Pathogen recognition and innate immunity

Cell

Volumn 124, Issue 4, 2006, Pages 783-801

  Akira, Shizuo ^a,b   Uematsu, Satoshi ^a   Takeuchi, Osamu ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOKINE; CYTOPLASMIC RECEPTOR; DOUBLE STRANDED RNA; FLAGELLIN; INTERFERON; LIGAND; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN 1; NUCLEOTIDE BINDING PROTEIN; PATTERN RECOGNITION RECEPTOR; RNA HELICASE; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS GLYCOPROTEIN;

ANTIGEN RECOGNITION; BACTERIAL CELL WALL; BACTERIUM; CELL ACTIVATION; CYTOKINE PRODUCTION; CYTOPLASM; DENDRITIC CELL; EXPOSURE; FUNGUS; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOST; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; MYCOBACTERIUM; NONHUMAN; PARASITE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTOZOON; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE; VIRUS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CELL WALL; CYTOKINES; CYTOPLASM; DROSOPHILA; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; IMMUNITY, NATURAL; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; RECEPTORS, CELL SURFACE; RNA HELICASES; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

BACTERIA (MICROORGANISMS); DNA VIRUSES; FUNGI; MYCOBACTERIUM; NEGIBACTERIA; POSIBACTERIA; PROTOZOA; VERTEBRATA;

EID: 32944464648     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2006.02.015     Document Type: Review

References (141)

1. K. Adachi, H. Tsutsui, S. Kashiwamura, E. Seki, H. Nakano, O. Takeuchi, K. Takeda, K. Okumura, L. Van Kaer, and H. Okamura Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism J. Immunol. 167 2001 5928 5934
2. S. Agrawal, A. Agrawal, B. Doughty, A. Gerwitz, J. Blenis, T. Van Dyke, and B. Pulendran Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos J. Immunol. 171 2003 4984 4989
3. P. Ahmad-Nejad, H. Hacker, M. Rutz, S. Bauer, R.M. Vabulas, and H. Wagner Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments Eur. J. Immunol. 32 2002 1958 1968
4. S. Akira, and K. Takeda Toll-like receptor signalling Nat. Rev. Immunol. 4 2004 499 511
5. L. Alexopoulou, A.C. Holt, R. Medzhitov, and R.A. Flavell Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 Nature 413 2001 732 738
6. L. Alexopoulou, V. Thomas, M. Schnare, Y. Lobet, J. Anguita, R.T. Schoen, R. Medzhitov, E. Fikrig, and R.A. Flavell Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice Nat. Med. 8 2002 878 884
7. E. Andersen-Nissen, K.D. Smith, K.L. Strobe, S.L. Barrett, B.T. Cookson, S.M. Logan, and A. Aderem Evasion of Toll-like receptor 5 by flagellated bacteria Proc. Natl. Acad. Sci. USA 102 2005 9247 9252
8. J. Andrejeva, K.S. Childs, D.F. Young, T.S. Carlos, N. Stock, S. Goodbourn, and R.E. Randall The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter Proc. Natl. Acad. Sci. USA 101 2004 17264 17269
9. S. Balachandran, E. Thomas, and G.N. Barber A FADD-dependent innate immune mechanism in mammalian cells Nature 432 2004 401 405
10. G.M. Barton, J.C. Kagan, and R. Medzhitov Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA Nat. Immunol. 7 2006 49 56
11. Y. Belkhadir, R. Subramaniam, and J.L. Dangl Plant disease resistance protein signaling: NBS-LRR proteins and their partners Curr. Opin. Plant Biol. 7 2004 391 399
12. B. Beutler Inferences, questions and possibilities in Toll-like receptor signalling Nature 430 2004 257 263
13. K. Bieback, E. Lien, I.M. Klagge, E. Avota, J. Schneider-Schaulies, W.P. Duprex, H. Wagner, C.J. Kirschning, V. Ter Meulen, and S. Schneider-Schaulies Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling J. Virol. 76 2002 8729 8736
14. J.M. Blander, and R. Medzhitov Regulation of phagosome maturation by signals from toll-like receptors Science 304 2004 1014 1018
15. A. Bowie, and L.A. O'Neill The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products J. Leukoc. Biol. 67 2000 508 514
