Microglia as a source and target of cytokines

GLIA

Volumn 40, Issue 2, 2002, Pages 140-155

  Hanisch, Uwe Karsten ^a,b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Lausitz University of Applied Sciences   (Germany)

Author keywords

Chemokine; Interferon; Interleukin; Macrophage; TNF

Indexed keywords

CYTOKINE;

ANIMAL; CELL COMMUNICATION; ENDOCRINE SYSTEM; GLIA; HUMAN; IMMUNOLOGY; METABOLISM; MICROGLIA; NERVE CELL; PHYSIOLOGY; REVIEW; VASCULAR ENDOTHELIUM;

ANIMALS; CELL COMMUNICATION; CYTOKINES; ENDOCRINE SYSTEM; ENDOTHELIUM, VASCULAR; HUMANS; MICROGLIA; NEUROGLIA; NEURONS;

EID: 0036849018     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.10161     Document Type: Review

References (179)

1. Akbar AN, Lord JM, Salmon M. 2000. IFN-alpha and IFN-beta: A link between immune memory and chronic inflammation. Immunol Today 21:337-342.
2. Akira S. 2000. The role of IL-18 in innate immunity. Curr Opin Immunol 12:59-63.
3. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T. 2000. Inflammation and Alzheimer's disease. Neurobiol Aging 21:383-421.
4. Alheim K, Bartfai T. 1998. The interleukin-1 system: Receptors, ligands, and ICE in the brain and their involvement in the fever response. Ann NY Acad Sci 840:51-58.
5. Allan SM, Rothwell NJ. 2001. Cytokines and acute neurodegeneration. Nat Rev Neurosci 2:734-744.
6. Aloisi F, Penna G, Cerase J, Menendez IB, Adorini L. 1997. IL-12 production by central nervous system microglia is inhibited by astrocytes. J Immunol 159:1604-1612.
7. Aloisi F. 2001. Immune function of microglia. Glia 36:165-179.
8. Angstwurm K, Freyer D, Dirnagl U, Hanisch UK, Schumann RR, Einhaupl KM, Weber JR. 1998. Tumour necrosis factor alpha induces only minor inflammatory changes in the central nervous system, but augments experimental meningitis. Neuroscience 86:627-634.
9. Antel JP, Becher B, Owens T. 1996. Immunotherapy for multiple sclerosis: From theory to practice. Nat Med 2:1074-1075.
10. Arendt T. 2001. Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization. Neuroscience 102:723-765.
11. Asensio VC, Campbell IL. 1999. Chemokines in the CNS: Plurifunctional mediators in diverse states. Trends Neurosci 22:504-512.
12. Ashkenazi A, Dixit VM. 1998. Death receptors: Signaling and modulation. Science 281:1305-1308.
13. Ashkenazi A, Dixit VM. 1999. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 11:255-260.
14. Badie B, Schartner J, Vorpahl J, Preston K. 2000. Interferon-gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro. Exp Neurol 162:290-296.
15. Balasingam V, Dickson K, Brade A, Yong VW. 1996. Astrocyte reactivity in neonatal mice: Apparent dependence on the presence of reactive microglia/macrophages. Glia 18:11-26.
16. Balasingam V, Yong VW. 1996. Attenuation of astroglial reactivity by interleukin-10. J Neurosci 16:2945-2955.
17. Bamberger ME, Landreth GE. 2001. Microglial interaction with beta-amyloid: Implications for the pathogenesis of Alzheimer's disease. Microsc Res Tech 54:59-70.
18. Banks WA, Ortiz L, Plotkin SR, Kastin AJ. 1991. Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther 259:988-996.
19. Banks WA, Kastin AJ. 1997. Relative contributions of peripheral and central sources to levels of IL-1 alpha in the cerebral cortex of mice: Assessment with species-specific enzyme immunoassays. J Neuroimmunol 79:22-28.
20. Bazan JF, Timans JC, Kastelein RA. 1996. A newly defined interleukin-1? Nature 379:591-591.
21. Becher B, Prat A, Antel JP. 2000. Brain-immune connection: Immunoregulatory properties of CNS-resident cells. Glia 29:293-304.
22. Benveniste EN, Nguyen VT, O'Keefe GM. 2001. Immunological aspects of microglia: Relevance to Alzheimer's disease. Neurochem Int 39:381-391.
