Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain

Acta Neuropathologica

Volumn 101, Issue 1, 2001, Pages 2-8

  Hoozemans, J J M ^a   Rozemuller, A J M ^c   Janssen, I ^a   De Groot, C J A ^a   Veerhuis, R ^a   Eikelenboom, P ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Alzheimer's disease; Cyclooxygenase 1; Cyclooxygenase 2; Microglia; Neurons

Indexed keywords

AMYLOID BETA PROTEIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BRAIN; BRAIN NERVE CELL; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DEMENTIA; ENZYME ACTIVATION; EPIDEMIOLOGY; FRONTAL CORTEX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MICROGLIA; NEUROBLASTOMA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; RISK; TEMPORAL CORTEX;

EID: 0035141118     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010000251     Document Type: Article

References (49)

1. 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
2. Inflammatory mechanisms in Alzheimer's disease: Implications for therapy
3. Microglia, amyloid and dementia
4. 2-macroglobulin indicate an acute phase state in Alzheimer's disease cortices
5. Expression and regulation of cyclooxygenase-2 in rat microglia
6. Mechanisms of inflammation in Alzheimer's disease
7. 2
8. Staging of Alzheimer's disease-related neurofibrillary changes
9. New epidemiologic strategies in Alzheimer's disease may provide clues to prevention and cause
10. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease
11. Cholinergic agonists and interleukin-1 regulate processing and secretion of the β/A4 amyloid protein precursor
12. Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: Immunophenotypical and functional characterization
13. Isolation and characterization of adult microglial cell cultures derived from postmortem human brains
14. Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo
15. Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures
16. Immunoglobulins and complement factors in senile plaques
17. 1-antichymotrypsin in cerebral β/A4 deposits in Alzheimer's disease
18. Inflammatory mechanisms in Alzheimer's disease
19. 2 induces interleukin-6 synthesis in human astrocytoma cells
20. Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer's disease
21. Amyloid β peptide potentiates cytokine secretion by interleukin-1β-activated human astrocytoma cells
22. Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells
23. Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution
24. Interleukin-1 injected in mammalian brain stimulates astrogliosis and neurovascularization
25. Prostaglandin synthase 2
26. Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients
27. Interleukin-6-associated inflammatory processes in Alzheimer's disease: New therapeutic options
28. Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor
29. 2 stimulates amyloid precursor protein gene expression: Inhibition by immunosuppressants
30. The inflammatory response system of brain: Implications for therapy of Alzheimer's disease and other neurodegenerative diseases
31. Anti-inflammatory drugs and Alzheimer's disease
32. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
33. Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenases
34. 2 by human cultured astroglial cells
35. Different intracellular locations for prostaglandin endoperoxide H synthase 1 and -2
36. Interleukin-1-β induces prostaglandin G/H synthase 2 (cyclooxygenase-2) in primary murine astrocyte cultures
37. Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: Specific localization in affected neurones and axons
38. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
39. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
40. Activated microglia and cerebral amyloid deposits in Alzheimer's disease
41. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
42. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2
43. Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6-mediated 'acute phase response' in the brain?
44. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
45. Cyclooxygenase 1 and 2
46. Do non-steroidal anti-inflammatory drugs (NSAID's) have a protective effect against dementia?
47. Amyloid β protein (Aβ) primes cultured rat microglial cells for an enhanced phorbol-myristate-acetate induced respiratory burst activity
48. Complement and cytokine gene expression in cultured microglia derived from post-mortem human brains
49. 2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations