AG-7088 Pfizer

Current Opinion in Investigational Drugs

Volumn 1, Issue 3, 2000, Pages 297-302

  Witherell, G ^a  

^a Questcor Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AG 6084; AG 7185; CYSTEINE PROTEINASE; INTERLEUKIN 6; INTERLEUKIN 8; PLECONARIL; PROTEINASE; PROTEINASE INHIBITOR; RUPINTRIVIR; UNCLASSIFIED DRUG;

CLINICAL TRIAL; COMMON COLD; DOSE RESPONSE; DRUG ACCUMULATION; DRUG SYNTHESIS; DRUG TOLERANCE; ENZYME INHIBITION; HUMAN; HUMAN RHINOVIRUS; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTIVIRAL AGENTS; CLINICAL TRIALS; DRUGS, INVESTIGATIONAL; HUMANS; ISOXAZOLES; PROTEASE INHIBITORS; PYRROLIDINONES; RHINOVIRUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033677384     PISSN: 09678298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. Agouron and Nastech to join forces in the battle against the common cold
2. In vitro isolation and characterization of a human rhinovirus variant resistant to a 3C protease inhibitor
3. In vitro selection of human rhinovirus relatively resistant to soluble intercellular adhesion molecule-1
4. Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: Design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements
5. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies
6. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies
7. Agouron reports results from preclinical testing of compound for treatment of common cold virus
8. Structure-based design of irreversible peptidyl and peptidomimetic human rhinovirus 3C protease inhibitors
9. American Chemical Society 217th National Meeting (Part VIII); Viral Proteases and Phosphorodiesterase Inhibitors, Anaheim, CA, USA
10. Structure-based design, synthesis and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics
11. Structure-based design, synthesis and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements
12. Structure-based design of irreversible tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
13. Comparative and in vitro antirhinoviral activity of AG-7088 and Pleconaril
14. Phase I evaluation of the safety and pharmacokinetics of intranasal AG-7088, a novel investigational 3-C protease inhibitor
15. Agouron initiates large clinical trial of AG7088 for treatment of the common cold
16. In vitro antiviral activity of AG-7088, a potent inhibitor of human rhinovirus 3C protease
17. Agouron's AG-7088 reduces cold symptoms in phase II trial
18. Protease inhibitors: Current status and future prospects
19. American Chemical Society 217th National Meeting (Part VIII); Viral Proteases and Phosphorodiesterase Inhibitors, Anaheim, CA, USA
20. Antiviral Research - 13th International Conference (Part XIII) Baltimore, MD, USA
21. Inhibition of human rhinovirus-induced cytokine production by AG-7088, a human rhinovirus 3C protease inhibitor
22. Design of rhinovirus protease inhibitors for the treatment of the common cold
23. AG-7088. Anti-rhinovirus drug HRV 3C protease inhibitor
24. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
25. First International Symposium on Influenza and Other Respiratory Viruses: Summary and overview: Kapalua, Maui, Hawaii, December 4-6, 1998
26. US major pharmaceutical model and pipeline book: 1st quarter 2000 issue
27. Protease inhibitors as antiviral agents
28. The common cold
29. The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds
30. The structures of picornaviral proteinases
31. Conservation of amino acids in human rhinovirus 3C protease correlates with broad spectrum antiviral activity of AG-7088, a novel HRV 3C protease inhibitor
32. The antiviral compound enviroxime targets the 3A coding region of rhinovirus and poliovirus
33. Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound
34. Discovery of pirodavir, a broad-spectrum inhibitor of rhinoviruses