23. Berkenbosch F, van Oers J, del Rey A, Tilders F, Besedovsky H. 1987. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238:524-526.
24. Berkenbosch F, de Goeij DE, del Rey AD, Besedovsky HO. 1989. Neuroendocrine, sympathetic and metabolic responses induced by interleukin-1. Neuroendocrinology 50:570-576.
25. Besedovsky HO, del Rey A. 1996. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev 17:64-102.
26. Bezzi P, Volterra A. 2001. A neuron-glia signalling network in the active brain. Curr Opin Neurobiol 11:387-394.
27. Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A. 2001. CXCR4-activated astrocyte glutamate release via TNFalpha: Amplification by microglia triggers neurotoxicity. Nat Neurosci 4:702-710.
28. Biber K, Sauter A, Brouwer N, Copray SC, Boddeke HW. 2001. Ischemia-induced neuronal expression of the microglia attracting chemokine secondary lymphoid-tissue chemokine (SLC). Glia 34:121-133.
29. Boehme SA, Lio FM, Maciejewski-Lenoir D, Bacon KB, Conlon PJ. 2000. The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia. J Immunol 165:397-403.
30. Boucsein C, Kettenmann H, Nolte C. 2000. Electrophysiological properties of microglial cells in normal and pathologic rat brain slices. Eur J Neurosci 12:2049-2058.
31. Brockhaus J, Ilschner S, Banati RB, Kettenmann H. 1993. Membrane properties of ameboid microglial cells in the corpus callosum slice from early postnatal mice. J Neurosci 13:4412-4421.
32. Campbell IL. 1998. Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology. Brain Res Brain Res Rev 26:327-336.
33. Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, Gahring LC. 1999. Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol 163:3963-3968.
34. Carrie A, Jun L, Bienvenu T, Vinet MC, McDonell N, Couvert P, Zemni R, Cardona A, Van Buggenhout G, Frints S, Hamel B, Moraine C, Ropers HH, Strom T, Howell GR, Whittaker A, Ross MT, Kahn A, Fryns JP, Beldjord C, Marynen P, Chelly J. 1999. A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Nat Genet 23:25-31.
35. Cartmell T, Luheshi GN, Rothwell NJ. 1999. Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. J Physiol Lond 518:585-594.
36. Chao CC, Molitor TW, Hu S. 1993. Neuroprotective role of IL-4 against activated microglia. J Immunol 151:1473-1481.
37. Cheng B, Christakos S, Mattson MP. 1994. Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12:139-153.
38. Combs CK, Karlo JC, Kao SC, Landreth GE. 2001. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha- dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 21:1179-1188.
39. Conti B, Jahng JW, Tinti C, Son JH, Joh TH. 1997. Induction of interferon-gamma inducing factor in the adrenal cortex. J Biol Chem 272:2035-2037.
40. Conti B, Park LC, Calingasan NY, Kim Y, Kim H, Bae Y, Gibson GE, Joh TH. 1999. Cultures of astrocytes and microglia express interleukin 18. Mol Brain Res 67:46-52.
41. Cooper NR, Bradt BM, O'Barr S, Yu JX. 2000. Focal inflammation in the brain: Role in Alzheimer's disease. Immunol Res 21:159-165.
42. Coughlin SR. 2000. Thrombin signalling and protease-activated receptors. Nature 407:258-264.
43. Culhane AC, Hall MD, Rothwell NJ, Luheshi GN. 1998. Cloning of rat brain interleukin-18 cDNA. Mol Psychiatry 3:362-366.
44. Dinarello CA. 1997a. Role of pro- and anti-inflammatory cytokines during inflammation: Experimental and clinical findings. J Biol Regul Homeost Agents 11:91-103.
45. Dinarello CA. 1997b. Blocking interleukin-1 and tumor necrosis factor in disease. Eur Cytokine Netw 8:294-296.
46. Dinarello CA. 1997c. Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol 24:S9-S9.
47. Dinarello CA. 1998a. Interleukin-1, interleukin-1 receptors and interleukin-1 antagonist. Int Rev Immunol 16:457-499.
48. Dinarello CA. 1998b. Interleukin-1. In: Thomson A, editor. The Cytokine Handbook. San Diego: Academic Press. p 35-72.
49. Dinarello CA. 1999. IL-18: A TH1-inducing, proinflammatory cytokine and a new member of the IL-1 family. J Allergy Clin Immunol 103:11-24.
