Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: Impact on STAT5 transcriptional activity

Molecular Endocrinology

Volumn 15, Issue 12, 2001, Pages 2157-2171

  Park, Soo Hee ^a   Yamashita, Hiroko ^b   Rui, Hallgeir ^b   Waxman, David J ^a  

^a Boston University   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BETA CASEIN; LUCIFERASE; PROTEIN SERINE KINASE; STAT PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; DIMERIZATION; DNA BINDING; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TARGETING; HORMONAL REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0035215369     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.15.12.0746     Document Type: Article

References (42)

1. STATs and gene regulation
2. Growth hormone action: Signaling via a JAK/STAT-coupled receptor
3. A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b
4. Maximal activation of transcription by Stat 1 and Stat3 requires both tyrosine and serine phosphorylation
5. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
6. Insulin stimulates the serine phosphorylation of the signal transducer and activator of transcription (STAT3) isoform
7. Serine phosphorylation of STATs
8. Interleukin-6-induced serine phosphorylation of transcription factor APRF: Evidence for a role in interleukin-6 target gene induction
9. 727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation
10. The carboxyl-terminal region of STAT3 controls gene induction by the mouse haptoglobin promoter
11. STAT3 serine phosphorylation by ERK-dependent and independent pathways negatively modulates its tyrosine phosphorylation
12. Stat5a and Stat5b: Fraternal twins of signal transduction and transcriptional activation
13. Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation
14. Regulation of STAT5b activation by the temporal pattern of growth hormone stimulation
15. Growth hormone (GH) induces the formation of protein complexes involving stat5, erk2, shc and serine phosphorylated proteins
16. Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes
17. Lactogenic hormone activation of Stat5 and transcription of the β-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen-activated protein kinase activity
18. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway
19. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells
20. Stat5a serine phosphorylation. Serine 779 is constitutively phosphorylated in the mammary gland, and serine 725 phosphorylation influences prolactin-stimulated in vitro DNA binding activity
21. Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a
22. Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5
23. STAT5 signalling in sexually dimorphic gene expression and growth patterns
24. Termination of growth hormone pulse-induced STAT5b signaling
25. Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5
26. Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver
27. 694 of Stat 5 (MGF), a prerequisite for DNA binding and induction of transcription
28. Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two γ-activated sites
29. DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites
30. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling
31. p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response
32. Conversion of threonine 757 to valine enhances stat5a transactivation potential
33. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
34. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
35. PhosphoBase, a database of phosphorylation sites: Release 2.0
36. Stat5a is mandatory for adult mammary gland development and lactogenesis
37. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
38. A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities
39. DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites
40. A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: A distinct biochemical difference between STAT5A and STAT5B
41. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of Stat5a gene disruption
42. Cloning and expression of Stat 5 and an additional homologue (Stat 5b) involved in prolactin signal transduction in mouse mammary tissue