S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids

European Journal of Biochemistry

Volumn 268, Issue 5, 2001, Pages 1206-1212

  Alves, Lira C ^a   Melo, Robson L ^a   Sanderson, Sanya J ^b   Mottram, Jeremy C ^c   Coombs, Graham H ^b   Caliendo, Giuseppe ^d   Santagada, Vincenzo ^d   Juliano, Luiz ^a   Juliano, Maria A ^a,e  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e NONE   (Brazil)

Author keywords

Cathepsin L; Cruzain; Cysteine proteinase of Leishmania mexicana; Papain

Indexed keywords

2 AMINOBENZOYLPHENYLALANYLARGINYLSERYLARGINYLGLUTAMINE N (2,4 DINITROPHENYL)ETHYLENEDIAMINE; AMINO ACID; CATHEPSIN L; CRUZIPAIN; CYSTEINE PROTEINASE; PAPAIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; CATHEPSIN; CRUZAIN, TRYPANOSOMA CRUZI; CYSTEINE PROTEINASE INHIBITOR; LMCPB PROTEIN, LEISHMANIA MEXICANA; PEPTIDE; PROTEINASE; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROLYSIS; LEISHMANIA MEXICANA; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BINDING SITE; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; KINETICS; METABOLISM; SYNTHESIS; THERMODYNAMICS;

LEISHMANIA MEXICANA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

ANIMALS; BINDING SITES; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; KINETICS; LEISHMANIA MEXICANA; PAPAIN; PEPTIDES; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0034745154     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.01973.x     Document Type: Article

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