Virtual gating and nuclear transport: The hole picture

Trends in Cell Biology

Volumn 13, Issue 12, 2003, Pages 622-628

  Rout, Michael P ^a   Aitchison, John D ^b   Magnasco, Marcelo O ^a   Chait, Brian T ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE;

BINDING SITE; CATALYSIS; CELL MEMBRANE TRANSPORT; CELL NUCLEUS MEMBRANE; CHANNEL GATING; CYTOPLASM; EUKARYOTE; MACROMOLECULE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 0242391971     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2003.10.007     Document Type: Article

References (54)

1. Wente S.R. Gatekeepers of the nucleus. Science. 288:2000;1374-1377.
2. Macara I.G. Transport into and out of the nucleus. Microbiol. Mol. Biol. Rev. 65:2001;570-594.
3. Suntharalingam M., Wente S.R. Peering through the pore. Nuclear pore complex structure, assembly, and function. Dev. Cell. 4:2003;775-789.
4. Rout M.P., Aitchison J.D. The nuclear pore complex as a ransport machine. J. Biol. Chem. 276:2001;16593-16596.
5. Weis K. Nucleocytoplasmic transport: cargo trafficking across the border. Curr. Opin. Cell Biol. 14:2002;328-335.
6. Rout M.P., et al. The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148:2000;635-651.
7. Smith A.E., et al. Systems analysis of Ran transport. Science. 295:2002;488-491.
8. Ribbeck K., Gorlich D. Kinetic analysis of translocation through nuclear pore complexes. EMBO J. 20:2001;1320-1330.
9. Gorlich D., Kutay U. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15:1999;607-660.
10. Lei E.P., Silver P.A. Protein and RNA export from the nucleus. Dev. Cell. 2:2002;261-272.
11. Wozniak R.W., et al. Karyopherins and kissing cousins. Trends Cell Biol. 8:1998;184-188.
12. Pemberton L.F., et al. Transport routes through the nuclear pore complex. Curr. Opin. Cell Biol. 10:1998;392-399.
13. Conti E., Izaurralde E. Nucleocytoplasmic transport enters the atomic age. Curr. Opin. Cell Biol. 13:2001;310-319.
14. Simos G., et al. Nuclear export of tRNA. Results Probl. Cell Differ. 35:2002;115-131.
15. Mattaj I.W., Englmeier L. Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem. 67:1998;265-306.
16. Moore M.S. Ran and nuclear transport. J. Biol. Chem. 273:1998;22857- 22860.
17. Cole C.N., Hammell C.M. Nucleocytoplasmic transport: driving and directing transport. Curr. Biol. 8:1998;R368-R372.
18. Purcell E.M. Life at low Reynolds numbers. Am. J. Phys. 45:1977;3-11.
19. Berg H.C. Random Walks in Biology. 1993;Princeton University Press.
20. Elbaum M. The nuclear pore complex: biochemical machine or Maxwell demon? C. R. Acad. Sci. Paris, t. 2. Série IV:2001;861-870.
21. Kiseleva E., et al. Active nuclear pore complexes in Chironomus: visualization of transporter configurations related to mRNP export. J. Cell Sci. 111:1998;223-236.
22. Feldherr C.M., Akin D. The location of the transport gate in the nuclear pore complex. J. Cell Sci. 110:1997;3065-3070.
23. Allen T.D., et al. The nuclear pore complex: mediator of translocation between nucleus and cytoplasm. J. Cell Sci. 113:2000;1651-1659.
24. Blobel G., Wozniak R.W. Proteomics for the pore. Nature. 403:2000;835-836.
25. Cronshaw J.M., et al. Proteomic analysis of the mammalian nuclear pore complex. J. Cell Biol. 158:2002;915-927.
26. Weis K., et al. Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J. 15:1996;7120-7128.
27. Schwoebel E.D., et al. Ran-dependent signal-mediated nuclear import does not require GTP hydrolysis by Ran. J. Biol. Chem. 273:1998;35170-35175.
28. Englmeier L., et al. Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis. Curr. Biol. 9:1999;30-41.
29. Ribbeck K., et al. The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy. Curr. Biol. 9:1999;47-50.
30. Buss F., et al. Role of different domains in the self-association of rat nucleoporin p62. J. Cell Sci. 107:1994;631-638.
31. Denning D.P., et al. Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded. Proc. Natl. Acad. Sci. U.S.A. 100:2003;2450-2455.
32. Atkins P.W. The elements of physical chemistry. 2001;W.H. Freeman.
33. Bayliss R., et al. Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats. EMBO J. 21:2002;2843-2853.
34. Chaillan-Huntington C., et al. Dissecting the interactions between NTF2, RanGDP, and the nucleoporin XFXFG repeats. J. Biol. Chem. 275:2000;5874-5879.
35. Bednenko J., et al. Nucleocytoplasmic transport: navigating the channel. Traffic. 4:2003;127-135.
36. Ribbeck K., Gorlich D. The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. EMBO J. 21:2002;2664-2671.
37. Dill K.A., Bromberg S. Molecular driving forces: statistical thermodynamics in chemistry and biology. 2003;Garland Science.
38. Gorlich D., et al. Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation. EMBO J. 22:2003;1088-1100.
39. Ribbeck K., et al. NTF2 mediates nuclear import of Ran. EMBO J. 17:1998;6587-6598.
40. Nachury M.V., Weis K. The direction of transport through the nuclear pore can be inverted. Proc. Natl. Acad. Sci. U.S.A. 96:1999;9622-9627.
41. Hoh J.H. Functional protein domains from the thermally driven motion of polypeptide chains: a proposal. Proteins. 32:1998;223-228.
42. Brown H.G., Hoh J.H. Entropic exclusion by neurofilament sidearms: a mechanism for maintaining interfilament spacing. Biochemistry. 36:1997;15035-15040.
43. Mukhopadhyay R., Hoh J.H. AFM force measurements on microtubule- associated proteins: the projection domain exerts a long-range repulsive force. FEBS Lett. 505:2001;374-378.
44. Bickel T., Bruinsma R. The nuclear pore complex mystery and anomalous diffusion in reversible gels. Biophys. J. 83:2002;3079-3087.
45. Shulga N., Goldfarb D.S. Binding dynamics of structural nucleoporins govern nuclear pore complex permeability and may mediate channel gating. Mol. Cell. Biol. 23:2003;534-542.
46. Shulga N., et al. Yeast nucleoporins involved in passive nuclear envelope permeability. J. Cell Biol. 149:2000;1027-1038.
47. Marelli M., et al. Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p. J. Cell Biol. 143:1998;1813-1830.
48. Ryan K.J., Wente S.R. The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm. Curr. Opin. Cell Biol. 12:2000;361-371.
49. Blobel G. Unidirectional and bidirectional protein traffic across membranes. Cold Spring Harb. Symp. Quant. Biol. 60:1995;1-10.
50. Akey C.W. Visualization of transport-related configurations of the nuclear pore transporter. Biophys. J. 58:1990;341-355.
51. Daneholt B. Assembly and transport of a premessenger RNP particle. Proc. Natl. Acad. Sci. U.S.A. 98:2001;7012-7017.
52. Izaurralde E. A novel family of nuclear transport receptors mediates the export of messenger RNA to the cytoplasm. Eur. J. Cell Biol. 81:2002;577-584.
53. Stutz F., Izaurralde E. The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol. 13:2003;319-327.
54. Lyman S.K., et al. Influence of cargo size on Ran and energy requirements for nuclear protein import. J. Cell Biol. 159:2002;55-67.