Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons

Neurochemistry International

Volumn 45, Issue 5, 2004, Pages 713-719

  Takadera, Tsuneo ^a   Shiraishi, Yoko ^a   Ohyashiki, Takao ^a  

^a HOKURIKU UNIVERSITY   (Japan)

Author keywords

Apoptosis; cAMP; Caspase 3; EP2; Hippocampal cells; Prostaglandin E2

Indexed keywords

BUTAPROST; CASPASE; CASPASE 3; CYCLOHEXIMIDE; CYCLOOXYGENASE 2; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; SULPROSTONE; BUCLADESINE; CASP3 PROTEIN, RAT; CYCLIC AMP; DRUG DERIVATIVE; PRIMER DNA; PROSTAGLANDIN E1; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FETUS; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL NUCLEUS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

ALPROSTADIL; ANIMALS; APOPTOSIS; BUCLADESINE; CASPASE 3; CASPASES; CELL NUCLEUS; CELLS, CULTURED; CYCLIC AMP; CYCLOHEXIMIDE; DINOPROSTONE; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HIPPOCAMPUS; NEURONS; PREGNANCY; PROTEIN SYNTHESIS INHIBITORS; RATS; RECEPTORS, PROSTAGLANDIN E; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 3042601107     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2004.02.005     Document Type: Article

References (26)

1. 2 prostanoid receptor subtypes. Eur. J. Pharmacol. 340:1997;227-241
2. Caggiano A.O., Kraig R.P. Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production. J. Neurochem. 72:1999;565-575
3. 2 signaling in hippocampal long-term synaptic plasticity. J. Neurophysiol. 87:2002;2851-2857
4. Coleman R.A., Smith W.L., Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46:1994;205-229
5. Dereski M.O., Chopp M., Knight R.A., Rodolosi L.C., Garcia J.H. The heterogeneous temporal evolution of focal ischemic neuronal damage in the rat. Acta Neuropathol. (Berl). 85:1993;327-333
6. Dichter M.A. Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation. Brain Res. 149:1978;279-293
7. Dirnagl U., Iadecola C., Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22:1999;391-397
8. Feschenko M.S., Stevenson E., Nairn A.C., Sweadner K.J. A novel cAMP-stimulated pathway in protein phosphatase 2A activation. J. Pharmacol. Exp. Ther. 302:2002;111-118
9. Furlan M., Marchal G., Viader F., Derlon J.M., Baron J.C. Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann. Neurol. 40:1996;216-226
10. Garcia J.H., Yoshida Y., Chen H., Li Y., Zhang Z.G., Lian J., Chen S., Chopp M. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am. J. Pathol. 142:1993;623-635
11. Glinghammar B., Inoue H., Rafter J.J. Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1. Carcinogenesis. 23:2002;839-845
12. Iadecola C., Niwa K., Nogawa S., Zhao X., Nagayama M., Araki E., Morham S., Ross M.E. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 98:2001;1294-1299
13. Kim S., Jee K., Kim D., Koh H., Chung J. Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J. Biol. Chem. 276:2001;12864-12870
14. Kuida K., Zheng T.S., Na S., Kuan C., Yang D., Karasuyama H., Rakic P., Flavell R.A. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 384:1996;368-372
15. Kurosu K., Saeki M., Kamisaki Y. Formation of high molecular weight caspase-3 complex in neonatal rat brain. Neurochem. Int. 44:2004;199-204
16. Maillet M., Robert S.J., Cacquevel M., Gastineau M., Vivien D., Bertoglio J., Zugaza J.L., Fischmeister R., Lezoualc'h F. Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha. Nat. Cell Biol. 5:2003;633-639
17. 2 to mice. Br. J. Pharmacol. 112:1994;735-740
18. Moon E.Y., Lerner A. PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A. Blood. 101:2003;4122-4130
19. Nakayama M., Uchimura K., Zhu R.L., Nagayama T., Rose M.E., Stetler R.A., Isakson P.C., Chen J., Graham S.H. Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc. Natl. Acad. Sci. U.S.A. 95:1998;10954-10959
20. Namba T., Sugimoto Y., Negishi M., Irie A., Ushikubi F., Kakizuka A., Ito S., Ichikawa A., Narumiya S. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature. 365:1993;166-170
21. Narumiya S., Sugimoto Y., Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79:1999;1193-1226
22. Nogawa S., Zhang F., Ross M.E., Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J. Neurosci. 17:1997;2746-2755
23. Rami A., Jansen S., Giesser I., Winckler J. Post-ischemic activation of caspase-3 in the rat hippocampus: evidence of an axonal and dendritic localisation. Neurochem. Int. 43:2003;211-223
24. Takadera T., Matsuda I., Ohyashiki T. Apoptotic cell death and caspase-3 activation induced by N-methyl-D-aspartate receptor antagonists and their prevention by insulin-like growth factor I. J. Neurochem. 73:1999;548-556
25. Takadera T., Shimada Y., Mohri T. Extracellular pH modulates N-methyl-D-aspartate receptor-mediated neurotoxicity and calcium accumulation in rat cortical cultures. Brain Res. 572:1992;126-131
26. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron. 11:1993;371-386