16. A. Bowie, E. Kiss-Toth, J.A. Symons, G.L. Smith, S.K. Dower, and L.A. O'Neill A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling Proc. Natl. Acad. Sci. USA 97 2000 10162 10167
17. G.D. Brown, P.R. Taylor, D.M. Reid, J.A. Willment, D.L. Williams, L. Martinez-Pomares, S.Y. Wong, and S. Gordon Dectin-1 is a major beta-glucan receptor on macrophages J. Exp. Med. 196 2002 407 412
18. D. Burzyn, J.C. Rassa, D. Kim, I. Nepomnaschy, S.R. Ross, and I. Piazzon Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus J. Virol. 78 2004 576 584
19. M. Chamaillard, M. Hashimoto, Y. Horie, J. Masumoto, S. Qiu, L. Saab, Y. Ogura, A. Kawasaki, K. Fukase, and S. Kusumoto An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid Nat. Immunol. 4 2003 702 707
20. J. Choe, M.S. Kelker, and I.A. Wilson Crystal structure of human toll-like receptor 3 (TLR3) ectodomain Science 309 2005 581 585
21. C. Coban, K.J. Ishii, T. Kawai, H. Hemmi, S. Sato, S. Uematsu, M. Yamamoto, O. Takeuchi, S. Itagaki, and N. Kumar Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin J. Exp. Med. 201 2005 19 25
22. T. Compton, E.A. Kurt-Jones, K.W. Boehme, J. Belko, E. Latz, D.T. Golenbock, and R.W. Finberg Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2 J. Virol. 77 2003 4588 4596
23. D.N. Cook, D.S. Pisetsky, and D.A. Schwartz Toll-like receptors in the pathogenesis of human disease Nat. Immunol. 5 2004 975 979
24. C. Couillault, N. Pujol, J. Reboul, L. Sabatier, J.F. Guichou, Y. Kohara, and J.J. Ewbank TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM Nat. Immunol. 5 2004 488 494
25. L. Deng, C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C. Pickart, and Z.J. Chen Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain Cell 103 2000 351 361
26. S.S. Diebold, T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Science 303 2004 1529 1531
27. E. Diez, S.H. Lee, S. Gauthier, Z. Yaraghi, M. Tremblay, S. Vidal, and P. Gros Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila Nat. Genet. 33 2003 55 60
28. G. DiPerna, J. Stack, A.G. Bowie, A. Boyd, G. Kotwal, Z. Zhang, S. Arvikar, E. Latz, K.A. Fitzgerald, and W.L. Marshall Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors J. Biol. Chem. 279 2004 36570 36578
29. C. Dostert, E. Jouanguy, P. Irving, L. Troxler, D. Galiana-Arnoux, C. Hetru, J.A. Hoffmann, and J.L. Imler The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of Drosophila Nat. Immunol. 6 2005 946 953
30. H. Echchannaoui, K. Frei, C. Schnell, S.L. Leib, W. Zimmerli, and R. Landmann Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation J. Infect. Dis. 186 2002 798 806
31. K.H. Edelmann, S. Richardson-Burns, L. Alexopoulou, K.L. Tyler, R.A. Flavell, and M.B. Oldstone Does Toll-like receptor 3 play a biological role in virus infections? Virology 322 2004 231 238
32. K.A. Fitzgerald, E.M. Palsson-McDermott, A.G. Bowie, C.A. Jefferies, A.S. Mansell, G. Brady, E. Brint, A. Dunne, P. Gray, and M.T. Harte Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction Nature 413 2001 78 83
33. K.A. Fitzgerald, S.M. McWhirter, K.L. Faia, D.C. Rowe, E. Latz, D.T. Golenbock, A.J. Coyle, S.M. Liao, and T. Maniatis IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway Nat. Immunol. 4 2003 491 496
34. K.A. Fitzgerald, D.C. Rowe, B.J. Barnes, D.R. Caffrey, A. Visintin, E. Latz, B. Monks, P.M. Pitha, and D.T. Golenbock LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF J. Exp. Med. 198 2003 1043 1055
35. S.M. Fortune, A. Solache, A. Jaeger, P.J. Hill, J.T. Belisle, B.R. Bloom, E.J. Rubin, and J.D. Ernst Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms J. Immunol. 172 2004 6272 6280
36. B.N. Gantner, R.M. Simmons, S.J. Canavera, S. Akira, and D.M. Underhill Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2 J. Exp. Med. 197 2003 1107 1117
