Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism

GLIA

Volumn 16, Issue 3, 1996, Pages 276-284

  Chao, Chun C ^a,c   Hu, Shuxian ^a   Sheng, Wen S ^a   Bu, Dingfang ^a   Bukrinsky, Michael I ^b   Peterson, Phillip K ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b PICOWER INST FOR MEDICAL RESEARCH   (United States)

^c MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Interleukin 1; Interleukin 1 receptor antagonist protein; Neurotoxicity

Indexed keywords

CYTOKINE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECOMBINANT PROTEIN;

ARTICLE; ASTROCYTE; CELL CULTURE; ENZYME INDUCTION; FETUS; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NERVE CELL; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY;

ASTROCYTES; BASE SEQUENCE; CELLS, CULTURED; CYTOKINES; ENZYME INDUCTION; FETUS; HUMANS; MOLECULAR SEQUENCE DATA; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 0030108525     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199603)16:3<276::AID-GLIA10>3.0.CO;2-X     Document Type: Article

References (37)

1. Araujo, D.M. and Cotman, C.W. (1992) β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res., 569:141-145.
2. Boje, K.M. and Arora, P.K. (1992) Microglia-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res., 587:250-256.
3. Brosnan, C.F., Battistina, L., Raine, C.S., Dickson, D.W., Casadevall, A., and Lee, S.C. (1994) Reactive nitrogen intermediates in human neuropathology: An overview. Dev. Neurosci., 16:152-161.
4. Bukrinsky, M.I., Nottet, H.S.L.M., Schmidtmayerova, H., Dubrovsky, L., Mullins, M.E., Lipton, S.A., and Gendelman, H.E. (1995) Regulation of nitric oxide synthase in HIV-1-infected monocytes: Implications for HIV-associated neurological disease. J. Exp. Med., 181: 735-745.
5. Chao, C.C., Hu, S., Molitor, T.W., Shaskan, E.G., and Peterson, P.K. (1992a) Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol., 149:2736-2741
6. Chao, C.C., Hu, S., Tsang, M., Weatherbee, J., Molitor, T.W., Anderson, W.R., and Peterson, P.K. (1992b) Effects of transforming growth factor-β on murine astrocyte glutamine synthetase activity: Implications in neuronal injury. J. Clin. Invest., 90:1786-1793.
7. Chao, C.C., Hu, S , Kravitz, F.H., Tsang, M., Anderson, W.R., and Peterson, P.K. (1994) Transforming growth factor-β protects human neurons against β-amyloid-induced injury. Mol. Chem. Neuropathol., 23:159-178.
8. Chao, C.C., Hu, S., and Peterson, P.K. (1995) Glia, cytokines, and neurotoxicity. Crit. Rev. Neurobiol., 9:189-205
9. Dawson, T.M., Dawson, V.L., and Snyder, S.H. (1992) A novel neuronal messenger molecule in brain: The free radical, nitric oxide. Ann. Neurol., 32:297-311.
10. Dickson, D.W , Mattiace, L.A., Kure, K., Hutchins, K., Lyman, W.D., and Brosnan, C.F. (1991) Microglia in human disease, with an emphasis on acquired immune deficiency syndrome. Lab. Invest., 64:135-156.
11. Dickson, D.W., Lee, S.C., Hatch, W., Mattiace, L.A., Brosnan, C.F., and Lyman, W.D. (1994) Macrophages and microglia in HIV-related CNS neuropathology. In: HIV, AIDS and the Brain R.W. Price and S.W. Perry, eds. Raven Press, New York, pp. 99-118.
12. Dinarello, C.A. and Thompson, R C. (1991) Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro. Immunol. Today, 12:404-410.
13. Eddleston, M. and Mucke, L. (1993) Molecular profile of reactive astrocytes - implications for their role in neurologic disease. Neuroscience, 54:15-36.
14. Fisher, S.N., Kim, Y.-U., and Shin, M L. (1994) Tyrosine kinase activation by newcastle disease virus is required for TNF-α gene induction in astrocytes. J. Immunol., 153:3210-3217.
15. Geller, D.A., Lowenstein, C.J., Shapiro, R.A., Nussler, A.K., Di Silvio, M., Wang, S.C., Nakayama, D.K., Simmons, R.L., Snyder, S.H., and Billiar, T.R. (1993) Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl Acad. Sci. USA, 90:3491-3495.
