad. Sci. USA 91:5232-5236.
6. Campos-González, R., and J. R. Glenney. 1992 Tyrosine phosphorylation of mitogen-activated protein kinase in cells with tyrosine-kinase negative epidermal growth factor receptors. J. Biol. Chem. 267:14535-14538.
7. Darnell, J., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
8. Dusanter-Fourt, I., O. Muller, A. Ziemiecki, P. Mayeux, B. Drucker, J. Djiane, A. Wilks, A. G. Harpur, S. Fischer, and S. Gisselbrecht. 1994. identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells. EMBO J. 13:2583-2591.
9. Field, J., J. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I. A. Wilson, R. A. Lerner, and M. Wigler. 1988 Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell. Biol. 8:2159-2165.
10. Fu, X.-Y., and J.-J. Zhang. 1993. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter. Cell 74:1135-1145.
11. Gouilleux, F., H. Wakao, M. Mundt, and B. Groner. 1994. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 13:4361-4369.
12. Guschin, D., N. Rogers, J. Briscoe, B. Witthuhn, D. Watling, F. Horn, S. Pellegrini, K. Yasukawa, P. Heinrich, G. R. Stark, J. N. Ihle, and I. M. Kerr. 1995. A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J. 14:1421-1429.
13. Harpur, A. G., A. C. Andres, A. Ziemiecki, R. R. Aston, and A. F. Walks. 1992. JAK2, a third member of the JAK family of protein tyrosine kinases Oncogene 7:1347-1353.
14. Hou, J., U. Schindler, W. J. Henzel, T. Chun Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor. IL-4 Stat. Science 265:1701-1706.
15. Hunter, T. 1993 Signal transduction. Cytokine connections. Nature (London) 366:114-116.
16. Ihle, J. N., and I. M. Kerr. 1995. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 11:69-74.
17. Johnston, J. A., M. Kawamura, R. A. Kirken, Y. Q. Chen, T. B. Blake, K. Shibuya, J. R. Ortaldo, B. W. McVicar, and J. J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature (London) 370:151-153.
18. Kashishian, A., and J. A. Cooper. Unpublished observations
19. Kashishian, A., A. Kazlauskas, and J. A. Cooper. 1992. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J. 11:1373-1382. (Erratum, 11:3809.)
20. Kazlauskas, A., and J. A. Cooper. 1989. Autophosphorylation of the PDGF receptor in the kinase insert region regulaties interactions with cell proteins. Cell 58:1121-1133.
21. Kishimoto, T., T. Taga, and S. Akira. 1994. Cytokine signal transduction. Cell 76:253-262.
22. Leaman, D. W., S. Pisharody, T. W. Flickinger, M. A. Commane, J. Schlessinger, I. M. Kerr, D. E. Levy, and G. R. Stark. 1996. Roles of JAKs in the activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol Cell. Biol. 16:369-375.
23. Loh, J. E., C. Schindler, A. Ziemiecki, A. G. Harpur, A. F. Wilks, and R. A. Flavell. 1994. Mutant cell lines unresponsive to alpha/beta and gamma interferon are defective in tyrosine phosphorylation of ISGF-3 alpha components. Mol. Cell. Biol. 14:2170-2179.
24. Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. BioTechniques 7:980-982, 984-986.
25. Müller, M., J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, A. G. Harpur, G. Barbieri, B. A. Witthuhn, C. Schindler, S. Pellegrini, A. F. Wilks, J. N. Ihle, G. R. Stark, and I. M. Kerr. 1993. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature (London) 366:129-135.
26. Müller, M., C. Laxton, J. Briscoe, C. Schindler, T. Improta, J. E. Darnell, Jr., G. R. Stark, and I. M. Kerr. 1993. Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathways. EMBO J 12:4221-4228.
27. Nicholson, S. E., A. C. Oates, A. G. Harpur, A. Ziemiecki, A. F. Wilks, and J. E. Layton. 1994. Tyrosine kinase JAKl is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. Proc. Natl. Acad. Sci. USA 91:2985-2988.
28. Pellegrini, S., J. John, M. Shearer, I. M. Kerr, and G. R. Stark. 1989. Use of a selectable marker regulated by alpha Interferon to obtain mutations in the signaling pathway. Mol. Cell Biol. 9:4605-4612.
29. Quelle, F. W., W. Thierfelder, B. A. Witthuhn, B. Tang, S. Cohen, and J. N. Ihle. 1995. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J. Biol. Chem. 270:20775-20780.
30. Raz, R., J. E. Durbin, and D. E. Levy. 1994. Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors. J. Biol Chem. 269:24391-24395
31. Ruff-Jamison, S., K. Chen, and S. Cohen. 1993. Induction by EGF and interferon-γ of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei Science 261:1733-1736.
32. Ruff-Jamison, S., K. Chen, and S. Cohen. 1995. Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat5 in mouse liver. Proc. Natl. Acad. Sci. USA 92:4215-4218.
33. Ruff-Jamison, S., Z. Zhong, Z. Wen, K. Chen, J. E. Darnell, Jr., and S. Cohen. 1994. Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver. J. Biol Chem. 269:21933-21935.
34. Sadowski, H. B., and M. Z. Gilman. 1993. Cell-free activation of a DNA-binding protein by epidermal growth factor. Nature (London) 362:79-83.
35. Sadowski, H. B., K. Shuai, J. E. Darnell, Jr., and M. Z. Gilman. 1993. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors Science 261:1739-1744.
36. Selva, E., D. L. Raden, and R. J. Davis. 1993. Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor. J. Biol Chem 268:2250-2254
37. Shuai, K. 1994. Interferon-activated signal transduction to the nucleus. Curr. Opin. Cell Biol. 6:253-259.
38. Shuai, K., A. Ziemiecki, A. F. Wilks, A. G. Harpur, H. B. Sadowski, M. Z. Gilman, and J. E. Darnell. 1993. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature (London) 366:580-583.
39. Silvennoinen, O., C. Schindler, J. Schlessinger, and D. E. Levy. 1993. Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. Science 261:1736-1739.
40. Silvennoinen, O., B. A. Witthuhn, F. W. Quelle, J. L. Cleveland, T. Yi, and J. N. Ihle. 1993 Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction Proc Natl. Acad. Sci. USA 90:8429-8433
41. Stahl, N., T. G. Boulton, T. Farruggella, N. Y. Ip, S. Davis, B. A. Witthuhn, F. W. Quelle, O. Silvennoinen, G. Barbieri, S. Pellegrini, J. N. Ihle, and G. D. Yancopoulos. 1994. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science 263:92-95.
42. Stahl, N., T. J. Farruggella, T. G. Boulton, Z. Zhong, J. E. Darnell, Jr., and G. D. Yancopoulos. 1995. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349-1353.
43. Stahl, N., and G. D. Yancopoulos. 1993. The alphas, betas, and kinases of cytokine receptor complexes. Cell 74:587-590.
44. Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251-255.
45. Velazquez, L., M. Fellous, G. R. Stark, and S. Pellegrini. 1992. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 70:313-322
46. Vignais, M.-L. Unpublished observations.
47. Wagner, B. J., T. E. Hayes, C. J. Hoban, and B. H. Cochran. 1990. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9:4477-4484.
48. Watling, D., D. Guschin, M. Muller, O. Silvennoinen, B. A. Witthuhn, F. W. Quelle, N. C. Rogers, C. Schindler, G. R. Stark, and J. N. Ihle. 1993. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature (London) 366:166-170.
49. Witthuhn, B. A., F. W. Quelle, O. Silvennoinen, T. Yi, B. Tang, O. Miura, and J. N. Ihle. 1993. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74:227-236.
50. Witthuhn, B. A., O. Silvennoinen, O. Miura, K. S. Lai, C. Cwik, E. T. Liu, and J. N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature (London) 370: 153-157.
51. Yamamoto, K., F. W. Quelle, W. E. Thierfelder, B. L. Kreider, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, O. Silvennoinen, and J. N. Ihle. 1994. Stat4, a novel gamma interteron activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14:4342-4349.
52. Yin, T., M. L. Tsang, and Y. C. Yang. 1994. JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes. J. Biol. Chem. 269:26614-26617.
53. Yu, C. L., D. J. Meyer, G. S. Campbell, A. C. Larner, C. Carter-Su, J. Schwartz, and J. R. 1995. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81-83.
54. Zhong, Z., Z. Wen, and J. E. Darnell, Jr. 1994. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95-98.
55. Zhuang, H., S. V. Patel, T.-C. He, S. K. Sonsteby, Z. Niu, and D. M. Wojchowski. 1994. Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J. Biol. Chem. 269:21411-21414.
56. Ziemiecki, A., A. G. Harpur, and A. F. Wilks. 1994 JAK protein tyrosine kinases: their role in cytokine signalling. Trends Cell Biol. 4:207-212.