메뉴 건너뛰기




Volumn 100, Issue 1-2, 1999, Pages 156-168

Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase

Author keywords

Alzheimer's Disease; Cerebellar granule neurons; iNOS; NSAIDs; PPAR

Indexed keywords

2 AMINO 5,6 DIHYDRO 6 METHYL 4H 1,3 TRIAZINE; GAMMA INTERFERON; IBUPROFEN; INDOMETACIN; INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROSTAGLANDIN J2; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0033378706     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00192-7     Document Type: Article
Times cited : (151)

References (66)
  • 1
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 2
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors PPARs: Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant O., Foufelle F., Scotto C., Dauca M., Wahli W. Differential expression of peroxisome proliferator-activated receptors PPARs: tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology. 137:1996;354-366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 3
    • 0025191219 scopus 로고
    • Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
    • Bredt D.S., Snyder S.H. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. U.S.A. 87:1990;682-685.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 682-685
    • Bredt, D.S.1    Snyder, S.H.2
  • 6
    • 0032528350 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: Correlation with induction of heme oxygenase 1
    • Colville N.P., Qureshi S.S., Willis D., Willoughby D.A. Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1. J. Immunol. 161:1998;978-984.
    • (1998) J. Immunol. , vol.161 , pp. 978-984
    • Colville, N.P.1    Qureshi, S.S.2    Willis, D.3    Willoughby, D.A.4
  • 7
    • 0031958152 scopus 로고    scopus 로고
    • Apoptosis decision cascades and neuronal degeneration in Alzheimer's Disease
    • Cotman C.W. Apoptosis decision cascades and neuronal degeneration in Alzheimer's Disease. Neurobiol. Aging. 19:1998;S29-S32.
    • (1998) Neurobiol. Aging , vol.19
    • Cotman, C.W.1
  • 8
    • 0028954988 scopus 로고
    • ADP ribosylation as a mechanism for the action of nitric oxide in the nervous system
    • Dawson T.M., Dawson V.L. ADP ribosylation as a mechanism for the action of nitric oxide in the nervous system. New Horiz. 3:1995;85-92.
    • (1995) New Horiz. , vol.3 , pp. 85-92
    • Dawson, T.M.1    Dawson, V.L.2
  • 9
    • 0026760948 scopus 로고
    • A novel neuronal messenger molecule in brain: The free radical, nitric oxide
    • see comments
    • Dawson T.M., Dawson V.L., Snyder S.H. A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann. Neurol. 32:1992;297-311. see comments.
    • (1992) Ann. Neurol. , vol.32 , pp. 297-311
    • Dawson, T.M.1    Dawson, V.L.2    Snyder, S.H.3
  • 10
    • 0028089896 scopus 로고
    • Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures
    • Dawson V.L., Brahmbhatt H.P., Mong J.A., Dawson T.M. Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology. 33:1994;1425-1430.
    • (1994) Neuropharmacology , vol.33 , pp. 1425-1430
    • Dawson, V.L.1    Brahmbhatt, H.P.2    Mong, J.A.3    Dawson, T.M.4
  • 11
    • 0027483920 scopus 로고
    • Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
    • D'Mello S.R., Galli C., Ciotti T., Calissano P. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. U.S.A. 90:1993;10989-10993.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 10989-10993
    • D'Mello, S.R.1    Galli, C.2    Ciotti, T.3    Calissano, P.4
  • 12
    • 0028356703 scopus 로고
    • Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons
    • D'Mello S.R., Anelli R., Calissano P. Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons. Exp. Cell Res. 211:1994;332-338.
    • (1994) Exp. Cell Res. , vol.211 , pp. 332-338
    • D'Mello, S.R.1    Anelli, R.2    Calissano, P.3
  • 14
    • 0030984429 scopus 로고    scopus 로고
    • Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons
    • Du Y., Dodel R.C., Bales K.R., Jemmerson R., Hamilton B.E., Paul S.M. Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons. J. Neurochem. 69:1997;1382-1388.