50. + channels in mouse brain microglia: Cells acquire responsiveness to pneumococcal cell wall components during late development. Neuroscience 89:1379-1390.
51. Dunn AJ, Wang J, Ando T. 1999. Effects of cytokines on cerebral neurotransmission: Comparison with the effects of stress. Adv Exp Med Biol 461:117-127.
52. Eddleston M, Mucke L. 1993. Molecular profile of reactive astrocytes: Implications for their role in neurologic disease. Neuroscience 54:15-36.
53. Elkabes S, DiCicco BE, Black IB. 1996. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 16:2508-2521.
54. Fassbender K, Mielke O, Bertsch T, Muehlhauser F, Hennerici M, Kurimoto M, Rossol S. 1999. Interferon-gamma-inducing factor (IL-18) and interferon-gamma in inflammatory CNS diseases. Neurology 53:1104-1106.
55. Fassbender K, Schneider S, Bertsch T, Schlueter D, Fatar M, Ragoschke A, Kuhl S, Kischka U, Hennerici M. 2000. Temporal profile of release of interleukin-1beta in neurotrauma. Neurosci Lett 284:135-138.
56. Ferrari D, Chiozzi P, Falzoni S, Hanau S, Di Virgilio F. 1997. Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J Exp Med 185:579-582.
57. Fields RD, Stevens B. 2000. ATP: An extracellular signaling molecule between neurons and glia. Trends Neurosci 23:625-633.
58. Gabay C, Smith JMF, Eidlen D, Arend WP. 1997. Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. J Clin Invest 99:2930-2940.
59. Gebicke-haerter PJ, Appel K, Taylor GD, Schobert A, Rich IN, Northoff H, Berger M. 1994. Rat microglial interleukin-3. J Neuroimmunol 50:203-214.
60. Gebicke-haerter PJ. 2001. Microglia in neurodegeneration: Molecular aspects. Microsc Res Tech 54:47-58.
61. Gingrich MB, Traynelis SF. 2000. Serine proteases and brain damage: Is there a link? Trends Neurosci 23:399-407.
62. Giulian D, Young DG, Woodward J, Brown DC, Lachman LB. 1988a. Interleukin-1 is an astroglial growth factor in the developing brain. J Neurosci 8:709-714.
63. Giulian D, Woodward J, Young DG, Krebs JF, Lachman LB. 1988b. Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J Neurosci 8:2485-2490.
64. Giulian D. 1993. Reactive glia as rivals in regulating neuronal survival. Glia 7:102-110.
65. Giulian D, Li J, Li X, George J, Rutecki PA. 1994a. The impact of microglia-derived cytokines upon gliosis in the CNS. Dev Neurosci 16:128-136.
66. Giulian D, Li J, Leara B, Keenen C. 1994b. Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture. Neurochem Int 25:227-233.
67. Giulian D. 1995. Microglia and neuronal dysfunction. In: Kettenmann H, Ransom BR, editors. Neuroglia. New York: Oxford University Press. p 671-684.
68. Glabinski AR, Ransohoff RM. 1999. Chemokines and chemokine receptors in CNS pathology. J Neurovirol 5:3-12.
69. Hanisch UK, Seto D, Quirion R. 1993. Modulation of hippocampal acetylcholine release: A potent central action of interleukin-2. J Neurosci 13:3368-3374.
70. Hanisch UK, Rowe W, Sharma S, Meaney MJ, Quirion R. 1994. Hypothalamic-pituitary-adrenal activity during chronic central administration of interleukin-2. Endocrinology 135:2465-2472.
71. Hanisch UK, Quirion R. 1996. Interleukin-2 as a neuroregulatory cytokine. Brain Res Brain Res Rev 21:246-284.
72. Hanisch UK, Neuhaus J, Quirion R, Kettenmann H. 1996. Neurotoxicity induced by interleukin-2: Involvement of infiltrating immune cells. Synapse 24:104-114.
73. Hanisch UK, Lyons SA, Prinz M, Nolte C, Weber JR, Kettenmann H, Kirchhoff F. 1997a. Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J Biol Chem 272:28853-28860.
74. Hanisch UK, Neuhaus J, Rowe W, van Rossum D, Moller T, Kettenmann H, Quirion R. 1997b. Neurotoxic consequences of central long-term administration of interleukin-2 in rats. Neuroscience 79:799-818.
