-
3
-
-
0009164009
-
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, Issue.10
, pp. 5591-5686
-
-
Shan, B.1
Medina, J.C.2
Santha, E.3
Frankmoelle, W.P.4
Chou, T.C.5
Learned, R.M.6
Narbut, M.R.7
Stott, D.8
Wu, P.9
Jaen, J.C.10
Rosen, T.11
Timmermans, P.B.12
Beckmann, H.13
-
6
-
-
0033552881
-
-
(1999)
J. Med. Chem
, vol.42
, Issue.1
, pp. 67-86
-
-
Turpin, J.A.1
Song, Y.2
Inman, J.K.3
Huang, M.4
Wallqvist, A.5
Maynard, A.6
Covell, D.G.7
Rice, W.G.8
Appella, E.9
-
7
-
-
15844366372
-
-
(1996)
Biochemistry
, vol.35
, Issue.18
, pp. 5838-5846
-
-
Baum, E.Z.1
Siegel, M.M.2
Bebernitz, G.A.3
Hulmes, J.D.4
Sridharan, L.5
Sun, L.6
Tabei, K.7
Johnston, S.H.8
Wildey, M.J.9
Nygaard, J.10
Jones, T.R.11
Gluzman, Y.12
-
9
-
-
0035227644
-
-
(2001)
Acta Biochim. Pol
, vol.48
, Issue.1
, pp. 1-20
-
-
Grzonka, Z.1
Jankowska, E.2
Kasprzykowski, F.3
Kasprzykowska, R.4
Lankiewicz, L.5
Wiczk, W.6
Wieczerzak, E.7
Ciarkowski, J.8
Drabik, P.9
Janowski, R.10
Kozak, M.11
Jaskolski, M.12
Grubb, A.13
-
25
-
-
85037012848
-
-
Cortech Inc., US Patent 6,004,933
-
-
-
-
26
-
-
85037008789
-
-
Apotex Inc., US Patent 6,162,791
-
-
-
-
35
-
-
0035514751
-
-
(2001)
J. Chem. Inf. Comput. Sci
, vol.41
, Issue.6
, pp. 1578-1586
-
-
Ekins, S.1
Durst, G.L.2
Stratford, R.E.3
Thorner, D.A.4
Lewis, R.5
Loncharich, R.J.6
Wikel, J.H.7
-
42
-
-
0035830510
-
-
(2001)
J. Org. Chem
, vol.66
, Issue.3
, pp. 697-706
-
-
Demarcus, M.1
Ganadu, M.L.2
Mura, G.M.3
Porcheddu, A.4
Quaranta, L.5
Reginato, G.6
Taddei, M.7
-
44
-
-
85037017686
-
-
PDB: www.rcsb.org/pdb
-
-
-
-
46
-
-
0035953314
-
-
(2001)
J. Med. Chem
, vol.44
, Issue.9
, pp. 1380-1395
-
-
Marquis, R.W.1
Ru, Y.2
LoCastro, S.M.3
Zeng, J.4
Yamashita, D.S.5
Oh, H.J.6
Erhard, K.F.7
Davis, L.D.8
Tomaszek, T.A.9
Tew, D.10
Salyers, K.11
Proksch, J.12
Ward, K.13
Smith, B.14
Levy, M.15
Cummings, M.D.16
Haltiwanger, R.C.17
Trescher, G.18
Wang, B.19
Hemling, C.J.20
Cheng, H.Y.21
Lin, F.22
Smith, W.W.23
Janson, C.A.24
Zhao, B.25
McQueney, M.S.26
D'Alessio, K.27
Lee, C.P.28
Marzulli, A.29
Dodds, R.A.30
Blake, S.31
Hwang, S.M.32
James, I.E.33
Gress, C.J.34
Bradley, B.R.35
Lark, M.W.36
Gowen, M.37
Veber, D.F.38
more..
