Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons

American Journal of Pathology

Volumn 157, Issue 4, 2000, Pages 1283-1298

  Dorpe, J V ^a   Smeijers, L ^a   Dewachter, I ^a   Nuyens, D ^a   Spittaels, K ^a   Van den Haute, C ^a   Mercken, M ^a   Moechars, D ^a   Laenen, I ^a   Kuiperi, C ^a   Bruynseels, K ^a   Tesseur, I ^a   Loos, R ^a   Vanderstichele, H ^a   Checler, F ^a   Sciot, R ^a   Van Leuven, F ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MUTANT PROTEIN;

AGING; ALZHEIMER DISEASE; ANEURYSM; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; DIFFUSION; GENE MUTATION; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SOLUBILITY; STRUCTURE ANALYSIS; TRANSGENIC MOUSE; VASCULAR AMYLOIDOSIS;

EID: 0033809909     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0002-9440(10)64644-5     Document Type: Article

References (49)

1. Cerebral amyloid angiopathy a critical review
2. Dementia in cerebral amyloid angiopathy: A clinicopathological study
3. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
4. The incidence of cerebral amyloid angiopathy in Alzheimer's disease
5. Cerebral amyloid angiopathy: Incidence and complications in the aging brain. I. Cerebral hemorrhage
6. Cerebral amyloid angiopathy: Amyloid β accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease
7. Clinicopathologic studies of primary cerebral amyloid angiopathy
8. Computer-assisted three-dimensional image analysis of cerebral amyloid angiopathy
9. Cerebral amyloid angiopathy: A significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly
10. Differences between vascular and plaque core amyloid in Alzheimer's disease
11. Protein chemical and immunocytochemical studies of meningovascular β-amyloid protein in Alzheimer's disease and normal aging
12. Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease
13. Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome
14. Animal models of cerebral β-amyloid angiopathy
15. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
16. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
17. Characterization of new polyclonal antibodies specific for 40 and 42 amino-acid long amyloid beta peptides: Their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases
18. Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
19. Pathology of cerebrospinal fluid and interstitial fluid of the CNS: Significance for Alzheimer's disease, prion disorders and multiple sclerosis
20. A novel missense mutation in the presenilin gene in a familial Alzheimer's disease pedigree with abundant amyloid angiopathy
21. Amyloid angiopathy in a Volga family with Alzheimer's disease and a presenilin-2 mutation (N141l)
22. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
23. Isolation and quantification of soluble Aizheimer's β-peptide from biological fluids
24. 2 in vivo
25. Production and increased detection of amyloid beta protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer's disease
26. Amyloid beta precursor protein-mRNA is expressed throughout cerebral vessel walls
27. Amyloid β-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells
28. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
29. Expression of human apolipoprotein in neurons causes hyperphosphorylation of protein Tau in the brain of transgenic mice
30. Structural neurology: Are seeds at the root of neuronal degeneration?
31. Accumulation of beta-amyloid fibrils in pancreas of transgenic mice
32. High levels of circulating β-amyloid peptide do not cause cerebral β-amyloidosis in transgenic mice
33. Anatomical relationship of the pia mater to cerebral blood vessels in man
34. Amyloid β-proteins 1-40 and 1-42 (43) in the soluble fraction of extra- and intracranial blood vessels
35. Visualization of Aβ 42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ 42(43)
36. Experimental deposition of Alzheimer amyloid beta-protein in canine leptomeningeal vessels
37. Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells
38. The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease
39. β-Amyloid protein of Alzheimer's disease is found in cerebral and spinal cord vascular malformations
40. Cerebral β amyloid deposition in patients with malignant neoplasms: Its prevalence with aging and effects of radiation therapy on vascular amyloid
41. β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer's disease
42. Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells
43. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease: An immunoelectron microscopic study
44. Hereditary cerebral hemorrhage with amyloidosis - Dutch type: Clinical and computed tomographic analysis of 24 cases
45. Leukoencephalopathy in cerebral amyloid angiopathy: MR Imaging in four cases
46. SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
47. Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease
48. Greenberg: Progression of cerebral amyloid angiopathy. Accumulation of amyloid-beta40 in affected vessels