메뉴 건너뛰기




Volumn 184, Issue 1-2, 2007, Pages 69-91

Inflammatory processes in Alzheimer's disease

Author keywords

Amyloid; Astrocyte; Cytokine; Innate immunity; Microglia; Neurodegeneration

Indexed keywords

AMYLOID BETA PROTEIN; CHEMOKINE; CHROMOGRANIN A; CYTOKINE; FLURBIPROFEN; FREE RADICAL; IBUPROFEN; INDOMETACIN; NAPROXEN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROSTAGLANDIN SYNTHASE; PROSTANOID;

EID: 33847613885     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.11.017     Document Type: Review
Times cited : (641)

References (324)
  • 1
    • 20244364226 scopus 로고    scopus 로고
    • Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APPSWE transgenic mice
    • Abbas N., Bednar I., Mix E., Marie S., Paterson D., Ljungberg A., Morris C., Winblad B., Nordberg A., and Zhu J. Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APPSWE transgenic mice. J. Neuroimmunol. 126 (2002) 50-57
    • (2002) J. Neuroimmunol. , vol.126 , pp. 50-57
    • Abbas, N.1    Bednar, I.2    Mix, E.3    Marie, S.4    Paterson, D.5    Ljungberg, A.6    Morris, C.7    Winblad, B.8    Nordberg, A.9    Zhu, J.10
  • 2
    • 0018305844 scopus 로고
    • Changes in the brain catecholamines in patients with dementia of Alzheimer type
    • Adolfsson R., Gottfries C.G., Roos B.E., and Winblad B. Changes in the brain catecholamines in patients with dementia of Alzheimer type. Br. J. Psychiatry 135 (1979) 216-223
    • (1979) Br. J. Psychiatry , vol.135 , pp. 216-223
    • Adolfsson, R.1    Gottfries, C.G.2    Roos, B.E.3    Winblad, B.4
  • 3
    • 0037475148 scopus 로고    scopus 로고
    • In vitro detection of S-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-1-[6-[2-[18F]fluoroethylmethylamino]-2-naphthyl]ethylidenemalono nitrile
    • Agdeppa E.D., Kepe V., Petri A., Satyamurthy N., Liu J., Huang S.C., Small G.W., Cole G.M., and Barrio J.R. In vitro detection of S-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-1-[6-[2-[18F]fluoroethylmethylamino]-2-naphthyl]ethylidenemalono nitrile. Neuroscience 117 (2003) 723-730
    • (2003) Neuroscience , vol.117 , pp. 723-730
    • Agdeppa, E.D.1    Kepe, V.2    Petri, A.3    Satyamurthy, N.4    Liu, J.5    Huang, S.C.6    Small, G.W.7    Cole, G.M.8    Barrio, J.R.9
  • 6
    • 0034081386 scopus 로고    scopus 로고
    • Lower counts of astroglia and activated microglia in patients with Alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs
    • Alafuzoff I., Overmyer M., Helisalmi S., and Soininen H. Lower counts of astroglia and activated microglia in patients with Alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs. J. Alzheimer's Dis. 2 (2000) 37-46
    • (2000) J. Alzheimer's Dis. , vol.2 , pp. 37-46
    • Alafuzoff, I.1    Overmyer, M.2    Helisalmi, S.3    Soininen, H.4
  • 7
    • 0033018506 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Almer G., Vukosavic S., Romero N., and Przedborski S. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 72 (1999) 2415-2425
    • (1999) J. Neurochem. , vol.72 , pp. 2415-2425
    • Almer, G.1    Vukosavic, S.2    Romero, N.3    Przedborski, S.4
  • 8
    • 0026760984 scopus 로고
    • Production of hemolymphopoietic cytokines Il-6, Il-8, colony-stimulating factors by normal human astrocytes in response to Il-1-beta and tumor-necrosis-factor-alpha
    • Aloisi F., Care A., Borsellino G., Gallo P., Rosa S., Bassani A., Cabibbo A., Testa U., Levi G., and Peschle C. Production of hemolymphopoietic cytokines Il-6, Il-8, colony-stimulating factors by normal human astrocytes in response to Il-1-beta and tumor-necrosis-factor-alpha. J. Immunol. 149 (1992) 2358-2366
    • (1992) J. Immunol. , vol.149 , pp. 2358-2366
    • Aloisi, F.1    Care, A.2    Borsellino, G.3    Gallo, P.4    Rosa, S.5    Bassani, A.6    Cabibbo, A.7    Testa, U.8    Levi, G.9    Peschle, C.10
  • 9
    • 0033029151 scopus 로고    scopus 로고
    • TGF-beta1, regulation of Alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization
    • Amara F.M., Junaid A., Clough R.R., and Liang B.H. TGF-beta1, regulation of Alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization. Mol. Brain Res. 71 (1999) 42-49
    • (1999) Mol. Brain Res. , vol.71 , pp. 42-49
    • Amara, F.M.1    Junaid, A.2    Clough, R.R.3    Liang, B.H.4
  • 11
    • 0035831189 scopus 로고    scopus 로고
    • Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology
    • Apelt R., and Schliebs J. Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology. Brain Res. 894 (2001) 21-30
    • (2001) Brain Res. , vol.894 , pp. 21-30
    • Apelt, R.1    Schliebs, J.2
  • 14
    • 0030610645 scopus 로고    scopus 로고
    • Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
    • Barger S.W., and Harmon A.D. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388 (1997) 878-881
    • (1997) Nature , vol.388 , pp. 878-881
    • Barger, S.W.1    Harmon, A.D.2
  • 16
    • 0029033167 scopus 로고
    • Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation
    • Barger S.W., Horster D., Furukawa K., Goodman Y., Krieglstein J., and Mattson M.P. Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 9328-9332
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9328-9332
    • Barger, S.W.1    Horster, D.2    Furukawa, K.3    Goodman, Y.4    Krieglstein, J.5    Mattson, M.P.6
  • 17
    • 3142655659 scopus 로고    scopus 로고
    • Microglia kill amyloid-beta1-42 damaged neurons by a CD14-dependent process
    • Bate C., Veerhuis R., Eikelenboom P., and Williarns A. Microglia kill amyloid-beta1-42 damaged neurons by a CD14-dependent process. Neuroreport 15 (2004) 1427-1430
    • (2004) Neuroreport , vol.15 , pp. 1427-1430
    • Bate, C.1    Veerhuis, R.2    Eikelenboom, P.3    Williarns, A.4
  • 19
    • 0031686954 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and Alzheimer's disease: a case-control study in Rochester, Minnesota, 1980 through 1984
    • Beard C.M., Waring S.C., O'Brien P.C., Kurland L.T., and Kokmen E. Nonsteroidal anti-inflammatory drug use and Alzheimer's disease: a case-control study in Rochester, Minnesota, 1980 through 1984. Mayo Clin. Proc. 73 (1998) 951-955
    • (1998) Mayo Clin. Proc. , vol.73 , pp. 951-955
    • Beard, C.M.1    Waring, S.C.2    O'Brien, P.C.3    Kurland, L.T.4    Kokmen, E.5
  • 20
    • 8744228195 scopus 로고    scopus 로고
    • Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice
    • Beglopoulos V., Sun X., Saura C.A., Lemere C.A., Kim R.D., and Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J. Biol. Chem. 279 (2004) 46907-46914
    • (2004) J. Biol. Chem. , vol.279 , pp. 46907-46914
    • Beglopoulos, V.1    Sun, X.2    Saura, C.A.3    Lemere, C.A.4    Kim, R.D.5    Shen, J.6
  • 21
    • 0034802570 scopus 로고    scopus 로고
    • Immunological aspects of microglia: relevance to Alzheimer's disease
    • Benveniste E.N., Nguyen V.T., and O'Keefe G.M. Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochem. Int. 39 (2001) 381-391
    • (2001) Neurochem. Int. , vol.39 , pp. 381-391
    • Benveniste, E.N.1    Nguyen, V.T.2    O'Keefe, G.M.3
  • 25
    • 0032621790 scopus 로고    scopus 로고
    • TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs
    • Blasko I., Marx F., Steiner E., Hartmann T., and Grubeck-Loebenstein B. TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. FASEB J. 13 (1999) 63-68
    • (1999) FASEB J. , vol.13 , pp. 63-68
    • Blasko, I.1    Marx, F.2    Steiner, E.3    Hartmann, T.4    Grubeck-Loebenstein, B.5
  • 26
    • 0034523456 scopus 로고    scopus 로고
    • Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes
    • Blasko I., Veerhuis R., Stampfer-Kountchev M., Saurwein-Teissl M., Eikelenboom P., and Grubeck-Loebenstein B. Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol. Dis. 7 (2000) 682-689
    • (2000) Neurobiol. Dis. , vol.7 , pp. 682-689
    • Blasko, I.1    Veerhuis, R.2    Stampfer-Kountchev, M.3    Saurwein-Teissl, M.4    Eikelenboom, P.5    Grubeck-Loebenstein, B.6
  • 28
    • 1842728419 scopus 로고    scopus 로고
    • Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase BACE-1
    • Blasko I., Beer R., Bigl M., Apelt J., Franz G., Rudzki D., Ransmayr G., Kampfl A., and Schliebs R. Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase BACE-1. J. Neural Transm. 111 (2004) 523-536
    • (2004) J. Neural Transm. , vol.111 , pp. 523-536
    • Blasko, I.1    Beer, R.2    Bigl, M.3    Apelt, J.4    Franz, G.5    Rudzki, D.6    Ransmayr, G.7    Kampfl, A.8    Schliebs, R.9
  • 29
    • 0026702955 scopus 로고
    • Microglial-produced nitric-oxide and reactive nitrogen-oxides mediate neuronal cell-death
    • Boje K.M., and Arora P.K. Microglial-produced nitric-oxide and reactive nitrogen-oxides mediate neuronal cell-death. Brain Res. 587 (1992) 250-256
    • (1992) Brain Res. , vol.587 , pp. 250-256
    • Boje, K.M.1    Arora, P.K.2
  • 32
    • 0031470830 scopus 로고    scopus 로고
    • Expression of TNF and TNF receptors p55 and p75 in the rat brain after focal cerebral ischemia
    • Botchkina G.I., Meistrell III M.E., Botchkina I.L., and Tracey K.J. Expression of TNF and TNF receptors p55 and p75 in the rat brain after focal cerebral ischemia. Mol. Med. 3 (1997) 765-781
    • (1997) Mol. Med. , vol.3 , pp. 765-781
    • Botchkina, G.I.1    Meistrell III, M.E.2    Botchkina, I.L.3    Tracey, K.J.4
  • 33
    • 0032462810 scopus 로고    scopus 로고
    • C1q knock-out mice for the study of complement deficiency in autoimmune disease
    • Botto M. C1q knock-out mice for the study of complement deficiency in autoimmune disease. Exp. Clin. Immunogenet. 15 (1998) 231-234
    • (1998) Exp. Clin. Immunogenet. , vol.15 , pp. 231-234
    • Botto, M.1
  • 34
    • 0031596284 scopus 로고    scopus 로고
    • Evolution of neuronal changes in the course of Alzheimer's disease
    • Braak H., and Braak E. Evolution of neuronal changes in the course of Alzheimer's disease. J. Neural Transm., Suppl. 53 (1998) 127-140
    • (1998) J. Neural Transm., Suppl. , vol.53 , pp. 127-140
    • Braak, H.1    Braak, E.2
  • 36
    • 0027483753 scopus 로고
    • Distribution and characterization of tumor necrosis factor-alpha-like immunoreactivity in the murine central nervous system
    • Breder C.D., Tsujimoto M., Terano Y., Scott D.W., and Saper C.B. Distribution and characterization of tumor necrosis factor-alpha-like immunoreactivity in the murine central nervous system. J. Comp. Neurol. 337 (1993) 543-567
    • (1993) J. Comp. Neurol. , vol.337 , pp. 543-567
    • Breder, C.D.1    Tsujimoto, M.2    Terano, Y.3    Scott, D.W.4    Saper, C.B.5
  • 37
    • 0025191219 scopus 로고
    • Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
    • Bredt D.S., and Snyder S.H. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 682-685
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 682-685
    • Bredt, D.S.1    Snyder, S.H.2
  • 38
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
    • Breidert T., Callebert J., Heneka M.T., Landreth G., Launay J.M., and Hirsch E.C. Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. J. Neurochem. 82 (2002) 615-624
    • (2002) J. Neurochem. , vol.82 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 39
    • 0030250376 scopus 로고    scopus 로고
    • Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: a current appraisal
    • Breitner J.C. Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: a current appraisal. Neurobiol. Aging 17 (1996) 789-794
    • (1996) Neurobiol. Aging , vol.17 , pp. 789-794
    • Breitner, J.C.1
  • 40
    • 0035936009 scopus 로고    scopus 로고
    • Do nonsteroidal antiinflammatory drugs reduce the risk of Alzheimer's disease?
