메뉴 건너뛰기




Volumn 71, Issue 3-4, 1999, Pages 405-422

The STAT family of proteins in cytokine signaling

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA BINDING PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; TRANSACTIVATOR PROTEIN;

EID: 0032921172     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0079-6107(98)00051-0     Document Type: Review
Times cited : (81)

References (117)
  • 1
    • 0031915126 scopus 로고    scopus 로고
    • Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling
    • Adams T.A., Hansen J.A., Starr R., Nicola N.A., Hilton D.J., Billestrup N. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273:1998;1285-1287.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1285-1287
    • Adams, T.A.1    Hansen, J.A.2    Starr, R.3    Nicola, N.A.4    Hilton, D.J.5    Billestrup, N.6
  • 2
    • 0028303977 scopus 로고
    • Molecular cloning of APRF: A novel ISGF3 p91-regulated transcription factor involved in the gp130-mediated signaling pathway
    • Akira S., Nishio Y., Inoue M., Wang X., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T. Molecular cloning of APRF: a novel ISGF3 p91-regulated transcription factor involved in the gp130-mediated signaling pathway. Cell. 77:1994;63-71.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.4    Wei, S.5    Matsusaka, T.6    Yoshida, K.7    Sudo, T.8    Naruto, M.9    Kishimoto, T.10
  • 3
    • 0031473350 scopus 로고    scopus 로고
    • Cytokine signaling: Cytokine-inducible signaling inhibitors
    • Aman J.M., Leonard W.J. Cytokine signaling: cytokine-inducible signaling inhibitors. Curr. Biol. 7:1997;R784-R788.
    • (1997) Curr. Biol. , vol.7
    • Aman, J.M.1    Leonard, W.J.2
  • 4
    • 0029936611 scopus 로고    scopus 로고
    • Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway
    • Beadling C., Ng J., Babbage J.W., Cantrell D.A. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J. 15:1996;1902-1913.
    • (1996) EMBO J. , vol.15 , pp. 1902-1913
    • Beadling, C.1    Ng, J.2    Babbage, J.W.3    Cantrell, D.A.4
  • 5
    • 0032499801 scopus 로고    scopus 로고
    • Three-dimensional structure of the Stat3b homodimer bound to DNA
    • Becker S., Groner B., Muller C.W. Three-dimensional structure of the Stat3b homodimer bound to DNA. Nature. 394:1998;145-151.
    • (1998) Nature , vol.394 , pp. 145-151
    • Becker, S.1    Groner, B.2    Muller, C.W.3
  • 7
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell. 1:1998;619-625.
    • (1998) Mol. Cell , vol.1 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 8
    • 0029091195 scopus 로고
    • STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modificatic nase
    • Boulton T.G., Zhong Z., Wen Z., Darnell J.E. Jr., Stahl N., Yancopoulos G.D. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modificatic nase. Natl. Acad. Sci. US. 92:1995;6915-6919.
    • (1995) Natl. Acad. Sci. US , vol.92 , pp. 6915-6919
    • Boulton, T.G.1    Zhong, Z.2    Wen, Z.3    Darnell J.E., Jr.4    Stahl, N.5    Yancopoulos, G.D.6
  • 9
    • 0031180973 scopus 로고    scopus 로고
    • TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T-lymphocytes
    • Bright J.J., Kerr L.D., Sriram S. TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T-lymphocytes. J. Immunol. 159:1997;175-183.
    • (1997) J. Immunol. , vol.159 , pp. 175-183
    • Bright, J.J.1    Kerr, L.D.2    Sriram, S.3
  • 11
    • 0029923780 scopus 로고    scopus 로고
    • Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
    • Chin Y.E., Kitagawa M., Su W.S., You Z.H., Iwamoto Y., Fu X.Y. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science. 272:1996;719-722.
    • (1996) Science , vol.272 , pp. 719-722
    • Chin, Y.E.1    Kitagawa, M.2    Su, W.S.3    You, Z.H.4    Iwamoto, Y.5    Fu, X.Y.6
  • 12
    • 0030788405 scopus 로고    scopus 로고
    • Activation of the STAT signaling pathway can cause expression of capsase 1 and apoptosis
    • Chin Y.E., Kitagawa M., Kuida K., Flavell R.A., Fu X.Y. Activation of the STAT signaling pathway can cause expression of capsase 1 and apoptosis. Mol. Cell. Biol. 17:1997;5237-5328.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5237-5328
    • Chin, Y.E.1    Kitagawa, M.2    Kuida, K.3    Flavell, R.A.4    Fu, X.Y.5
  • 13
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science. 278:1997;1803-1805.
