Regulation of Phagosome Maturation by Signals from Toll-Like Receptors

Science

Volumn 304, Issue 5673, 2004, Pages 1014-1018

  Blander, J Magarian ^a   Medzhitov, Rusian ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; CELLS; MICROORGANISMS; PATHOLOGY; SIGNALING;

APOPTOTIC CELLS; PHAGOCYTOSIS; SIGNALING PATHWAYS;

BIOTECHNOLOGY;

GREEN FLUORESCENT PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; ENZYME INHIBITOR; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYD88 PROTEIN, MOUSE; RECOMBINANT PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

MEDICINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FLUORESCENCE ACTIVATED CELL SORTING; HOST RESISTANCE; INTERNALIZATION; LYSOSOME; MACROPHAGE; METAZOON; MICROBIAL DEGRADATION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; BACTERIUM; DRUG ANTAGONISM; ENZYME ACTIVATION; ESCHERICHIA COLI; GENETICS; IMMUNOELECTRON MICROSCOPY; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; ULTRASTRUCTURE;

ANIMALIA; METAZOA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; APOPTOSIS; BACTERIA; ENZYME ACTIVATION; ENZYME INHIBITORS; ESCHERICHIA COLI; LYSOSOMES; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICROSCOPY, IMMUNOELECTRON; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID DIFFERENTIATION FACTOR 88; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHAGOCYTOSIS; PHAGOSOMES; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; TOLL-LIKE RECEPTORS;

EID: 2342525996     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1096158     Document Type: Article

References (24)

1. E. Metchnikoff, Immunity in Infective Diseases (Cambridge Univ. Press, Cambridge. 1905).
2. A. Aderem, D. M. Underhill, Annu. Rev. Immunol. 17, 593 (1999).
3. S. Greenberg, S. Grinstein, Curr. Opin. Immunol. 14, 136 (2002).
4. P. M. Henson, D. L. Bratton, V. A. Fadok, Curr. Biol. 11, R795 (2001).
5. P. H. Henson, D. L. Bratton, V. A. Fadok, Nature Rev. Mol. Cell Biol. 2, 627 (2001).
6. D. M. Underhill, A. Ozinsky, Annu. Rev. Immunol. 20, 825 (2002).
7. J. Gruenberg, F. R. Maxfield, Curr. Opin. Cell Biol. 7, 552 (1995).
8. K. Takeda, T. Kaisho, S. Akira, Annu. Rev. Immunol. 21, 335 (2003).
9. E. Caron, A. Hall, Science 282, 1717 (1998).
10. Information on materials and methods is available on Science Online.
11. J. M. Blander, R. Medzhitov, unpublished observations.
12. O. V. Vieira, R. J. Botelho, S. Grinstein, Biochem. J. 366, 689 (2002).
13. S. Kornfeld, I. Mellman, Annu. Rev. Cell Biol. 5, 483 (1989).
14. B. Storrie, M. Desjardins, Bioessays 18, 895 (1996).
15. I. Mellman, R. M. Steinman, Cell 106, 255 (2001).
16. L. E. Via et al., J. Cell Sci. 111, 897 (1998).
17. C. L. Howe et al., Proc. Natl. Acad. Sci. U.S.A. 85, 7577 (1988).
18. B. L. Granger et al., J. Biol. Chem. 265, 12036 (1990).
19. O. Takeuchi et al., Immunity 11, 443 (1999).
20. E. S. Trombetta, M. Ebersold, W. Garrett, M. Pypaert, I. Mellman, Science 299, 1400 (2003).
21. V. Cavalli et al., Mol. Cell 7, 421 (2001).
22. S. R. Pfeffer, Trends Cell Biol. 11, 487 (2001).
23. C. M. Rosenberger, B. B. Finlay, Nature Rev. Mol. Cell Biol. 4, 385 (2003).
24. We are indebted to I. Mellman, P. Cresswell, M. Pypaert, S. Ebersold, A. Rudensky, J. Galan, L. Hernandez, J. Shanabrough, N. Dometios, C. Annicelli, T. Potselueva, J. Kagan, A. Unni, D. Amsen, and S. Biander. J.M.B. was supported by a J. V. Satterfield Arthritis Investigator Award. R.M. was supported by the Howard Hughes Medical Institute and NIH grant AI46688.