-
47
-
-
0035282807
-
-
(2001)
J. Med. Chem
, vol.44
, Issue.5
, pp. 725-736
-
-
Marquis, R.W.1
Ru, Y.2
Zeng, J.3
Trout, R.E.4
LoCastro, S.M.5
Gribble, A.D.6
Witherington, J.7
Fenwick, A.E.8
Garnier, B.9
Tomaszek, T.10
Tew, D.11
Hemling, M.E.12
Quinn, C.J.13
Smith, W.W.14
Zhao, B.15
McQueney, M.S.16
Janson, C.A.17
D'Alessio, K.18
Veber, D.F.19
-
48
-
-
0035924180
-
-
(2001)
J. Med. Chem
, vol.44
, pp. 4524-4534
-
-
Greenspan, P.D.1
Clark, K.L.2
Tommasi, R.A.3
Cowen, S.D.4
McQuire, L.W.5
Farley, D.L.6
van Duzer, J.H.7
Goldberg, R.L.8
Zhou, H.9
Du, Z.10
Fitt, J.J.11
Coppa, D.E.12
Fang, Z.13
Macchia, W.14
Zhu, L.15
Michael, P.16
-
49
-
-
0034719344
-
-
(2000)
Biochem. Biophys. Res. Commun
, vol.267
, Issue.3
, pp. 850-854
-
-
Katunuma, N.1
Matsui, A.2
Inubushi, T.3
Murata, E.4
Kakegawa, H.5
Ohba, Y.6
Turk, D.7
Turk, V.8
Tada, Y.9
Asao, T.10
-
86
-
-
85037018957
-
-
Clinical trial database: www.centerwatch.com
-
-
-
-
87
-
-
85037008908
-
-
Clinical trial database: www.biospace.com
-
-
-
-
88
-
-
0034805342
-
-
(2001)
Biochem. Biophys. Res. Commun
, vol.283
, Issue.2
, pp. 334-339
-
-
Hashimoto, Y.1
Kakegawa, H.2
Narita, Y.3
Hachiya, Y.4
Hayakawa, T.5
Kos, J.6
Turk, V.7
Katunuma, N.8
-
91
-
-
0033850811
-
-
(2000)
Eur. J. Biochem
, vol.267
, pp. 5404-5412
-
-
Klemencic, I.1
Carmona, A.K.2
Cezari, M.H.S.3
Juliano, M.A.4
Juliano, L.5
Gunkar, G.6
Turk, D.7
Krizaj, T.8
Turk, V.9
Turk, B.10
-
92
-
-
0034930050
-
-
(2001)
Biol. Chem
, vol.382
, Issue.5
, pp. 839-845
-
-
Ménard, R.1
Therrien, C.2
Lachance, P.3
Sulea, T.4
Qo, H.5
Alvarez-Hernandez, A.D.6
Roush, W.R.7
-
93
-
-
0035814913
-
-
(2001)
Biochemistry
, vol.40
, Issue.9
, pp. 2702-2711
-
-
Therrien, C.1
Lachance, P.2
Sulea, T.3
Purisima, E.O.4
Qi, H.5
Ziomek, E.6
Alvarez-Hernandez, A.7
Roush, W.R.8
Ménard, R.9
-
94
-
-
0035079963
-
-
(2001)
Arthritis Rheum
, vol.44
, Issue.3
, pp. 703-711
-
-
Biroc, S.L.1
Gay, S.2
Hummel, K.3
Magill, C.4
Palmer, J.T.5
Spencer, D.R.6
Sa, S.7
Klaus, J.L.8
Michel, B.A.9
Rasnick, D.10
Gay, R.E.11
-
95
-
-
0033802292
-
-
(2000)
J. Exp. Med
, vol.192
, Issue.6
, pp. 789-799
-
-
Punturieri, A.1
Filippov, S.2
Allen, E.3
Caras, I.4
Murray, R.5
Reddy, V.6
Weiss, S.J.7
-
98
-
-
0034043560
-
-
(2000)
J. Antibiot. (Tokyo)
, vol.53
, Issue.5
, pp. 449-458
-
-
Otsuka, T.1
Muramatsu, Y.2
Nakanishi, T.3
Hatanaka, H.4
Okamoto, M.5
Hino, M.6
Hashimoto, S.7
-
99
-
-
0032817682
-
-
(1999)
J. Antibiot. (Tokyo)
, vol.52
, Issue.6
, pp. 536-541
-
-
Otsuka, T.1
Muramatsu, Y.2
Higaki, T.3
Nakanishi, T.4
Takase, S.5
Hatanaka, H.6
Okamoto, M.7
Hino, M.8
Hashimoto, S.9
-
100
-
-
0032561376
-
-
(1998)
J. Med. Chem
, vol.41
, Issue.22
, pp. 4301-4308