16. Giulian, D., and Lachman, L.B. (1985) Interleukin-1 stimulation of astroglial proliferation after brain injury. Science, 228:497-500.
17. Hannum, C.H., Wilcox, C.J., Arend, W.P., Joslin, F.G., Dripps, D.J., Heimdal, P.L., Armes, L.G., Sommer, A., Eisenberg, S.P., and Thompson, R.C. (1990) Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature, 343:336-346.
18. Hokari, A., Zeniya, M., and Esumi, H. (1994) Cloning and functional expression of human inducible nitric oxide synthase (NOS) cDNA from a glioblastoma cell line A-172. J. Biochem., 116:575-581.
19. Hu, J., and El-Fakahany, E.E. (1993) β-Amyloid 25-35 activates nitric oxide synthase in a neuronal clone. Neuroreport, 4:760-762.
20. Lee, S.C , Dickson, D.W., Liu, W., and Brosnan, C.F. (1993a) Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-gamma. J. Neuroimmunol., 46:19-24.
21. Lee, S.C., Liu, W, Dickson, D.W., Brosnan, C.F., and Berman, J.W. (1993b) Cytokine production by human fetal microglia and astrocytes: Differential induction by lipopolysaccharide and IL-1β. J Immunol., 150:2659-2667.
22. Lee, S.C., Dickson, D.W., Brosnan, C.F., and Casadevall, A. (1994) Human astrocytes inhibit Cryptococcus neoformans growth by a nitric oxide-mediated mechanism. J. Exp. Med., 180:365-369.
23. Merrill, J.E. and Chen, I.S.Y. (1991) HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease. FASEB J., 5: 2391-2397.
24. Murphy, S., Simmons, M.L., Aqullo, L., Garcia, A., Feinstein, D.L., Galea, E., Reis, D.J., Minc-Golomb, D., and Schwartz, J.P. (1993) Synthesis of nitric oxide in CNS glial cells. Trends Neurosci., 10:323-328.
25. Nathan, C.F and Hibbs, J.B., Jr. (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol., 3:65-70.
26. Nedergaard, M. (1994) Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science, 263:1768-1771.
27. Norris, J.G., Tang, L.-P., Sparacio, S.M., and Benveniste, E.N. (1994) Signal transduction pathways mediating astrocyte IL-6 induction by IL-1β and tumor necrosis factor-α. J. Immunol., 152:841-850.
28. Parpura, V., Bassarsky, T.A., Liu, F., Jeftinija, K., Jeftinija, S., and Haydon, P.G. (1994) Glutamate-mediated astrocyte-neuron signalling. Nature, 369:744-747.
29. Peterson, P.K., Hu, S., Anderson, W.R., and Chao, C.C. (1994) Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain. J Infect. Dis., 170:457-460.
30. Peterson, P.K., Gekker, G., Hu, S., and Chao, C.C. (1995) Human astrocytes inhibit intracellular multiplication of Toxoplasma gondii by a nitric oxide-mediated mechanism. J. Infect. Dis., 171:516-518.
31. Reiner, N.E. (1994) Altered cell signaling and mononuclear phagocyte deactivation during intracellular infection. Immunol. Today, 15: 374-381.
32. Relton, J.K. and Rothwell, N.J. (1992) Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res. Bull., 29:243-246.
33. Rogers, J., Luber-Nardo, J., Styren, S.D., and Civin, W.H. (1988) Expression of immune system-associated antigens by cells of the central nervous system: Relationship to the pathology of Alzheimer's disease. Neurobiol. Aging, 9:339-349.
34. Schmidt, H.H.H.W., Hofmann, H., Ogilvie, P., Sennefelder, H., and Weinberg, R.J. (1994) Biochemistry and regulation of nitric oxide synthase. In: Nitric Oxide. H. Takagi, N. Toda, and R.D. Hawkins, eds. CRC Press, Boca Raton, pp. 3-18.
35. Sebire, G., Emilie, D., Wallon, C., Hery, C., Devergne, O., Delfraissy, J.-F., Galanaud, P., and Tardieu, M. (1993) In vitro production of IL-6, IL-1β, and tumor necrosis factor-α by human embryonic microglial and neural cells. J. Immunol., 150:1517-1523.
36. Spencer, D.C. and Price, R.W. (1992) Human immunodeficiency virus and the central nervous system. Annu. Rev. Microbiol., 46:655-693.
37. Zheng, Y.M., Schafer, M.H.-H., Ehihe, E., Sheng, H., Corisdeo, S., Fu, Z.F., Koprowski, H., and Dietzschold, B. (1993) Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase. J. Virol., 67:5786-5791.