    • (1997) Science , vol.278 , pp. 1803-1805
    • Chung, C.D.1    Liao, J.2    Liu, B.3    Rao, X.4    Jay, P.5    Berta, P.6    Shuai, K.7
  • 14
    • 0030772458 scopus 로고    scopus 로고
    • STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    • Chung J., Uchida E., Grammer T.C., Blenis J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol. Cell. Biol. 17:1997;6508-6516.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6508-6516
    • Chung, J.1    Uchida, E.2    Grammer, T.C.3    Blenis, J.4
  • 15
    • 0028018268 scopus 로고
    • The ubiquitin-proteasome proteolytic pathway
    • Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell. 79:1994;13-21.
    • (1994) Cell , vol.79 , pp. 13-21
    • Ciechanover, A.1
  • 16
    • 0028895654 scopus 로고
    • Modular binding domains in signal transduction proteins
    • Cohen G.B., Ren R., Baltimore D. Modular binding domains in signal transduction proteins. Cell. 80:1995;237-248.
    • (1995) Cell , vol.80 , pp. 237-248
    • Cohen, G.B.1    Ren, R.2    Baltimore, D.3
  • 17
    • 0028234529 scopus 로고
    • JAK-STAT pathways and transcriptional activation in response to IFN's and other extracellular signaling proteins
    • Darnell J.E. Jr., Kerr I.M., Stark G.M. JAK-STAT pathways and transcriptional activation in response to IFN's and other extracellular signaling proteins. Science. 264:1994;1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell J.E., Jr.1    Kerr, I.M.2    Stark, G.M.3
  • 18
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell J.E. Jr. STATs and gene regulation. Science. 277:1997;1630.
    • (1997) Science , vol.277 , pp. 1630
    • Darnell J.E., Jr.1
  • 19
    • 0027443228 scopus 로고
    • A nuclear tyrosine phosphatase downregulates interferon-induced gene expression
    • David M., Grimley P.M., Finbloom D.S., Larner A.C. A nuclear tyrosine phosphatase downregulates interferon-induced gene expression. Mol. Cell. Biol. 13:1993;7515-7521.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7515-7521
    • David, M.1    Grimley, P.M.2    Finbloom, D.S.3    Larner, A.C.4
  • 20
    • 0026019924 scopus 로고
    • Cytoplasmic activation of GAF, an IFN-gamma regulated DNA binding factor
    • Decker T., Lew D.J., Mirkovitch J., Darnell J.E. Jr. Cytoplasmic activation of GAF, an IFN-gamma regulated DNA binding factor. EMBO J. 10:1991;927-932.
    • (1991) EMBO J. , vol.10 , pp. 927-932
    • Decker, T.1    Lew, D.J.2    Mirkovitch, J.3    Darnell J.E., Jr.4
  • 21
    • 0028841492 scopus 로고
    • Make it or break it: The role of ubiquitin-dependent proteolysis in cellular regulation
    • Deshaiis R.J. Make it or break it: the role of ubiquitin-dependent proteolysis in cellular regulation. Trends Cell Biol. 5:1995;428-434.
    • (1995) Trends Cell Biol. , vol.5 , pp. 428-434
    • Deshaiis, R.J.1
  • 22
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin J.E., Hackenmiller R., Simon M.C., Levy D.E. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 84:1996;443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 24
    • 0025172081 scopus 로고
    • ISGF3, the transcriptional activator induced by interferon-α, consists of multiple interacting polypeptide chains
    • Fu X.-Y., Kessler D.S., Veals S.A., Levy D.E., Darnell J.E. Jr. ISGF3, the transcriptional activator induced by interferon-α, consists of multiple interacting polypeptide chains. Proc. Natl. Acad. Sci. USA. 87:1990;8555-8559.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8555-8559
    • Fu, X.-Y.1    Kessler, D.S.2    Veals, S.A.3    Levy, D.E.4    Darnell J.E., Jr.5
  • 25
    • 0026723419 scopus 로고
    • A trascriptional factor with SH2 and SH3 domains is directly activated by an interferon a-induced cytoplasmic protein tyrosine kinase(s)
    • Fu X.-Y. A trascriptional factor with SH2 and SH3 domains is directly activated by an interferon a-induced cytoplasmic protein tyrosine kinase(s). Cell. 70:1992;323-335.
    • (1992) Cell , vol.70 , pp. 323-335
    • Fu, X.-Y.1
  • 26
    • 0026686488 scopus 로고
    • The proteins of ISGF-3: The interferon-α-induced transcriptional activator, define a gene family involved in signal transduction
    • Fu X.-Y., Schindler C., Improta T., Aebersold R., Darnell J.E. Jr. The proteins of ISGF-3: the interferon-α-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. USA. 89:1992;7840-7843.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7840-7843
    • Fu, X.-Y.1    Schindler, C.2    Improta, T.3    Aebersold, R.4    Darnell J.E., Jr.5
  • 27
    • 0027372119 scopus 로고
    • Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter
    • Fu X.-Y., Zhang J.-J. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter. Cell. 74:1993;1135-1145.
    • (1993) Cell , vol.74 , pp. 1135-1145
    • Fu, X.-Y.1    Zhang, J.-J.2
  • 28
    • 0028175454 scopus 로고
    • Ligand-induced IFN-gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system
    • Greenlund A.C., Farrar M.A., Viviano B.L., Schreiber R.D. Ligand-induced IFN-gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system. EMBO J. 13:1994;1591-1600.
    • (1994) EMBO J. , vol.13 , pp. 1591-1600
    • Greenlund, A.C.1    Farrar, M.A.2    Viviano, B.L.3    Schreiber, R.D.4
  • 29
    • 0029869176 scopus 로고    scopus 로고
    • The SH2 domains of Stat1 and Stat 2 mediate multiple interactions in the transduction of IFN-alpha signals
    • Gupta S., Yan H., Wong L.H., Ralph S., Krolewski J., Schindler C. The SH2 domains of Stat1 and Stat 2 mediate multiple interactions in the transduction of IFN-alpha signals. EMBO J. 5:1996;1075-1084.
    • (1996) EMBO J. , vol.5 , pp. 1075-1084
    • Gupta, S.1    Yan, H.2    Wong, L.H.3    Ralph, S.4    Krolewski, J.5    Schindler, C.6
  • 30
    • 0028983210 scopus 로고
    • IFN-gamma induces a p91/Stat1 alpha-related transcription factor with distinct activation and binding properties
    • Guyer N.B., Severns C.W., Wong P., Feghali C.A., Wright T.M. IFN-gamma induces a p91/Stat1 alpha-related transcription factor with distinct activation and binding properties. J. Immunol. 155:1995;179-186.
    • (1995) J. Immunol. , vol.155 , pp. 179-186
    • Guyer, N.B.1    Severns, C.W.2    Wong, P.3    Feghali, C.A.4    Wright, T.M.5
  • 31
    • 0028791664 scopus 로고
    • Roles of protein-tyrosine phosphotases in Stat1-alpha-mediated cell signaling
    • Haque S.J., Flati V., Deb A., Williams B.R.G. Roles of protein-tyrosine phosphotases in Stat1-alpha-mediated cell signaling. J. Biol. Chem. 270:1995;25709-25714.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25709-25714
    • Haque, S.J.1    Flati, V.2    Deb, A.3    Williams, B.R.G.4
  • 33
    • 0029972194 scopus 로고    scopus 로고
    • The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase
    • Haspel R.L., Salditt-Georgieff M., Darnell J.E. Jr. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J. 15:1996;6262-6268.
    • (1996) EMBO J. , vol.15 , pp. 6262-6268
    • Haspel, R.L.1    Salditt-Georgieff, M.2    Darnell J.E., Jr.3
  • 34
    • 0028946158 scopus 로고
    • Contribution of STAT SH2 groups to specific interferon signaling by the JAK-STAT pathway
    • Heim M.H., Kerr I.M., Stark G.R., Darnell J.E. Jr. Contribution of STAT SH2 groups to specific interferon signaling by the JAK-STAT pathway. Science. 267:1995;1347-1349.
    • (1995) Science , vol.267 , pp. 1347-1349
    • Heim, M.H.1    Kerr, I.M.2    Stark, G.R.3    Darnell J.E., Jr.4
  • 36
    • 0028935165 scopus 로고
    • Ubiquitin, proteasomes and the regulation of intercellular protein degradation
    • Hochstrasser M. Ubiquitin, proteasomes and the regulation of intercellular protein degradation. Curr. Opin. Cell. Biol. 7:1995;215-223.
    • (1995) Curr. Opin. Cell. Biol. , vol.7 , pp. 215-223
    • Hochstrasser, M.1
  • 37
    • 0028913109 scopus 로고
    • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
    • Horvath C.M., Wen Z., Darnell J.E. Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:1995;984-994.