37. R.T. Gazzinelli, C. Ropert, and M.A. Campos Role of the Toll/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites Immunol. Rev. 201 2004 9 25
38. M. Gilleron, V.F. Quesniaux, and G. Puzo Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response J. Biol. Chem. 278 2003 29880 29889
39. S.E. Girardin, I.G. Boneca, L.A. Carneiro, A. Antignac, M. Jehanno, J. Viala, K. Tedin, M.K. Taha, A. Labigne, and U. Zahringer Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan Science 300 2003 1584 1587
40. L. Gomez-Gomez, and T. Boller FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis Mol. Cell 5 2000 1003 1011
41. M. Gottar, V. Gobert, T. Michel, M. Belvin, G. Duyk, J.A. Hoffmann, D. Ferrandon, and J. Royet The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein Nature 416 2002 640 644
42. H. Hacker, H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G.B. Lipford, and H. Wagner CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation EMBO J. 17 1998 6230 6240
43. H. Hacker, V. Redecke, B. Blagoev, I. Kratchmarova, L.C. Hsu, G.G. Wang, M.P. Kamps, E. Raz, H. Wagner, and G. Hacker Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 Nature 439 2006 204 207
44. T.R. Hawn, A. Verbon, K.D. Lettinga, L.P. Zhao, S.S. Li, R.J. Laws, S.J. Skerrett, B. Beutler, L. Schroeder, and A. Nachman A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease J. Exp. Med. 198 2003 1563 1572
45. F. Hayashi, K.D. Smith, A. Ozinsky, T.R. Hawn, E.C. Yi, D.R. Goodlett, J.K. Eng, S. Akira, D.M. Underhill, and A. Aderem The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 Nature 410 2001 1099 1103
46. F. Heil, H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, and S. Bauer Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 Science 303 2004 1526 1529
47. H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira A Toll-like receptor recognizes bacterial DNA Nature 408 2000 740 745
48. H. Hemmi, T. Kaisho, O. Takeuchi, S. Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, and S. Akira Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway Nat. Immunol. 3 2002 196 200
49. H. Hemmi, O. Takeuchi, S. Sato, M. Yamamoto, T. Kaisho, H. Sanjo, T. Kawai, K. Hoshino, K. Takeda, and S. Akira The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection J. Exp. Med. 199 2004 1641 1650
50. H. Hochrein, B. Schlatter, M. O'Keeffe, C. Wagner, F. Schmitz, M. Schiemann, S. Bauer, M. Suter, and H. Wagner Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways Proc. Natl. Acad. Sci. USA 101 2004 11416 11421
51. K. Hoebe, X. Du, P. Georgel, E. Janssen, K. Tabeta, S.O. Kim, J. Goode, P. Lin, N. Mann, and S. Mudd Identification of Lps2 as a key transducer of MyD88-independent TIR signalling Nature 424 2003 743 748
52. J.A. Hoffmann The immune response of Drosophila Nature 426 2003 33 38
53. K. Honda, H. Yanai, T. Mizutani, H. Negishi, N. Shimada, N. Suzuki, Y. Ohba, A. Takaoka, W.C. Yeh, and T. Taniguchi Role of a transductional- transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling Proc. Natl. Acad. Sci. USA 101 2004 15416 15421
54. K. Honda, Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction Nature 434 2005 1035 1040
55. K. Honda, H. Yanai, H. Negishi, M. Asagiri, M. Sato, T. Mizutani, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida, and T. Taniguchi IRF-7 is the master regulator of type-I interferon-dependent immune responses Nature 434 2005 772 777
56. T. Horng, G.M. Barton, and R. Medzhitov TIRAP: an adapter molecule in the Toll signaling pathway Nat. Immunol. 2 2001 835 841
57. T. Horng, G.M. Barton, R.A. Flavell, and R. Medzhitov The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors Nature 420 2002 329 333
58. N. Inohara, M. Chamaillard, C. McDonald, and G. Nunez NOD-LRR proteins: role in host-microbial interactions and inflammatory disease Annu. Rev. Biochem. 74 2005 355 383
