Expression and regulation of cyclooxygenase-2 in rat microglia

European Journal of Biochemistry

Volumn 243, Issue 3, 1997, Pages 726-731

  Bauer, M K A ^a   Lieb, K ^a   Schulze Osthoff, K ^a   Berger, M ^a   Gebicke Haerter, P J ^a   Bauer, J ^a   Fiebich, B L ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Brain; Cyclooxygenase; Microglia; Nuclear factor B; Prostaglandin

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; ANTIOXIDANT; CYCLOOXYGENASE 2; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MELOXICAM; MESSENGER RNA; PROSTAGLANDIN E2; PROTEIN KINASE C INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; BRAIN; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0031015384     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.00726.x     Document Type: Article

References (40)

1. Appleby, S. B., Ristimaki, A., Neilson, K., Narko, K. & Hla, T. (1994) Structure of the human cyclooxygenase‐2 gene, Biochern. J. 302, 723–727.
2. Banati, R. B., Gehrmann, J., Schubert, P. & Kreutzberg, G. W. (1993) Cytotoxicity of microglia, Glia 7, 111–118.
3. Brown, D. R., Schmidt, B. & Kretzschmar, H. A. (1996) Role of microglia and host prion protein in neurotoxicity of a prim protein fragment, Nature 380, 345–347.
4. Chao, C. C., Hu, S., Close, K., Choi, C. S., Molitor, T. W., Novick, W. J. & Peterson, P. K. (1992) Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone, J. Infect. Dis. 164, 847–853.
5. Chao, C. C., Hu, S., Sheng, W. S. & Peterson, P. K. (1995) Tumor necrosis factor‐alpha production by human fetal microglial cells: Regulation by other cytokines, Dev. Neurosci. 17, 97–105.
6. Chen, J., Marsh, T., Zhang, J. S. & Graham, S. H. (1995) Expression of cyclooxygenase‐2 in rat brain following kainate treatment, Neuroreport, 6, 245–248.
7. Chen, S. T., Hsu, C. Y., Hogan, E. L., Halushka, P. V., Linet, O. I. & Yatsu, F. M. (1986) Thromboxane, prostacyclin, and leukotrienes in cerebral ischemia, Neurology 36, 466–470.
8. Dickson, D. W., Lee, S. C., Mattiace, L. A., Yen, S. & Brosnan, C. F. (1993) Microglia in neurological disease, with special reference to AIDS and Alzheimer's disease, Glia 7, 75–83.
9. Feng, L., Sun, W., Xia, Y., Tang, W. W., Chanmugam, P., Soyoola, E., Wilson, C. B. & Hwang, D. (1993) Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression, Arch. Biochem. Biophys. 307, 361–368.
10. Fiebich, B. L., Biber, K., Lieb, K., Van Calker, D., Berger, M., Bauer, J. & Gebicke‐Haerter, P. J. (1996) Cyclooxygenase‐2 expression in rat microglia is induced by adenosine A 2a ‐receptors, Glia 18, 152–160.
11. Fretland, D. J. (1992) Potential role of prostaglandins and leukotrienes in multiple sclerosis and experimental allergic encephalomyelitis, Prostaglandins Leukot. Essent. Fatty Acids 45, 249–257.
12. Fu, J. Y., Masferrer, J. L., Seibert, K., Raz, A. & Needleman, P. (1990) The induction and supression of prostaglandin H 2 synthase (cyclooxygenase) in human monocytes, J. Biol. Chem. 265, 16737–16740.
13. Gebicke‐Haerter, P. J., Bauer, J., Schobert, A. & Northoff, H. (1989) Lipopolysaccharide‐free conditions in primary astrocyte cultures allow growth and isolation of microglial cells, J. Neurosci. 9, 183–194.
14. Gebicke‐Haerter, P. J., Van Calker, D., Nörenberg, W. & Illes, P. (1996) Molecular mechanisms of microglial activation. A. Implications for regeneration and neurodegenerative diseases, Neurochem Int. 29, 1–12.
15. Gehrmann, J., Matsumoto, Y. & Kreutzberg, G. W. (1996) Microglia: intrinsic immunoeffector cells of the brain, Brain Res. Rev. 20, 269–287.
16. Griffin, D. E., Wesselingh, S. L. & McArthur, J. C. (1994) Elevated central nervous system prostaglandins in human immunodeficiency virus‐associated dementia, Ann. Neurol. 35, 592–597.
17. Hayaishi, O. (1991) Molecular mechanism of sleep wake regulation: roles of prostaglandins D 2 and E 2, FASEB J. 5, 25–75.
18. Kaufmann, W. E., Worley, P. F., Pegg, J., Bremer, M. & Isakson, P. (1996) COX‐2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex, Proc. Natl Acad. Sci. USA 93, 2317–2321.
