Microglial activation resulting from CD40-CD40l interaction after β- amyloid stimulation

Science

Volumn 286, Issue 5448, 1999, Pages 2352-2355

  Tan, Jun ^a   Town, Terrence ^a   Paris, Daniel ^a   Mori, Takashi ^a   Suo, Zhiming ^a   Crawford, Fiona ^a   Mattson, Mark P ^b   Flavell, Richard A ^c   Mullan, Michael ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CD40 ANTIGEN; GLYCOPROTEIN GP 39; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; MICROGLIA; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIGENS, CD40; CD40 LIGAND; CELL DEATH; CELLS, CULTURED; INTERFERON TYPE II; INTERLEUKINS; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; MICROGLIA; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TAU PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0033579382     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5448.2352     Document Type: Article

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33. We are grateful to D. Roskamp and R. Roskamp for their generous support, which made this work possible. We thank T. Reading for his support. R.A.F. is an investigator of the Howard Hughes Medical Institute. We thank P. Ricciardi-Castagnoli for providing the murine microglial cell lines (N9), J.-Y. Bonnefoy for providing the human CD40L, H. Yu for assistance in maintaining the CD40L-deficient mice, and A. Placzek for assistance in mice genotyping.