-
-
Yasuma, T.1
Oi, S.2
Choh, N.3
Nomura, T.4
Furuyama, N.5
Nishimura, A.6
Fujisawa, Y.7
Sohda, T.8
-
101
-
-
0029944602
-
-
(1996)
Eur. J. Pharmacol
, vol.300
, pp. 131-135
-
-
Woo, J.T.1
Yamaguchi, K.2
Hayami, T.3
Kobori, T.4
Sigeizumi, S.5
Sugimoto, K.6
Kondo, K.7
Tsugi, T.8
Ohba, Y.9
Tagami, K.10
Sumitani, K.11
-
102
-
-
0035804301
-
-
(2001)
J. Med. Chem
, vol.44
, Issue.1
, pp. 94-104
-
-
Falgueyret, J.P.1
Oballa, R.M.2
Okamoto, O.3
Wesolowski, G.4
Aubin, Y.5
Rydzewski, R.M.6
Prasit, P.7
Riendeau, D.8
Rodan, S.B.9
Percival, M.D.10
-
103
-
-
0035853837
-
-
(2001)
J. Biol. Chem
, vol.276
, Issue.15
, pp. 11507-11511
-
-
James, I.E.1
Marquis, R.W.2
Blake, S.M.3
Hwang, S.M.4
Gress, C.J.5
Ru, Y.6
Zembryki, D.7
Yamashita, D.S.8
McQueney, M.S.9
Tomaszek, T.A.10
Oh, H.J.11
Gowen, M.12
Veber, D.F.13
Lark, M.W.14
-
104
-
-
0034808707
-
-
(2001)
J. Bone Miner. Res
, vol.16
, Issue.10
, pp. 1739-1746
-
-
Stroup, G.B.1
Lark, M.W.2
Veber, D.F.3
Bhattacharyya, A.4
Blake, S.5
Dare, L.C.6
Erhard, K.F.7
Hoffman, S.J.8
James, I.E.9
Marquis, R.W.10
Ru, Y.11
Vasko-Moser, J.A.12
Smith, B.R.13
Tomaszek, T.14
Gowen, M.15
-
108
-
-
0009088677
-
-
(1992)
Scrip
, vol.1765
, pp. 11
-
-
-
111
-
-
0032952098
-
-
(1999)
Biochim. Biophys. Acta
, vol.1431
, Issue.2
, pp. 290-305
-
-
Czaplewski, C.1
Grzonka, Z.2
Jaskolski, M.3
Kasprzykowski, F.4
Kozak, M.5
Politowska, E.6
Ciarkowski, J.7
-
112
-
-
0027969276
-
-
(1994)
J. Antibiot. (Tokyo)
, vol.47
, Issue.9
, pp. 1065-1068
-
-
Morishita, A.1
Ishikawa, S.2
Ito, Y.3
Ogawa, K.4
Takada, M.5
Yaginuma, S.6
Yamamoto, S.7
-
115
-
-
0029869327
-
-
(1996)
J. Antibiot. (Tokyo)
, vol.49
, Issue.4
, pp. 395-397
-
-
Yu, C.M.1
Curtis, J.M.2
Walter, J.A.3
Wright, J.L.4
Ayer, S.W.5
Kaleta, J.6
Querengesser, L.7
Fathi-Afshar, Z.R.8
-
117
-
-
0009089809
-
-
(1995)
Biochemistry
, vol.34
, Issue.14
, pp. 4197-4791
-
-
Turk, D.1
Podobnik, M.2
Popovik, T.3
Katunuma, N.4
Bode, W.5
Huber, R.6
Turk, V.7
-
118
-
-
0030961306
-
-
(1997)
J. Biochem
, vol.121
, pp. 974-977
-
-
Yamamoto, A.1
Hara, T.2
Tomoo, K.3
Ishida, T.4
Fujii, T.5
Hata, Y.6
Murata, M.7
Kitamura, K.8
-
129
-
-
0032988367
-
-
(1999)
Bioorg. Med. Chem
, vol.7
, pp. 571-579
-
-
Ando, R.1
Sakaki, T.2
Morinaka, Y.3
Takahashi, C.4
Tamao, Y.5
Yoshii, N.6
Katayama, S.7
Saito, K.-I.8
Tokuyama, H.9
Isaka, M.10
Nakamura, E.11
-
134
-
-
85037016771
-
"Chemistry and Properties of 1,2,4- Thiadiazoles"
-
Synergy Apotex Scientific Affairs Technical Symposium, Toronto, 22-Nov-2000
-
(2000)
-
-
Tam, T.1
Leung-Toung, R.2
Wodzinska, J.3
Li, W.4
Bryson, S.5
Ngooi, T.-K.6
Karimian, K.7
-
139
-
-
0035914606
-
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, Issue.22