    • (1995) Genes Dev. , vol.9 , pp. 984-994
    • Horvath, C.M.1    Wen, Z.2    Darnell J.E., Jr.3
  • 39
    • 0030040691 scopus 로고    scopus 로고
    • Marelle acts downstream of the Drosophila HOP/JAK kinase andencodes a protein similar to the mammalian STAT's
    • Hou X.S., Melnick M.B., Perrimon N. Marelle acts downstream of the Drosophila HOP/JAK kinase andencodes a protein similar to the mammalian STAT's. Cell. 84:1996;411-419.
    • (1996) Cell , vol.84 , pp. 411-419
    • Hou, X.S.1    Melnick, M.B.2    Perrimon, N.3
  • 40
    • 0028845212 scopus 로고
    • Cytokine receptor signaling
    • Ihle J.N. Cytokine receptor signaling. Nature. 377:1995;591-594.
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 41
    • 0028921573 scopus 로고
    • Jaks and Stats in signaling by the cytokine receptor superfamily
    • Ihle J.N., Kerr I.M. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet. 11:1995;69-74.
    • (1995) Trends Genet. , vol.11 , pp. 69-74
    • Ihle, J.N.1    Kerr, I.M.2
  • 43
    • 0028242693 scopus 로고
    • Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein
    • Improta T., Schindler C., Horvath C.M., Kerr I.M., Stark G.R., Darnell J.E. Jr. Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. Proc. Natl. Acad. Sci. USA. 91:1994;4776-4780.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4776-4780
    • Improta, T.1    Schindler, C.2    Horvath, C.M.3    Kerr, I.M.4    Stark, G.R.5    Darnell J.E., Jr.6
  • 44
    • 0027165321 scopus 로고
    • Induction of the Ly-6A/E gene by both interferon alpha/beta and gamma requires a DNA element to which a tyrosine phosphorylated 91 kDa protein binds
    • Kahn K.D., Shuai K., Lindwall G., Maher S.E., Darnell J.E. Jr., Bothwell A.L.M. Induction of the Ly-6A/E gene by both interferon alpha/beta and gamma requires a DNA element to which a tyrosine phosphorylated 91 kDa protein binds. Proc. Natl. Acad. Sci. USA. 90:1993;6806-6810.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6806-6810
    • Kahn, K.D.1    Shuai, K.2    Lindwall, G.3    Maher, S.E.4    Darnell J.E., Jr.5    Bothwell, A.L.M.6
  • 45
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of TH2 cells in STAT4-deficient mice
    • Kaplan M.H., Sun Y.L., Hoey T., Grusby M.J. Impaired IL-12 responses and enhanced development of TH2 cells in STAT4-deficient mice. Nature. 6587:1996;174-177.
    • (1996) Nature , vol.6587 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 46
    • 0028322193 scopus 로고
    • Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors
    • Karin M. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr. Opin. Cell. Biol. 6:1994;415-424.
    • (1994) Curr. Opin. Cell. Biol. , vol.6 , pp. 415-424
    • Karin, M.1
  • 48
    • 0025084603 scopus 로고
    • Interferon-alpha regulated nuclear translocation and DNA-binding affinity of ISGF-3, a multimeric transcriptional activator
    • Kessler D.S., Veals S.A., Fu X.-Y., Levy D.E. Interferon-alpha regulated nuclear translocation and DNA-binding affinity of ISGF-3, a multimeric transcriptional activator. Genes and Dev. 4:1990;1753-1765.
    • (1990) Genes and Dev. , vol.4 , pp. 1753-1765
    • Kessler, D.S.1    Veals, S.A.2    Fu, X.-Y.3    Levy, D.E.4
  • 49
    • 0000413462 scopus 로고    scopus 로고
    • Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway
    • Kim T.K., Maniatis T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science. 273:1996;1717-1719.
    • (1996) Science , vol.273 , pp. 1717-1719
    • Kim, T.K.1    Maniatis, T.2
  • 50
    • 0030659512 scopus 로고    scopus 로고
    • Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
    • Kumar A., Commane M., Flickinger T.W., Horvath C.M., Stark G.R. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science. 278:1997;1630-1632.
    • (1997) Science , vol.278 , pp. 1630-1632
    • Kumar, A.1    Commane, M.2    Flickinger, T.W.3    Horvath, C.M.4    Stark, G.R.5
  • 51
    • 0023987751 scopus 로고
    • Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative control
    • Levy D.E., Kessler D.S., Pine R., Reich N., Darnell J.E. Jr. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative control. Genes Dev. 2:1988;383-393.
