Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

EMBO Journal

Volumn 18, Issue 2, 1999, Pages 375-385

  Nicholson, Sandra E ^a   Willson, Tracy A ^a   Farley, Alison ^a   Starr, Robyn ^a   Zhang, Jian Guo ^a   Baca, Manuel ^a   Alexander, Warren S ^a   Metcalf, Donald ^a   Hilton, Douglas J ^a   Nicola, Nicos A ^a  

^a Department of Civil and Environmental Engineering   (Australia)

Author keywords

Cytokines; JAKs; Negative regulators; Signal transduction; SOCS

Indexed keywords

CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; MUTANT PROTEIN; PHOSPHOTRANSFERASE; SUPPRESSOR FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; FIBROBLAST; GENE EXPRESSION REGULATION; MACROPHAGE; MONOCYTIC LEUKEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; REPORTER GENE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE; CYTOKINES; DNA-BINDING PROTEINS; GROWTH INHIBITORS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA INHIBITORY FACTOR; LYMPHOKINES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PHOSPHORYLATION; PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TYROSINE;

ANIMALIA; MURINAE;

EID: 0033555258     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.2.375     Document Type: Article

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