    • Breitner J.C., and Zandi P.P. Do nonsteroidal antiinflammatory drugs reduce the risk of Alzheimer's disease?. N. Engl. J. Med. 345 (2001) 1567-1568
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1567-1568
    • Breitner, J.C.1    Zandi, P.P.2
  • 42
    • 0041784698 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria
    • Brown G.C., and Bal-Price A. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol. Neurobiol. 27 (2003) 325-355
    • (2003) Mol. Neurobiol. , vol.27 , pp. 325-355
    • Brown, G.C.1    Bal-Price, A.2
  • 43
    • 18844378852 scopus 로고    scopus 로고
    • Presenilin function and gamma-secretase activity
    • Brunkan A.L., and Goate A.M. Presenilin function and gamma-secretase activity. J. Neurochem. 93 (2005) 769-792
    • (2005) J. Neurochem. , vol.93 , pp. 769-792
    • Brunkan, A.L.1    Goate, A.M.2
  • 44
    • 20444364844 scopus 로고    scopus 로고
    • Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective
    • Butovsky O., Talpalar A.E., Ben Yaakov K., and Schwartz M. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol. Cell. Neurosci. 29 (2005) 381-393
    • (2005) Mol. Cell. Neurosci. , vol.29 , pp. 381-393
    • Butovsky, O.1    Talpalar, A.E.2    Ben Yaakov, K.3    Schwartz, M.4
  • 46
    • 0041302369 scopus 로고    scopus 로고
    • Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia
    • Candelario-Jalil E., Gonzalez-Falcon A., Garcia-Cabrera M., Alvarez D., Al Dalain S., Martinez G., Leon O.S., and Springer J.E. Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. J. Neurochem. 86 (2003) 545-555
    • (2003) J. Neurochem. , vol.86 , pp. 545-555
    • Candelario-Jalil, E.1    Gonzalez-Falcon, A.2    Garcia-Cabrera, M.3    Alvarez, D.4    Al Dalain, S.5    Martinez, G.6    Leon, O.S.7    Springer, J.E.8
  • 47
    • 0024323353 scopus 로고
    • Interleukin-6. The major regulator of acute-phase protein synthesis in man and rat
    • discussion 100-1, 87-99
    • Castell J.V., Andus T., Kunz D., and Heinrich P.C. Interleukin-6. The major regulator of acute-phase protein synthesis in man and rat. Ann. N. Y. Acad. Sci. 557 (1989) 87-99 discussion 100-1, 87-99
    • (1989) Ann. N. Y. Acad. Sci. , vol.557 , pp. 87-99
    • Castell, J.V.1    Andus, T.2    Kunz, D.3    Heinrich, P.C.4
  • 48
    • 0030108525 scopus 로고    scopus 로고
    • Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism
    • Chao C.C., Hu S., Sheng W.S., Bu D., Bukrinsky M.I., and Peterson P.K. Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism. Glia 16 (1996) 276-284
    • (1996) Glia , vol.16 , pp. 276-284
    • Chao, C.C.1    Hu, S.2    Sheng, W.S.3    Bu, D.4    Bukrinsky, M.I.5    Peterson, P.K.6
  • 49
    • 32144454172 scopus 로고    scopus 로고
    • Mechanisms of disease-the many roles of chemokines and chemokine receptors in inflammation
    • Charo I.F., and Ransohoff R.M. Mechanisms of disease-the many roles of chemokines and chemokine receptors in inflammation. N. Engl. J. Med. 354 (2006) 610-621
    • (2006) N. Engl. J. Med. , vol.354 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 50
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla A., Barak Y., Nagy L., Liao D., Tontonoz P., and Evans R.M. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7 (2001) 48-52
    • (2001) Nat. Med. , vol.7 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 51
    • 0030700349 scopus 로고    scopus 로고
    • Effect of a carboxy-terminal fragment of the Alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells
    • Chong Y. Effect of a carboxy-terminal fragment of the Alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells. Life Sci. 61 (1997) 2323-2333
    • (1997) Life Sci. , vol.61 , pp. 2323-2333
    • Chong, Y.1
  • 52
    • 33847649449 scopus 로고    scopus 로고
    • Chromogranin A triggers the expression of neurotoxic phenotype in microglia and induces apoptosis in neuronal/microglial cocultures
    • Ciesielski-Treska J., Ulrich G., Aunis D., and Bader M.F. Chromogranin A triggers the expression of neurotoxic phenotype in microglia and induces apoptosis in neuronal/microglial cocultures. Eur. J. Neurosci. 10 (1998) 164
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 164
    • Ciesielski-Treska, J.1    Ulrich, G.2    Aunis, D.3    Bader, M.F.4
  • 54
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
    • Combs C.K., Johnson D.E., Karlo J.C., Cannady S.B., and Landreth G.E. Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J. Neurosci. 20 (2000) 558-567
    • (2000) J. Neurosci. , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 55
    • 0035866060 scopus 로고    scopus 로고
    • beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • Combs C.K., Karlo J.C., Kao S.C., and Landreth G.E. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J. Neurosci. 21 (2001) 1179-1188
    • (2001) J. Neurosci. , vol.21 , pp. 1179-1188
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.C.3    Landreth, G.E.4
  • 58
    • 2942618440 scopus 로고    scopus 로고
    • Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma
    • Cunard R., Eto Y., Muljadi J.T., Glass C.K., Kelly C.J., and Ricote M. Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma. J. Immunol. 172 (2004) 7530-7536
    • (2004) J. Immunol. , vol.172 , pp. 7530-7536
    • Cunard, R.1    Eto, Y.2    Muljadi, J.T.3    Glass, C.K.4    Kelly, C.J.5    Ricote, M.6
  • 59
    • 2542431100 scopus 로고    scopus 로고
    • The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
    • D'Andrea M.R., Cole G.M., and Ard M.D. The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol. Aging 25 (2004) 675-683
    • (2004) Neurobiol. Aging , vol.25 , pp. 675-683
    • D'Andrea, M.R.1    Cole, G.M.2    Ard, M.D.3
  • 60
    • 0042285737 scopus 로고    scopus 로고
    • What can rodent models tell us about cognitive decline in Alzheimer's disease?
    • Davis S., and Laroche S. What can rodent models tell us about cognitive decline in Alzheimer's disease?. Mol. Neurobiol. 27 (2003) 249-276
    • (2003) Mol. Neurobiol. , vol.27 , pp. 249-276
    • Davis, S.1    Laroche, S.2
  • 61
    • 0028089896 scopus 로고
    • Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures
    • Dawson V.L., Brahmbhatt H.P., Mong J.A., and Dawson T.M. Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology 33 (1994) 1425-1430
    • (1994) Neuropharmacology , vol.33 , pp. 1425-1430
    • Dawson, V.L.1    Brahmbhatt, H.P.2    Mong, J.A.3    Dawson, T.M.4
  • 62
    • 0036779687 scopus 로고    scopus 로고
    • Emerging roles of PPARs in inflammation and immunity
    • Daynes R.A., and Jones D.C. Emerging roles of PPARs in inflammation and immunity. Nat. Rev., Immunol. 2 (2002) 748-759
    • (2002) Nat. Rev., Immunol. , vol.2 , pp. 748-759
    • Daynes, R.A.1    Jones, D.C.2
  • 63
    • 0037089102 scopus 로고    scopus 로고
    • APP knockout attenuates microglial activation and enhances neuron survival in substantia nigra compacta after axotomy
    • DeGiorgio L.A., Shimizu Y., Chun H.S., Cho B.P., Sugama S., Joh T.H., and Volpe B.T. APP knockout attenuates microglial activation and enhances neuron survival in substantia nigra compacta after axotomy. Glia 38 (2002) 174-178
    • (2002) Glia , vol.38 , pp. 174-178
    • DeGiorgio, L.A.1    Shimizu, Y.2    Chun, H.S.3    Cho, B.P.4    Sugama, S.5    Joh, T.H.6    Volpe, B.T.7
  • 64
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation
    • Dehmer T., Heneka M.T., Sastre M., Dichgans J., and Schulz J.B. Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J. Neurochem. 88 (2004) 494-501
    • (2004) J. Neurochem. , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 65
    • 0033979993 scopus 로고    scopus 로고
    • Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
    • del Zoppo G., Ginis I., Hallenbeck J.M., Iadecola C., Wang X., and Feuerstein G.Z. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol. 10 (2000) 95-112
    • (2000) Brain Pathol. , vol.10 , pp. 95-112
    • del Zoppo, G.1    Ginis, I.2    Hallenbeck, J.M.3    Iadecola, C.4    Wang, X.5    Feuerstein, G.Z.6
  • 66
    • 0027221653 scopus 로고
    • Nitric oxide synthase induction in glial cells: effect on neuronal survival
    • Demerle-Pallardy C., Lonchampt M.O., Chabrier P.E., and Braquet P. Nitric oxide synthase induction in glial cells: effect on neuronal survival. Life Sci. 52 (1993) 1883-1890
    • (1993) Life Sci. , vol.52 , pp. 1883-1890
    • Demerle-Pallardy, C.1    Lonchampt, M.O.2    Chabrier, P.E.3    Braquet, P.4
  • 67
    • 0036499074 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta12,14-prostaglandin J2 ameliorates experimental autoimmune encephalomyelitis
    • Diab A., Deng C., Smith J.D., Hussain R.Z., Phanavanh B., Lovett-Racke A.E., Drew P.D., and Racke M.K. Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta12,14-prostaglandin J2 ameliorates experimental autoimmune encephalomyelitis. J. Immunol. 168 (2002) 2508-2515
    • (2002) J. Immunol. , vol.168 , pp. 2508-2515
    • Diab, A.1    Deng, C.2    Smith, J.D.3    Hussain, R.Z.4    Phanavanh, B.5    Lovett-Racke, A.E.6    Drew, P.D.7    Racke, M.K.8
  • 68
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • Dickson D.W., Lee S.C., Mattiace L.A., Yen S.H., and Brosnan C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7 (1993) 75-83
    • (1993) Glia , vol.7 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.H.4    Brosnan, C.5
  • 69
    • 0000920292 scopus 로고    scopus 로고
    • Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease
    • Du Y.S., Zhu H., Fu J., Yan S.F., Roher A., Tourtellotte W.W., Rajavashisth T., Chen X., Godman G.C., Stern D., and Schmidt A.M. Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 5296-5301
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 5296-5301
    • Du, Y.S.1    Zhu, H.2    Fu, J.3    Yan, S.F.4    Roher, A.5    Tourtellotte, W.W.6    Rajavashisth, T.7    Chen, X.8    Godman, G.C.9    Stern, D.10    Schmidt, A.M.11
  • 71
    • 1542283611 scopus 로고    scopus 로고
    • Neuroinflammatory perspectives on the two faces of Alzheimer's disease
    • Eikelenboom P., and van Gool W.A. Neuroinflammatory perspectives on the two faces of Alzheimer's disease. J. Neural Transm. 111 (2004) 281-294
    • (2004) J. Neural Transm. , vol.111 , pp. 281-294
    • Eikelenboom, P.1    van Gool, W.A.2
  • 72
    • 0030250852 scopus 로고    scopus 로고
    • The role of complement and activated microglia in the pathogenesis of Alzheimer's disease
    • Eikelenboom P., and Veerhuis R. The role of complement and activated microglia in the pathogenesis of Alzheimer's disease. Neurobiol. Aging 17 (1996) 673-680
    • (1996) Neurobiol. Aging , vol.17 , pp. 673-680
    • Eikelenboom, P.1    Veerhuis, R.2
  • 75
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies
    • Etminan M., Gill S., and Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 19 327 (2003) 128
    • (2003) BMJ , vol.19 , Issue.327 , pp. 128
