Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions

Neurobiology of Disease

Volumn 3, Issue 3, 1996, Pages 197-204

  Pasinetti, G M ^a   Tocco, G ^b   Sakhi, S ^c   Musleh, W D ^b   DeSimoni, M G ^d   Mascarucci, P ^d   Schreiber, S ^c   Baudry, M ^b   Finch, C E ^e  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; APOLIPOPROTEIN E; CALCIUM ION; COMPLEMENT COMPONENT C5; EXCITOTOXIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; INTERLEUKIN 6; KAINIC ACID; LIPOPOLYSACCHARIDE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID; TUMOR NECROSIS FACTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INJURY; COMPLEMENT DEFICIENCY; COMPLEMENT SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; EXCITATORY POSTSYNAPTIC POTENTIAL; FRAMESHIFT MUTATION; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL;

EID: 0030175273     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1996.0020     Document Type: Article

References (47)

1. 1. Eikelenboom, P., Zhan, S-S., van Gool, W. A., & Allsop, D. (1994) Inflammatory mechanisms in Alzheimer's disease. Trends Pharmacol. Sci. 15, 447-450.
2. 2. McGeer, P. L., & McGeer, E. G. (1992) Complement proteins and complement inhibitors in Alzheimer's disease. Res. Immunol. 143, 621-623.
3. 3. Lampert-Etchells, M., Pasinetti, G. M., Finch, C. E., & Johnson, S. A. (1993) Regional localization of cells containing C1qb and C4 mRNAs in the frontal cortex during Alzheimer disease. Neurodegeneration 2, 111-121.
4. 4. Johnson, S. A., Lampert-Etchells, M., Rozovsky, I., et al. (1992) Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental lesions. Neurobiol. Aging 13, 641-648.
5. 5. Finch, C. E., & Marchalonis, J. (1996) An evolutionary perspective on amyloid and inflammatory features of Alzheimer disease. Neurobiol. Aging 17, 809-815.
6. 6. Pasinetti, G. M. (1996) Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: The role of the complement system. Neurobiol. Aging 17, 707-716.
7. 7. Veerhuis, R., van der Valk, P., Janssen, I., Zhan, S. S., et al. (1995) Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3. Virchows Arch. 426, 603-610.
8. 8. Pasinetti, G. M., Johnson, S. A., Rozovsky, I., et al. (1992) Complement mRNA responses to lesioning in rat brain. Exp. Neurol. 118, 117-125.
9. 9. Rozovsky, I., Morgan, T. E., Willoughby, D. A., et al. (1994) Selective expression of clusterin (SGP-2) and complement C1q and C4 during responses to neurotoxins in vivo and in vitro. Neuroscience 62, 741-758.
10. 10. Finch, C. E., & May, P. (1995) Recent findings on clusterin in neural tissues: Neuroanatomy, cell sources, development and aging, Alzheimer disease and other brain lesions. In: Clusterin: Function in Vertebrate Organ Development and Adaptation (J. Harmony, Ed.), pp. 163-185. R. G. Landis, Austin.
11. 11. Johnson, S. A., Pasinetti, G. M., & Finch, C. E. (1994) Expression of complement C1qB and C4 mRNAs during rat brain development. Dev. Brain Res. 80, 163-174.
12. 12. Yang, C., Jones, J. L., & Barnum, S. R. (1993) Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46), and CD 59 in the human astroglioma cell line D54-MG, and primary astrocytes. J. Neuroimmunol 47, 123-132.
13. 13. Levi-Strauss, M., & Mallat, M. (1987) Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation. J. Immunol. 139, 2361-2366.
14. 14. Gasque, P., Fontaine, M., & Morgan, P. B. (1995) Complement expression in human brain: Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J. Immunol. 154, 4726-4733.
15. 15. Cinader, B., Dubiski, S., & Wardlaw, C. (1964) Distribution, inheritance, and properties of an antigen, MuB1, and its relation to hemolytic complement. J. Exp. Med. 120, 897-924.
16. 16. Ooi, Y. M., & Colten, H. R. (1979) Genetic defect in secretion of complement C5 in mice. Nature 282, 207-208.
17. 17. Wetsel, R. A., Fleischer, D. T., & Haviland, D. L. (1990) Deficiency of the murine fifth complement component (C5): A 2-base pair gene deletion in a 5′-exon. J. Biol. Chem. 265, 2435-2440.
18. 18. Massicotte, G., Oliver, M., Lynch, G., & Baudry, M. (1990) Effect of bromophenacylbromide, a phospholipase A2 inhibitor, on the induction and maintenance of LTP in hippocampal slices. Brain Res. 537, 49-53.
19. 19. Tocco, G., Massicotte, G., Standley, S., et al. (1992) Effect of temperature and calcium on the binding properties of the AMPA receptor in frozen rat brain sections. Eur. J. Neurosci. 4, 1093-1103.
20. 20. Poirier, J., Hess, M., May, P. C., & Finch, C. E. (1991) Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Mol. Brain. Res. 11, 97-106.
