메뉴 건너뛰기




Volumn 21, Issue 4, 2001, Pages 1179-1188

β-amyloid stimulation of microglia anti monocytes results in TNFα-dependent expression of inducible nitric oxide synthase and neuronal apoptosis

Author keywords

Alzheimer's disease; Apoptosis; Cytokines; Inflammation; Lyn; Microglia; Neurotoxicity; Nitric oxide; Nitrotyrosine; Peroxynitrite; Signal transduction; Syk; THP 1 monocytes; TNF ; Tyrosine kinase; amyloid

Indexed keywords

AMYLOID BETA PROTEIN; NITRIC OXIDE SYNTHASE; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0035866060     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-04-01179.2001     Document Type: Article
Times cited : (638)

References (85)
  • 1
    • 0031031312 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease: Mechanisms and therapeutic strategies
    • (1997) Gerontology , vol.43 , pp. 143-149
    • Aisen, P.S.1
  • 3
    • 0032502351 scopus 로고    scopus 로고
    • N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase
    • (1998) J Biol Chem , vol.273 , pp. 8882-8889
    • Babu, B.1    Griffith, O.2
  • 9
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 11
    • 0028577356 scopus 로고
    • Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures
    • (1994) Dev Neurosci , vol.16 , pp. 172-179
    • Chao, C.C.1    Hu, S.2
  • 12
    • 0030004897 scopus 로고    scopus 로고
    • Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity
    • (1996) Cell , vol.84 , pp. 853-862
    • Chen, Z.J.1    Parent, L.2    Maniatis, T.3
  • 14
    • 0037615532 scopus 로고    scopus 로고
    • Tumor necrosis factoralpha and phorbol 12-myristate 13-acetate differentially modulate cytotoxic effect of nitric oxide generated by serum deprivation in neuronal PC12 cells
    • (1999) J Neurochem , vol.72 , pp. 1482-1488
    • Chung, K.C.1    Park, J.H.2    Kim, C.H.3    Ahn, Y.S.4
  • 21
    • 0025884625 scopus 로고
    • Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level
    • (1991) FEBS Lett , vol.285 , pp. 199-212
    • Fiers, W.1
  • 38
    • 0033600604 scopus 로고    scopus 로고
    • The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation
    • (1999) J Biol Chem , vol.274 , pp. 27339-27342
    • Karin, M.1
  • 40
    • 0031056029 scopus 로고    scopus 로고
    • Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factoralpha
    • (1997) Brain Res , vol.747 , pp. 114-121
    • Klegeris, A.1    Walker, D.G.2    McGeer, P.L.3
  • 45
    • 0030981128 scopus 로고    scopus 로고
    • beta-Amyloid-induced IL-1 beta release from an activated human monocyte cell line is calcium- and G-protein-dependent
    • (1997) Mech Ageing Dev , vol.94 , pp. 199-211
    • Lorton, D.1
  • 48
    • 0030611750 scopus 로고    scopus 로고
    • Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
    • (1997) J Neurosci Res , vol.49 , pp. 681-697
    • Mattson, M.P.1    Goodman, Y.2    Luo, H.3    Fu, W.4    Furukawa, K.5
  • 51
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • (1995) Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 72


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.