Up-regulated production and activation of the complement system in Alzheimer's disease brain

American Journal of Pathology

Volumn 154, Issue 3, 1999, Pages 927-936

  Yasojima, Koji ^a   Schwab, Claudia ^a   McGeer, Edith G ^a   McGeer, Patrick L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3D; COMPLEMENT COMPONENT C4D; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C6; COMPLEMENT COMPONENT C7; COMPLEMENT COMPONENT C8; COMPLEMENT COMPONENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; MESSENGER RNA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENILE PLAQUE; TEMPORAL LOBE;

EID: 0033061855     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65340-0     Document Type: Article

References (35)

1. Eikelenboom P, Stam FC: Immunoglobulins and complement factors in senile plaques: an immunoperoxidase study. Acta Neuropathol 1982, 57:239-242
2. Eikelboom P, Hack CE, Rozemuller JM, Stam FC: Complement activation in amyloid plaques in Alzheimer's dementia. Arch Cell Pathol 1989, 56:259-262
3. Ishii T, Haga S: Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques. Acta Neuropathol (Berl) 1984, 63:296-300
4. McGeer PL, Akiyama H, Itagaki S, McGeer EG: Immune system response in Alzheimer's disease. Can J Neurol Sci 1989, 16:516-527
5. McGeer PL, McGeer EG: The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 1995, 21:195-218
6. Rogers J, Cooper NR, Webster S, Schultz J, McGeer PL, Styren S, Civin WH, Brachova L, Bradt B, Ward P, Lieberburg I: Complement activation by β-amyloid in Alzheimer disease. Proc Natl Acad Sci USA 1992, 89:10016-10020
7. Barnum SR: Complement biosynthesis in the central nervous system. Crit Rev Oral Biol Med 1995, 6:132-146
8. Gasque P, Fontane M, Morgan BP: Complement expression in human brain: biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J Immunol 1995, 154:4726-4733
9. Shen Y, Sullivan T, Lee CM, Meri S, Shiosaka K, Lin CW: Induced expression of neuronal membrane attack complex and cell death by Alzheimer's β-amyloid peptide. Brain Res 1998, 796:187-197
10. Walker DG, McGeer PL: Complement gene expression in neuroblastoma and astrocytoma cell lines of human origin. Neurosci Lett 1993, 157:99-102
11. Walker DG, Kim SU, McGeer PL: Complement and cytokine gene expression in cultured microglia derived from postmortem human brains. J Neurosci Res 1995, 40:478-493
12. Singhrao SK, Neal JW, Gasque P, Morgan BP, Newman GR: Role of complement in the aetiology of Pick's disease. J Neuropathol Exp Neurol 1996, 55:578-593
13. Terai K, Walker DG, McGeer EG, McGeer PL: Neurons express proteins of the classical complement pathway in Alzheimer disease. Brain Res 1997, 769:385-390
14. Shen Y, Li R, McGeer EG, McGeer PL: Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain. Brain Res 1997, 769:391-395
15. Johnson SA, Lampert-Etchells M, Pasinetti GM, Rozovsky I, Finch CE: Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning. Neurobiol Aging 1992, 13:641-648
16. Yasojima K, Schwab C, McGeer EG, McGeer PL: Human heart generates complement proteins which are upregulated and activated following myocardial infarction. Circ Res 1998 83:860-869
17. Nakayama H, Yokoi H, Fujita J: Quantification of mRNA by non-radioactive RT-PCR and CCD imaging system. Nucleic Acids Res 1992, 20:4939
18. Takahashi M, Yamada T, Tooyama I, Moroo I, Kimura H, Yamamoto T, Okada H: Insulin receptor mRNA in the substantia nigra in Parkinson's disease. Neurosci Lett 1996, 204:201-204
19. Lowry OH, Rosebrough NJ, Farr AL, Randall EJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275
20. Holm S: A simple sequentially repetitive multiple test procedure. Scand J Statist 1979, 6:65-70
21. Walker DG, McGeer PL: Complement gene expression in human brain: comparison between normal and Alzheimer disease cases. Mol Brain Res 1992, 14:109-116
22. Brachova L, Lue L-F, Schultz J, Rashidy TE, Rogers J: Association cortex, cerebellum and serum concentration of C1q and factor B in Alzheimer's disease. Mol Brain Res 1993, 18:329-334
23. Afagh A, Cummings BJ, Cribbs DH, Cotman CW, Tenner AJ: Localization and cell association of C1q in Alzheimer's disease brain. Exp Neurol 1996, 138:22-32
24. Webster S, Lue L-F, Brachova L, Tenner AJ, McGeer PL, Terai K, Walker DG, Bradt B, Cooper NR, Rogers J: Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease. Neurobiol Aging 1997, 18:415-421
25. Yasojima K, Kilgore KS, Washington RA, Lucchesi BR, McGeer PL: Complement gene expression by rabbit heart: upregulation by ischemia and reperfusion. Circ Res 1998, 82:1224-1230
26. Kalaria RN, Galloway PG, Perry G: Widespread amyloid P component immunoreactivity in cortical amyloid deposits and the neurofibrillary pathology of Alzheimer's disease and other degenerative disorders. Neuropathol Appl Neurobiol 1991, 17:189-201
27. Coria F, Castano E, Prelli F, Larrondo-Lillo M, Van Duinen S, Shelanski ML, Frangione B: Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. Lab Invest 1988, 58:454-458
28. Duong T, Pommier EC, Schiebel AB: Immunodetection of the amyloid P component in Alzheimer's disease Acta Neuropathol 1989, 78: 429-437
29. Akiyama H, Yamada T, Kawamata T, McGeer PL: Association of amyloid P component with complement proteins in neurologically diseased tissue. Brain Res 1991, 548:349-352
30. Iwamoto N, Nihiyama E, Ohwada J, Arai H: Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections. Neurosci Lett 1994, 177:23-26
31. Yasuhara O, Walker DG, McGeer PL: Hageman factor and its binding sites are present in senile plaques of Alzheimer's disease. Brain Res 1994, 654:234-240
32. Schwab C, Steele JC, McGeer EG, McGeer PL: Amyloid P immunoreactivity precedes C4d deposition on extracellular neurofibrillary tangles. Acta Neuropathol 1997, 93:87-91
33. McGeer PL, Schulzer M, McGeer EG: Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiological studies. Neurology 1996, 47:425-432
34. Stewart WF, Kawas C, Corrada M, Metter EJ: Risk of Alzheimer's disease and duration of NSAID use. Neurology 1997, 48:626-632
35. Rogers J, Kirby LC, Hempelman SR, Berry DL, McGeer PL, Kaszniak AW, Zalinski J, Cofield M, Mansukhani L, Willson P, Kogan F: Clinical trial of indomethacin in Alzheimer's disease. Neurology 1993, 43: 1609-1611