    • (1997) J. Neurochem. , vol.69 , pp. 1382-1388
    • Du, Y.1    Dodel, R.C.2    Bales, K.R.3    Jemmerson, R.4    Hamilton, B.E.5    Paul, S.M.6
  • 17
    • 0026486613 scopus 로고
    • Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures
    • Galea E., Feinstein D.L., Reis D.J. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc. Natl. Acad. Sci. U.S.A. 89:1992;10945-10949.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 10945-10949
    • Galea, E.1    Feinstein, D.L.2    Reis, D.J.3
  • 18
    • 0028211176 scopus 로고
    • Cloning and expression of inducible nitric oxide synthase from rat astrocytes
    • Galea E., Reis D.J., Feinstein D.L. Cloning and expression of inducible nitric oxide synthase from rat astrocytes. J. Neurosci. Res. 37:1994;406-414.
    • (1994) J. Neurosci. Res. , vol.37 , pp. 406-414
    • Galea, E.1    Reis, D.J.2    Feinstein, D.L.3
  • 19
    • 0031832025 scopus 로고    scopus 로고
    • Cerebellar stimulation reduces inducible nitric oxide synthase expression and protects brain from ischemia
    • Galea, E., Golanov, E.V., Feinstein, D.L., Kobylarz, K., Glickstein, S.B., Reis, D.J., 1999. Cerebellar stimulation reduces inducible nitric oxide synthase expression and protects brain from ischemia. Am. J. Physiol., H2035-H2045.
    • (1999) Am. J. Physiol.
    • Galea, E.1    Golanov, E.V.2    Feinstein, D.L.3    Kobylarz, K.4    Glickstein, S.B.5    Reis, D.J.6
  • 20
    • 0026077959 scopus 로고
    • Glutamate, nitric oxide and cell-cell signalling in the nervous system
    • Garthwaite J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci. 14:1991;60-67.
    • (1991) Trends Neurosci. , vol.14 , pp. 60-67
    • Garthwaite, J.1
  • 21
    • 0028868773 scopus 로고
    • Monitoring intracellular nitric oxide formation by dichlorofluorescein in neuronal cells
    • Gunasekar P.G., Kanthasamy A.G., Borowitz J.L., Isom G.E. Monitoring intracellular nitric oxide formation by dichlorofluorescein in neuronal cells. J. Neurosci. Methods. 61:1995;15-21.
    • (1995) J. Neurosci. Methods , vol.61 , pp. 15-21
    • Gunasekar, P.G.1    Kanthasamy, A.G.2    Borowitz, J.L.3    Isom, G.E.4
  • 22
    • 2642605346 scopus 로고    scopus 로고
    • Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide
    • Heneka M.T., Loschmann P.A., Gleichmann M., Weller M., Schulz J.B., Wullner U., Klockgether T. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. J. Neurochem. 71:1998;88-94.
    • (1998) J. Neurochem. , vol.71 , pp. 88-94
    • Heneka, M.T.1    Loschmann, P.A.2    Gleichmann, M.3    Weller, M.4    Schulz, J.B.5    Wullner, U.6    Klockgether, T.7
  • 23
    • 0033510184 scopus 로고    scopus 로고
    • Induction of argininosuccinate synthetase in rat brain glial cells after striatal microinjection of immunostimulants
    • Heneka M.T., Schmidlin A., Wiesinger H. Induction of argininosuccinate synthetase in rat brain glial cells after striatal microinjection of immunostimulants. J. Cereb. Blood Flow Metab. 19:1999;898-907.
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 898-907
    • Heneka, M.T.1    Schmidlin, A.2    Wiesinger, H.3
  • 24
    • 0023092102 scopus 로고
    • Macrophage cytotoxicity: Role for L-arginine deaminase and imino nitrogen oxidation to nitrite
    • Hibbs-JB J., Taintor R.R., Vavrin Z. Macrophage cytotoxicity: role for L-arginine deaminase and imino nitrogen oxidation to nitrite. Science. 235:1987;473-476.