    • (1988) Genes Dev. , vol.2 , pp. 383-393
    • Levy, D.E.1    Kessler, D.S.2    Pine, R.3    Reich, N.4    Darnell J.E., Jr.5
  • 52
    • 0024721567 scopus 로고
    • Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha stimulated transcription, reconstituted in vitro
    • Levy D.E., Kessler D.S., Pine R.I., Darnell J.E. Jr. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha stimulated transcription, reconstituted in vitro. Genes Dev. 3:1989;1362-1372.
    • (1989) Genes Dev. , vol.3 , pp. 1362-1372
    • Levy, D.E.1    Kessler, D.S.2    Pine, R.I.3    Darnell J.E., Jr.4
  • 54
  • 55
  • 57
    • 0029790559 scopus 로고    scopus 로고
    • Requirements for interleukin-4- induced gene expression and functional characterization of Stat6
    • Mikita T., Campbell D., Wu P., Williamson K., Schindler U. Requirements for interleukin-4- induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 10:1996;5811-5820.
    • (1996) Mol. Cell. Biol. , vol.10 , pp. 5811-5820
    • Mikita, T.1    Campbell, D.2    Wu, P.3    Williamson, K.4    Schindler, U.5
  • 60
    • 0027434082 scopus 로고
    • Complementation of a mutant cell line: Central role of the 91-kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathway
    • Muller M., Laxton C., Briscoe J., Schindler C., Improta T., Darnell J.E. Jr., Stark G.R., Kerr I.M. Complementation of a mutant cell line: Central role of the 91-kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathway. EMBO J. 12:1993;4221-4228.
    • (1993) EMBO J. , vol.12 , pp. 4221-4228
    • Muller, M.1    Laxton, C.2    Briscoe, J.3    Schindler, C.4    Improta, T.5    Darnell J.E., Jr.6    Stark, G.R.7    Kerr, I.M.8
  • 62
    • 0030882317 scopus 로고    scopus 로고
    • Stat 3 is a serine kinase target in T-lymphocytes. Interleukin 2 and T-cell antigen receptor signals coverage uponserine 727
    • Ng J., Cantrell D. Stat 3 is a serine kinase target in T-lymphocytes. Interleukin 2 and T-cell antigen receptor signals coverage uponserine 727. J. Biol. Chem. 272:1997;24542-24549.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24542-24549
    • Ng, J.1    Cantrell, D.2
  • 66
    • 0031457622 scopus 로고    scopus 로고
    • Signaling through scaffold, anchoring and adaptor proteins
    • Pawson T., Scott J.D. Signaling through scaffold, anchoring and adaptor proteins. Science. 278:1997;2075-2080.
    • (1997) Science , vol.278 , pp. 2075-2080
    • Pawson, T.1    Scott, J.D.2
  • 67
    • 0024404483 scopus 로고
    • Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathways
    • Pellegrini S., John J., Shearer M., Kerr M., Stark G.R. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathways. Mol. Cell. Biol. 11:1989;4605-4612.
    • (1989) Mol. Cell. Biol. , vol.11 , pp. 4605-4612
    • Pellegrini, S.1    John, J.2    Shearer, M.3    Kerr, M.4    Stark, G.R.5
  • 68
    • 0030804219 scopus 로고    scopus 로고
    • The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs)
    • Pellegrini S., Dusanter F.I. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur. J. Biochem. 3:1997;615-633.
    • (1997) Eur. J. Biochem. , vol.3 , pp. 615-633
    • Pellegrini, S.1    Dusanter, F.I.2
  • 69
    • 0030999696 scopus 로고    scopus 로고
    • STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor
    • Pfeffer L.M., Mullersman J.E., Pfeffer S.R., Murti A., Shi W., Yang C.H. STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. Science. 276:1997;1418-1420.
    • (1997) Science , vol.276 , pp. 1418-1420
    • Pfeffer, L.M.1    Mullersman, J.E.2    Pfeffer, S.R.3    Murti, A.4    Shi, W.5    Yang, C.H.6
  • 70
    • 0028097932 scopus 로고
    • Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma and is likely to autoregulate the p91 gene
    • Pine R., Canova A., Schindler C. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma and is likely to autoregulate the p91 gene. EMBO J. 13:1994;158-167.
    • (1994) EMBO J. , vol.13 , pp. 158-167
    • Pine, R.1    Canova, A.2    Schindler, C.3
  • 71
    • 0029655971 scopus 로고    scopus 로고
    • Function of Stat2 protein in transcriptional activation by alpha interferon
    • Qureshi S.A., Leung S., Kerr I.M., Stark G.R., Darnell J.E. Jr. Function of Stat2 protein in transcriptional activation by alpha interferon. Mol. Cell. Biol. 16(1):1996;288-293.