75. Hanisch UK. 2001a. Microglia as a source and target of cytokine activities in the brain. In: Streit WJ, editor. Microglia in the Degenerating and Regenerating CNS. New York: Springer Verlag. p 79-124.
76. Hanisch UK. 2001b. Effects of interleukin-2 and interferons on the nervous system. In: Ader R, Felten DL, Cohen N, edsitors. Psychoneuroimmunology. San Diego: Academic Press. p 585-631.
77. Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR. 2001. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur J Immunol 31:2104-2115.
78. Harrison JK, Jiang Y, Chen S, Xia Y, Maciejewski D, McNamara RK, Streit WJ, Salafranca MN, Adhikari S, Thompson DA, Botti P, Bacon KB, Feng L. 1998. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci USA 95:10896-10901.
79. Heppner FL, Prinz M, Aguzzi A. 2001. Pathogenesis of prion diseases: Possible implications of microglial cells. Prog Brain Res 132:737-750.
80. Hickey WF. 2001. Basic principles of immunological surveillance of the normal central nervous system. Glia 36:118-124.
81. Hide I, Tanaka M, Inoue A, Nakajima K, Kohsaka S, Inoue K, Nakata Y. 2000. Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J Neurochem 75:965-972.
82. Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM, Blom B, Homola ME, Streit WJ, Brown MH, Barclay AN, Sedgwick JD. 2000. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290:1768-1771.
83. Honda S, Sasaki Y, Ohsawa K, Imai Y, Nakamura Y, Inoue K, Kohsaka S. 2001. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci 21:1975-1982.
84. Hopkins SJ, Rothwell NJ. 1995. Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci 18:83-88.
85. Katsuki H, Nakai S, Hirai Y, Akaji K, Kiso Y, Satoh M. 1990. Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. Eur J Pharmacol 181:323-326.
86. Kitamura Y, Taniguchi T, Kimura H, Nomura Y, Gebicke-haerter PJ. 2000. Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures. J Neuroimmunol 106:95-104.
87. Kohno K, Kurimoto M. 1998. Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both. Clin Immunol Immunopathol 86:11-15.
88. Konsman JP, Parnet P, Dantzer R. 2002. Cytokine-induced sickness behaviour: Mechanisms and implications. Trends Neurosci 25:154-159.
89. Kreutzberg GW. 1996. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
90. Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR. 2000. Identification and initial characterization of four novel members of the interleukin-1 familiy. J Biol Chem 275:10308-10314.
91. Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW. 1993. Cytokine production by human fetal microglia and astrocytes. J Immunol 150:2659-2667.
92. Liu JS, John GR, Sikora A, Lee SC, Brosnan CF. 2000. Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. J Neurosci 20:5292-5299.
93. Locati M, Murphy PM. 1999. Chemokines and chemokine receptors: Biology and clinical relevance in inflammation and AIDS. Ann Rev Med 50:425-440.
94. Loddick SA, Liu C, Takao T, Hashimoto K, De Souza EB. 1998. Interleukin-1 receptors: Cloning studies and role in central nervous system disorders. Brain Res Rev 26:306-319.
95. Luheshi GN, Gardner JD, Rushforth DA, Loudon AS, Rothwell NJ. 1999. Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl Acad Sci USA 96:7047-7052.
96. Luk WP, Zhang Y, White TD, Lue FA, Wu C, Jiang CG, Zhang L, Moldofsky H. 1999. Adenosine: a mediator of interleukin-1beta-induced hippocampal synaptic inhibition. J Neurosci 19:4238-4244.
97. Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB. 1999. Characterization of fractalkine in rat brain cells: Migratory and activation signals for CX3CR-1-expressing microglia. J Immunol 163:1628-1635.
98. Maier SF, Goehler LE, Fleshner M, Watkins LR. 1998. The role of the vagus nerve in cytokine-to-brain communication. Ann NY Acad Sci 840:289-300.
99. Martino G, Furlan R, Brambilla E, Bergami A, Ruffini F, Gironi M, Poliani PL, Grimaldi LM, Comi G. 2000. Cytokines and immunity in multiple sclerosis: The dual signal hypothesis. J Neuroimmunol 109:3-9.
100. Mason JL, Suzuki K, Chaplin DD, Matsushima GK. 2001, Interleukin-1beta promotes repair of the CNS. J Neurosci 21:7046-7052.
