Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs

Brain Research

Volumn 830, Issue 2, 1999, Pages 226-236

  Yasojima, Koji ^a   Schwab, Claudia ^a   McGeer, Edith G ^a   McGeer, Patrick L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Heart; Inflammation; Intestine; Kidney; Liver; Neuron; Polymerase chain reaction; Spleen

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN H2;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMALE; GENE LOCATION; HEART; HOMEOSTASIS; HOUSEKEEPING GENE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTESTINE; KIDNEY; LIVER; MALE; NERVE FUNCTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SPLEEN; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; BRAIN CHEMISTRY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HUMANS; INTESTINES; ISOENZYMES; KIDNEY; LIVER; MEMBRANE PROTEINS; MIDDLE AGED; MYOCARDIUM; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN;

EID: 0033526660     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01389-X     Document Type: Article

References (36)

1. Adams J., Collaco-Moraes Y., de Belleroche J. Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. J. Neurochem. 66:1996;6-13.
2. Cao C., Matsumura K., Yamagata K., Watanabe Y. Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res. 697:1995;187-196.
3. Chang J.W., Coleman P.D., O'Banion M.K. Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. Neurobiol. Aging. 17:1996;801-808.
4. Crofford L.J. COX-1 and COX-2 tissue expression: implications and predictions. J. Rheumatol. 24:1997;15-19. suppl. 49.
5. Dinchuk J.E., Car B.D., Focht R.J., Johnston J.J., Jaffee B.D., Covington M.B., Contel N.R., Eng V.M., Collins R.J., Czerniak P.M., Gorry S.A., Trzaskos J.M. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 378:1995;406-409.
6. Hara K., Kong D.L., Sharp F.R., Weinstein P.R. Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats. Neurosci. Lett. 256:1998;53-56.
7. Ho L., Osaka H., Aisen P.s., Pasinetti G.M. Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death. J. Neuroimmunol. 89:1998;142-149.
8. Holm S. A simple sequentially repetitive multiple test procedure. Scand. J. Stat. 6:1979;65-70.
9. Inoue H., Yokoyama C., Hara S., Tone Y., Tanabe T. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. J. Biol. Chem. 270:1995;24965-24971.
10. Ichitani Y., Shi T., Haeggstrom J.Z., Samuelsson B., Hokfelt T. Increased levels of cyclooxygenase-2 mRNA in the rat spinal cord after peripheral inflammation: an in situ hybridization study. NeuroReport. 8:1997;2949-2952.
11. Kaufmann W.E., Worley R.F., Pegg J., Bremer M., Isakson P. COX-2, a synaptically induced exzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. U.S.A. 93:1996;2317-2321.
12. Kaufmann W.E., Worley P.F., Taylor C.V., Bremer M., Isakson P.C. Cyclooxygenase-2 expression during rat neocortical development and in Rett syndrome. Brain Develop. 19:1997;25-34.
13. 2α on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro. Brain Res. 330:1985;235-244.
14. Langenbach R., Morham S.G., Tiano H.F., Loftin C.D., Ghanayem B.I., Chulada P.C., Mahler J.F., Lee C.A., Goulding E.H., Kluckman K.D., Kim H.S., Smithies O. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 83:1995;483-492.
15. Lukiw W.J., Bazan N.G. Strong nuclear factor-κB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J. Neurosci. Res. 53:1998;583-592.
16. Masferrer J.L., Zweifel B.S., Manning P.T., Hauser S.D., Leahy K.M., Smith W.G., Isakson P.C., Seibert K. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. U.S.A. 91:1994;3228-3232.
17. Mackenzie I.R.A., Munoz D.G. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology. 50:1998;986-990.
18. McGeer P.L., McGeer E.G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev. 21:1995;195-218.
19. McGeer P.L., Schulzer M., McGeer E.G. Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiological studies. Neurology. 47:1996;425-432.
20. Morham S.G., Langebach R., Loftin C.D., Tiano H.F., Vouloumanos N., Jennette J.C., Mahler J.F., Kluckman K.D., Ledford A., Lee C.A., Smithies O. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell. 83:1995;473-482.
21. Morris J.K., Richards J.S. An E-box region within the prostaglandin endoperoxide synthase-2 (PGS-2) promoter is required for transcription in rat ovarian granulosa cells. J. Biol. Chem. 271:1996;16633-16643.
22. Oka A., Takashima S. Induction of cyclooxygenase-2 in brains of patients with Down's syndrome and dementia of the Alzheimer type: specific localization in affected neurones. NeuroReport. 8:1997;1161-1164.
23. Pasinetti G.M. Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions. J. Neurosci. Res. 54:1998;1-6.
24. Pasinetti G.M., Aisen P.S. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience. 87:1998;319-324.
25. Planas A.M., Soriano M.A., Rodriguez-Farre E., Ferrer I. Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain. Neurosci. Lett. 200:1995;187-190.
26. Quan N., Whiteside M., Herkenham M. Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide. Brain Res. 802:1998;189-197.
27. Rogers J., Kirby L.C., Hempelman S.R., Berry D.L., McGeer P.L., Kaszniak A.W., Zalinski J., Cofield M., Mansukhani L., Willson P., Kogan F. Clinical trial of indomethacin in Alzheimer's disease. Neurology. 43:1993;1609-1611.
28. Smith W.L., Garavito R.M., DeWitt D.L. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J. Biol. Chem. 271:1996;33157-33160.
29. Terai K., Walker D.C., McGeer E.G., McGeer P.L. Neurons express proteins of the classical complement pathway in Alzheimer disease. Brain Res. 769:1997;385-390.
30. Tocco G., Freire-Moar J., Schreiber S.S., Sakhi S.H., Aisen P.S., Pasinetti G.M. Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease. Exp. Neurol. 144:1997;339-349.
31. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, New Biol. 231:1971;232-235.
32. Xie W., Herschman H.R. v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J. Biol. Chem. 270:1995;27622-27628.
33. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron. 11:1993;371-386.
34. Yamamoto K., Arakawa T., Ueda N., Yamamoto S. Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumour necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270:1995;31315-31320.
35. Yasojima K., Kilgore K.S., Washington R.A., Lucchesi B.R., McGeer P.L. Complement gene expression by rabbit heart: upregulation by ischemia and reperfusion. Circ. Res. 82:1998;1224-1230.
36. Yasojima K., Schwab C., McGeer E.G., McGeer P.L. Human heart generates complement proteins that are upregulated and activated after myocardial infarction. Circ. Res. 83:1998;860-869.