19. Keller, M., Jackisch, R., Seregi, A. & Hertting, G. (1985) Comparison of prostanoid forming capacity of neuronal and astroglia cells in primary culture, Neurochem. Int. 7, 655–665.
20. Koka, P., He, K., Zack, J. A., Kitchen, S., Peacock, W., Fried, I., Tran, T., Yashar, S. S. & Merrill, J. E. (1995) Human immunodeficiency virus 1 envelope proteins induce interleukin‐1, tumor necrosis factor α, and nitric oxide in glial cultures derived from fetal neonatal and adult human brain. J. Exp. Med. 182, 941–952.
21. Lee, S., Li, W., Roth, P., Dickson, D. W., Berman, J. W. & Brosnan, C. F. (1993) Macrophage colony‐stimulating factor in human fetal astrocytes and microglia. Differential regulation of cytokines and lipopolysaccharide, and modulation of class II MHC on microglia, J. Immunol. 150, 594–604.
22. Lee, S. H., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, S., Simmons, D. & Hwang, D. (1992) Selective expression of mitogen‐inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide, J. Biol. Chem. 267, 25934–25938.
23. Lieb, K., Kaltschmidt, C., Kaltschmidt, K., Baeuerle, P. A., Berger, M., Bauer, J. & Fiebich, B. L. (1996) Interleukin‐1β uses common and distinct signaling pathways for induction of the interleukin‐6 and tumor necrosis factor α genes in the human astrocytoma cell line U373, J. Neurochem. 66, 1496–1503.
24. Loll, P. J. & Garavito, M. (1994) The isoforms of cyclooxygenase: structure and function, Exp. Opin. Invest. Drugs 3, 1171–1180.
25. Loughlin, A. J., Woodroofe, M. N. & Cruzner, M. L. (1992) Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumor necrosis factor, interleulun‐1, and lipopolysaccharide: effects on interferon‐gamma‐induced activation, Immunology 75, 170–175.
26. Minghetti, L. & Levi, G. (1995) Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures, J. Neurochem. 65, 2690–2698.
27. Mrak, R. E., Sheng, J. G. & Griffin, W. S. T. (1995) Glial cytokines in Alzheimer's disease: review and pathogenic implications, Hum. Pathol. 26, 816–823.
28. Murphy, S., Pearce, B., Jereny, J. & Dandona, P. (1988) Astrocytes as eicosanoid‐producing cells, Glia 1, 241–245.
29. O'Neill, G. P. & Ford‐Hutchinson, A. W. (1993) Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues, FEBS Lett. 330, 156–160.
30. Panck, R. B. & Benveniste, E. N. (1995) Class II MHC gene expression in microglia: Regulation by the cytokines IFN‐γ, TNF‐α, and TGF‐β, J. Immunol. 154, 2846–2854.
31. Perry, V. H., Andersson, P.‐B. & Gordon, S. (1993) Macrophages and inflammation in the central nervous system, Trends Neurosci. 16, 268–273.
32. Rothwell, N. J. (1992) Eicosanoids, thermogenesis and thermoregulation, Prostaglandins Leukot. Essent. Fatty Acids 46, 1–7.
33. Sawada, M., Suzumura, A. & Marunouchi, T. (1992) TNFα induces IL‐6 production by astrocytes but not by microglia, Brain Res. 583, 296–299.
34. Seibert, K. & Masferrer, J. L. (1994) Role of inducible cyclooxygenase (COX‐2) in inflammation, Receptor 4, 17–23.
35. Shimizu, T. & Wolfe, L. S. (1990) Arachidonic acid cascade and signal transduction, J. Neurochem. 55, 1–15.
36. Shrikant, P., Weber, E., Jilling, T. & Benveniste, E. N. (1995) Intercellular adhesion molecule‐1 gene expression by glial cells. Differential mechanisms of inhibition by IL‐10 and IL‐6, J. Immunol. 155, 14889–14901.
37. Williams, A. E., Van Dam, A. M., Man‐A‐Hing, W. K., Berkenbosch, F., Eikelenboom, P. & Fraser, H. (1994) Cytokines, prostaglandins and lipocortin‐1 are present in the brains of scrapie‐infected mice, Brain Res. 654, 200–206.
38. Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A. & Worley, P. F. (1993) Expression of a mitogen‐inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids, Neuron 11, 371–386.
39. Yamamoto, K., Arakawa, T., Ueda, N. & Yamamoto, S. (1995) Transcriptional roles of nuclear factor kappaB and nuclear factor‐interleukin‐6 in the tumor necrosis factor a‐dependent induction of cyclooxygenase‐2 in MC3T3‐E1 cells, J. Biol. Chem. 270, 31315–31320.
40. Zabel, U., Henkel, T., Silva, M. S. & Baeuerle, P. A. (1993) Nuclear uptake control of NF‐kappa B by MAD‐3, an I kappa B protein present in the nucleus, EMBO J. 12, 201–211.