59. K.J. Ishii, C. Coban, H. Kato, K. Takahashi, Y. Torii, F. Takeshita, H. Ludwig, G. Sutter, K. Suzuki, and H. Hemmi A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA Nat. Immunol. 7 2005 40 48 10.1038/ni1282 Published online November 13, 2005
60. C.A. Janeway Jr., and R. Medzhitov Innate immune recognition Annu. Rev. Immunol. 20 2002 197 216
61. T. Kaisho, O. Takeuchi, T. Kawai, K. Hoshino, and S. Akira Endotoxin-induced maturation of MyD88-deficient dendritic cells J. Immunol. 166 2001 5688 5694
62. D.C. Kang, R.V. Gopalkrishnan, Q. Wu, E. Jankowsky, A.M. Pyle, and P.B. Fisher mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties Proc. Natl. Acad. Sci. USA 99 2002 637 642
63. T.D. Kanneganti, N. Ozoren, M. Body-Malapel, A. Amer, J.H. Park, L. Franchi, J. Whitfield, W. Barchet, M. Colonna, and P. Vandenabeele Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 Nature 2006 10.1038/nature04517 Published online January 11, 2006
64. H. Kato, S. Sato, M. Yoneyama, M. Yamamoto, S. Uematsu, K. Matsui, T. Tsujimura, K. Takeda, T. Fujita, O. Takeuchi, and S. Akira Cell type-specific involvement of RIG-I in antiviral response Immunity 23 2005 19 28
65. T. Kawai, S. Sato, K.J. Ishii, C. Coban, H. Hemmi, M. Yamamoto, K. Terai, M. Matsuda, J. Inoue, and S. Uematsu Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 Nat. Immunol. 5 2004 1061 1068
66. T. Kawai, K. Takahashi, S. Sato, C. Coban, H. Kumar, H. Kato, K.J. Ishii, O. Takeuchi, and S. Akira IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction Nat. Immunol. 6 2005 981 988 10.1038/ni1243 Published online August 28, 2005
67. K.S. Kobayashi, M. Chamaillard, Y. Ogura, O. Henegariu, N. Inohara, G. Nunez, and R.A. Flavell Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract Science 307 2005 731 734
68. A.M. Krieg CpG motifs in bacterial DNA and their immune effects Annu. Rev. Immunol. 20 2002 709 760
69. A. Krug, S. Rothenfusser, V. Hornung, B. Jahrsdorfer, S. Blackwell, Z.K. Ballas, S. Endres, A.M. Krieg, and G. Hartmann Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells Eur. J. Immunol. 31 2001 2154 2163
70. A. Krug, A.R. French, W. Barchet, J.A. Fischer, A. Dzionek, J.T. Pingel, M.M. Orihuela, S. Akira, W.M. Yokoyama, and M. Colonna TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function Immunity 21 2004 107 119
71. A. Krug, G.D. Luker, W. Barchet, D.A. Leib, S. Akira, and M. Colonna Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9 Blood 103 2004 1433 1437
72. S.R. Krutzik, M.T. Ochoa, P.A. Sieling, S. Uematsu, Y.W. Ng, A. Legaspi, P.T. Liu, S.T. Cole, P.J. Godowski, and Y. Maeda Activation and regulation of Toll-like receptors 2 and 1 in human leprosy Nat. Med. 9 2003 525 532
73. E.A. Kurt-Jones, L. Popova, L. Kwinn, L.M. Haynes, L.P. Jones, R.A. Tripp, E.E. Walsh, M.W. Freeman, D.T. Golenbock, L.J. Anderson, and R.W. Finberg Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus Nat. Immunol. 1 2000 398 401
74. E.A. Kurt-Jones, M. Chan, S. Zhou, J. Wang, G. Reed, R. Bronson, M.M. Arnold, D.M. Knipe, and R.W. Finberg Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis Proc. Natl. Acad. Sci. USA 101 2004 1315 1320
75. E. Latz, A. Schoenemeyer, A. Visintin, K.A. Fitzgerald, B.G. Monks, C.F. Knetter, E. Lien, N.J. Nilsen, T. Espevik, and D.T. Golenbock TLR9 signals after translocating from the ER to CpG DNA in the lysosome Nat. Immunol. 5 2004 190 198
76. B. Lemaitre, E. Nicolas, L. Michaut, J.M. Reichhart, and J.A. Hoffmann The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults Cell 86 1996 973 983
77. K. Li, E. Foy, J.C. Ferreon, M. Nakamura, A.C. Ferreon, M. Ikeda, S.C. Ray, M. Gale Jr., and S.M. Lemon Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF Proc. Natl. Acad. Sci. USA 102 2005 2992 2997
78. S. Li, A. Strelow, E.J. Fontana, and H. Wesche IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase Proc. Natl. Acad. Sci. USA 99 2002 5567 5572
