Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells

European Journal of Immunology

Volumn 31, Issue 7, 2001, Pages 2154-2163

  Krug, Anne ^a   Rothenfusser, Simon ^a   Hornung, Veit ^a   Jahrsdrfer, Bernd ^b   Blackwell, Susan ^a   Ballas, Zuhair K ^b   Endres, Stefan ^a   Krieg, Arthur M ^a   Hartmann, Gunther ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

CpG oligonucleotide; Dendritic cell; IFN IFN ; Plasmacytoid dendritic cell; Type I interferon

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD4 ANTIGEN; GAMMA INTERFERON; OLIGODEOXYNUCLEOTIDE; OLIGONUCLEOTIDE; T LYMPHOCYTE RECEPTOR;

ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; CPG ISLAND; CYTOLYSIS; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE SYSTEM; INTERFERON INDUCTION; INTERFERON PRODUCTION; MOLECULAR RECOGNITION; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; PERIPHERAL LYMPHOCYTE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN METHYLATION; PROTEIN MOTIF; SEQUENCE ANALYSIS; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; DENDRITIC CELLS; HUMANS; INTERFERON TYPE I; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-BETA; KILLER CELLS, NATURAL; MEMBRANE GLYCOPROTEINS; OLIGODEOXYRIBONUCLEOTIDES; STEM CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034933019     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U     Document Type: Article

References (53)

1. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons
2. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
3. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
4. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
5. Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro
6. CpG motifs in bacterial DNA trigger direct B cell activation
7. Heterogeneity of genomes: Measures and values
8. Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses?
9. A Toll-like receptor recognizes bacterial DNA
10. Mechanisms and therapeutic applications of immune stimulatory CpG DNA
11. The role of CpG motifs in innate immunity
12. Bacterial CpG DNA activates immune cells to signal infectious danger
13. Mechanism and function of a newly identified CpG DNA motif in human primary cells
14. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
15. CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orang utans
16. Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys
17. Dendritic cells and the control of immunity
18. Human blood dendritic cell-like B cells isolated by the 5G9 monoclonal antibody reactive with a novel 220-kDa antigen
19. A novel dendritic cell population in human blood: One-step immunomagnetic isolation by a specific mAb (M-DC8) and in vitro priming of cytotoxic T lymphocytes
20. + subset of human blood dendritic cells is a direct precursor of Langerhans cells
21. CpG DNA as a signal for growth, activation and maturation of human dendritic cells
22. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
23. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium
24. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
25. Human peripheral blood dendritic cell subsets. Isolation and characterization of precursor and mature antigen-presenting cells
26. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
27. Distinct signals control the hematopoiesis of lymphoid-related dendritic cells
28. The nature of the principal type 1 interferon-producing cells in human blood
29. Dendritic cells and IFN-alpha-producing cells are two functionally distinct non-B, non-monocytic HLA-DR+ cell subsets in human peripheral blood
30. Phenotype of human alpha-interferon producing leucocytes identified by monoclonal antibodies
31. Human natural interferon-alpha producing cells
32. Natural interferon alpha/beta-producing cells link innate and adaptive immunity
33. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
34. + peripheral blood dendritic cells are differentially regulated by cytokines
35. CpG DNA and LPS induce distinct patterns of activation in human monocytes
36. Immunostimulatory CpG motifs trigger a T helper-1 immune response to human immunodeficiency virus type-1 (HIV-1) gp 160 envelope proteins
37. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
38. DNA activates human immune cells through a CpG sequence-dependent manner
39. CpG-oligodeoxynucleotides enhance T cell receptor-triggered interferon-gamma production and upregulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12
40. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro
41. Phylogenetic perspectives in innate immunity
42. Linking innate and adaptive immunity
43. Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices
44. Oligonucleotides tethered to a short polyguanylic acid stretch are targeted to macrophages: Enhanced antiviral activity of a vesicular stomatitis virus-specific antisense oligonucleotide
45. Two roads diverged: Interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection
46. IFN-alpha-expressing tumor cells enhance generation and promote survival of tumor-specific CTLs
47. Type I interferons keep activated T cells alive
48. Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs
49. + T cells in vivo by IL-15
50. The human interferon-alpha species and hybrid proteins
51. Specific suppression of human tumor necrosis factor-alpha synthesis by antisense oligodeoxynucleotides
52. Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes
53. + lymphokine-activated killer subset