    • (1987) Science , vol.235 , pp. 473-476
    • Hibbs-Jb, J.1    Taintor, R.R.2    Vavrin, Z.3
  • 25
    • 0030580053 scopus 로고    scopus 로고
    • S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway
    • Hu J., Van E.L. S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway. Biochim. Biophys. Acta. 1313:1996;239-245.
    • (1996) Biochim. Biophys. Acta , vol.1313 , pp. 239-245
    • Hu, J.1    Van, E.L.2
  • 26
    • 0032473596 scopus 로고    scopus 로고
    • Amyloid-beta peptide activates cultured astrocytes: Morphological alterations, cytokine induction and nitric oxide release
    • Hu J., Akama K.T., Krafft G.A., Chromy B.A., Van E.L. Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Res. 785:1998;195-206.
    • (1998) Brain Res. , vol.785 , pp. 195-206
    • Hu, J.1    Akama, K.T.2    Krafft, G.A.3    Chromy, B.A.4    Van, E.L.5
  • 27
    • 0030013534 scopus 로고    scopus 로고
    • Beta-amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity
    • Ii M., Sunamoto M., Ohnishi K., Ichimori Y. Beta-amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity. Brain Res. 720:1996;93-100.
    • (1996) Brain Res. , vol.720 , pp. 93-100
    • Ii, M.1    Sunamoto, M.2    Ohnishi, K.3    Ichimori, Y.4
  • 28
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C., Ting A.T., Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature. 391:1998;82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 29
    • 0029875978 scopus 로고    scopus 로고
    • Regulation of the manganese superoxide dismutase and inducible nitric oxide synthase gene in rat neuronal and glial cells
    • Kifle Y., Monnier J., Chesrown S.E., Raizada M.K., Nick H.S. Regulation of the manganese superoxide dismutase and inducible nitric oxide synthase gene in rat neuronal and glial cells. J. Neurochem. 66:1996;2128-2135.
    • (1996) J. Neurochem. , vol.66 , pp. 2128-2135
    • Kifle, Y.1    Monnier, J.2    Chesrown, S.E.3    Raizada, M.K.4    Nick, H.S.5
  • 33
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • Krey G., Braissant O., Horset F., Kalkhoven E., Perroud M., Parker M.G., Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11:1997;779-791.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    Horset, F.3    Kalkhoven, E.4    Perroud, M.5    Parker, M.G.6    Wahli, W.7
  • 34
    • 0027221998 scopus 로고
    • NMDA-dependent superoxide production and neurotoxicity
    • Lafon C.M., Pietri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 364:1993;535-537.
    • (1993) Nature , vol.364 , pp. 535-537
    • Lafon, C.M.1    Pietri, S.2    Culcasi, M.3    Bockaert, J.4
  • 35
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann J.M., Lenhard J.M., Oliver B.B., Ringold G.M., Kliewer S.A. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272:1997;3406-3410.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 36
    • 0031442999 scopus 로고    scopus 로고
    • Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide
    • Leist M., Volbracht C., Kuhnle S., Fava E., Ferrando M.E., Nicotera P. Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide. Mol. Med. 3:1997;750-764.
    • (1997) Mol. Med. , vol.3 , pp. 750-764
    • Leist, M.1    Volbracht, C.2    Kuhnle, S.3    Fava, E.4    Ferrando, M.E.5    Nicotera, P.6
  • 37
    • 0029731662 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology
    • Lemberger T., Desvergne B., Wahli W. Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu. Rev. Cell Dev. Biol. 12:1996;335-363.
    • (1996) Annu. Rev. Cell Dev. Biol. , vol.12 , pp. 335-363
    • Lemberger, T.1    Desvergne, B.2    Wahli, W.3
  • 39
    • 0026729267 scopus 로고
    • Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme
    • Lowenstein C.J., Glatt C.S., Bredt D.S., Snyder S.H. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. U.S.A. 89:1992;6711-6715.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 6711-6715
    • Lowenstein, C.J.1    Glatt, C.S.2    Bredt, D.S.3    Snyder, S.H.4
  • 40
    • 0026747874 scopus 로고
    • N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis
    • Marini A.M., Paul S.M. N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis. Proc. Natl. Acad. Sci. U.S.A. 89:1992;6555-6559.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 6555-6559
    • Marini, A.M.1    Paul, S.M.2
  • 41
    • 0032080868 scopus 로고    scopus 로고
    • Activation of caspase-3 and apoptosis in cerebellar granule cells
    • Marks N., Berg M.J., Guidotti A., Saito M. Activation of caspase-3 and apoptosis in cerebellar granule cells. J. Neurosci. Res. 52:1998;334-341.