, pp. 2951-2954
-
-
Smith, R.A.1
Bhargava, A.2
Browe, C.3
Chen, J.4
Dumas, J.5
Hatoum-Mokdad, H.6
Romero, R.7
-
140
-
-
85037013221
-
-
Malaria Foundation International, Roll Back Malaria (08-Jan-)
-
(2002)
-
-
-
148
-
-
0035935182
-
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, Issue.20
, pp. 2759-2762
-
-
Roush, W.R.1
Cheng, J.2
Knapp-Reed, B.3
Alvarez-Hernandez, A.4
McKerrow, J.H.5
Hansell, E.6
Engel, J.C.7
-
150
-
-
0035357889
-
-
(2001)
J. Eur. J. Med. Chem
, vol.36
, Issue.6
, pp. 555-560
-
-
Dominguez, J.N.1
Charris, J.E.2
Lobo, G.3
Gamboa de Dominguez, N.4
Moreno, M.M.5
Riggione, F.6
Sanchez, E.7
Olson, J.8
Rosenthal, P.9
-
152
-
-
0035946353
-
-
(2001)
Mol. Biochem. Parasitol
, vol.114
, Issue.1
, pp. 41-52
-
-
Lima, A.P.1
dos Reis, F.C.2
Serveau, C.3
Lalmanach, G.4
Juliano, L.5
Menard, R.6
Vernet, T.7
Thomas, D.Y.8
Storer, A.C.9
Scharfstein, J.10
-
157
-
-
0034910189
-
-
(2001)
Mol. Biochem. Parasitol
, vol.116
, Issue.1
, pp. 1-9
-
-
Alves, L.C.1
Judice, W.A.2
St Hilaire, P.M.3
Meldal, M.4
Sanderson, S.J.5
Mottram, J.C.6
Coombs, G.H.7
Juliano, L.8
Juliano, M.A.9
-
158
-
-
0035946413
-
-
(2001)
Mol. Biochem. Parasitol
, vol.114
, Issue.1
, pp. 81-88
-
-
Alves, L.C.1
St Hilaire, P.M.2
Meldal, M.3
Sanderson, S.J.4
Mottram, J.C.5
Coombs, G.H.6
Juliano, L.7
Juliano, M.A.8
-
159
-
-
0034745154
-
-
(2001)
Eur. J. Biochem
, vol.268
, Issue.5
, pp. 1206-1212
-
-
Alves, L.C.1
Melo, R.L.2
Sanderson, S.J.3
Mottram, J.C.4
Coombs, G.H.5
Caliendo, G.6
Santagada, V.7
Juliano, L.8
Juliano, M.A.9
-
161
-
-
0032080601
-
-
(1998)
Bioorg. Med. Chem. Lett
, vol.8
, Issue.9
, pp. 993-998
-
-
Billson, J.1
Clark, J.2
Conway, S.P.3
Hart, T.4
Johnson, T.5
Langston, S.P.6
Ramjee, M.7
Quibell, M.8
Scott, R.K.9
-
162
-
-
0027984212
-
-
(1994)
J. Antibiot. (Tokyo)
, vol.47
, Issue.11
, pp. 1195-1201
-
-
Alvarez, M.E.1
Houck, D.R.2
White, C.B.3
Brownell, J.E.4
Bobko, M.A.5
Rodger, C.A.6
Stawicki, M.B.7
Sun, H.H.8
Gillum, A.M.9
Cooper, R.10
-
169
-
-
0034095571
-
-
(2000)
Chem. Biol
, vol.7
, Issue.6
, pp. 423-432
-
-
Wei, Y.1
Fox, T.2
Chambers, S.P.3
Sintchak, J.4
Coll, J.T.5
Golec, J.M.6
Swenson, L.7
Wilson, K.P.8
Charifson, P.S.9
-
170
-
-
0003139889
-
-
(2002)
Bioorg. Med. Chem
, vol.10
, Issue.1
, pp. 31-40
-
-
Shahripour, A.B.1
Plummer, M.S.2
Lunney, E.A.3
Albrecht, H.P.4
Hays, S.J.5
Kostlan, C.R.6
Sawyer, T.K.7
Walker, N.P.8
Brady, K.D.9
Allen, H.J.10
Talanian, R.V.11
Wong, W.W.12
Humblet, C.13
-
171
-
-
0035935185
-
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, Issue.20
, pp. 2779-2782
-
-
Shahripour, A.B.1
Plummer, M.S.2
Lunney, E.A.3
Sawyer, T.K.4
Stankovic, C.J.5
Connolly, M.K.6