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 80
    • 22244458574 scopus 로고    scopus 로고
    • Neuroscience. Brain under surveillance: the microglia patrol
    • Fetler L., and Amigorena S. Neuroscience. Brain under surveillance: the microglia patrol. Science 309 (2005) 392-393
    • (2005) Science , vol.309 , pp. 392-393
    • Fetler, L.1    Amigorena, S.2
  • 81
    • 0028675999 scopus 로고
    • Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha
    • Feuerstein G.Z., Liu T., and Barone F.C. Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha. Cerebrovasc. Brain Metab. Rev. 6 (1994) 341-360
    • (1994) Cerebrovasc. Brain Metab. Rev. , vol.6 , pp. 341-360
    • Feuerstein, G.Z.1    Liu, T.2    Barone, F.C.3
  • 82
    • 0035205575 scopus 로고    scopus 로고
    • Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C
    • Fiebich B.L., Schleicher S., Spleiss O., Czygan M., and Hull M. Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. J. Neurochem. 79 (2001) 950-958
    • (2001) J. Neurochem. , vol.79 , pp. 950-958
    • Fiebich, B.L.1    Schleicher, S.2    Spleiss, O.3    Czygan, M.4    Hull, M.5
  • 84
    • 33646841989 scopus 로고    scopus 로고
    • Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner
    • Floden A.M., and Combs C.K. Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner. J. Neurosci. 26 (2006) 4644-4648
    • (2006) J. Neurosci. , vol.26 , pp. 4644-4648
    • Floden, A.M.1    Combs, C.K.2
  • 85
    • 3242766671 scopus 로고    scopus 로고
    • Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
    • Fonseca M.I., Zhou J., Botto M., and Tenner A.J. Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J. Neurosci. 24 (2004) 6457-6465
    • (2004) J. Neurosci. , vol.24 , pp. 6457-6465
    • Fonseca, M.I.1    Zhou, J.2    Botto, M.3    Tenner, A.J.4
  • 86
    • 0000892153 scopus 로고
    • Pathology of Parkinsonism
    • Forno L.S. Pathology of Parkinsonism. J. Neurosurg. (1966) 266-271
    • (1966) J. Neurosurg. , pp. 266-271
    • Forno, L.S.1
  • 88
    • 0016717376 scopus 로고
    • Histochemical characterization of a neocortical projection of the nucleus locus coeruleus in the squirrel monkey
    • Freedman R., Foote S.L., and Bloom F.E. Histochemical characterization of a neocortical projection of the nucleus locus coeruleus in the squirrel monkey. J. Comp. Neurol. 164 (1975) 209-231
    • (1975) J. Comp. Neurol. , vol.164 , pp. 209-231
    • Freedman, R.1    Foote, S.L.2    Bloom, F.E.3
  • 89
    • 0026660901 scopus 로고
    • Production of macrophage colony-stimulating factor by astrocytes and brain macrophages
    • Frei K., Nohava K., Malipiero U.V., Schwerdel C., and Fontana A. Production of macrophage colony-stimulating factor by astrocytes and brain macrophages. J. Neuroimmunol. 40 (1992) 189-196
    • (1992) J. Neuroimmunol. , vol.40 , pp. 189-196
    • Frei, K.1    Nohava, K.2    Malipiero, U.V.3    Schwerdel, C.4    Fontana, A.5
  • 90
    • 0024353437 scopus 로고
    • Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals
    • Fritschy J.M., and Grzanna R. Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals. Neuroscience 30 (1989) 181-197
    • (1989) Neuroscience , vol.30 , pp. 181-197
    • Fritschy, J.M.1    Grzanna, R.2
  • 91
    • 0026486613 scopus 로고
    • Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures
    • Galea E., Feinstein D.L., and Reis D.J. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 10945-10949
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 10945-10949
    • Galea, E.1    Feinstein, D.L.2    Reis, D.J.3
  • 93
    • 0029053689 scopus 로고
    • Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines
    • Gasque P., Fontaine M., and Morgan B.P. Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J. Immunol. 154 (1995) 4726-4733
    • (1995) J. Immunol. , vol.154 , pp. 4726-4733
    • Gasque, P.1    Fontaine, M.2    Morgan, B.P.3
  • 96
    • 0032943113 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in CNS pathology
    • Glabinski A.R., and Ransohoff R.M. Chemokines and chemokine receptors in CNS pathology. J. Neurovirology 5 (1999) 3-12
    • (1999) J. Neurovirology , vol.5 , pp. 3-12
    • Glabinski, A.R.1    Ransohoff, R.M.2
  • 97
    • 0032504715 scopus 로고    scopus 로고
    • Cellular localization of tumor necrosis factor alpha following focal cerebral ischemia in mice
    • Gong C., Qin Z., Betz A.L., Liu X.H., and Yang G.Y. Cellular localization of tumor necrosis factor alpha following focal cerebral ischemia in mice. Brain Res. 801 (1998) 1-8
    • (1998) Brain Res. , vol.801 , pp. 1-8
    • Gong, C.1    Qin, Z.2    Betz, A.L.3    Liu, X.H.4    Yang, G.Y.5
  • 99
    • 0035690770 scopus 로고    scopus 로고
    • Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
    • Grammas P., and Ovase R. Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiol. Aging 22 (2001) 837-842
    • (2001) Neurobiol. Aging , vol.22 , pp. 837-842
    • Grammas, P.1    Ovase, R.2
  • 100
    • 33847666729 scopus 로고    scopus 로고
    • IL-1 and the cytokine cycle in Alzheimer's disease
    • Griffin W.S.T. IL-1 and the cytokine cycle in Alzheimer's disease. J. Neurochem. 74 (2000) S52
    • (2000) J. Neurochem. , vol.74
    • Griffin, W.S.T.1
  • 102
    • 33846583006 scopus 로고    scopus 로고
    • Grudzien, A., Shaw, P., Weintraub, S., Bigio, E., Mash, D.C., Mesulam, M.M., in press. Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol. Aging. (Mar 27, Electronic publication ahead of print. doi:10.1016/j.neurobiolaging.2006.02.007).
  • 103
    • 0037101616 scopus 로고    scopus 로고
    • Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis
    • Guo J.T., Yu J., Grass D., de Beer F.C., and Kindy M.S. Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis. J. Neurosci. 22 (2002) 5900-5909
    • (2002) J. Neurosci. , vol.22 , pp. 5900-5909
    • Guo, J.T.1    Yu, J.2    Grass, D.3    de Beer, F.C.4    Kindy, M.S.5
  • 105
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch U.K. Microglia as a source and target of cytokines. Glia 40 (2002) 140-155
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 106
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J., and Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12 (1991) 383-388
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 108
    • 0035283321 scopus 로고    scopus 로고
    • Expression and function of inducible nitric oxide synthase in neurons
    • Heneka M.T., and Feinstein D.L. Expression and function of inducible nitric oxide synthase in neurons. J. Neuroimmunol. 114 (2001) 8-18
    • (2001) J. Neuroimmunol. , vol.114 , pp. 8-18
    • Heneka, M.T.1    Feinstein, D.L.2
  • 109
    • 2642605346 scopus 로고    scopus 로고
    • Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide
    • Heneka M.T., Loschmann P.A., Gleichmann M., Weller M., Schulz J.B., Wullner U., and Klockgether T. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. J. Neurochem. 71 (1998) 88-94
    • (1998) J. Neurochem. , vol.71 , pp. 88-94
    • Heneka, M.T.1    Loschmann, P.A.2    Gleichmann, M.3    Weller, M.4    Schulz, J.B.5    Wullner, U.6    Klockgether, T.7
  • 110
    • 0033378706 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase
    • Heneka M.T., Feinstein D.L., Galea E., Gleichmann M., Wullner U., and Klockgether T. Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase. J. Neuroimmunol. 100 (1999) 156-168
    • (1999) J. Neuroimmunol. , vol.100 , pp. 156-168
    • Heneka, M.T.1    Feinstein, D.L.2    Galea, E.3    Gleichmann, M.4    Wullner, U.5    Klockgether, T.6
  • 111
    • 0034666289 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo
    • Heneka M.T., Klockgether T., and Feinstein D.L. Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J. Neurosci. 20 (2000) 6862-6867
    • (2000) J. Neurosci. , vol.20 , pp. 6862-6867
    • Heneka, M.T.1    Klockgether, T.2    Feinstein, D.L.3
  • 114
    • 0037387636 scopus 로고    scopus 로고
    • Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression
    • Heneka M.T., Gavrilyuk V., Landreth G.E., O'Banion M.K., Weinberg G., and Feinstein D.L. Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression. J. Neurochem. 85 (2003) 387-398
    • (2003) J. Neurochem. , vol.85 , pp. 387-398
    • Heneka, M.T.1    Gavrilyuk, V.2    Landreth, G.E.3    O'Banion, M.K.4    Weinberg, G.5    Feinstein, D.L.6
  • 115
    • 27644595378 scopus 로고    scopus 로고
    • Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
    • Heneka M.T., Sastre M., Dumitrescu-Ozimek L., Dewachter I., Walter J., Klockgether T., and Van Leuven F. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J. Neuroinflam. 2 (2005) 22
    • (2005) J. Neuroinflam. , vol.2 , pp. 22
    • Heneka, M.T.1    Sastre, M.2    Dumitrescu-Ozimek, L.3    Dewachter, I.4    Walter, J.5    Klockgether, T.6    Van Leuven, F.7
  • 119
    • 0032892888 scopus 로고    scopus 로고
    • Chemokine and chemokine receptor expression in the central nervous system
    • Hesselgesser J., and Horuk R. Chemokine and chemokine receptor expression in the central nervous system. J. Neurovirology 5 (1999) 13-26
    • (1999) J. Neurovirology , vol.5 , pp. 13-26
    • Hesselgesser, J.1    Horuk, R.2
  • 120
    • 0027932457 scopus 로고
    • Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS
    • Hewett S.J., Csernansky C.A., and Choi D.W. Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS. Neuron 13 (1994) 487-494
    • (1994) Neuron , vol.13 , pp. 487-494
    • Hewett, S.J.1    Csernansky, C.A.2    Choi, D.W.3
  • 121
    • 0031028141 scopus 로고    scopus 로고
    • Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
    • Heyser C.J., Masliah E., Samimi A., Campbell I.L., and Gold L.H. Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 1500-1505
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 1500-1505
    • Heyser, C.J.1    Masliah, E.2    Samimi, A.3    Campbell, I.L.4    Gold, L.H.5
  • 125
    • 33847640046 scopus 로고    scopus 로고
    • Neuronal immunoreactivity for COX-2 and phosphorylation of prb precede P38 MAPK activation and neurofibrillary changes in ad temporal cortex
    • Hoozemans J., Veerhuis R., Rozemuller A., Arendt T., and Eikelenboom P. Neuronal immunoreactivity for COX-2 and phosphorylation of prb precede P38 MAPK activation and neurofibrillary changes in ad temporal cortex. Neurobiol. Aging 25 (2004) S416
    • (2004) Neurobiol. Aging , vol.25
    • Hoozemans, J.1    Veerhuis, R.2    Rozemuller, A.3    Arendt, T.4    Eikelenboom, P.5
  • 126
    • 0033559312 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide NO production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome
    • Hori K., Burd P.R., Furuke K., Kutza J., Weih K.A., and Clouse K.A. Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide NO production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome. Blood 93 (1999) 1843-1850
    • (1999) Blood , vol.93 , pp. 1843-1850