101. McCann SM, Kimura M, Karanth S, Yu WH, Rettori V. 1997. Nitric oxide controls the hypothalamic-pituitary response to cytokines. Neuroimmunomodulation 4:98-106.
102. McGeer EG, McGeer PL. 1999. Brain inflammation in Alzheimer disease and the therapeutic implications. Curr Pharm Des 5:821-836.
103. McGeer PL, McGeer EG. 2001. Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22:799-809.
104. Meda L, Baron P, Scarlato G. 2001. Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins. Neurobiol Aging 22:885-893.
105. Mennicken F, Maki R, De Souza EB, Quirion R. 1999. Chemokines and chemokine receptors in the CNS: A possible role in neuroinflammation and patterning. Trends Pharmacol Sci 20:73-78.
106. Merrill JE, Benveniste EN. 1996. Cytokines in inflammatory brain lesions: Helpful and harmful. Trends Neurosci 19:331-338.
107. Merrill JE, Scolding NJ. 1999. Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease. Neuropathol Appl Neurobiol 25:435-458.
108. Mertsch K, Hanisch UK, Kettenmann H, Schnitzer J. 2001. Characterization of microglial cells and their response to stimulation in an organotypic retinal culture system. J Comp Neurol 431:217-227.
109. Meucci O, Fatatis A, Simen AA, Miller RJ. 2000. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci USA 97:8075-8080.
110. Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. 2000. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408:982-985.
111. Möller T, Hanisch UK, Ransom BR. 2000. Thrombin-induced activation of cultured rodent microglia. J Neurochem 75:1539-1547.
112. Mrak RE, Griffin WS. 2000. Interleukin-1 and the immunogenetics of Alzheimer disease. J Neuropathol Exp Neurol 59:471-476.
113. Nakajima K, Honda S, Tohyama Y, Imai Y, Kohsaka S, Kurihara T. 2001. Neurotrophin secretion from cultured microglia. J Neurosci Res 65:322-331.
114. Nau R, Bruck W. 2002. Neuronal injury in bacterial meningitis: Mechanisms and implications for therapy. Trends Neurosci 25:38-45.
115. Neumann H. 2001. Control of glial immune function by neurons. Glia 36:191-199.
116. Nicoll JA, Mrak RE, Graham DI, Stewart J, Wilcock G, MacGowan S, Esiri MM, Murray LS, Dewar D, Love S, Moss T, Griffin WS. 2000. Association of interleukin-1 gene polymorphisms with Alzheimer's disease. Ann Neurol 47:365-368.
117. Nishiyori A, Minami M, Ohtani Y, Takami S, Yamamoto J, Kawaguchi N, Kume T, Akaike A, Satoh M. 1998. Localization of fractalkine and CX3CR1 mRNAs in rat brain: Does fractalkine play a role in signaling from neuron to microglia? FEBS Lett 429:167-172.
118. O'Connor JJ, Coogan AN. 1999. Actions of the pro-inflammatory cytokine IL-1 beta on central synaptic transmission. Exp Physiol 84:601-614.
119. O'Garra A, Arai N. 2000. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 10:542-550.
120. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, Akita K, Namba M, Tanabe F, Konishi K, Fokuda S, Kurimoto M. 1995. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378:88-91.
121. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715-725.
122. Pahan K, Khan M, Singh I. 2000. Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine- induced ceramide production through the activation of phosphatidylinositol 3-kinase. J Neurochem 75:576-582.
123. Pahan K, Sheikh FG, Liu X, Hilger S, McKinney M, Petro TM. 2001. Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells. J Biol Chem 276:7899-7905.
124. Perry RT, Collins JS, Wiener H, Acton R, Go RC. 2001. The role of TNF and its receptors in Alzheimer's disease. Neurobiol Aging 22:873-883.
125. Petitto JM, McNamara RK, Gendreau PL, Huang Z, Jackson AJ. 1999. Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion. J Neurosci Res 56:441-446.
126. Priller J, Flugel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernandez-Klett F, Prass K, Bechmann I, de Boer BA, Frotscher M, Kreutzberg GW, Persons DA, Dirnagl U. 2001. Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment. Nat Med 7:1356-1361.
127. Prinz M, Hanisch UK, Kettenmann H, Kirchhoff F. 1998. Alternative splicing of mouse IL-15 is due to the use of an internal splice site in exon 5. Mol Brain Res 63:155-162.
