Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

Journal of Neuroscience

Volumn 23, Issue 5, 2003, Pages 1605-1611

  Li, Yuekui ^a   Liu, Ling ^a   Barger, Steven W ^a,b,c,d   Griffin, W Sue T ^a,b,c,d,e  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^d Geriatric   (United States)

^e Department of Geriatric   (United States)

Author keywords

Alzheimer's disease; Cortical neuron; Interleukin 1; Microglia; Mitogen activated protein kinase; Phosphorylated tau; Synaptophysin; amyloid precursor protein

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIBODY; INTERLEUKIN 1; INTERLEUKIN 1 BETA ANTIBODY; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT INTERLEUKIN 1BETA; SYNAPTOPHYSIN; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; CYTOSKELETON; EMBRYO; MICROGLIA; NEUROFIBRILLARY TANGLE; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; RAT;

EID: 0037336701     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-05-01605.2003     Document Type: Article

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