79. R. Lin, R.S. Noyce, S.E. Collins, R.D. Everett, and K.L. Mossman The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes J. Virol. 78 2004 1675 1684
80. C.B. Lopez, B. Moltedo, L. Alexopoulou, L. Bonifaz, R.A. Flavell, and T.M. Moran TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses J. Immunol. 173 2004 6882 6889
81. J. Lund, A. Sato, S. Akira, R. Medzhitov, and A. Iwasaki Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells J. Exp. Med. 198 2003 513 520
82. D. Malhotra, V. Relhan, B.S. Reddy, and R. Bamezai TLR2 Arg677Trp polymorphism in leprosy: revisited Hum. Genet. 116 2005 413 415
83. S. Mariathasan, K. Newton, D.M. Monack, D. Vucic, D.M. French, W.P. Lee, M. Roose-Girma, S. Erickson, and V.M. Dixit Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf Nature 430 2004 213 218
84. S. Mariathasan, D.S. Weiss, K. Newton, J. McBride, K. O'Rourke, M. Roose-Girma, W.P. Lee, Y. Weinrauch, D.M. Monack, and V.M. Dixit Cryopyrin activates the inflammasome in response to toxins and ATP Nature 2006 10.1038/nature04515 Published online January 11, 2006
85. F. Martinon, and J. Tschopp NLRs join TLRs as innate sensors of pathogens Trends Immunol. 26 2005 447 454
86. F. Martinon, K. Burns, and J. Tschopp The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta Mol. Cell 10 2002 417 426
87. F. Martinon, V. Petrilli, A. Mayor, A. Tardivel, and J. Tschopp Gout-associated uric acid crystals activate the NALP3 inflammasome Nature 2006 10.1038/nature04516 Published online January 11, 2006
88. S.M. McWhirter, K.A. Fitzgerald, J. Rosains, D.C. Rowe, D.T. Golenbock, and T. Maniatis IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts Proc. Natl. Acad. Sci. USA 101 2004 233 238
89. E. Meylan, K. Burns, K. Hofmann, V. Blancheteau, F. Martinon, M. Kelliher, and J. Tschopp RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation Nat. Immunol. 5 2004 503 507
90. E. Meylan, J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager, and J. Tschopp Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus Nature 437 2005 1167 1172
91. T. Michel, J.M. Reichhart, J.A. Hoffmann, and J. Royet Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Nature 414 2001 756 759
92. M.G. Netea, C. Van der Graaf, J.W. Van der Meer, and B.J. Kullberg Recognition of fungal pathogens by Toll-like receptors Eur. J. Clin. Microbiol. Infect. Dis. 23 2004 672 676
93. G. Oganesyan, S.K. Saha, B. Guo, J.Q. He, A. Shahangian, B. Zarnegar, A. Perry, and G. Cheng Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response Nature 439 2006 208 211
94. H. Oshiumi, M. Matsumoto, K. Funami, T. Akazawa, and T. Seya TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction Nat. Immunol. 4 2003 161 167
95. A. Ozinsky, D.M. Underhill, J.D. Fontenot, A.M. Hajjar, K.D. Smith, C.B. Wilson, L. Schroeder, and A. Aderem The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors Proc. Natl. Acad. Sci. USA 97 2000 13766 13771
96. R.K. Pai, M. Convery, T.A. Hamilton, W.H. Boom, and C.V. Harding Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion J. Immunol. 171 2003 175 184
97. A.K. Perry, E.K. Chow, J.B. Goodnough, W.C. Yeh, and G. Cheng Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection J. Exp. Med. 199 2004 1651 1658
98. C. Picard, A. Puel, M. Bonnet, C.L. Ku, J. Bustamante, K. Yang, C. Soudais, S. Dupuis, J. Feinberg, and C. Fieschi Pyogenic bacterial infections in humans with IRAK-4 deficiency Science 299 2003 2076 2079
99. S. Pichyangkul, K. Yongvanitchit, U. Kum-arb, H. Hemmi, S. Akira, A.M. Krieg, D.G. Heppner, V.A. Stewart, H. Hasegawa, and S. Looareesuwan Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway J. Immunol. 172 2004 4926 4933
100. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, and C. Galanos Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
101. N. Pujol, E.M. Link, L.X. Liu, C.L. Kurz, G. Alloing, M.W. Tan, K.P. Ray, R. Solari, C.D. Johnson, and J.J. Ewbank A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans Curr. Biol. 11 2001 809 821