    • (1996) Mol. Cell. Biol. , vol.16 , Issue.1 , pp. 288-293
    • Qureshi, S.A.1    Leung, S.2    Kerr, I.M.3    Stark, G.R.4    Darnell J.E., Jr.5
  • 72
    • 0028206119 scopus 로고
    • JAK3: A novel JAK kinase associated with terminal differentiation of hematopoietic cells
    • Rane S.G., Reddy E.P. JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells. Oncogene. 9:1994;2415-2423.
    • (1994) Oncogene , vol.9 , pp. 2415-2423
    • Rane, S.G.1    Reddy, E.P.2
  • 73
    • 0342535752 scopus 로고
    • Interferon-induced transcription of a gene encoding a 15 kDa protein depends on an upstream enhancer element
    • Reich N., Evans B., Levy D.E., Fahey D., Knight E. Jr., Darnell J.E. Jr. Interferon-induced transcription of a gene encoding a 15 kDa protein depends on an upstream enhancer element. Proc. Natl. Acad. Sci. USA. 84:1987;6394-6398.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 6394-6398
    • Reich, N.1    Evans, B.2    Levy, D.E.3    Fahey, D.4    Knight E., Jr.5    Darnell J.E., Jr.6
  • 74
    • 0027496114 scopus 로고
    • A common nuclear signal transduction pathway activated by growth factor and cytokine receptors
    • Sadowski H.B., Shuai K., Darnell J.E. Jr., Gilman M.Z. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science. 261:1993;1739-1744.
    • (1993) Science , vol.261 , pp. 1739-1744
    • Sadowski, H.B.1    Shuai, K.2    Darnell J.E., Jr.3    Gilman, M.Z.4
  • 75
    • 0026725868 scopus 로고
    • Proteins of transcription factor ISGF-3: One gene encodes the 91 and 84 kDa ISGF-3 proteins that are activated by interferon-alpha
    • Schindler C., Fu X.-Y., Improta T., Aebersold R., Darnell J.E. Jr. Proteins of transcription factor ISGF-3: one gene encodes the 91 and 84 kDa ISGF-3 proteins that are activated by interferon-alpha. Proc. Natl. Acad. Sci. USA. 89:1992;7836-7839.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7836-7839
    • Schindler, C.1    Fu, X.-Y.2    Improta, T.3    Aebersold, R.4    Darnell J.E., Jr.5
  • 76
    • 0026770248 scopus 로고
    • Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
    • Schindler C., Shuai K., Prezioso V.R., Darnell J.E. Jr. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 257:1992;809-815.
    • (1992) Science , vol.257 , pp. 809-815
    • Schindler, C.1    Shuai, K.2    Prezioso, V.R.3    Darnell J.E., Jr.4
  • 77
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
    • Schindler C., Darnell J.E. Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Ann. Rev. Biochem. 64:1995;621-651.
    • (1995) Ann. Rev. Biochem. , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell J.E., Jr.2
  • 78
    • 0029795639 scopus 로고    scopus 로고
    • Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways
    • Sengupta T.K., Schmitt E.M., Ivashkiv L.B. Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways. Proc. Natl. Acad. Sci. USA. 93:1996;9499-94504.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9499-94504
    • Sengupta, T.K.1    Schmitt, E.M.2    Ivashkiv, L.B.3
  • 79
    • 0027090310 scopus 로고
    • Activation of transcription by IFN-g: Tyrosine phosphorylation of a 91 kD DNA binding protein
    • Shuai K., Schindler C., Prezioso V.R., Darnell J.E. Jr. Activation of transcription by IFN-g: tyrosine phosphorylation of a 91 kD DNA binding protein. Science. 259:1992;1808-1812.
    • (1992) Science , vol.259 , pp. 1808-1812
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell J.E., Jr.4
  • 80
    • 0027493650 scopus 로고
    • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma
    • Shuai K., Stark G.R., Kerr I.M., Darnell J.E. Jr. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science. 261:1993;1744-1746.
    • (1993) Science , vol.261 , pp. 1744-1746
    • Shuai, K.1    Stark, G.R.2    Kerr, I.M.3    Darnell J.E., Jr.4
  • 82
    • 0028331926 scopus 로고
    • Interferon-activated signal transduction to the nucleus
    • Shuai K. Interferon-activated signal transduction to the nucleus. Curr. Opin. Cell. Biol. 6:1994;253-259.