    • Hori, K.1    Burd, P.R.2    Furuke, K.3    Kutza, J.4    Weih, K.A.5    Clouse, K.A.6
  • 127
  • 128
    • 0032473596 scopus 로고    scopus 로고
    • Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release
    • Hu J.G., Akama K.T., Krafft G.A., Chromy B.A., and Van Eldik L.J. Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Res. 785 (1998) 195-206
    • (1998) Brain Res. , vol.785 , pp. 195-206
    • Hu, J.G.1    Akama, K.T.2    Krafft, G.A.3    Chromy, B.A.4    Van Eldik, L.J.5
  • 130
    • 0030988629 scopus 로고    scopus 로고
    • Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease
    • Ishizuka K., Kimura T., Igata-yi R., Katsuragi S., Takamatsu J., and Miyakawa T. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin. Neurosci. 51 (1997) 135-138
    • (1997) Psychiatry Clin. Neurosci. , vol.51 , pp. 135-138
    • Ishizuka, K.1    Kimura, T.2    Igata-yi, R.3    Katsuragi, S.4    Takamatsu, J.5    Miyakawa, T.6
  • 131
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer-disease
    • Itagaki S., McGeer P.L., Akiyama H., Zhu S., and Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer-disease. J. Neuroimmunol. 24 (1989) 173-182
    • (1989) J. Neuroimmunol. , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 133
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C., Ting A.T., and Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391 (1998) 82-86
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 134
    • 0024445028 scopus 로고
    • Adrenergic receptors in aging and Alzheimer's disease: increased beta 2-receptors in prefrontal cortex and hippocampus
    • Kalaria R.N., Andorn A.C., Tabaton M., Whitehouse P.J., Harik S.I., and Unnerstall J.R. Adrenergic receptors in aging and Alzheimer's disease: increased beta 2-receptors in prefrontal cortex and hippocampus. J. Neurochem. 53 (1989) 1772-1781
    • (1989) J. Neurochem. , vol.53 , pp. 1772-1781
    • Kalaria, R.N.1    Andorn, A.C.2    Tabaton, M.3    Whitehouse, P.J.4    Harik, S.I.5    Unnerstall, J.R.6
  • 135
    • 0028990941 scopus 로고
    • *4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism
    • *4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism. Nat. Genet. 10 (1995) 486-488
    • (1995) Nat. Genet. , vol.10 , pp. 486-488
    • Kamboh, M.I.1    Sanghera, D.K.2    Ferrell, R.E.3    DeKosky, S.T.4
  • 138
    • 0347756655 scopus 로고    scopus 로고
    • Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA
    • Kelly D., Campbell J.I., King T.P., Grant G., Jansson E.A., Coutts A.G., Pettersson S., and Conway S. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat. Immunol. 5 (2004) 104-112
    • (2004) Nat. Immunol. , vol.5 , pp. 104-112
    • Kelly, D.1    Campbell, J.I.2    King, T.P.3    Grant, G.4    Jansson, E.A.5    Coutts, A.G.6    Pettersson, S.7    Conway, S.8
  • 139
    • 33847612303 scopus 로고    scopus 로고
    • Beta-amyloid up-regulates expression of cytokines and chemokines in human microglia and human microglia cell line
    • Kim S.U., Nagai A., Nakagawa E., Hatori K., Choi H.B., and Lee M.A. Beta-amyloid up-regulates expression of cytokines and chemokines in human microglia and human microglia cell line. J. Neuropathol. Exp. Neurol. 60 (2001) 546
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 546
    • Kim, S.U.1    Nagai, A.2    Nakagawa, E.3    Hatori, K.4    Choi, H.B.5    Lee, M.A.6
  • 141
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • Kitazawa M., Oddo S., Yamasaki T.R., Green K.N., and Laferla F.M. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 25 (2005) 8843-8853
    • (2005) J. Neurosci. , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    Laferla, F.M.5
  • 144
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19 (1996) 312-318
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 145
    • 0033360402 scopus 로고    scopus 로고
    • Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice
    • Lamb B.T., Bardel K.A., Kulnane L.S., Anderson J.J., Holtz G., Wagner S.L., Sisodia S.S., and Hoeger E.J. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nat. Neurosci. 2 (1999) 695-697
    • (1999) Nat. Neurosci. , vol.2 , pp. 695-697
    • Lamb, B.T.1    Bardel, K.A.2    Kulnane, L.S.3    Anderson, J.J.4    Holtz, G.5    Wagner, S.L.6    Sisodia, S.S.7    Hoeger, E.J.8
  • 146
    • 0035693506 scopus 로고    scopus 로고
    • Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease
    • Landreth G.E., and Heneka M.T. Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiol. Aging 22 (2001) 937-944
    • (2001) Neurobiol. Aging , vol.22 , pp. 937-944
    • Landreth, G.E.1    Heneka, M.T.2
  • 147
    • 0026604063 scopus 로고
    • Glutamate differentially inhibits the expression of class II MHC antigens on astrocytes and microglia
    • Lee S.C., Collins M., Vanguri P., and Shin M.L. Glutamate differentially inhibits the expression of class II MHC antigens on astrocytes and microglia. J. Immunol. 148 (1992) 3391-3397
    • (1992) J. Immunol. , vol.148 , pp. 3391-3397
    • Lee, S.C.1    Collins, M.2    Vanguri, P.3    Shin, M.L.4
  • 148
    • 0032707107 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase immunoreactivity in the Alzheimer disease hippocampus: association with Hirano bodies, neurofibrillary tangles, and senile plaques
    • Lee S.C., Zhao M.L., Hirano A., and Dickson D.W. Inducible nitric oxide synthase immunoreactivity in the Alzheimer disease hippocampus: association with Hirano bodies, neurofibrillary tangles, and senile plaques. J. Neuropathol. Exp. Neurol. 58 (1999) 1163-1169
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1163-1169
    • Lee, S.C.1    Zhao, M.L.2    Hirano, A.3    Dickson, D.W.4
  • 150
    • 0036644961 scopus 로고    scopus 로고
    • Cytokines, chemokines, and cytokine receptors in human microglia
    • Lee Y.B., Nagai A., and Kim S.U. Cytokines, chemokines, and cytokine receptors in human microglia. J. Neurosci. Res. 69 (2002) 94-103
    • (2002) J. Neurosci. Res. , vol.69 , pp. 94-103
    • Lee, Y.B.1    Nagai, A.2    Kim, S.U.3
  • 151
    • 4444271426 scopus 로고    scopus 로고
    • Mechanisms involved in prostaglandin E2-mediated neuroprotection against TNF-alpha: possible involvement of multiple signal transduction and beta-catenin/T-cell factor
    • Lee E.O., Shin Y.J., and Chong Y.H. Mechanisms involved in prostaglandin E2-mediated neuroprotection against TNF-alpha: possible involvement of multiple signal transduction and beta-catenin/T-cell factor. J. Neuroimmunol. 155 (2004) 21-31
    • (2004) J. Neuroimmunol. , vol.155 , pp. 21-31
    • Lee, E.O.1    Shin, Y.J.2    Chong, Y.H.3
  • 152
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann J.M., Lenhard J.M., Oliver B.B., Ringold G.M., and Kliewer S.A. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272 (1997) 3406-3410
    • (1997) J. Biol. Chem. , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 153
    • 0034121698 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene
    • Li M., Pascual G., and Glass C.K. Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 20 (2000) 4699-4707
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4699-4707
    • Li, M.1    Pascual, G.2    Glass, C.K.3
  • 154
    • 0037336701 scopus 로고    scopus 로고
    • Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
    • Li Y.K., Liu L., Barger S.W., and Griffin W.S.T. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J. Neurosci. 23 (2003) 1605-1611
    • (2003) J. Neurosci. , vol.23 , pp. 1605-1611
    • Li, Y.K.1    Liu, L.2    Barger, S.W.3    Griffin, W.S.T.4
  • 155
    • 27744462871 scopus 로고    scopus 로고
    • Deletion of the prostaglandin E-2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease
    • Liang X.B., Wang Q., Hand T., Wu L.J., Breyer R.M., Montine T.J., and Andreasson K. Deletion of the prostaglandin E-2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J. Neurosci. 25 (2005) 10180-10187
    • (2005) J. Neurosci. , vol.25 , pp. 10180-10187
    • Liang, X.B.1    Wang, Q.2    Hand, T.3    Wu, L.J.4    Breyer, R.M.5    Montine, T.J.6    Andreasson, K.7
  • 158
  • 159
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • Liu B., and Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 304 (2003) 1-7
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 162
    • 0035691035 scopus 로고    scopus 로고
    • Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures
    • Lue L.F., Walker D.G., and Rogers J. Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures. Neurobiol. Aging 22 (2001) 945-956
    • (2001) Neurobiol. Aging , vol.22 , pp. 945-956
    • Lue, L.F.1    Walker, D.G.2    Rogers, J.3
  • 163
    • 0031453714 scopus 로고    scopus 로고
    • Cyclooxygenase 2 RNA message abundance, stability, and hypervariability in sporadic Alzheimer neocortex
    • Lukiw W.J., and Bazan N.G. Cyclooxygenase 2 RNA message abundance, stability, and hypervariability in sporadic Alzheimer neocortex. J. Neurosci. Res. 50 (1997) 937-945
    • (1997) J. Neurosci. Res. , vol.50 , pp. 937-945
    • Lukiw, W.J.1    Bazan, N.G.2
  • 164
    • 0032509889 scopus 로고    scopus 로고
    • Chemokines-chemotactic cytokines that mediate inflammation
    • Luster A.D. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338 (1998) 436-445
    • (1998) N. Engl. J. Med. , vol.338 , pp. 436-445
    • Luster, A.D.1
  • 165
    • 0028173205 scopus 로고
    • Amyloid-associated proteins alpha1-antichymotrypsin and apolipoprotein-e promote assembly of Alzheimer beta-protein into filaments
    • Ma J.Y., Yee A., Brewer H.B., Das S., and Potter H. Amyloid-associated proteins alpha1-antichymotrypsin and apolipoprotein-e promote assembly of Alzheimer beta-protein into filaments. Nature 372 (1994) 92-94
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.Y.1    Yee, A.2    Brewer, H.B.3    Das, S.4    Potter, H.5
  • 166
    • 0035696167 scopus 로고    scopus 로고
    • Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation
    • Mackenzie I.R. Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation. Neurobiol. Aging 22 (2001) 819-822
    • (2001) Neurobiol. Aging , vol.22 , pp. 819-822
    • Mackenzie, I.R.1
  • 167
    • 0031900411 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
    • Mackenzie I.R., and Munoz D.G. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology 50 (1998) 986-990
    • (1998) Neurology , vol.50 , pp. 986-990
    • Mackenzie, I.R.1    Munoz, D.G.2
  • 168
    • 0027494752 scopus 로고
    • Electrophysiological changes accompanying DSP-4 lesions of rat locus coeruleus neurons
    • Magnuson D.S., Staines W.A., and Marshall K.C. Electrophysiological changes accompanying DSP-4 lesions of rat locus coeruleus neurons. Brain Res. 19 628 (1993) 317-320
    • (1993) Brain Res. , vol.19 , Issue.628 , pp. 317-320
    • Magnuson, D.S.1    Staines, W.A.2    Marshall, K.C.3
  • 169
    • 0018857625 scopus 로고