102. V. Quesniaux, C. Fremond, M. Jacobs, S. Parida, D. Nicolle, V. Yeremeev, F. Bihl, F. Erard, T. Botha, and M. Drennan Toll-like receptor pathways in the immune responses to mycobacteria Microbes Infect. 6 2004 946 959
103. J.C. Roach, G. Glusman, L. Rowen, A. Kaur, M.K. Purcell, K.D. Smith, L.E. Hood, and A. Aderem The evolution of vertebrate Toll-like receptors Proc. Natl. Acad. Sci. USA 102 2005 9577 9582
104. N.C. Rogers, E.C. Slack, A.D. Edwards, M.A. Nolte, O. Schulz, E. Schweighoffer, D.L. Williams, S. Gordon, V.L. Tybulewicz, G.D. Brown, and E.S.C. Reis Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins Immunity 22 2005 507 517
105. S. Rothenfusser, N. Goutagny, G. Diperna, M. Gong, B.G. Monks, A. Schoenemeyer, M. Yamamoto, S. Akira, and K.A. Fitzgerald The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I J. Immunol. 175 2005 5260 5268
106. M. Rutz, J. Metzger, T. Gellert, P. Luppa, G.B. Lipford, H. Wagner, and S. Bauer Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner Eur. J. Immunol. 34 2004 2541 2550
107. S. Sakaguchi, H. Negishi, M. Asagiri, C. Nakajima, T. Mizutani, A. Takaoka, K. Honda, and T. Taniguchi Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock Biochem. Biophys. Res. Commun. 306 2003 860 866
108. O. Schulz, S.S. Diebold, M. Chen, T.I. Naslund, M.A. Nolte, L. Alexopoulou, Y.T. Azuma, R.A. Flavell, P. Liljestrom, and C. Reis e Sousa Toll-like receptor 3 promotes cross-priming to virus-infected cells Nature 433 2005 887 892
109. R.B. Seth, L. Sun, C.K. Ea, and Z.J. Chen Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3 Cell 122 2005 669 682
110. S. Sharma, B.R. tenOever, N. Grandvaux, G.P. Zhou, R. Lin, and J. Hiscott Triggering the interferon antiviral response through an IKK-related pathway Science 300 2003 1148 1151
111. R. Shimazu, S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4 J. Exp. Med. 189 1999 1777 1782
112. A. Sing, D. Rost, N. Tvardovskaia, A. Roggenkamp, A. Wiedemann, C.J. Kirschning, M. Aepfelbacher, and J. Heesemann Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression J. Exp. Med. 196 2002 1017 1024
113. J. Stack, I.R. Haga, M. Schroder, N.W. Bartlett, G. Maloney, P.C. Reading, K.A. Fitzgerald, G.L. Smith, and A.G. Bowie Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence J. Exp. Med. 201 2005 1007 1018
114. N. Suzuki, N.J. Chen, D.G. Millar, S. Suzuki, T. Horacek, H. Hara, D. Bouchard, K. Nakanishi, J.M. Penninger, P.S. Ohashi, and W.C. Yeh IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses J. Immunol. 170 2003 4031 4035
115. K. Tabeta, P. Georgel, E. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, and J. Goode Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Proc. Natl. Acad. Sci. USA 101 2004 3516 3521
116. K. Takahara, Y. Yashima, Y. Omatsu, H. Yoshida, Y. Kimura, Y.S. Kang, R.M. Steinman, C.G. Park, and K. Inaba Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins Int. Immunol. 16 2004 819 829
117. A. Takaoka, H. Yanai, S. Kondo, G. Duncan, H. Negishi, T. Mizutani, S. Kano, K. Honda, Y. Ohba, T.W. Mak, and T. Taniguchi Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors Nature 434 2005 243 249
118. O. Takeuchi, K. Hoshino, and S. Akira Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection J. Immunol. 165 2000 5392 5396
119. O. Takeuchi, T. Kawai, P.F. Muhlradt, M. Morr, J.D. Radolf, A. Zychlinsky, K. Takeda, and S. Akira Discrimination of bacterial lipoproteins by Toll-like receptor 6 Int. Immunol. 13 2001 933 940
120. O. Takeuchi, S. Sato, T. Horiuchi, K. Hoshino, K. Takeda, Z. Dong, R.L. Modlin, and S. Akira Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins J. Immunol. 169 2002 10 14