Rubin, J.R.7
Walker, N.P.8
Brady, K.D.9
Allen, H.J.10
Talanian, R.V.11
Wong, W.W.12
Humblet, C.13
-
176
-
-
0035821595
-
-
(2001)
J. Med. Chem
, vol.44
, Issue.12
, pp. 2015-2026
-
-
Lee, D.1
Long, S.A.2
Murray, J.H.3
Adams, J.L.4
Nuttall, M.E.5
Nadeau, D.P.6
Kikly, K.7
Winkler, J.D.8
Sung, C.M.9
Ryan, M.D.10
Levy, M.A.11
Keller, P.M.12
DeWolf W.E., Jr.13
-
177
-
-
0034717269
-
-
(2000)
J. Biol. Chem
, vol.275
, Issue.21
, pp. 16007-16014
-
-
Lee, D.1
Long, S.A.2
Adams, J.L.3
Chan, G.4
Vaidya, K.S.5
Francis, T.A.6
Kikly, K.7
Winkler, J.D.8
Sung, C.M.9
Debouck, C.10
Richardson, S.11
Levy, M.A.12
DeWolf W.E., Jr.13
Keller, P.M.14
Tomaszek, T.15
Head, M.S.16
Ryan, M.D.17
Haltiwanger, R.C.18
Liang, C.A.19
McDevitt, P.J.20
Johanson, K.21
Concha, N.O.22
Chan, W.23
Abdel-Meguid, S.S.24
Badger, A.M.25
Lark, M.W.26
Nadeau, D.P.27
Suva, L.J.28
Gowen, M.29
Nuttall, M.E.30
more..
-
178
-
-
0034756945
-
-
(2001)
J. Pharmacol. Exp. Ther
, vol.299
, Issue.2
, pp. 775-781
-
-
Lamprecht, A.1
Ubrich, N.2
Yamamoto, H.3
Schafer, U.4
Takeuchi, H.5
Maincent, P.6
Kawashima, Y.7
Lehr, C.M.8
-
184
-
-
0036481561
-
-
(2002)
Int. J. Mol. Med
, vol.9
, Issue.2
, pp. 131-134
-
-
Colasanti, M.1
Gradoni, L.2
Mattu, M.3
Persichini, T.4
Salvati, L.5
Venturini, G.6
Ascenzi, P.7
-
185
-
-
0037060908
-
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, Issue.5
, pp. 733-738
-
-
Dragovich, P.S.1
Prins, T.J.2
Zhou, R.3
Johnson, T.O.4
Brown, E.L.5
Maldonado, F.C.6
Fuhrman, S.A.7
Zalman, L.S.8
Patick, A.K.9
Matthews, D.A.10
Hou, X.11
Meador J.W. III12
Ferre, R.A.13
Worland, S.T.14
-
186
-
-
0009243946
-
-
ASAP Article Web Release Date: March 8
-
(2002)
J. Med. Chem
-
-
Dragovich, P.S.1
Prins, T.J.2
Zhou, R.3
Brown, E.L.4
Maldonado, F.C.5
Fuhrman, S.A.6
Zalman, L.S.7
Tuntland, T.8
Lee, C.A.9
Patick, A.K.10
Matthews, D.A.11
Hendrickson, T.F.12
Kosa, M.B.13
Liu, B.14
Batugo, M.R.15
Gleeson, J.-P.R.16
Sakata J.W., III.17
Ferre, R.A.18
Worland, S.T.19
-
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-
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-
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188
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85037015456
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(press release 08-Jan-02)
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189
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85037008426
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(press release 05-Feb-02)
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190
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(press release 31-Jan-02)
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