STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells

Blood

Volumn 99, Issue 1, 2002, Pages 95-101

  Snow, Jonathan W ^a   Abraham, Ninan ^a   Ma, Melissa C ^a   Abbey, Nancy W ^a   Herndier, Brian ^a   Goldsmith, Mark A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STAT5 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; CELL VIABILITY; COLONY FORMING UNIT S; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; FLOW CYTOMETRY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; TRANSGENIC MOUSE;

EID: 0036098153     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.1.95     Document Type: Article

References (33)

1. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
2. Identification of clonogenic common lymphoid progenitors in mouse bone marrow
3. Translating stem and progenitor cell biology to the clinic: Barriers and opportunities
4. Humoral regulation of hematopoietic stem cells
5. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
6. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
7. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
8. The role of STATs in transcriptional control and their impact on cellular function
9. STATs: Signal transducers and activators of transcription
10. The Jak-Stat pathway in normal and perturbed hematopoiesis
11. Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation
12. Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation
13. Stat5a is mandatory for adult mammary gland development and lactogenesis
14. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
15. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression
16. An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction
17. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
18. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
19. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
20. -/-mice: A direct role for Stat5 in Bcl-X(L) induction
21. Anti-apoptotic activity of Stat5 required during terminal stages of myeloid differentiation
22. Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells
23. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
24. Loss of FancC function results in decreased hematopoietic stem cell repopulating ability
25. High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro and in vivo
26. Self-renewal, differentiation or death: Regulation and manipulation of hematopoietic stem cell fate
27. Short- and long-term multilineage repopulating hematopoietic stem cells in late fetal and newborn mice: Models for human umbilical cord blood
28. Hematopoietic colony studies, V: Effects of hematopoietic organ stroma on differentiation of pluripotent stem cells
29. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling
30. Role of c-mpl in early hematopoiesis
31. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
32. Targeted disruption of theflk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
33. Myelodysplasia syndrome and acutemyeloid leukemia in patients with congenital neutropenia receiving G-CSF therapy