    • Changes in the monoamine containing neurones of the human CNS in senile dementia
    • Mann D.M., Lincoln J., Yates P.O., Stamp J.E., and Toper S. Changes in the monoamine containing neurones of the human CNS in senile dementia. Br. J. Psychiatry 136 (1980) 533-541
    • (1980) Br. J. Psychiatry , vol.136 , pp. 533-541
    • Mann, D.M.1    Lincoln, J.2    Yates, P.O.3    Stamp, J.E.4    Toper, S.5
  • 170
    • 0020059233 scopus 로고
    • The noradrenergic system in Alzheimer and multi-infarct dementias
    • Mann D.M., Yates P.O., and Hawkes J. The noradrenergic system in Alzheimer and multi-infarct dementias. J. Neurol. Neurosurg. Psychiatry 45 (1982) 113-119
    • (1982) J. Neurol. Neurosurg. Psychiatry , vol.45 , pp. 113-119
    • Mann, D.M.1    Yates, P.O.2    Hawkes, J.3
  • 171
    • 0023001412 scopus 로고
    • The topography of cell loss from locus caeruleus in Alzheimer's disease
    • Marcyniuk B., Mann D.M., and Yates P.O. The topography of cell loss from locus caeruleus in Alzheimer's disease. J. Neurol. Sci. 76 (1986) 335-345
    • (1986) J. Neurol. Sci. , vol.76 , pp. 335-345
    • Marcyniuk, B.1    Mann, D.M.2    Yates, P.O.3
  • 173
    • 3943092621 scopus 로고    scopus 로고
    • ways towards and away from Alzheimer's disease
    • Mattson M.P. ways towards and away from Alzheimer's disease. Nature 430 (2004) 631-639
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 174
    • 0025853857 scopus 로고
    • Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: a possible role for the locus coeruleus in the progression of Parkinson's disease
    • Mavridis M., Degryse A.D., Lategan A.J., Marien M.R., and Colpaert F.C. Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: a possible role for the locus coeruleus in the progression of Parkinson's disease. Neuroscience 41 (1991) 507-523
    • (1991) Neuroscience , vol.41 , pp. 507-523
    • Mavridis, M.1    Degryse, A.D.2    Lategan, A.J.3    Marien, M.R.4    Colpaert, F.C.5
  • 176
    • 0035835451 scopus 로고    scopus 로고
    • Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study
    • McCusker S.M., Curran M.D., Dynan K.B., McCullagh C.D., Urquhart D.D., Middleton D., Patterson C.C., McIlroy S.P., and Passmore A.P. Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study. Lancet 357 (2001) 436-439
    • (2001) Lancet , vol.357 , pp. 436-439
    • McCusker, S.M.1    Curran, M.D.2    Dynan, K.B.3    McCullagh, C.D.4    Urquhart, D.D.5    Middleton, D.6    Patterson, C.C.7    McIlroy, S.P.8    Passmore, A.P.9
  • 177
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer P.L., and McGeer E.G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain. Res. Brain Res. Rev. 21 (1995) 195-218
    • (1995) Brain. Res. Brain Res. Rev. , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 178
    • 0036841667 scopus 로고    scopus 로고
    • The possible role of complement activation in Alzheimer disease
    • McGeer P.L., and McGeer E.G. The possible role of complement activation in Alzheimer disease. Trends Mol. Med. 8 (2002) 519-523
    • (2002) Trends Mol. Med. , vol.8 , pp. 519-523
    • McGeer, P.L.1    McGeer, E.G.2
  • 179
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies
    • McGeer P.L., Schulzer M., and McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 47 (1996) 425-432
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 180
    • 0034237388 scopus 로고    scopus 로고
    • Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology
    • Mehlhorn G., Hollborn M., and Schliebs R. Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology. Int. J. Dev. Neurosci. 18 (2000) 423-431
    • (2000) Int. J. Dev. Neurosci. , vol.18 , pp. 423-431
    • Mehlhorn, G.1    Hollborn, M.2    Schliebs, R.3
  • 181
    • 0030994412 scopus 로고    scopus 로고
    • Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs
    • Minghetti L., Polazzi E., Nicolini A., Creminon C., and Levi G. Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs. Eur. J. Neurosci. 9 (1997) 934-940
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 934-940
    • Minghetti, L.1    Polazzi, E.2    Nicolini, A.3    Creminon, C.4    Levi, G.5
  • 183
    • 0026663451 scopus 로고
    • Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions
    • Moncada C., Lekieffre D., Arvin B., and Meldrum B. Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions. Neuroreport 3 (1992) 530-532
    • (1992) Neuroreport , vol.3 , pp. 530-532
    • Moncada, C.1    Lekieffre, D.2    Arvin, B.3    Meldrum, B.4
  • 186
    • 0035137507 scopus 로고    scopus 로고
    • Aminoguanidine prevented the impairment of learning behavior and hippocampal long-term potentiation following transient cerebral ischemia
    • Mori K., Togashi H., Ueno K., Matsumoto M., and Yoshioka M. Aminoguanidine prevented the impairment of learning behavior and hippocampal long-term potentiation following transient cerebral ischemia. Behav. Brain Res. 120 (2001) 159-168
    • (2001) Behav. Brain Res. , vol.120 , pp. 159-168
    • Mori, K.1    Togashi, H.2    Ueno, K.3    Matsumoto, M.4    Yoshioka, M.5
  • 187
    • 19344361883 scopus 로고    scopus 로고
    • Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid Abeta pathology in Alzheimer's models
    • Morihara T., Teter B., Yang F., Lim G.P., Boudinot S., Boudinot F.D., Frautschy S.A., and Cole G.M. Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid Abeta pathology in Alzheimer's models. Neuropsychopharmacology 30 (2005) 1111-1120
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1111-1120
    • Morihara, T.1    Teter, B.2    Yang, F.3    Lim, G.P.4    Boudinot, S.5    Boudinot, F.D.6    Frautschy, S.A.7    Cole, G.M.8
  • 188
    • 0036434305 scopus 로고    scopus 로고
    • Acute neuroinflammation exacerbates excitotoxicity in rat hippocampus in vivo
    • Morimoto K., Murasugi T., and Oda T. Acute neuroinflammation exacerbates excitotoxicity in rat hippocampus in vivo. Exp. Neurol. 177 (2002) 95-104
    • (2002) Exp. Neurol. , vol.177 , pp. 95-104
    • Morimoto, K.1    Murasugi, T.2    Oda, T.3
  • 189
    • 0035690976 scopus 로고    scopus 로고
    • Interleukin-1, neuroinflammation, and Alzheimer's disease
    • Mrak R.E., and Griffin W.S. Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol. Aging 22 (2001) 903-908
    • (2001) Neurobiol. Aging , vol.22 , pp. 903-908
    • Mrak, R.E.1    Griffin, W.S.2
  • 190
    • 0033562393 scopus 로고    scopus 로고
    • Nature of the retrograde signal from injured nerves that induces interleukin-6 mRNA in neurons
    • Murphy P.G., Borthwick L.S., Johnston R.S., Kuchel G., and Richardson P.M. Nature of the retrograde signal from injured nerves that induces interleukin-6 mRNA in neurons. J. Neurosci. 19 (1999) 3791-3800
    • (1999) J. Neurosci. , vol.19 , pp. 3791-3800
    • Murphy, P.G.1    Borthwick, L.S.2    Johnston, R.S.3    Kuchel, G.4    Richardson, P.M.5
  • 191
    • 0032523168 scopus 로고    scopus 로고
    • Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation
    • Murray C.A., and Lynch M.A. Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation. J. Neurosci. 18 (1998) 2974-2981
    • (1998) J. Neurosci. , vol.18 , pp. 2974-2981
    • Murray, C.A.1    Lynch, M.A.2
  • 192
    • 14744296610 scopus 로고    scopus 로고
    • Inflammatory process in Parkinson's disease: Role for cytokines
    • Nagatsu T., and Sawada M. Inflammatory process in Parkinson's disease: Role for cytokines. Curr. Pharm. Des. 11 (2005) 999-1016
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 999-1016
    • Nagatsu, T.1    Sawada, M.2
  • 193
    • 0037427384 scopus 로고    scopus 로고
    • Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
    • Nagele R.G., D'Andrea M.R., Lee H., Venkataraman V., and Wang H.Y. Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res. 971 (2003) 197-209
    • (2003) Brain Res. , vol.971 , pp. 197-209
    • Nagele, R.G.1    D'Andrea, M.R.2    Lee, H.3    Venkataraman, V.4    Wang, H.Y.5
  • 194
    • 0032823306 scopus 로고    scopus 로고
    • Prostanoid receptors: structures, properties, and functions
    • Narumiya S., Sugimoto Y., and Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79 (1999) 1193-1226
    • (1999) Physiol. Rev. , vol.79 , pp. 1193-1226
    • Narumiya, S.1    Sugimoto, Y.2    Ushikubi, F.3
  • 195
    • 0036546185 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation
    • Natarajan C., and Bright J.J. Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Genes Immun. 3 (2002) 59-70
    • (2002) Genes Immun. , vol.3 , pp. 59-70
    • Natarajan, C.1    Bright, J.J.2
  • 197
    • 0035341427 scopus 로고    scopus 로고
    • Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma
    • Niino M., Iwabuchi K., Kikuchi S., Ato M., Morohashi T., Ogata A., Tashiro K., and Onoe K. Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma. J. Neuroimmunol. 116 (2001) 40-48
    • (2001) J. Neuroimmunol. , vol.116 , pp. 40-48
    • Niino, M.1    Iwabuchi, K.2    Kikuchi, S.3    Ato, M.4    Morohashi, T.5    Ogata, A.6    Tashiro, K.7    Onoe, K.8
  • 198
    • 0025742695 scopus 로고
    • DSP4 treatment worsens hippocampal pyramidal cell damage after transient ischemia
    • Nishino K., Lin C.S., Morse J.K., and Davis J.N. DSP4 treatment worsens hippocampal pyramidal cell damage after transient ischemia. Neuroscience 43 (1991) 361-367
    • (1991) Neuroscience , vol.43 , pp. 361-367
    • Nishino, K.1    Lin, C.S.2    Morse, J.K.3    Davis, J.N.4
  • 200
    • 0032896588 scopus 로고    scopus 로고
    • Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology
    • O'Banion M.K. Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit. Rev. Neurobiol. 13 (1999) 45-82
    • (1999) Crit. Rev. Neurobiol. , vol.13 , pp. 45-82
    • O'Banion, M.K.1
  • 201
    • 0029953089 scopus 로고    scopus 로고
    • Interleukin-1 beta induces prostaglandin G/H synthase-2 cyclooxygenase-2 in primary murine astrocyte cultures
    • O'Banion M.K., Miller J.C., Chang J.W., Kaplan M.D., and Coleman P.D. Interleukin-1 beta induces prostaglandin G/H synthase-2 cyclooxygenase-2 in primary murine astrocyte cultures. J. Neurochem. 66 (1996) 2532-2540
    • (1996) J. Neurochem. , vol.66 , pp. 2532-2540
    • O'Banion, M.K.1    Miller, J.C.2    Chang, J.W.3    Kaplan, M.D.4    Coleman, P.D.5
  • 202
    • 0030395410 scopus 로고    scopus 로고
    • Decreased expression of prostaglandin G/H synthase-2 PGHS-2 in Alzheimer's disease brain
    • O'Banion M.K., Chang J.W., and Coleman P.D. Decreased expression of prostaglandin G/H synthase-2 PGHS-2 in Alzheimer's disease brain. Adv. Exp. Med. Biol. 407 (1997) 171-177
    • (1997) Adv. Exp. Med. Biol. , vol.407 , pp. 171-177
    • O'Banion, M.K.1    Chang, J.W.2    Coleman, P.D.3
  • 204
    • 33144487701 scopus 로고    scopus 로고
    • Temporal profile of amyloid-beta A beta oligomerization in an in vivo model of Alzheimer disease - a link between A beta and tau pathology
