The Janus kinases (Jaks)

Genome Biology

Volumn 5, Issue 12, 2004, Pages

  Yamaoka, Kunihiro ^a   Saharinen, Pipsa ^b   Pesu, Marko ^a   Holt III, Vance E T ^a   Silvennoinen, Olli ^c,d   O'Shea, John J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF TAMPERE   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; CYTOKINE RECEPTOR; ERYTHROCYTE BAND 4.1 PROTEIN; EZRIN; FOCAL ADHESION KINASE 1; IMMUNOSUPPRESSIVE AGENT; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; JANUS KINASE 3 INHIBITOR; MOESIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE 2 INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RADIXIN; STAT PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; AUTOIMMUNE DISEASE; AUTOSOMAL RECESSIVE DISORDER; BIRD; CATALYSIS; CELL LINE; COMBINED IMMUNODEFICIENCY; DEVELOPMENTAL DISORDER; DROSOPHILA; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; FISH; GENE TARGETING; GENETIC ORGANIZATION; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INSECT; LEUKEMOID REACTION; MAMMAL; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; EVOLUTION; HUMANS; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES;

AVES; HEXAPODA; JANUS; MAMMALIA;

EID: 19944427133     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: 10.1186/gb-2004-5-12-253     Document Type: Review

References (56)

