STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 4, 2003, Pages 1879-1884

  Welte, Thomas ^a   Zhang, Samuel S M ^a   Wang, Tian ^a   Zhang, Zhiyuan ^a   Hesslein, David G T ^a   Yin, Zhinan ^a   Kano, Arihiro ^a   Iwamoto, Yoshiki ^a,b,d   Li, En ^c   Craft, Joseph E ^a   Bothwell, Alfred L M ^a   Fikrig, Erol ^a   Koni, Pandelakis A ^a,e   Flavell, Richard A ^a   Fu, Xin Yuan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

^e RIKEN YOKOHAMA INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; CROHN DISEASE; ENZYME INHIBITION; GENE DELETION; GENE DISRUPTION; GRANULOMA; HEMATOPOIESIS; IMMUNE RESPONSE; IMMUNITY; IMMUNOREGULATION; INFLAMMATORY CELL; INTESTINE ULCER; LETHALITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CROHN DISEASE; DNA-BINDING PROTEINS; GENE DELETION; HEMATOPOIESIS; IMMUNITY; MICE; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

ANIMALIA; EUKARYOTA;

EID: 0037452789     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0237137100     Document Type: Article

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