Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 20, 2001, Pages 2779-2782

  Shahripour, Aurash B ^a   Plummer, Mark S ^a   Lunney, Elizabeth A ^a   Sawyer, Tomi K ^a   Stankovic, Charles J ^a   Connolly, Michael K ^a   Rubin, John R ^a   Walker, Nigel P C ^b   Brady, Kenneth D ^b   Allen, Hamish J ^b   Talanian, Robert V ^b   Wong, Winnie W ^b   Humblet, Christine ^a  

^a PFIZER INC   (United States)

^b BASF Bioresearch Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE INHIBITOR; DIPHENYL ETHER; DIPHENYL ETHER SULFONAMIDE; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HYDROPHOBICITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CASPASE 1; DRUG DESIGN; ENZYME INHIBITORS; ETHERS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0035935185     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00573-X     Document Type: Article

References (13)