Costimulatory effects of interferon-β and interleukin-1β or tumor necrosis factor α on the synthesis of Aβ1-40 and Aβ1-42 by human astrocytes

Neurobiology of Disease

Volumn 7, Issue 6, 2000, Pages 682-689

  Blasko, I ^a   Veerhuis, R ^b   Stampfer Kountchev, M ^a   Saurwein Teissl, M ^a   Eikelenboom, P ^b   Grubeck Loebenstein, B ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Alzheimer's disease; APP; A ; Cytokines; Primary human astrocytes

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; ASTROCYTOMA CELL; ASTROCYTOSIS; CHRONIC INFLAMMATION; DRUG EFFECT; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS;

EID: 0034523456     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0321     Document Type: Article

References (43)

1. TGF-beta(1), regulation of alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization
2. TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs
3. NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: The involvement of prostaglandin E2
4. Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells
5. Inflammatory mechanisms in Alzheimer's disease: Inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
6. Differential expression of transforming growth factor-beta 1,-beta 2, and-beta 3 by glioblastoma cells, astrocytes, and microglia
7. Ethical aspects to be considered in brain banking
8. Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: Immunophenotypical and functional characterization
9. The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha
10. Long-term changes in the aggregation state and toxic effects of beta-amyloid injected into the rat brain
11. Intraneuronal A beta42 accumulation in human brain
12. Regulated O-glycosylation of the Alzheimer beta-A4 amyloid precursor protein in thyrocytes
13. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides
14. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
15. Amyloid beta-peptide is produced by cultured cells during normal metabolism
16. Mutant and native human beta-amyloid precursor proteins in transgenic mouse brain
17. Amyloid-beta peptide activates cultured astrocytes: Morphological alterations, cytokine induction and nitric oxide release
18. Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
19. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
20. A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced
21. Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells
22. Inflammatory molecule release by beta-amyloid-treated T98G astrocytoma cells: Role of prostaglandins and modulation by paracetamol
23. Processing of amyloid precursor protein in human primary neuron and astrocyte cultures
24. Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)
25. Characterization of glial cultures from rapid autopsies of Alzheimer's and control patients
26. The role of the protein glycosylation state in the control of cellular transport of the amyloid beta precursor protein
27. The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Research
28. Interferon gamma gene expression in sensory neurons: Evidence for autocrine gene regulation
29. Impaired brain development and reduced astrocyte response to injury in transgenic mice expressing IGF binding protein-1
30. Expression of tumour necrosis factor-alpha,-beta and interferon-gamma genes within human neuroglial tumour cells and brain specimens
31. Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB
32. Neuronal interferon-gamma immunoreactive molecule: Bioactivities and purification
33. Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences
34. Interfering with the pathologic activation of microglial cells and astrocytes in dementia
35. Interferon-gamma enhancement of E-selectin expression on endothelial cells is inhibited by monensin
36. Interferon gamma and iodide increase the inducibility of the 72 kD heat shock protein in cultured human thyroid epithelial cells
37. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism
38. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
39. Complement C1-inhibitor expression in Alzheimer's disease
40. IFN-gamma production of adult rat astrocytes triggered by TNF-alpha
41. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
42. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease
43. Temporal relations among amyloid beta-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses