메뉴 건너뛰기




Volumn 5, Issue 10, 2004, Pages 1045-1050

Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance

Author keywords

Fibrates; Glucose disposal; Hepatic glucose production; Insulin resistance; PPARs; Thiazolidinediones

Indexed keywords

ANTIDIABETIC AGENT; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

EID: 16644381634     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (35)

References (48)
  • 1
    • 5444269110 scopus 로고    scopus 로고
    • The cellular fate of glucose and its relevance in type 2 diabetes
    • doi:10.1210/er.2003-0026
    • Bouche C, Serdy S, Kahn CR, Goldfine AB: The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev (2004): doi:10.1210/er.2003-0026.
    • (2004) Endocr Rev
    • Bouche, C.1    Serdy, S.2    Kahn, C.R.3    Goldfine, A.B.4
  • 2
    • 0034713444 scopus 로고    scopus 로고
    • Roles of PPARs in health and disease
    • Kersten S, Desvergne B, Wahli W: Roles of PPARs in health and disease. Nature (2000) 405(6785):421-424.
    • (2000) Nature , vol.405 , Issue.6785 , pp. 421-424
    • Kersten, S.1    Desvergne, B.2    Wahli, W.3
  • 3
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • Evans RM, Barish GD, Wang YX: PPARs and the complex journey to obesity. Nat Med (2004) 10(4):355-361.
    • (2004) Nat Med , vol.10 , Issue.4 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.X.3
  • 4
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W: Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocr Rev (1999) 20(5):649- 688.
    • (1999) Endocr Rev , vol.20 , Issue.5 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 5
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem (1995) 270(22):12953-12956.
    • (1995) J Biol Chem , vol.270 , Issue.22 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 6
    • 0034801882 scopus 로고    scopus 로고
    • Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, Desvergne B: Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology (2001) 142(10):4195-4202.
    • Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, Desvergne B: Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology (2001) 142(10):4195-4202.
  • 7
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat
    • Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology (1996) 137(1):354-366.
    • (1996) Endocrinology , vol.137 , Issue.1 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 11
    • 0034666157 scopus 로고    scopus 로고
    • Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
    • Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, Gonzalez FJ, Desvergne B, Wahli W: Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem (2000) 275(37):28488-28493.
    • (2000) J Biol Chem , vol.275 , Issue.37 , pp. 28488-28493
    • Kersten, S.1    Mandard, S.2    Tan, N.S.3    Escher, P.4    Metzger, D.5    Chambon, P.6    Gonzalez, F.J.7    Desvergne, B.8    Wahli, W.9
  • 12
    • 0035091701 scopus 로고    scopus 로고
    • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
    • Way JM, Harrington WW, Brown KK, Gottschalk WK, Sundseth SS, Mansfield TA, Ramachandran RK, Wllson TM, Kliewer SA: Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology (2001) 142(3):1269-1277.
    • (2001) Endocrinology , vol.142 , Issue.3 , pp. 1269-1277
    • Way, J.M.1    Harrington, W.W.2    Brown, K.K.3    Gottschalk, W.K.4    Sundseth, S.S.5    Mansfield, T.A.6    Ramachandran, R.K.7    Wllson, T.M.8    Kliewer, S.A.9
  • 14
    • 0032905885 scopus 로고    scopus 로고
    • The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects
    • Chen X, Iqbal N, Boden G: The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J Clin Invest (1999) 103(3):365-372.
    • (1999) J Clin Invest , vol.103 , Issue.3 , pp. 365-372
    • Chen, X.1    Iqbal, N.2    Boden, G.3
  • 15
    • 0029861999 scopus 로고    scopus 로고
    • Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs
    • Rebrin K, Steil GM, Mittelman SD, Bergman RN: Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest (1996) 98(3):741-749.
    • (1996) J Clin Invest , vol.98 , Issue.3 , pp. 741-749
    • Rebrin, K.1    Steil, G.M.2    Mittelman, S.D.3    Bergman, R.N.4
  • 17
    • 0036797450 scopus 로고    scopus 로고
    • A futile metabolic cycle activated in adipocytes by antidiabetic agents
    • Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA: A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med (2002) 8(10):1122-1128.
    • (2002) Nat Med , vol.8 , Issue.10 , pp. 1122-1128
    • Guan, H.P.1    Li, Y.2    Jensen, M.V.3    Newgard, C.B.4    Steppan, C.M.5    Lazar, M.A.6
  • 21
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM: Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA (2003) 100(26):15712-15717.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.26 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3    Olson, P.4    Liao, D.5    Le, J.6    Nelson, M.7    Ong, E.8    Olefsky, J.M.9    Evans, R.M.10
  • 26
    • 0346003777 scopus 로고    scopus 로고
    • Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression
    • Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, Rao MS, Gonzalez FJ, Reddy JK: Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression. J Biol Chem (2003) 278(1):498-505.
    • (2003) J Biol Chem , vol.278 , Issue.1 , pp. 498-505
    • Yu, S.1    Matsusue, K.2    Kashireddy, P.3    Cao, W.Q.4    Yeldandi, V.5    Yeldandi, A.V.6    Rao, M.S.7    Gonzalez, F.J.8    Reddy, J.K.9
  • 29