    • Oddo S., Caccamo A., Tran L., Lambert M.P., Glabe C.G., Klein W.L., and Laferla F.M. Temporal profile of amyloid-beta A beta oligomerization in an in vivo model of Alzheimer disease - a link between A beta and tau pathology. J. Biol. Chem. 281 (2006) 1599-1604
    • (2006) J. Biol. Chem. , vol.281 , pp. 1599-1604
    • Oddo, S.1    Caccamo, A.2    Tran, L.3    Lambert, M.P.4    Glabe, C.G.5    Klein, W.L.6    Laferla, F.M.7
  • 205
    • 0030951257 scopus 로고    scopus 로고
    • Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons
    • Oka A., and Takashima S. Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons. Neuroreport 8 (1997) 1161-1164
    • (1997) Neuroreport , vol.8 , pp. 1161-1164
    • Oka, A.1    Takashima, S.2
  • 206
    • 0020528723 scopus 로고
    • Decreased activity of locus coeruleus neurons in the rat after DSP-4 treatment
    • Olpe H.R., Laszlo J., Dooley D.J., Heid J., and Steinmann M.W. Decreased activity of locus coeruleus neurons in the rat after DSP-4 treatment. Neurosci. Lett. 40 (1983) 81-84
    • (1983) Neurosci. Lett. , vol.40 , pp. 81-84
    • Olpe, H.R.1    Laszlo, J.2    Dooley, D.J.3    Heid, J.4    Steinmann, M.W.5
  • 207
    • 0344141389 scopus 로고    scopus 로고
    • Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia
    • Orzylowska O., Oderfeld-Nowak B., Zaremba M., Januszewski S., and Mossakowski M. Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia. Neurosci. Lett. 263 (1999) 72-76
    • (1999) Neurosci. Lett. , vol.263 , pp. 72-76
    • Orzylowska, O.1    Oderfeld-Nowak, B.2    Zaremba, M.3    Januszewski, S.4    Mossakowski, M.5
  • 208
    • 0033562337 scopus 로고    scopus 로고
    • Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity
    • Osaka H., Mukherjee P., Aisen P.S., and Pasinetti G.M. Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity. J. Cell. Biochem. 73 (1999) 303-311
    • (1999) J. Cell. Biochem. , vol.73 , pp. 303-311
    • Osaka, H.1    Mukherjee, P.2    Aisen, P.S.3    Pasinetti, G.M.4
  • 210
    • 0032914896 scopus 로고    scopus 로고
    • A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease
    • Papassotiropoulos A., Bagli M., Jessen F., Bayer T.A., Maier W., Rao M.L., and Heun R. A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease. Ann. Neurol. 45 (1999) 666-668
    • (1999) Ann. Neurol. , vol.45 , pp. 666-668
    • Papassotiropoulos, A.1    Bagli, M.2    Jessen, F.3    Bayer, T.A.4    Maier, W.5    Rao, M.L.6    Heun, R.7
  • 211
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
    • Paresce D.M., Ghosh R.N., and Maxfield F.R. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 17 (1996) 553-565
    • (1996) Neuron , vol.17 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 212
    • 0030175273 scopus 로고    scopus 로고
    • Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions
    • Pasinetti G.M., Tocco G., Sakhi S., Musleh W.D., DeSimoni M.G., Mascarucci P., Schreiber S., Baudry M., and Finch C.E. Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions. Neurobiol. Dis. 3 (1996) 197-204
    • (1996) Neurobiol. Dis. , vol.3 , pp. 197-204
    • Pasinetti, G.M.1    Tocco, G.2    Sakhi, S.3    Musleh, W.D.4    DeSimoni, M.G.5    Mascarucci, P.6    Schreiber, S.7    Baudry, M.8    Finch, C.E.9
  • 213
    • 16644381634 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance
    • Patsouris D., Muller M., and Kersten S. Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance. Curr. Opin. Investig. Drugs 5 (2004) 1045-1050
    • (2004) Curr. Opin. Investig. Drugs , vol.5 , pp. 1045-1050
    • Patsouris, D.1    Muller, M.2    Kersten, S.3
  • 214
    • 26044437911 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway
    • Pavlov V.A., and Tracey K.J. The cholinergic anti-inflammatory pathway. Brain Behav. Immun. 19 (2005) 493-499
    • (2005) Brain Behav. Immun. , vol.19 , pp. 493-499
    • Pavlov, V.A.1    Tracey, K.J.2
  • 215
    • 0035826546 scopus 로고    scopus 로고
    • Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age-matched controls
    • Perry R.T., Collins J.S., Harrell L.E., Acton R.T., and Go R.C. Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age-matched controls. Am. J. Med. Genet. 105 (2001) 332-342
    • (2001) Am. J. Med. Genet. , vol.105 , pp. 332-342
    • Perry, R.T.1    Collins, J.S.2    Harrell, L.E.3    Acton, R.T.4    Go, R.C.5
  • 216
    • 0028864801 scopus 로고
    • Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha
    • Probert L., Akassoglou K., Pasparakis M., Kontogeorgos G., and Kollias G. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 11294-11298
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 11294-11298
    • Probert, L.1    Akassoglou, K.2    Pasparakis, M.3    Kontogeorgos, G.4    Kollias, G.5
  • 219
  • 222
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote M., Li A.C., Willson T.M., Kelly C.J., and Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391 (1998) 79-82
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 223
    • 3543067962 scopus 로고    scopus 로고
    • Neurodegenerative disorders associated with diabetes mellitus
    • Ristow M. Neurodegenerative disorders associated with diabetes mellitus. J. Mol. Med. 82 (2004) 510-529
    • (2004) J. Mol. Med. , vol.82 , pp. 510-529
    • Ristow, M.1
  • 226
    • 0033525735 scopus 로고    scopus 로고
    • Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences
    • Rogers J.T., Leiter L.M., McPhee J., Cahill C.M., Zhan S.S., Potter H., and Nilsson L.N. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences. J. Biol. Chem. 274 (1999) 6421-6431
    • (1999) J. Biol. Chem. , vol.274 , pp. 6421-6431
    • Rogers, J.T.1    Leiter, L.M.2    McPhee, J.3    Cahill, C.M.4    Zhan, S.S.5    Potter, H.6    Nilsson, L.N.7
  • 227
    • 0030583248 scopus 로고    scopus 로고
    • Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes
    • Rossi F., and Bianchini E. Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes. Biochem. Biophys. Res. Commun. 225 (1996) 474-478
    • (1996) Biochem. Biophys. Res. Commun. , vol.225 , pp. 474-478
    • Rossi, F.1    Bianchini, E.2
  • 228
    • 0034610759 scopus 로고    scopus 로고
    • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I kappa B kinase
    • Rossi A., Kapahi P., Natoli G., Takahashi T., Chen Y., Karin M., and Santoro M.G. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I kappa B kinase. Nature 403 (2000) 103-108
    • (2000) Nature , vol.403 , pp. 103-108
    • Rossi, A.1    Kapahi, P.2    Natoli, G.3    Takahashi, T.4    Chen, Y.5    Karin, M.6    Santoro, M.G.7
  • 229
    • 13244264935 scopus 로고    scopus 로고
    • Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme
    • Rossner S., Lange-Dohna C., Zeitschel U., and Perez-Polo J.R. Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. J. Neurochem. 92 (2005) 226-234
    • (2005) J. Neurochem. , vol.92 , pp. 226-234
    • Rossner, S.1    Lange-Dohna, C.2    Zeitschel, U.3    Perez-Polo, J.R.4
  • 230
    • 33745252827 scopus 로고    scopus 로고
    • Increased intrathecal TGF-beta 1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients
    • Rota E., Bellone G., Rocca P., Bergamasco B., Emanuelli G., and Ferrero P. Increased intrathecal TGF-beta 1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients. Neurol. Sci. 27 (2006) 33-39
    • (2006) Neurol. Sci. , vol.27 , pp. 33-39
    • Rota, E.1    Bellone, G.2    Rocca, P.3    Bergamasco, B.4    Emanuelli, G.5    Ferrero, P.6
  • 231
    • 0024394987 scopus 로고
    • Microglial cells around amyloid plaques in Alzheimers-disease express leukocyte adhesion molecules of the Lfa-1 family
    • Rozemuller J.M., Eikelenboom P., Pals S.T., and Stam F.C. Microglial cells around amyloid plaques in Alzheimers-disease express leukocyte adhesion molecules of the Lfa-1 family. Neurosci. Lett. 101 (1989) 288-292
    • (1989) Neurosci. Lett. , vol.101 , pp. 288-292
    • Rozemuller, J.M.1    Eikelenboom, P.2    Pals, S.T.3    Stam, F.C.4
  • 232
    • 0024428072 scopus 로고
    • A4-protein in Alzheimers-disease - primary and secondary cellular events in extracellular amyloid deposition
    • Rozemuller J.M., Eikelenboom P., Stam F.C., Beyreuther K., and Masters C.L. A4-protein in Alzheimers-disease - primary and secondary cellular events in extracellular amyloid deposition. J. Neuropathol. Exp. Neurol. 48 (1989) 674-691
    • (1989) J. Neuropathol. Exp. Neurol. , vol.48 , pp. 674-691
    • Rozemuller, J.M.1    Eikelenboom, P.2    Stam, F.C.3    Beyreuther, K.4    Masters, C.L.5
  • 233
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    • Sastre M., Dewachter I., Landreth G.E., Willson T.M., Klockgether T., Van Leuven F., and Heneka M.T. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J. Neurosci. 23 (2003) 9796-9804
    • (2003) J. Neurosci. , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3    Willson, T.M.4    Klockgether, T.5    Van Leuven, F.6    Heneka, M.T.7
  • 235
    • 0034114456 scopus 로고    scopus 로고
    • Cascading glia reactions: a common pathomechanism and its differentiated control by cyclic nucleotide signaling
    • Schubert P., Morino T., Miyazaki H., Ogata T., Nakamura Y., Marchini C., and Ferroni S. Cascading glia reactions: a common pathomechanism and its differentiated control by cyclic nucleotide signaling. Ann. N. Y. Acad. Sci. 903 (2000) 24-33
    • (2000) Ann. N. Y. Acad. Sci. , vol.903 , pp. 24-33
    • Schubert, P.1    Morino, T.2    Miyazaki, H.3    Ogata, T.4    Nakamura, Y.5    Marchini, C.6    Ferroni, S.7
  • 236
    • 23044489284 scopus 로고    scopus 로고
    • Toward a remembrance of things past: deciphering Alzheimer disease
    • Selkoe D.J. Toward a remembrance of things past: deciphering Alzheimer disease. Harvey Lect. 99 (2003) 23-45
    • (2003) Harvey Lect. , vol.99 , pp. 23-45
    • Selkoe, D.J.1
  • 237
    • 13444293174 scopus 로고    scopus 로고
    • Defining molecular targets to prevent Alzheimer disease
    • Selkoe D.J. Defining molecular targets to prevent Alzheimer disease. Arch. Neurol. 62 (2005) 192-195
    • (2005) Arch. Neurol. , vol.62 , pp. 192-195
    • Selkoe, D.J.1
  • 238
    • 0025092159 scopus 로고
    • Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor
    • Selmaj K.W., Farooq M., Norton W.T., Raine C.S., and Brosnan C.F. Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J. Immunol. 144 (1990) 129-135
    • (1990) J. Immunol. , vol.144 , pp. 129-135
    • Selmaj, K.W.1    Farooq, M.2    Norton, W.T.3    Raine, C.S.4    Brosnan, C.F.5
  • 239
    • 25144435958 scopus 로고    scopus 로고
    • Systemic inflammation induces apoptosis with variable vulnerability of different brain regions
    • Semmler A., Okulla T., Sastre M., Dumitrescu-Ozimek L., and Heneka M.T. Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J. Chem. Neuroanat. 30 (2005) 144-157
    • (2005) J. Chem. Neuroanat. , vol.30 , pp. 144-157
    • Semmler, A.1    Okulla, T.2    Sastre, M.3    Dumitrescu-Ozimek, L.4    Heneka, M.T.5