    • (1994) Curr. Opin. Cell. Biol. , vol.6 , pp. 253-259
    • Shuai, K.1
  • 83
    • 0028349904 scopus 로고
    • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    • Shuai K., Horvath C.M., Tsai-Huang L.H., Qureshi S., Cowburn D., Darnell J.E. Jr. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell. 76:1994;821-828.
    • (1994) Cell , vol.76 , pp. 821-828
    • Shuai, K.1    Horvath, C.M.2    Tsai-Huang, L.H.3    Qureshi, S.4    Cowburn, D.5    Darnell J.E., Jr.6
  • 84
    • 0029742102 scopus 로고    scopus 로고
    • Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1
    • Shuai K., Liao J., Song M.M. Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol. Cell. Biol. 16:1996;4932-4941.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4932-4941
    • Shuai, K.1    Liao, J.2    Song, M.M.3
  • 88
    • 0028964465 scopus 로고
    • Cytokine signaling through nonreceptor protein tyrosine kinase
    • Taniguchi T. Cytokine signaling through nonreceptor protein tyrosine kinase. Science. 268:1995;251-255.
    • (1995) Science , vol.268 , pp. 251-255
    • Taniguchi, T.1
  • 91
    • 0029935418 scopus 로고    scopus 로고
    • Regulation of transcription by MAP kinase cascades
    • Treisman R. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell. Biol. 8:1996;205-215.
    • (1996) Curr. Opin. Cell. Biol. , vol.8 , pp. 205-215
    • Treisman, R.1
  • 92
    • 0028828561 scopus 로고
    • Interaction of the trascriptional activator Stat-2 with the type I interferon receptor
    • Uddin S., Chamdin A., Platanias L.C. Interaction of the trascriptional activator Stat-2 with the type I interferon receptor. J. Biol. Chem. 270:1995;24627-24630.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24627-24630
    • Uddin, S.1    Chamdin, A.2    Platanias, L.C.3
  • 95
    • 0026778338 scopus 로고
    • Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding protein
    • Veals S.A., Schindler C., Leonard D., Fu X.-Y., Aebersold R., Darnell J.E. Jr., Levy D.E. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding protein. Mol. Cell. Biol. 12:1992;3315-3324.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3315-3324
    • Veals, S.A.1    Schindler, C.2    Leonard, D.3    Fu, X.-Y.4    Aebersold, R.5    Darnell J.E., Jr.6    Levy, D.E.7
  • 96
    • 0026632288 scopus 로고
    • A protein tyrosine kinase in the interferon alpha/beta signalling pathway
    • Velazquez L., Fellows M., Stark G.R., Pellegrini S. A protein tyrosine kinase in the interferon alpha/beta signalling pathway. Cell. 70:1992;313-322.
    • (1992) Cell , vol.70 , pp. 313-322
    • Velazquez, L.1    Fellows, M.2    Stark, G.R.3    Pellegrini, S.4
  • 97
    • 0029903770 scopus 로고    scopus 로고
    • DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: Interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites
    • Vinkemeier U., Cohen S.L., Moarefi I., Chait B.T., Kuriyan J., Darnell J.E. Jr. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 15:1996;5616-5626.
    • (1996) EMBO J. , vol.15 , pp. 5616-5626
    • Vinkemeier, U.1    Cohen, S.L.2    Moarefi, I.3    Chait, B.T.4    Kuriyan, J.5    Darnell J.E., Jr.6
  • 98
    • 0032512661 scopus 로고    scopus 로고
    • Structure of the amino-terminal protein interaction domain of STAT-4
    • Vinkemeier U., Moarefi I., Darnell J.E. Jr., Kuriyan J. Structure of the amino-terminal protein interaction domain of STAT-4. Science. 279:1998;1048-1052.
    • (1998) Science , vol.279 , pp. 1048-1052
    • Vinkemeier, U.1    Moarefi, I.2    Darnell J.E., Jr.3    Kuriyan, J.4
  • 99
    • 0028217452 scopus 로고
    • Mammary gland factor (MGF) is a nobel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    • Wakao H., Gouilleux F., Groner B. Mammary gland factor (MGF) is a nobel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 13:1994;2182-2191.
    • (1994) EMBO J. , vol.13 , pp. 2182-2191
    • Wakao, H.1    Gouilleux, F.2    Groner, B.3
  • 101
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z., Zhong Z., Darnell J.E. Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 82:1995;241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell J.E., Jr.3
  • 102
    • 0030744123 scopus 로고    scopus 로고
    • Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
    • Wen Z., Darnell J.E. Jr. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucl. Acids Res. 25:1997;2062-2067.
