Decreased expression of prostaglandin G/H synthase-2 (PGHS-2) in Alzheimer's disease brain

Advances in Experimental Medicine and Biology

Volumn 407, Issue , 1996, Pages 171-177

  O'Banion, M Kerry ^a   Chang, Julia W ^a   Coleman, Paul D ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN SYNTHASE;

AGED; ALZHEIMER DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; NEOCORTEX; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTROCYTES; BRAIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEURONS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; TEMPORAL LOBE;

EID: 0030395410     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (15)

1. Badley, J.E., Bishop, G., St. John, T., and Frelinger, J.A., 1988, A simple, rapid method for the purification of poly A+ RNA, Biotechniques 6:114.
2. Breitner, J.C.S., Welsh, K.A., Helms, M.J., Gaskell, P.C., Gau, B.A., Roses, A.D., Pericak-Vance, M.A., and Saunders, A.M., 1995, Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs, Neurobiol. Aging 16:523.
3. Callahan, L.M., and Coleman, P.D., 1995, Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease, Neurobiol. Aging 16:311.
4. Callahan, L.M., Selski, D.J., Martzen, M.R., Cheetham, J.E., and Coleman, P.D., 1994, Preliminary evidence: decreased GAP-43 message in tangle-bearing neurons relative to adjacent tangle-free neurons in Alzheimer's disease parahippocampal gyrus, Neurobiol. Aging 15:381.
5. DeKosky, S.T., and Scheff, S.W., 1990, Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity, Ann. Neurol. 27:457.
6. Kaufmann, W.E., Worley, P.F., Pegg, J., Bremer, M., and Isakson, P., 1996, Cox-2, a synaptically-induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex, Proc. Natl. Acad. Sci. USA In Press.
7. O'Banion, M.K., Coleman, P.D., and Callahan, L.M., 1994, Regional neuronal loss in aging and Alzheimer's disease: a brief review, Sem. Neurosci. 6:307.
8. O'Banion, M.K., Dusel, J.C., Chang, J.W., Kaplan, M.D., and Coleman, P.D., 1996, Interleukin-1β induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures, J. Neurochem. In Press.
9. O'Banion, M.K., Sadowski, H.B., Winn, V., and Young, D.A., 1991, A serum- and glucocorticoid-regulated 4 kb mRNA encodes a cyclooxygenase related protein, J. Biol. Chem. 266:23261.
10. O'Banion, M.K., Winn, V.D., and Young, D.A., 1992, cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase, Proc. Natl. Acad. Sci. USA 89:4888.
11. Pike, C.J., Cummings, B.J., and Cotman, C.W., 1995, Early association of reactive astrocytes with senile plaques in Alzheimer's disease, Exp. Neurol. 132:172.
12. Rogers, J., Kirby, L.C., Hempelman, S.R., Berry, D.L., McGeer, P.L., Kasznaik, A.W., Zalinski, J., Cofield, M., Mansukhani, L., Willson, P., and Kogan, F., 1993, Clinical trial of indomethacin in Alzheimer's disease, Neurology 43:1609.
13. Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., DeTeresa, R., Hill, R., Hansen, L.A., and Katzman, R., 1991. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment, Ann. Neurol. 30:572.
14. West, M.J., Coleman, P.D., Flood, D.G., and Troncoso, J.D., 1994, Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease, Lancet 344:769.
15. Yamagata, K., Andreasoon, K.I., Kaufmann, W.I., Barnes, C.A., and Worley, P.F., 1993, Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids, Neuron 11:371.