  • 241
    • 0141991166 scopus 로고    scopus 로고
    • Yin and Yang: complement activation and regulation in Alzheimer's disease
    • Shen Y., and Meri S. Yin and Yang: complement activation and regulation in Alzheimer's disease. Prog. Neurobiol. 70 (2003) 463-472
    • (2003) Prog. Neurobiol. , vol.70 , pp. 463-472
    • Shen, Y.1    Meri, S.2
  • 242
    • 0034042595 scopus 로고    scopus 로고
    • Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo
    • Sheng J.G., Zhu S.G., Jones R.A., Griffin W.S.T., and Mrak R.E. Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo. Exp. Neurol. 163 (2000) 388-391
    • (2000) Exp. Neurol. , vol.163 , pp. 388-391
    • Sheng, J.G.1    Zhu, S.G.2    Jones, R.A.3    Griffin, W.S.T.4    Mrak, R.E.5
  • 243
    • 0042835437 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice
    • Sheng J.G., Bora S.H., Xu G., Borchelt D.R., Price D.L., and Koliatsos V.E. Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol. Dis. 14 (2003) 133-145
    • (2003) Neurobiol. Dis. , vol.14 , pp. 133-145
    • Sheng, J.G.1    Bora, S.H.2    Xu, G.3    Borchelt, D.R.4    Price, D.L.5    Koliatsos, V.E.6
  • 244
    • 17144380506 scopus 로고    scopus 로고
    • Microglia lacking E prostanoid receptor subtype 2 have enhanced abeta phagocytosis yet lack abeta-activated neurotoxicity
    • Shie F.S., Breyer R.M., and Montine T.J. Microglia lacking E prostanoid receptor subtype 2 have enhanced abeta phagocytosis yet lack abeta-activated neurotoxicity. Am. J. Pathol. 166 (2005) 1163-1172
    • (2005) Am. J. Pathol. , vol.166 , pp. 1163-1172
    • Shie, F.S.1    Breyer, R.M.2    Montine, T.J.3
  • 245
    • 27444436866 scopus 로고    scopus 로고
    • Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity
    • Shie F.S., Montine K.S., Breyer R.M., and Montine T.J. Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity. Glia 52 (2005) 70-77
    • (2005) Glia , vol.52 , pp. 70-77
    • Shie, F.S.1    Montine, K.S.2    Breyer, R.M.3    Montine, T.J.4
  • 247
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard A.R., Soulet D., Gowing G., Julien J.P., and Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49 (2006) 489-502
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 248
    • 0026774797 scopus 로고
    • Induction of nitric oxide synthase in glial cells
    • Simmons M.L., and Murphy S. Induction of nitric oxide synthase in glial cells. J. Neurochem. 59 (1992) 897-905
    • (1992) J. Neurochem. , vol.59 , pp. 897-905
    • Simmons, M.L.1    Murphy, S.2
  • 249
    • 0028896346 scopus 로고
    • Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via the nitridergic pathway
    • Skaper S.D., Facci L., and Leon A. Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via the nitridergic pathway. J. Neurochem. 64 (1995) 266-276
    • (1995) J. Neurochem. , vol.64 , pp. 266-276
    • Skaper, S.D.1    Facci, L.2    Leon, A.3
  • 250
    • 4444274138 scopus 로고    scopus 로고
    • Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum
    • Slawik H., Volk B., Fiebich B., and Hull M. Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum. Neurochem. Int. 45 (2004) 653-660
    • (2004) Neurochem. Int. , vol.45 , pp. 653-660
    • Slawik, H.1    Volk, B.2    Fiebich, B.3    Hull, M.4
  • 251
    • 0035704245 scopus 로고    scopus 로고
    • Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Sly L.M., Krzesicki R.F., Brashler J.R., Buhl A.E., McKinley D.D., Carter D.B., and Chin J.E. Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res. Bull. 56 (2001) 581-588
    • (2001) Brain Res. Bull. , vol.56 , pp. 581-588
    • Sly, L.M.1    Krzesicki, R.F.2    Brashler, J.R.3    Buhl, A.E.4    McKinley, D.D.5    Carter, D.B.6    Chin, J.E.7
  • 256
    • 0031656782 scopus 로고    scopus 로고
    • Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient SCID mice with astrocyte-targeted expression of tumor necrosis factor
    • Stalder A.K., Carson M.J., Pagenstecher A., Asensio V.C., Kincaid C., Benedict M., Powell H.C., Masliah E., and Campbell I.L. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient SCID mice with astrocyte-targeted expression of tumor necrosis factor. Am. J. Pathol. 153 (1998) 767-783
    • (1998) Am. J. Pathol. , vol.153 , pp. 767-783
    • Stalder, A.K.1    Carson, M.J.2    Pagenstecher, A.3    Asensio, V.C.4    Kincaid, C.5    Benedict, M.6    Powell, H.C.7    Masliah, E.8    Campbell, I.L.9
  • 258
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart W.F., Kawas C., Corrada M., and Metter E.J. Risk of Alzheimer's disease and duration of NSAID use. Neurology 48 (1997) 626-632
    • (1997) Neurology , vol.48 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 261
    • 0001509578 scopus 로고
    • Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide
    • Stuehr D.J., and Marletta M.A. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 7738-7742
    • (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , pp. 7738-7742
    • Stuehr, D.J.1    Marletta, M.A.2
  • 263
    • 9644275598 scopus 로고    scopus 로고
    • Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease
    • Sung S., Yang H., Uryu K., Lee E.B., Zhao L., Shineman D., Trojanowski J.Q., Lee V.M., and Pratico D. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. Am. J. Pathol. 165 (2004) 2197-2206
    • (2004) Am. J. Pathol. , vol.165 , pp. 2197-2206
    • Sung, S.1    Yang, H.2    Uryu, K.3    Lee, E.B.4    Zhao, L.5    Shineman, D.6    Trojanowski, J.Q.7    Lee, V.M.8    Pratico, D.9
  • 264
    • 0033525574 scopus 로고    scopus 로고
    • Cerebral neurons express interleukin-6 after transient forebrain ischemia in gerbils
    • Suzuki S., Tanaka K., Nagata E., Ito D., Dembo T., and Fukuuchi Y. Cerebral neurons express interleukin-6 after transient forebrain ischemia in gerbils. Neurosci. Lett. 262 (1999) 117-120
    • (1999) Neurosci. Lett. , vol.262 , pp. 117-120
    • Suzuki, S.1    Tanaka, K.2    Nagata, E.3    Ito, D.4    Dembo, T.5    Fukuuchi, Y.6
  • 265
    • 0035255055 scopus 로고    scopus 로고
    • IL-4, IL-10 and IL-13 modulate A beta1-42-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line
    • Szczepanik A.M., Funes S., Petko W., and Ringheim G.E. IL-4, IL-10 and IL-13 modulate A beta1-42-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. J. Neuroimmunol. 113 (2001) 49-62
    • (2001) J. Neuroimmunol. , vol.113 , pp. 49-62
    • Szczepanik, A.M.1    Funes, S.2    Petko, W.3    Ringheim, G.E.4
  • 266
    • 0035085610 scopus 로고    scopus 로고
    • Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo
    • Szczepanik A.M., Rampe D., and Ringheim G.E. Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo. J. Neurochem. 77 (2001) 304-317
    • (2001) J. Neurochem. , vol.77 , pp. 304-317
    • Szczepanik, A.M.1    Rampe, D.2    Ringheim, G.E.3
  • 268
    • 3042601107 scopus 로고    scopus 로고
    • Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons
    • Takadera T., Shiraishi Y., and Ohyashiki T. Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons. Neurochem. Int. 45 (2004) 713-719
    • (2004) Neurochem. Int. , vol.45 , pp. 713-719
    • Takadera, T.1    Shiraishi, Y.2    Ohyashiki, T.3
  • 272
    • 0033943842 scopus 로고    scopus 로고
    • The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK
    • Tancredi V., D'Antuono M., Cafe C., Giovedi S., Bue M.C., D'Arcangelo G., Onofri F., and Benfenati F. The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK. J. Neurochem. 75 (2000) 634-643
    • (2000) J. Neurochem. , vol.75 , pp. 634-643
    • Tancredi, V.1    D'Antuono, M.2    Cafe, C.3    Giovedi, S.4    Bue, M.C.5    D'Arcangelo, G.6    Onofri, F.7    Benfenati, F.8
  • 273
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
    • Tanzi R.E., and Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120 (2005) 545-555
    • (2005) Cell , vol.120 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 274
    • 0029964265 scopus 로고    scopus 로고
    • Chromogranin a triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cells
    • Taupenot L., CiesielskiTreska J., Ulrich G., ChasserotGolaz S., Aunis D., and Bader M.F. Chromogranin a triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cells. Neuroscience 72 (1996) 377-389
    • (1996) Neuroscience , vol.72 , pp. 377-389
    • Taupenot, L.1    CiesielskiTreska, J.2    Ulrich, G.3    ChasserotGolaz, S.4    Aunis, D.5    Bader, M.F.6
  • 276
    • 0028203479 scopus 로고
    • TNF alpha gene expression is induced in neurones after a hippocampal lesion
    • Tchelingerian J.L., Vignais L., and Jacque C. TNF alpha gene expression is induced in neurones after a hippocampal lesion. Neuroreport 5 (1994) 585-588
    • (1994) Neuroreport , vol.5 , pp. 585-588
    • Tchelingerian, J.L.1    Vignais, L.2    Jacque, C.3
  • 277
    • 0037440372 scopus 로고    scopus 로고
    • Alzheimer's disease is associated with a selective increase in alpha 7 nicotinic acetylcholine receptor immunoreactivity in astrocytes
    • Teaktong T., Graham A., Court J., Perry R., Jaros E., Johnson M., Hall R., and Perry E. Alzheimer's disease is associated with a selective increase in alpha 7 nicotinic acetylcholine receptor immunoreactivity in astrocytes. Glia 41 (2003) 207-211
    • (2003) Glia , vol.41 , pp. 207-211
    • Teaktong, T.1    Graham, A.2    Court, J.3    Perry, R.4    Jaros, E.5    Johnson, M.6    Hall, R.7    Perry, E.8
  • 279
    • 0026722679 scopus 로고
    • Interleukin-1 and tumor-necrosis-factor-alpha stimulate the production of colony-stimulating factor-I by murine astrocytes
    • Thery C., Stanley E.R., and Mallat M. Interleukin-1 and tumor-necrosis-factor-alpha stimulate the production of colony-stimulating factor-I by murine astrocytes. J. Neurochem. 59 (1992) 1183-1186
    • (1992) J. Neurochem. , vol.59 , pp. 1183-1186
    • Thery, C.1    Stanley, E.R.2    Mallat, M.3
  • 280
    • 0028248331 scopus 로고
    • The role of the l-arginine: nitric oxide pathway in circulatory shock
    • Thiemermann C. The role of the l-arginine: nitric oxide pathway in circulatory shock. Adv. Pharmacol. 28 (1994) 45-79
    • (1994) Adv. Pharmacol. , vol.28 , pp. 45-79
    • Thiemermann, C.1
  • 281
    • 0035968743 scopus 로고    scopus 로고
    • Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation
    • Thomas T., Nadackal T.G., and Thomas K. Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation. Neuroreport 12 (2001) 3263-3267
    • (2001) Neuroreport , vol.12 , pp. 3263-3267
    • Thomas, T.1    Nadackal, T.G.2    Thomas, K.3
  • 282
    • 0031127741 scopus 로고    scopus 로고
    • Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease
    • Tocco G., Freire-Moar J., Schreiber S.S., Sakhi S.H., Aisen P.S., and Pasinetti G.M. Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease. Exp. Neurol. 144 (1997) 339-349
    • (1997) Exp. Neurol. , vol.144 , pp. 339-349