    • (1997) Nucl. Acids Res. , vol.25 , pp. 2062-2067
    • Wen, Z.1    Darnell J.E., Jr.2
  • 104
    • 0011280342 scopus 로고
    • Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction
    • Wilks A.F. Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc. Natl. Acad. Sci. USA. 86:1989;1603-1607.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1603-1607
    • Wilks, A.F.1
  • 105
    • 0026081302 scopus 로고
    • Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain define a new class of protein kinase
    • Wilks A.F., Harpur A., Kurlan R.R., Ralph S.J., Zurder G., Ziemiecki A. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain define a new class of protein kinase. Mol. Cell. Biol. 11:1991;2057-2065.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 2057-2065
    • Wilks, A.F.1    Harpur, A.2    Kurlan, R.R.3    Ralph, S.J.4    Zurder, G.5    Ziemiecki, A.6
  • 107
    • 0027955575 scopus 로고
    • A unique palindromic element mediates gamma interferon induction of mig gene expression
    • Wong P., Sevewrns C.W., Guyerm N.B., Wright T.M. A unique palindromic element mediates gamma interferon induction of mig gene expression. Mol. Cell. Biol. 155:1995;914-922.
    • (1995) Mol. Cell. Biol. , vol.155 , pp. 914-922
    • Wong, P.1    Sevewrns, C.W.2    Guyerm, N.B.3    Wright, T.M.4
  • 108
    • 0031193356 scopus 로고    scopus 로고
    • Miz1, a novel zing finger transcription factor that interacts with Msx2 and enhances its affinity for DNA
    • Wu L., Wu H., Sangiorgi F., Wu N., Bell J.R., Lyons G.E., Maxson R. Miz1, a novel zing finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech. Devel. 65:1997;3-17.
    • (1997) Mech. Devel. , vol.65 , pp. 3-17
    • Wu, L.1    Wu, H.2    Sangiorgi, F.3    Wu, N.4    Bell, J.R.5    Lyons, G.E.6    Maxson, R.7
  • 109
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
    • Xu X., Sun Y.L., Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science. 273:1996;794-797.
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Sun, Y.L.2    Hoey, T.3
  • 111
    • 0029670220 scopus 로고    scopus 로고
    • Phosphorylated interferon-alpha receptor 1 subunit IFNaR1 acts as a docking site for the latent form of the 113 kDa STAT2 protein
    • Yan H., Krishman K., Greenland A.C., Gupta S., Lim J.T., Schreiber R.D., Schindler C.W., Krolewski J.J. Phosphorylated interferon-alpha receptor 1 subunit IFNaR1 acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15:1996;1064-1074.
    • (1996) EMBO J. , vol.15 , pp. 1064-1074
    • Yan, H.1    Krishman, K.2    Greenland, A.C.3    Gupta, S.4    Lim, J.T.5    Schreiber, R.D.6    Schindler, C.W.7    Krolewski, J.J.8
  • 112
    • 0001514956 scopus 로고    scopus 로고
    • Identification of a Stat gene that functions in Drosophila development
    • Yan R., Small S., Desplan C., Dearolf C.R., Darnell J.E. Jr. Identification of a Stat gene that functions in Drosophila development. Cell. 84:1996;421-430.
    • (1996) Cell , vol.84 , pp. 421-430
    • Yan, R.1    Small, S.2    Desplan, C.3    Dearolf, C.R.4    Darnell J.E., Jr.5
  • 113
    • 0029014206 scopus 로고
    • A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    • Yoshimura A., Ohkubo T., Kiguchi T., Jenkins N.A., Gilbert D.J., Copeland N.G., Hara T., Miyajima A. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:1995;2816-2826.
    • (1995) EMBO J. , vol.14 , pp. 2816-2826
    • Yoshimura, A.1    Ohkubo, T.2    Kiguchi, T.3    Jenkins, N.A.4    Gilbert, D.J.5    Copeland, N.G.6    Hara, T.7    Miyajima, A.8
  • 115
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • Zhang X., Blenis J., Li H.C., Schindler C., Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science. 267:1995;1990-1994.
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.C.3    Schindler, C.4    Chen-Kiang, S.5
  • 116
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z., Wen Z., Darnell J.E. Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 264:1994;95-98.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell J.E., Jr.3
  • 117
    • 0028284762 scopus 로고
    • Stat3 and Stat4: Members of the family of signal transducers and activators of transcription
    • Zhong Z., Wen Z., Darnell J.E. Jr. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc. Natl. Acad. Sci. USA. 91:1995;4806-4810.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4806-4810
    • Zhong, Z.1    Wen, Z.2    Darnell J.E., Jr.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.