Ibuprofen suppresses plaque pathology and inflammation in a mouse model for alzheimer's disease

Journal of Neuroscience

Volumn 20, Issue 15, 2000, Pages 5709-5714

  Lim, G P ^a,c   Yang, F ^a,c   Chu, T ^a,c   Chen, P ^a,c   Beech, W ^a,c   Teter, B ^a,c   Tran, T ^a,c   Ubeda, O ^a,c   Ashe, K Hsiao ^e   Frautschy, S A ^a,b,c,d   Cole, G M ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Alzheimer; Amyloid; Cytokines; Inflammation; Microglia; NSAID

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; IBUPROFEN; INTERLEUKIN 1BETA; NONSTEROID ANTIINFLAMMATORY AGENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; FEMALE; MALE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE; TREATMENT OUTCOME;

EID: 0034254924     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-15-05709.2000     Document Type: Article

References (34)

1. Scavenging of Alzheimer's amyloid beta-protein by microglia in culture
2. Evidence for glial-mediated inflammation in aged APPSw transgenic mice
3. Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs
4. Inflammatory mechanisms in Alzheimer's disease: Inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
5. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
6. 2 levels in mouse brain
7. In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents
8. Microglial response to amyloid plaques in APPsw transgenic mice
9. Nonsteroidal anti-inflammatory drugs, ulcers and risk: A collaborative meta-analysis
10. Glial-neuronal interactions in Alzheimer's disease: The potential role of a 'cytokine cycle' in disease progression
11. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
12. Effects of transforming growth factor-beta (Isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures
13. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
14. NSAIDs and incident Alzheimer's disease. The Rotterdam study
15. APPsw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1
16. Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-γ, in Alzheimer's disease brain
17. Water-soluble Abeta (n-40, N-42) oligomers in normal and Alzheimer disease brains
18. Glial fibrillary acidic protein: Regulation by hormones, cytokines, and growth factors
19. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
20. The negative mucosal potential: Separating central and peripheral effects of NSAIDs in man
21. Age-related impairment in long-term potentiation in hippocampus: A role for the cytokine, interleukin-1 beta?
22. Role of microglia in senile plaque formation
23. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
24. Polyclonals to β-amyloid (1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum
25. The importance of inflammatory mechanisms in Alzheimer disease
26. Glial cytokines in Alzheimer's disease: Review and pathogenic implications
27. Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria
28. Prostaglandins as putative neurotoxins in Alzheimer's disease
29. Inflammation and Alzheimer's disease pathogenesis
30. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
31. Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: Implications for neuritic plaque formation in Alzheimer's disease
32. Risk of Alzheimer's disease and duration of NSAID use
33. Amyloidogenic role of cytokine TGF-beta-1 in transgenic mice and in Alzheimer's disease