    • 0033766035 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor-γ (PPARγ) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes
    • Mukherjee R, Hoener PA, Jow L, Bilakovics J, Klausing K, Mais DE, Faulkner A, Croston GE, Paterniti JR Jr: A selective peroxisome proliferator-activated receptor-γ (PPARγ) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes. Mol Endocrinol (2000) 14(9):1425-1433.
    • (2000) Mol Endocrinol , vol.14 , Issue.9 , pp. 1425-1433
    • Mukherjee, R.1    Hoener, P.A.2    Jow, L.3    Bilakovics, J.4    Klausing, K.5    Mais, D.E.6    Faulkner, A.7    Croston, G.E.8    Paterniti Jr, J.R.9
  • 31
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
    • Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W: Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J Clin Invest (1999) 103(11):1489-1498.
    • (1999) J Clin Invest , vol.103 , Issue.11 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 33
    • 1542335555 scopus 로고    scopus 로고
    • Hepatic de novo synthesis of glucose 6-phosphate is not affected in peroxisome proliferator-activated receptor α-deficient mice but is preferentially directed toward hepatic glycogen stores after a short term fast
    • Bandsma RH, Van Dijk TH, Harmsel At A, Kok T, Reijngoud DJ, Staels B, Kuipers F: Hepatic de novo synthesis of glucose 6-phosphate is not affected in peroxisome proliferator-activated receptor α-deficient mice but is preferentially directed toward hepatic glycogen stores after a short term fast. J Biol Chem (2004) 279(10):8930-8937.
    • (2004) J Biol Chem , vol.279 , Issue.10 , pp. 8930-8937
    • Bandsma, R.H.1    Van Dijk, T.H.2    Harmsel, A.A.3    Kok, T.4    Reijngoud, D.J.5    Staels, B.6    Kuipers, F.7
  • 38
    • 0041820128 scopus 로고    scopus 로고
    • Differential influences of peroxisome proliferator-activated receptors-γ and -α on food intake and energy homeostasis
    • Larsen PJ, Jensen PB, Sorensen RV, Larsen LK, Vrang N, Wulff EM, Wassermann K: Differential influences of peroxisome proliferator-activated receptors-γ and -α on food intake and energy homeostasis. Diabetes (2003) 52(9):2249-2259.
    • (2003) Diabetes , vol.52 , Issue.9 , pp. 2249-2259
    • Larsen, P.J.1    Jensen, P.B.2    Sorensen, R.V.3    Larsen, L.K.4    Vrang, N.5    Wulff, E.M.6    Wassermann, K.7
  • 39
    • 0042822095 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-α activation prevents diabetes in OLETF rats: Comparison with PPAR-γ activation
    • Koh EH, Kim MS, Park JY, Kim HS, Youn JY, Park HS, Youn JH, Lee KU: Peroxisome proliferator-activated receptor (PPAR)-α activation prevents diabetes in OLETF rats: Comparison with PPAR-γ activation. Diabetes (2003) 52(9):2331-2337.
    • (2003) Diabetes , vol.52 , Issue.9 , pp. 2331-2337
    • Koh, E.H.1    Kim, M.S.2    Park, J.Y.3    Kim, H.S.4    Youn, J.Y.5    Park, H.S.6    Youn, J.H.7    Lee, K.U.8
  • 42
    • 0035800338 scopus 로고    scopus 로고
    • Regulation of p85α phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells
    • Rieusset J, Roques M, Bouzakri K, Chevillotte E, Vidal H: Regulation of p85α phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells. FEBS Lett (2001) 502(3):98-102.
    • (2001) FEBS Lett , vol.502 , Issue.3 , pp. 98-102
    • Rieusset, J.1    Roques, M.2    Bouzakri, K.3    Chevillotte, E.4    Vidal, H.5
  • 43
    • 0037025390 scopus 로고    scopus 로고
    • WY14,643, a peroxisome proliferator-activated receptor α (PPARα) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice
    • Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, Reitman ML: WY14,643, a peroxisome proliferator-activated receptor α (PPARα) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. J Biol Chem (2002) 277(27):24484-24489.
    • (2002) J Biol Chem , vol.277 , Issue.27 , pp. 24484-24489
    • Chou, C.J.1    Haluzik, M.2    Gregory, C.3    Dietz, K.R.4    Vinson, C.5    Gavrilova, O.6    Reitman, M.L.7
  • 44
    • 0035141142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-α activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: Comparison with PPAR-γ activation
    • Ye JM, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ, Kraegen EW: Peroxisome proliferator-activated receptor (PPAR)-α activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: Comparison with PPAR-γ activation. Diabetes (2001) 50(2):411-417.
    • (2001) Diabetes , vol.50 , Issue.2 , pp. 411-417
    • Ye, J.M.1    Doyle, P.J.2    Iglesias, M.A.3    Watson, D.G.4    Cooney, G.J.5    Kraegen, E.W.6
  • 45
    • 0037135623 scopus 로고    scopus 로고
    • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knock-out mice. Evidence for compensatory regulation by PPAR δ
    • Muoio DM, MacLean PS, Lang DB, Li S, Houmard JA, Way JM, Winegar DA, Corton JC, Dohm GL, Kraus WE: Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knock-out mice. Evidence for compensatory regulation by PPAR δ. J Biol Chem (2002) 277(29):26089-26097.
    • (2002) J Biol Chem , vol.277 , Issue.29 , pp. 26089-26097
    • Muoio, D.M.1    MacLean, P.S.2    Lang, D.B.3    Li, S.4    Houmard, J.A.5    Way, J.M.6    Winegar, D.A.7    Corton, J.C.8    Dohm, G.L.9    Kraus, W.E.10
  • 47
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM: Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell (2003) 113(2):159-170.
    • (2003) Cell , vol.113 , Issue.2 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5    Kang, H.6    Evans, R.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.