Pyogenic bacterial infections in humans with IRAK-4 deficiency

Science

Volumn 299, Issue 5615, 2003, Pages 2076-2079

  Picard, Capucine ^a   Puel, Anne ^a   Bonnet, Marion ^a   Ku, Cheng Lung ^a   Bustamante, Jacinta ^a   Yang, Kun ^a   Soudais, Claire ^a   Dupuis, Stéphanie ^a   Feinberg, Jacqueline ^a   Fieschi, Claire ^a   Elbim, Carole ^b   Hitchcock, Remi ^c   Lammas, David ^d   Davies, Graham ^e   Al Ghonaium, Abdulaziz ^f   Al Rayes, Hassan ^f   Al Jumaah, Sulaiman ^f   Al Hajjar, Sami ^f   Al Mohsen, Ibrahim Zaid ^f   Frayha, Husn H ^f   Rucker, Rajivi ^c   Hawn, Thomas R ^g   Aderem, Alan ^g   Tufenkeji, Haysam ^f   Haraguchi, Soichi ^c   Day, Noorbibi K ^c   Good, Robert A ^c   Gougerot Pocidalo, Marie Anne ^b   Ozinsky, Adrian ^g   Casanova, Jean Laurent ^a,h   more..

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Faculté Xavier Bichat   (France)

^c JOHNS HOPKINS ALL CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^f KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^g INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^h HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; HEALTH CARE; IMMUNIZATION; MOLECULES;

LIGANDS;

BACTERIA;

ADAPTOR PROTEIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

BACTERIAL DISEASE; BIOLOGY;

ARTICLE; BACTERIAL INFECTION; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENZYME DEFICIENCY; FIBROBLAST; GENE MUTATION; HUMAN; IMMUNE RESPONSE; INFECTION SENSITIVITY; LIGAND BINDING; MYCOBACTERIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; SALMONELLA; SIGNAL TRANSDUCTION;

ALLELES; CHILD; CODON, TERMINATOR; CYTOKINES; DROSOPHILA PROTEINS; FEMALE; FIBROBLASTS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKINS; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; MONOCYTES; MUTATION; NEUTROPHILS; PEDIGREE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PNEUMOCOCCAL INFECTIONS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM; SALMONELLA;

EID: 0037471003     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1081902     Document Type: Article

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30. We would like to thank L. Abel and J.-C. Weill for critical reading A. Casrouge, G. Courtois, M.-C. Fondanèche, C. Hivroz, S. Kayal, S. Weller and S. Stork for helpful discussions; and D. Recan for the EBV transformation of B cells. C.P. was supported by the INSERM, A.P. by a grant from the European Union, M.B. by the Legs Poix, C.LK. by the French-Taiwan research program, J.B. by Fondation Schlumberger, and R.A.G. and N.K.D. by the Newland Foundation and the Eleanor Naylor Dana Foundation, New York. This work was supported by the Fondation BNP-Paribas and the Fondation Schlumberger.