Reduced β-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice

Journal of Biological Chemistry

Volumn 279, Issue 45, 2004, Pages 46907-46914

  Beglopoulos, Vassilios ^a   Sun, Xiaoyan ^a   Saura, Carlos A ^a   Lemere, Cynthia A ^a   Kim, Richard D ^b   Shen, Jie ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Harvard Partners Center for Genetics and Genomics   (United States)

^c Center for Neurologic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOLOGICAL MEMBRANES; BRAIN; CELLS; ENZYMES; GENES; LIVING SYSTEMS STUDIES; MOLECULAR STRUCTURE; PLASTICITY;

ALZHEIMER'S DISEASES; POSTNATAL FOREBRAIN; PRESENILINS (PS);

DISEASES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CATHEPSIN S; COMPLEMENT COMPONENT C1Q; GLIAL FIBRILLARY ACIDIC PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DNA MICROARRAY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; GENE MUTATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KNOCKOUT MOUSE; MICROGLIA; MOUSE; NEOCORTEX; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

AMYLOID BETA-PROTEIN; ANIMALS; ANTIGENS, CD45; BLOTTING, WESTERN; BRAIN; CATHEPSINS; CEREBRAL CORTEX; COMPLEMENT C1Q; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEURODEGENERATIVE DISEASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; PHENOTYPE; PRESENILIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

ANIMALIA;

EID: 8744228195     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409544200     Document Type: Article

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