128. Prinz M, Hanisch UK. 1999. Murine microglial cells produce and respond to interleukin-18. J Neurochem 72:2215-2218.
129. Prinz M, Kann O, Draheim HJ, Schumann RR, Kettenmann H, Weber JR, Hanisch UK. 1999. Microglial activation by components of Gram-positive and -negative bacteria: Distinct and common routes to the induction of ion channels and cytokines. J Neuropathol Exp Neurol 58:1078-1089.
130. Prinz M, Hausler KG, Kettenmann H, Hanisch U. 2001. β-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia. Brain Res 899:264-270.
131. Raivich G, Bluethmann H, Kreutzberg GW. 1996. Signaling molecules and neuroglial activation in the injured central nervous system. Keio J Med 45:239-247.
132. Raivich G, Bohatschek M, Kloss CU, Werner A, Jones LL, Kreutzberg GW. 1999a. Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev 30:77-105.
133. Raivich G, Jones LL, Werner A, Bluthmann H, Doetschmann T, Kreutzberg GW. 1999b. Molecular signals for glial activation: Pro- and anti-inflammatory cytokines in the injured brain. Acta Neurochit (Wien) 73(Suppl):21-30.
134. Ren L, Lubrich B, Biber K, Gebicke-Haerter PJ. 1999. Differential expression of inflammatory mediators in rat microglia cultured from different brain regions. Brain Res Mol Brain Res 65:198-205.
135. Rogers J, Lue LF. 2001. Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem Int 39:333-340.
136. Rossi D, Zlotnik A. 2000. The biology of chemokines and their receptors. Ann Rev Immunol 18:217-242.
137. Rothwell NJ, Hopkins SJ. 1995. Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci 18:130-136.
138. Rothwell NJ, Luheshi GN. 1996. Brain TNF: Damage limitation or damaged reputation? Nat Med 2:746-747.
139. Rothwell NJ. 1997. Cytokines and acute neurodegeneration. Mol Psychiatry 2:120-121.
140. Rothwell N, Allan S, Toulmond S. 1997. Perspectives series: cytokines and the brain. J Clin Invest 100:2648-2652.
141. Rothwell NJ, Luheshi GN. 2000. Interleukin 1 in the brain: Biology, pathology and therapeutic target. Trends Neurosci 23:618-625.
142. Sanz JM, Di Virgilio F. 2000. Kinetics and mechanism of ATP-dependent IL-1β release from microglial cells. J Immunol 164:4893-4898.
143. Sawada M, Suzumura A, Hosoya H, Marunouchi T, Nagatsu T. 1999. Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia. J Neurochem 72:1466-1471.
144. Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P. 1999. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-177.
145. Schneider H, Pitossi F, Balschun D, Wagner A, del Rey A, Besedovsky HO. 1998. A neuromodulatory role of interleukin-1β in the hippocampus. Proc Natl Acad Sci USA 95:7778-7783.
146. Schubert P, Morino T, Miyazaki H, Ogata T, Nakamura Y, Marchini C, Ferroni S. 2000. Cascading glia reactions: A common pathomechanism and its differentiated control by cyclic nucleotide signaling. Ann NY Acad Sci 903:24-33.
147. Schwaiger FW, Hager G, Raivich G, Kreutzberg GW. 1998. Cellular activation in neuroregeneration. Prog Brain Res 117:197-210.
148. Seto D, Kar S, Quirion R. 1997. Evidence for direct and indirect mechanisms in the potent modulatory action ofinterleukin-2 on the release of acetylcholine in rat hippocampal slices. Br J Pharmacol 120:1151-1157.
149. Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE. 2000. Four new members expand the interleukin-1 superfamily. J Biol Chem 275:1169-1175.
150. Smith ME, van-der MK, Somera FP. 1998. Macrophage and microglial responses to cytokines in vitro: Phagocytic activity, proteolytic enzyme release, and free radical production. J Neurosci Res 54:68-78.
151. Smith ME, Hoerner MT. 2000. Astrocytes modulate macrophage phagocytosis of myelin in vitro. J Neuroimmunol 102:154-162.
152. Stalder AK, Pagenstecher A, Yu NC, Kincaid C, Chiang CS, Hobbs MV, Bloom FE, Campbell IL. 1997. Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia. J Immunol 159:1344-1351.