21. 21. McCarthy, K. D., & deVellis, J. S. (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85, 890-892.
22. 22. DeSimoni, M. G., Gemma, C., Faggioni, R., et al. (1992) Central nervous system-mediated induction of systemic IL-6 and TNF. In: Pathophysiology and Pharmacology of Cytokines (A. Mantovani & P. Ghezzi, Eds.), pp. 143-148. Biomedical Press, New York.
23. 23. DeSimoni, M. G., DeLuigi, A., Sironi, M. et al. (1993) Modulation of systemic interleukin-6 induction by central interleukin-1. Am. J. Physiol. 265, R739-R742.
24. 24. Choi, D. W. (1987) Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7, 369-379.
25. 25. Virgil, T., Megan, P., Contestable, A., & Barnaby, O. (1992) Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: Effect of MK-801 and C.P. 39551 on neurotransmitter and glial markers. Neuropharmacology 31, 469-474.
26. 26. Standley, S., Tocco, G., Tourigny, M., et al. (1995) Developmental changes in AMPA receptor properties and expression in the rat hippocampus. Neuroscience 67, 881-892.
27. 27. Bruce, A. J., Boling, W., Kind, M. S., Peschon, J., et al. (1996). Altered neuronal and microglial responses to excitotoxic and ischaemic brain injury in mice lacking TNF receptors. Nature Med. 2, 788-794.
28. 28. Yamada, M., & Hatanaka, H. (1994) Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death. Brain Res. 643, 173-180.
29. 29. Standley, S., Bi, X., & Baudry, M. (1996) AMPA-glutamate receptor regulation and synaptic plasticity. In: Long-Term Potentiation (M. Baudry & J. L. Davis, Eds.), Vol. III, pp. 17-40. MIT Press, Cambridge.
30. 30. Wehner, J. M., Sleight, S., & Upchurch, M. (1990) Hippocampal protein kinase C activity is reduced in poor spatial learners. Brain Res. 523, 181-187.
31. 31. Morgan, B. P., & Walport, W. J. (1991) Complement deficiency and disease. Immunol. Today 12, 301-306.
32. 32. McKusick, V. A. Mendelian Inheritance in Man, 11th ed. Johns Hopkins Press, Baltimore.
33. 33. Campbell, I. L., Abraham, C. R., Masliah, E., et al. (1993) Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA 90, 10061-10065.
34. 34. Rogers, J., Cooper, N., Schulz, J., McGeer, P., et al. (1993) Complement activation by β-amyloid in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 89, 10016-10020.
35. 35. Jiang, H., Burdick, D., Glabe, C. G., Cotman, C. W., & Tenner, A. J. β-amyloid activates complement by binding to a specific region of the collagen-like domain of the C1qA chain. J. Immunol. 152, 5050-5059.
36. 36. Yao, J., Harvath, L., Gilbert, D. L., & Colton, C. A. (1990) Chemotaxis by a CNS macrophage, the microglia. J. Neurosci. Res. 27, 36-32.
37. 37. Johnson, S. A., Laping, N., Young-Chan, C. S., & Finch, C. E. (1996) Perforant path transection induces complement C9 deposition in hippocampus. Exp. Neurol. 138, 198-205.
38. 1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress. Exp. Neurol. 136, 22-31.
39. 39. Bertrand, P., Poirier, J., Oda, T., Finch, C. E., & Pasinetti, G. M. (1995) Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease. Mol. Brain. Res. 33, 174-178.
40. 40. Scholz, W., McClurg, M. R., Cardenas, G. J., Smith, M., et al. (1990) C5a-mediated release of interleukin 6 by human monocytes. Clin. Immunol. Immunopathol. 57, 297-307.
41. 41. Nolte, C. H., Moller, T. H., Walter, T., & Kettenmann, H. (1995) Intracellular signaling mechanisms mediating microglial motility induced by complement 5A (C5a). Soc. Neurosci. Abstr. 21, 1070.
42. 42. Hogan, B., Costantini, F., & Lacy, E. (1986) Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
43. 43. Taketo, M., Schroeder, A. C., Mobraaten, L. E., et al. (1991) FVB/N: An inbred mouse strain preferable for transgenic analyses. Proc. Nat. Acad. Sci. USA 88, 2065-2069.
44. 44. Hsiao, K. K., Borchelt, D. R., Olson, K., et al. (1995) Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor protein. Neuron 15, 1203-1218.
45. 45. Coutinho, M., Zahedi, K., Whitehead, A. S., & Davis, A. E., III. (1992) C5 deficiency in A/J mice is not associated with resistance to the development of secondary amyloidosis. Eur. J. Immunogenet. 19, 419-423.
46. 46. Finch, C. E. (1994) Recent findings on clusterin in neural tissues: Neuroanatomy, cell sources, development and aging, Alzheimer disease and other brain lesions. In: The SAM Model of Senescence (T. Takeda et al., Eds.), Excerpta Med. Int. Congr. Ser. 1062, 3-7. Elsevier, Amsterdam.
47. 47. Lathe, R. (1996) Mice, gene targeting and behavior: More than just genetic background. Trends Neurosci. 19, 183-189.