1. Firmbach-Kraft I, Byers M, Shows T, Dalla-Favera R, Krolewski JJ: Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene 1990, 5:1329-1336.
2. Wilks AF: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc Natl Acad Sci USA 1989, 86:1603-1607.
3. Wilks AF: Cloning members of protein-tyrosine kinase family using polymerase chain reaction. Methods Enzymol 1991, 200:533-546.
4. Harpur AG, Andres AC, Ziemiecki A, Aston RR, Wilks AF: JAK2, a third member of the JAK family of protein tyrosine kinases. Oncogene 1992, 7:1347-1353.
5. Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R. Identification and chromosomal mapping of new human tyrosine kinase genes. Oncogene 1990, 5:277-282.
6. Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR, et al.: Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl Acad Sci USA 1994, 91:6374-6378.
7. Perrimon N, Mahowald AP: 1(1)hopscotch, a larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila. Dev Biol 1986, 118:28-41.
8. Binari R, Perrimon N: Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev 1994, 8:300-312.
9. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S: The protein kinase complement of the human genome. Science 2002, 298:1912-1934.
10. Chen M, Cheng A, Candotti F, Zhou YJ, Hymel A, Fasth A, Notarangelo LD, O'Shea JJ: Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains. Mol Cell Biol 2000, 20:947-956.
11. Saharinen P, Takaluoma K, Silvennoinen O: Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol Cell Biol 2000, 20:3387-3395.
12. Hanratty WP, Dearolf CR: The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Mol Gen Genet 1993, 238:33-37.
13. Jinks TM, Polydorides AD, Calhoun G, Schedl P: The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster. Mol Cell 2000, 5: 81-587.
14. Johansen KA, Iwaki DD, Lengyel JA: Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium. Development 2003, 130:135-145.
15. Saharinen P, Silvennoinen O: The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem 2002, 277:47954-47963.
16. Velazquez L, Fellous M, Stark GR, Pellegrini S: A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 1992, 70:313-322.
17. Huang LJ, Constantinescu SN, Lodish HF: The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell 2001, 8:1327-1338.
18. Zhou YJ, Chen M, Cusack NA, Kimmel LH, Magnuson KS, Boyd JG, Lin W, Roberts JL, Lengi A, Buckley RH, et al.: Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell 2001, 8: 59-969.
19. Musso T, Johnston JA, Linnekin D, Varesio L, Rowe TK, O'Shea JJ, McVicar DW: Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. J Exp Med 1995, 181:1425-1431.
20. Tortolani PJ, Lal BK, Riva A, Johnston JA, Chen YQ, Reaman GH, Beckwith M, Longo D, Ortaldo JR, Bhatia K, et al.: Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J Immunol 1995, 155:5220-5226.
21. Hofmann SR, Lam AQ, Frank S, Zhou YJ, Ramos HL, Kanno Y, Agnello D, Youle RJ, O'Shea JJ: Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited. Mol Cell Biol 2004, 24:5039-5049.
22. Ragimbeau J, Dondi E, Alcover A, Eid P, Uze G, Pellegrini S: The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. EMBO J 2003, 22:537-547.
23. Argetsinger LS, Campbell GS, Yang X, Witthuhn BA, Silvennoinen O, Ihle JN, Carter-Su C: Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 1993, 74:237-244.
24. Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O, Ihle JN: JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 1993, 74:227-236.
25. Muller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, et al.: The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 1993, 366:129-135.
26. Silvennoinen O, Ihle JN, Schlessinger J, Levy DE: Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature 1993, 366:583-585.
27. Shimoda K, Kato K, Aoki K, Matsuda T, Miyamoto A, Shibamori M, Yamashita M, Numata A, Takase K, Kobayashi S, et al.: Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 2000, 13: 61-571.
28. Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, et al.: Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 2000, 13:549-560.
29. Karaghiosoff M, Steinborn R, Kovarik P, Kriegshauser G, Baccarini M, Donabauer B, Reichart U, Kolbe T, Bogdan C, Leanderson T, et al.: Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol 2003, 4:471-477.
30. Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, et al.: Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 1998, 93: 73-383.
31. Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K: Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 1998, 93:397-409.
32. Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 1998, 93:385-395.
33. Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, Ugazio AG, Johnston JA, Candotti F, O'Shea JJ, et al.: Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995, 377:65-68.
34. Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone TS, Noguchi M, Markert ML, Buckley RH, et al.: Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995, 270:797-800.
35. O'Shea JJ, Pesu M, Borie DC, Changelian PS: A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat Rev Drug Discov 2004, 3:555-564.
36. Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN: Defective lymphoid development in mice lacking Jak3. Science 1995, 270: 00-802.
37. Park SY, Saijo K, Takahashi T, Osawa M, Arase H, Hirayama N, Miyake K, Nakauchi H, Shirasawa T, Saito T: Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 1995, 3:771-782.
38. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995, 270:794-797.
39. Sorrentino RP, Melk JP, Govind S: Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila. Genetics 2004, 166:1343-1356.
40. Luo H, Asha H, Kockel L, Parke T, Mlodzik M, Dearolf CR: The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye. Dev Biol 1999, 213: 32-441.
41. Callus BA, Mathey-Prevot B: SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. Oncogene 2002, 21:4812-4821.
42. Chen X, Oh SW, Zheng Z, Chen HW, Shin HH, Hou SX: Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Dev Cell 2003, 4:179-190.
43. O'Shea JJ, Gadina M, Schreiber RD: Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002, 109 Suppl:S121-S131.
44. Hombria JC, Brown S: The fertile field of Drosophila Jak/STAT signalling. Curr Biol 2002, 12:R569-R575.
45. Harrison DA, Binari R, Nahreini TS, Gilman M, Perrimon N: Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J 1995, 14: 857-2865.
46. Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rornpaey L, Baens M, Van den Berghe H, Marynen P: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 1997, 90: 535-2540.
47. Cools J, Peeters P, Voet T, Aventin A, Mecucci C, Grandchamp B, Marynen P: Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia. Cytogenet Cell Genet 1999, 85: 60-266.
48. Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA: A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 1997, 278:1309-1312.
49. Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G, Leonard WJ: Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-1. Science 1995, 269:79-81.
50. Zhou YJ, Hanson EP, Chen YQ, Magnuson K, Chen M, Swann PG, Wange RL, Changelian PS, O'Shea JJ: Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc Natl Acad Sci USA 1997, 94: 3850-13855.
51. Kurzer JH, Argetsinger LS, Zhou YJ, Kouadio JL, O'Shea JJ, Carter-Su C: Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. Mol Cell Biol 2004, 24:4557-4570.
52. Feener EP, Rosario F, Dunn SL, Stancheva Z, Myers MG Jr: Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol 2004, 24:4968-4978.
53. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y: Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol 2004, 6:547-554.
54. Josten F, Fuss B, Feix M, Meissner T, Hoch M: Cooperation of JAK/STAT and Notch signaling in the Drosophila foregut. Dev Biol 2004, 267:181-189.
55. Bach EA, Vincent S, Zeidler MP, Perrimon N: A sensitized genetic screen to identify novel regulators and components of the Drosophila Janus kinase/signal transducer and activator of transcription pathway. Genetics 2003, 165:1149-1166.
56. Changelian PS, Flanagan ME, Ball DJ, Kent CR, Magnuson KS, Martin WH, Rizzuti BJ, Sawyer PS, Perry BD, Brissette WH, et al.: Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 2003, 302:875-878.