121. S. Thoma-Uszynski, S. Stenger, O. Takeuchi, M.T. Ochoa, M. Engele, P.A. Sieling, P.F. Barnes, M. Rollinghoff, P.L. Bolcskei, and M. Wagner Induction of direct antimicrobial activity through mammalian toll-like receptors Science 291 2001 1544 1547
122. L.H. Travassos, S.E. Girardin, D.J. Philpott, D. Blanot, M.A. Nahori, C. Werts, and I.G. Boneca Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition EMBO Rep. 5 2004 1000 1006
123. S. Uematsu, S. Sato, M. Yamamoto, T. Hirotani, H. Kato, F. Takeshita, M. Matsuda, C. Coban, K.J. Ishii, and T. Kawai Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction J. Exp. Med. 201 2005 915 923
124. D.M. Underhill, E. Rossnagle, C.A. Lowell, and R.M. Simmons Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production Blood 106 2005 2543 2550
125. D. Verthelyi, K.J. Ishii, M. Gursel, F. Takeshita, and D.M. Klinman Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs J. Immunol. 166 2001 2372 2377
126. C. Wang, L. Deng, M. Hong, G.R. Akkaraju, J. Inoue, and Z.J. Chen TAK1 is a ubiquitin-dependent kinase of MKK and IKK Nature 412 2001 346 351
127. T. Wang, T. Town, L. Alexopoulou, J.F. Anderson, E. Fikrig, and R.A. Flavell Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis Nat. Med. 10 2004 1366 1373
128. C. Werts, R.I. Tapping, J.C. Mathison, T.H. Chuang, V. Kravchenko, I. Saint Girons, D.A. Haake, P.J. Godowski, F. Hayashi, and A. Ozinsky Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism Nat. Immunol. 2 2001 346 352
129. L.G. Xu, Y.Y. Wang, K.J. Han, L.Y. Li, Z. Zhai, and H.B. Shu VISA is an adapter protein required for virus-triggered IFN-beta signaling Mol. Cell 19 2005 727 740
130. M. Yamamoto, S. Sato, H. Hemmi, H. Sanjo, S. Uematsu, T. Kaisho, K. Hoshino, O. Takeuchi, M. Kobayashi, and T. Fujita Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 Nature 420 2002 324 329
131. M. Yamamoto, S. Sato, K. Mori, K. Hoshino, O. Takeuchi, K. Takeda, and S. Akira Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling J. Immunol. 169 2002 6668 6672
132. M. Yamamoto, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Sanjo, O. Takeuchi, M. Sugiyama, M. Okabe, K. Takeda, and S. Akira Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway Science 301 2003 640 643
133. M. Yamamoto, S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, T. Kaisho, O. Takeuchi, K. Takeda, and S. Akira TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway Nat. Immunol. 4 2003 1144 1150
134. M. Yamamoto, S. Yamazaki, S. Uematsu, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Kuwata, O. Takeuchi, and K. Takeshige Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta Nature 430 2004 218 222
135. F. Yarovinsky, D. Zhang, J.F. Andersen, G.L. Bannenberg, C.N. Serhan, M.S. Hayden, S. Hieny, F.S. Sutterwala, R.A. Flavell, S. Ghosh, and A. Sher TLR11 activation of dendritic cells by a protozoan profilin-like protein Science 308 2005 1626 1629
136. R.M. Yates, and D.G. Russell Phagosome maturation proceeds independently of stimulation of toll-like receptors 2 and 4 Immunity 23 2005 409 417
137. K. Yonekura, S. Maki-Yonekura, and K. Namba Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy Nature 424 2003 643 650
138. M. Yoneyama, M. Kikuchi, T. Natsukawa, N. Shinobu, T. Imaizumi, M. Miyagishi, K. Taira, S. Akira, and T. Fujita The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Nat. Immunol. 5 2004 730 737
139. M. Yoneyama, M. Kikuchi, K. Matsumoto, T. Imaizumi, M. Miyagishi, K. Taira, E. Foy, Y.M. Loo, M. Gale Jr., and S. Akira Shared and unique functions of the DExD/H-Box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity J. Immunol. 175 2005 2851 2858
140. Y. Yu, S.E. Wang, and G.S. Hayward The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation Immunity 22 2005 59 70
141. D. Zhang, G. Zhang, M.S. Hayden, M.B. Greenblatt, C. Bussey, R.A. Flavell, and S. Ghosh A toll-like receptor that prevents infection by uropathogenic bacteria Science 303 2004 1522 1526