    • (1998) J. Neurosci. Res. , vol.52 , pp. 334-341
    • Marks, N.1    Berg, M.J.2    Guidotti, A.3    Saito, M.4
  • 42
    • 0032450274 scopus 로고    scopus 로고
    • Glial cell reactions in neurodegenerative diseases: Pathophysiology and therapeutic interventions
    • Suppl.
    • McGeer P.L., McGeer E.G. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzheimer Dis. Assoc. Disord. 12(2):1998;S1-S6. Suppl.
    • (1998) Alzheimer Dis. Assoc. Disord. , vol.12 , Issue.2
    • McGeer, P.L.1    McGeer, E.G.2
  • 43
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's Disease: A review of 17 epidemiologic studies
    • see comments
    • McGeer P.L., Schulzer M., McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's Disease: a review of 17 epidemiologic studies. Neurology. 47:1996;425-432. see comments.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 44
    • 0028365824 scopus 로고
    • Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine
    • Minc G.D., Tsarfaty I., Schwartz J.P. Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine. Br. J. Pharmacol. 112:1994;720-722.
    • (1994) Br. J. Pharmacol. , vol.112 , pp. 720-722
    • Minc, G.D.1    Tsarfaty, I.2    Schwartz, J.P.3
  • 45
    • 85088670832 scopus 로고
    • Expression of the inducible nitric oxide synthase by neurons following exposure to endotoxin and cytokine
    • Minc G.D., Yadid G., Tsarfaty I., Resau J.H., Schwartz J.P. Expression of the inducible nitric oxide synthase by neurons following exposure to endotoxin and cytokine. J. Neurochem. 66:1994;1504-1509.
    • (1994) J. Neurochem. , vol.66 , pp. 1504-1509
    • Minc, G.D.1    Yadid, G.2    Tsarfaty, I.3    Resau, J.H.4    Schwartz, J.P.5
  • 46
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S., Higgs A. The L-arginine-nitric oxide pathway. New Engl. J. Med. 329:1993;2002-2012.
    • (1993) New Engl. J. Med. , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 47
    • 0022516186 scopus 로고
    • The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells
    • Nicoletti F., Wroblewski J.T., Novelli A., Alho H., Guidotti A., Costa E. The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. J. Neurosci. 6:1986;1905-1911.
    • (1986) J. Neurosci. , vol.6 , pp. 1905-1911
    • Nicoletti, F.1    Wroblewski, J.T.2    Novelli, A.3    Alho, H.4    Guidotti, A.5    Costa, E.6
  • 48
    • 0032551633 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's Disease brain
    • Pasinetti G.M., Aisen P.S. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's Disease brain. Neuroscience. 87:1998;319-324.
    • (1998) Neuroscience , vol.87 , pp. 319-324
    • Pasinetti, G.M.1    Aisen, P.S.2
  • 51
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote M., Li A.C., Willson T.M., Kelly C.J., Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 391:1998;79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 53
    • 0028853993 scopus 로고
    • Induction of calcium-independent nitric oxide synthase activity in cultured cerebellar granule neurons
    • Sato I., Kim Y., Himi T., Murota S. Induction of calcium-independent nitric oxide synthase activity in cultured cerebellar granule neurons. Neurosci. Lett. 184:1995;145-148.
    • (1995) Neurosci. Lett. , vol.184 , pp. 145-148
    • Sato, I.1    Kim, Y.2    Himi, T.3    Murota, S.4
  • 54
    • 0030028520 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced nitric oxide synthase activity in cultured cerebellar granule neurons
    • Sato I., Himi T., Murota S. Lipopolysaccharide-induced nitric oxide synthase activity in cultured cerebellar granule neurons. Neurosci. Lett. 205:1996;45-48.
    • (1996) Neurosci. Lett. , vol.205 , pp. 45-48
    • Sato, I.1    Himi, T.2    Murota, S.3
  • 55
    • 0032402262 scopus 로고    scopus 로고
    • Argininosuccinate synthetase: Localization in astrocytes and role in the production of glial nitric oxide
    • Schmidlin A., Wiesinger H. Argininosuccinate synthetase: localization in astrocytes and role in the production of glial nitric oxide. Glia. 24:1998;428-436.
    • (1998) Glia , vol.24 , pp. 428-436
    • Schmidlin, A.1    Wiesinger, H.2
  • 56
    • 0029954311 scopus 로고    scopus 로고
    • Potassium deprivation-induced apoptosis of cerebellar granule neurons: A sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species
    • Schulz J.B., Weller M., Klockgether T. Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J. Neurosci. 16:1996;4696-4706.
    • (1996) J. Neurosci. , vol.16 , pp. 4696-4706
    • Schulz, J.B.1    Weller, M.2    Klockgether, T.3
  • 57
    • 0026774797 scopus 로고
    • Induction of nitric oxide synthase in glial cells
    • Simmons M.L., Murphy S. Induction of nitric oxide synthase in glial cells. J. Neurochem. 59:1992;897-905.
    • (1992) J. Neurochem. , vol.59 , pp. 897-905
    • Simmons, M.L.1    Murphy, S.2
  • 58
    • 0028896346 scopus 로고
    • Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via the nitridergic pathway
    • Skaper S.D., Facci L., Leon A. Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via the nitridergic pathway. J. Neurochem. 64:1995;266-276.
    • (1995) J. Neurochem. , vol.64 , pp. 266-276
    • Skaper, S.D.1    Facci, L.2    Leon, A.3
  • 60
    • 0024584020 scopus 로고
    • Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
    • Stuehr D.J., Nathan C.F. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 169:1989;1543-1555.
    • (1989) J. Exp. Med. , vol.169 , pp. 1543-1555
    • Stuehr, D.J.1    Nathan, C.F.2
  • 61
    • 0024549389 scopus 로고
    • Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide
    • Stuehr D.J., Gross S.S., Sakuma I., Levi R., Nathan C.F. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J. Exp. Med. 169:1989;1011-1020.
    • (1989) J. Exp. Med. , vol.169 , pp. 1011-1020
    • Stuehr, D.J.1    Gross, S.S.2    Sakuma, I.3    Levi, R.4    Nathan, C.F.5
  • 62
    • 0032955601 scopus 로고    scopus 로고
    • Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH-SY5Y cells
    • Uehara T., Kikuchi Y., Nomura Y. Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH-SY5Y cells. J. Neurochem. 72:1999;196-205.
    • (1999) J. Neurochem. , vol.72 , pp. 196-205
    • Uehara, T.1    Kikuchi, Y.2    Nomura, Y.3
  • 64
    • 0026463018 scopus 로고
    • Niacinamide blocks 3-acetylpyridine toxicity of cerebellar granule cells in vitro
    • Weller M., Marini A.M., Paul S.M. Niacinamide blocks 3-acetylpyridine toxicity of cerebellar granule cells in vitro. Brain Res. 594:1992;160-164.
    • (1992) Brain Res. , vol.594 , pp. 160-164
    • Weller, M.1    Marini, A.M.2    Paul, S.M.3
  • 65
    • 0030451897 scopus 로고    scopus 로고
    • Discovery of ligands for the nuclear peroxisome proliferator-activated receptors
    • Willson T.M., Lehmann J.M., Kliewer S.A. Discovery of ligands for the nuclear peroxisome proliferator-activated receptors. Ann. N.Y. Acad. Sci. 804:1996;276-283.
    • (1996) Ann. N.Y. Acad. Sci. , vol.804 , pp. 276-283
    • Willson, T.M.1    Lehmann, J.M.2    Kliewer, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.