    • Tocco, G.1    Freire-Moar, J.2    Schreiber, S.S.3    Sakhi, S.H.4    Aisen, P.S.5    Pasinetti, G.M.6
  • 284
    • 0026541591 scopus 로고
    • The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
    • Tugwood J.D., Issemann I., Anderson R.G., Bundell K.R., McPheat W.L., and Green S. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J. 11 (1992) 433-439
    • (1992) EMBO J. , vol.11 , pp. 433-439
    • Tugwood, J.D.1    Issemann, I.2    Anderson, R.G.3    Bundell, K.R.4    McPheat, W.L.5    Green, S.6
  • 285
    • 4944258716 scopus 로고    scopus 로고
    • The role of inflammation in Alzheimer's disease
    • Tuppo E.E., and Arias H.R. The role of inflammation in Alzheimer's disease. Int. J. Biochem. Cell Biol. 37 (2005) 289-305
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 289-305
    • Tuppo, E.E.1    Arias, H.R.2
  • 286
    • 0033542873 scopus 로고    scopus 로고
    • Medical significance of peroxisome proliferator-activated receptors
    • Vamecq J., and Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet 354 (1999) 141-148
    • (1999) Lancet , vol.354 , pp. 141-148
    • Vamecq, J.1    Latruffe, N.2
  • 287
    • 0037791771 scopus 로고    scopus 로고
    • Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection
    • van Beek J., Elward K., and Gasque P. Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection. Ann. N. Y. Acad. Sci. 992 (2003) 56-71
    • (2003) Ann. N. Y. Acad. Sci. , vol.992 , pp. 56-71
    • van Beek, J.1    Elward, K.2    Gasque, P.3
  • 291
    • 0031127418 scopus 로고    scopus 로고
    • Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques
    • Wallace M.N., Geddes J.G., Farquhar D.A., and Masson M.R. Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques. Exp. Neurol. 144 (1997) 266-272
    • (1997) Exp. Neurol. , vol.144 , pp. 266-272
    • Wallace, M.N.1    Geddes, J.G.2    Farquhar, D.A.3    Masson, M.R.4
  • 292
    • 5344277556 scopus 로고    scopus 로고
    • Deciphering the molecular basis of memory failure in Alzheimer's disease
    • Walsh D.M., and Selkoe D.J. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 44 (2004) 181-193
    • (2004) Neuron , vol.44 , pp. 181-193
    • Walsh, D.M.1    Selkoe, D.J.2
  • 293
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., and Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 (2002) 535-539
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 297
    • 3042798841 scopus 로고    scopus 로고
    • Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
    • Wang Q., Rowan M.J., and Anwyl R. Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide. J. Neurosci. 24 (2004) 6049-6056
    • (2004) J. Neurosci. , vol.24 , pp. 6049-6056
    • Wang, Q.1    Rowan, M.J.2    Anwyl, R.3
  • 300
    • 0032521111 scopus 로고    scopus 로고
    • Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
    • Weldon D.T., Rogers S.D., Ghilardi J.R., Finke M.P., Cleary J.P., O'Hare E., Esler W.P., Maggio J.E., and Mantyh P.W. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J. Neurosci. 18 (1998) 2161-2173
    • (1998) J. Neurosci. , vol.18 , pp. 2161-2173
    • Weldon, D.T.1    Rogers, S.D.2    Ghilardi, J.R.3    Finke, M.P.4    Cleary, J.P.5    O'Hare, E.6    Esler, W.P.7    Maggio, J.E.8    Mantyh, P.W.9
  • 302
    • 14744283139 scopus 로고    scopus 로고
    • Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation
    • White J.A., Manelli A.M., Holmberg K.H., Van Eldik L.J., and Ladu M.J. Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiol. Dis. 18 (2005) 459-465
    • (2005) Neurobiol. Dis. , vol.18 , pp. 459-465
    • White, J.A.1    Manelli, A.M.2    Holmberg, K.H.3    Van Eldik, L.J.4    Ladu, M.J.5
  • 303
    • 0023952347 scopus 로고
    • The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type
    • Wilcock G.K., Esiri M.M., Bowen D.M., and Hughes A.O. The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type. J. Neurol. Neurosurg. Psychiatry 51 (1988) 842-849
    • (1988) J. Neurol. Neurosurg. Psychiatry , vol.51 , pp. 842-849
    • Wilcock, G.K.1    Esiri, M.M.2    Bowen, D.M.3    Hughes, A.O.4
  • 304
    • 0033571331 scopus 로고    scopus 로고
    • IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide
    • Willenborg D.O., Fordham S.A., Staykova M.A., Ramshaw I.A., and Cowden W.B. IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J. Immunol. 163 (1999) 5278-5286
    • (1999) J. Immunol. , vol.163 , pp. 5278-5286
    • Willenborg, D.O.1    Fordham, S.A.2    Staykova, M.A.3    Ramshaw, I.A.4    Cowden, W.B.5
  • 305
    • 0033400628 scopus 로고    scopus 로고
    • Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review
    • Willenborg D.O., Staykova M.A., and Cowden W.B. Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review. J. Neuroimmunol. 100 (1999) 21-35
    • (1999) J. Neuroimmunol. , vol.100 , pp. 21-35
    • Willenborg, D.O.1    Staykova, M.A.2    Cowden, W.B.3
  • 306
    • 0029077755 scopus 로고
    • Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1
    • Wyss-Coray T., Feng L., Masliah E., Ruppe M.D., Lee H.S., Toggas S.M., Rockenstein E.M., and Mucke L. Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. Am. J. Pathol. 147 (1995) 53-67
    • (1995) Am. J. Pathol. , vol.147 , pp. 53-67
    • Wyss-Coray, T.1    Feng, L.2    Masliah, E.3    Ruppe, M.D.4    Lee, H.S.5    Toggas, S.M.6    Rockenstein, E.M.7    Mucke, L.8
  • 308
    • 0033900999 scopus 로고    scopus 로고
    • Chronic overproduction of transforming growth factor-beta 1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice
    • Wyss-Coray T., Lin C., Sanan D.A., Mucke L., and Masliah E. Chronic overproduction of transforming growth factor-beta 1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. Am. J. Pathol. 156 (2000) 139-150
    • (2000) Am. J. Pathol. , vol.156 , pp. 139-150
    • Wyss-Coray, T.1    Lin, C.2    Sanan, D.A.3    Mucke, L.4    Masliah, E.5
  • 311
    • 0032917904 scopus 로고    scopus 로고
    • Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease
    • Xia M.Q., and Hyman B.T. Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. J. Neurovirology 5 (1999) 32-41
    • (1999) J. Neurovirology , vol.5 , pp. 32-41
    • Xia, M.Q.1    Hyman, B.T.2
  • 312
    • 0031848322 scopus 로고    scopus 로고
    • Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
    • Xia M.Q., Qin S.X., Wu L.J., Mackay C.R., and Hyman B.T. Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am. J. Pathol. 153 (1998) 31-37
    • (1998) Am. J. Pathol. , vol.153 , pp. 31-37
    • Xia, M.Q.1    Qin, S.X.2    Wu, L.J.3    Mackay, C.R.4    Hyman, B.T.5
  • 313
    • 0027290813 scopus 로고
    • Expression of a mitogen-inducible cyclooxygenase in brain neurons-regulation by synaptic activity and glucocorticoids
    • Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., and Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons-regulation by synaptic activity and glucocorticoids. Neuron 11 (1993) 371-386
    • (1993) Neuron , vol.11 , pp. 371-386
    • Yamagata, K.1    Andreasson, K.I.2    Kaufmann, W.E.3    Barnes, C.A.4    Worley, P.F.5
  • 314
    • 0029076397 scopus 로고
    • Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide
    • Yan S.D., Yan S.F., Chen X., Fu J., Chen M., Kuppusamy P., Smith M.A., Perry G., Godman G.C., Nawroth P., et al. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nat. Med. 1 (1995) 693-699
    • (1995) Nat. Med. , vol.1 , pp. 693-699
    • Yan, S.D.1    Yan, S.F.2    Chen, X.3    Fu, J.4    Chen, M.5    Kuppusamy, P.6    Smith, M.A.7    Perry, G.8    Godman, G.C.9    Nawroth, P.10
  • 316
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
    • Yan Q., Zhang J., Liu H., Babu-Khan S., Vassar R., Biere A.L., Citron M., and Landreth G. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J. Neurosci. 23 (2003) 7504-7509
    • (2003) J. Neurosci. , vol.23 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3    Babu-Khan, S.4    Vassar, R.5    Biere, A.L.6    Citron, M.7    Landreth, G.8
  • 317
    • 0033526660 scopus 로고    scopus 로고
    • Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs
    • Yasojima K., Schwab C., McGeer E.G., and McGeer P.L. Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res. 830 (1999) 226-236
    • (1999) Brain Res. , vol.830 , pp. 226-236
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3    McGeer, P.L.4
  • 318
    • 0033061855 scopus 로고    scopus 로고
    • Up-regulated production and activation of the complement system in Alzheimer's disease brain
    • Yasojima K., Schwab C., McGeer E.G., and McGeer P.L. Up-regulated production and activation of the complement system in Alzheimer's disease brain. Am. J. Pathol. 154 (1999) 927-936
    • (1999) Am. J. Pathol. , vol.154 , pp. 927-936
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3    McGeer, P.L.4
  • 319
    • 0021049766 scopus 로고
    • Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome
    • Yates C.M., Simpson J., Gordon A., Maloney A.F., Allison Y., Ritchie I.M., and Urquhart A. Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. Brain Res. 280 (1983) 119-126
    • (1983) Brain Res. , vol.280 , pp. 119-126
    • Yates, C.M.1    Simpson, J.2    Gordon, A.3    Maloney, A.F.4    Allison, Y.5    Ritchie, I.M.6    Urquhart, A.7
  • 320
    • 0033694033 scopus 로고    scopus 로고
    • Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders
    • Yermakova A., and O'Banion M.K. Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders. Curr. Pharm. Des. 6 (2000) 1755-1776
    • (2000) Curr. Pharm. Des. , vol.6 , pp. 1755-1776
    • Yermakova, A.1    O'Banion, M.K.2
  • 321
    • 0035693794 scopus 로고    scopus 로고
    • Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease
    • Yermakova A.V., and O'Banion M.K. Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol. Aging 22 (2001) 823-836
    • (2001) Neurobiol. Aging , vol.22 , pp. 823-836
    • Yermakova, A.V.1    O'Banion, M.K.2
  • 322
    • 0032725481 scopus 로고    scopus 로고
    • Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons
    • Yermakova A.V., Rollins J., Callahan L.M., Rogers J., and O'Banion M.K. Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons. J. Neuropathol. Exp. Neurol. 58 (1999) 1135-1146
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1135-1146
    • Yermakova, A.V.1    Rollins, J.2    Callahan, L.M.3    Rogers, J.4    O'Banion, M.K.5
  • 323
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Jarvinen H. Thiazolidinediones. N. Engl. J. Med. 351 (2004) 1106-1118
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1
  • 324
    • 0037337815 scopus 로고    scopus 로고
    • Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    • Zarow C., Lyness S.A., Mortimer J.A., and Chui H.C. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch. Neurol. 60 (2003) 337-341
    • (2003) Arch. Neurol. , vol.60 , pp. 337-341
    • Zarow, C.1    Lyness, S.A.2    Mortimer, J.A.3    Chui, H.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.