Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

Nature

Volumn 430, Issue 6996, 2004, Pages 218-222

  Yamamoto, Masahiro ^a   Yamazaki, Soh ^c   Uematsu, Satoshi ^a   Sato, Shintaro ^a,b   Hemmmi, Hiroaki ^a   Hoshino, Katsuaki ^e   Kaisho, Tsuneyasu ^e   Kuwata, Hirotaka ^a   Takeuchi, Osamu ^a,b   Takeshige, Koichiro ^c   Saitoh, Tatsuya ^f   Yamaoka, Shoji ^f   Yamamoto, Naoki ^f   Yamamoto, Shunsuke ^g   Muta, Tatsushi ^c,d   Takeda, Kiyoshi ^d   Akira, Shizuo ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e RIKEN YOKOHAMA INSTITUTE   (Japan)

^f TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^g BEPPU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; IMMUNOLOGY; POLYSACCHARIDES; PROTEINS; TUMORS;

PATHOGENS; TOLL-LIKE RECEPTORS (TLR);

GENES;

CYTOKINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 12; LIGAND; LIPOPOLYSACCHARIDE; NUCLEAR PROTEIN; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

GENETICS;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOLOGY; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RETROVIRUS;

ANIMALS; GENE EXPRESSION REGULATION; INTERLEUKIN-12; INTERLEUKIN-6; KINETICS; LIGANDS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN-1; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 3142581432     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02738     Document Type: Article

References (30)

1. Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol. 21, 335-376 (2003).
2. Janeway, C. A. Jr & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197-216 (2002).
3. O'Neill, L. A. Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. Curr. Opin. Pharmacol. 3, 396-403 (2003).
4. Yamazaki, S., Muta, T. & Takeshige, K. A novel IκB protein, IκB-ζ, induced by proinflammatory stimuli, negatively regulates nuclear factor-κB in the nuclei. J. Biol. Chem. 276, 27657-27662 (2001).
5. Kitamura, H., Kanehira, K., Okita, K., Morimatsu, M. & Saito, M. MAIL, a novel nuclear IκB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 485, 53-56 (2000).
6. Haruta, H., Kato, A. & Todokoro, K. Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. J. Biol. Chem. 276, 12485-12488 (2001).
7. Muzio, M., Ni, J., Feng, P. & Dixit, V. M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612-1615 (1997).
8. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847 (1997).
9. Medzhitov, R. et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2, 253-258 (1998).
10. Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732-738 (2001).
11. Kawai, T. et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167, 5887-5894 (2001).
12. Doyle, S. et al. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 17, 251-263 (2002).
13. Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell 109 (suppl.), S81-S96 (2002).
14. Zhang, G. & Ghosh, S. Molecular mechanisms of NF-κB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J. Endotoxin Res. 6, 453-457 (2000).
15. Janssens, S. & Beyaert, R. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell 11, 293-302 (2003).
16. Eto, A., Muta, T., Yamazaki, S. & Takeshige, K. Essential roles for NF-κB and a Toll/IL-1 receptor domain-specific signal(s) in the induction of IκB-ζ. Biochem. Biophys. Res. Commun. 301, 495-501 (2003).
17. Akira, S., Taga, T. & Kishimoto, T. Interleukin-6 in biology and medicine. Adv. Immunol. 54, 1-78 (1993).
18. Matsusaka, T. et al. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad. Sci. USA 90, 10193-10197 (1993).
19. Zhong, H., May, M. J., Jimi, E. & Ghosh, S. The phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-1. Mol. Cell 9, 625-636 (2002).
20. Sha, W. C., Liou, H. C., Tuomanen, E. I. & Baltimore, D. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80, 321-330 (1995).
21. Sanjabi, S., Hoffmann, A., Liou, H. C., Baltimore, D. & Smale, S. T. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc. Natl Acad. Sci. USA 97, 12705-12710 (2000).
22. Hoffmann, A., Leung, T. H. & Baltimore, D. Genetic analysis of NF-κB/Rel transcription factors defines functional specificities. EMBO J. 22, 5530-5539 (2003).
23. Hill, M. R. & McCallum, R. E. Identification of tumor necrosis factor as a transcriptional regulator of the phosphoenolpyruvate carboxykinase gene following endotoxin treatment of mice. Infect. Immun. 60, 4040-4050 (1992).
24. Pasparakis, M. et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 417, 861-866 (2002).
25. Douni, E. et al. Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. J. Inflamm. 47, 27-38 (1995).
26. Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent Toll-Like Receptor signaling pathway. Science 301, 640-643 (2003).
27. Kinoshita, S., Akira, S. & Kishimoto, T. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad. Sci. USA 89, 1473-1476 (1992).
28. Saitoh, T. et al. TWEAK induces NF-κB2 p100 processing and long lasting NF-κB activation. J. Biol. Chem. 278, 36005-36012 (2003).
29. Toshchakov, V. et al. TLR4, but not TLR2, mediates IFN-β-induced STAT1α/β-dependent gene expression in macrophages. Nature Immunol. 3, 392-398 (2002).
30. Kuwata, H. et al. IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages. Blood 102, 4123-4129 (2003).