153. Stohwasser R, Giesebrecht J, Kraft R, Müller E-C, Häusler KG, Kettenmann H, Hanisch UK, Kloetzel P-M. 2000. Biochemical analysis of proteasomes from microglia: Induction of immunoproteasomes by interferon-g and lipopolysaccharide. Glia 29:355-365.
154. Stoll G, Jander S. 1999. The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 58:233-247.
155. Stoll G, Jander S, Schroeter M. 2000. Cytokines in CNS disorders: Neurotoxicity versus neuroprotection. J Neural Transm 59(Suppl):81-89.
156. Streit WJ, Walter SA, Pennel NA. 2000a. Reactive microgliosis. Prog Neurobiol 57:563-581.
157. Streit WJ, Hurley SD, McGraw TS, Semple-Rowland SL. 2000b. Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration. J Neurosci Res 61:10-20.
158. Suzumura A, Sawada M, Itoh Y, Marunouchi T. 1994. Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression. J Neuroimmunol 53:209-218.
159. Suzumura A, Sawada M, Takayanagi T. 1998. Production of interleukin-12 and expression of its receptors by murine microglia. Brain Res 787:139-142.
160. Szczepanik AM, Funes S, Petko W, Ringheim GE. 2001. IL-4, IL-10 and IL-13 modulate Abeta(1-42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. J Neuroimmunol 113:49-62.
161. Takahashi S, Kapas L, Fang J, Krueger JM. 1999. Somnogenic relationships between tumor necrosis factor and interleukin-1. Am J Physiol 276:R1132-R1140.
162. Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M. 1999. Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science 286:2352-2355.
163. Taoufik Y, de Goer de Herve MG, Giron-Michel J, Durali D, Cazes E, Tardieu M, Azzarone B, Delfraissy JF. 2001. Human microglial cells express a functional IL-12 receptor and produce IL-12 following IL-12 stimulation. Eur J Immunol 31:3228-3239.
164. Thomas WE. 1999. Brain macrophages: On the role of pericytes and perivascular cells. Brain Res Brain Res Rev 31:42-57.
165. Tran EH, Prince EN, Owens T. 2000. IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 164:2759-2768.
166. Tringali G, Dello-Russo C, Preziosi P, Navarra P. 1998. Hypothalamic interleukin-1 in physiology and pathology. Toxicol Lett 102:295-299.
167. Vilcek J. 1998. The cytokines: An overview. In: Thomson A, editor. The Cytokine Handbook. San Diego: Academic Press. p 1-20.
168. Vitkovic L, Bockaert J, Jacque C. 2000. "Inflammatory" cytokines: Neuromodulators in normal brain? J Neurochem 74:457-471.
169. Ware CF, Santee S, Glass A. 1998. Tumor necrosis factor-related ligands and receptors. In: Thomson A, editor. The Cytokine Handbook. San Diego: Academic Press. p 549-592.
170. Wei R, Jonakait GM. 1999. Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL- 10, IL-11 and transforming growth factor-beta1 (TGF-beta1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia. J Neuroimmunol 95:8-18.
171. Wheeler RD, Culhane AC, Hall MD, Pickering-Brown S, Rothwell N, Luheshi GN. 2000. Detection of the interleukin 18 family in rat brain by RT-PCR. Mol Brain Res 77:290-293.
172. Wildbaum G, Youssef S, Grabie N, Karin N. 1998. Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. J Immunol 161:6368-6374.
173. Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN. 2000. Lymphoid/neuronal cell surface OX2 glyco-protein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13:233-242.
174. Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L. 2001. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med 7:612-618.
175. Yates SL, Burgess LH, Kocsis-Angle J, Antal JM, Dority MD, Embury PB, Piotrkowski AM, Brunden KR. 2000. Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. J Neurochem 74:1017-1025.
176. Zhang GX, Baker CM, Kolson DL, Rostami AM. 2000. Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis. Mult Scler 6:3-13.
177. Zhang M, Tracey KJ. 1998. Tumor necrosis factor. In: Thomson A, editor. The Cytokine Handbook. San Diego: Academic Press. p 517-548.
178. Zielasek J, Hartung HP. 1996. Molecular mechanisms of microglial activation. Adv Neuroimmunol 6:191-222.
179. Zujovic V, Benavides J, Vige X, Carter C, Taupin V. 2000. Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 29:305-315.